Inside the Science of Pediatric Lung Disease

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Speeding Up Science With Patient-Derived Xenografts

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Cultivating Culture in a High-Growth, High-Performance Organization

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Catherine Krawczeski, MD
Cultivating Culture in a High-Growth, High-Performance Organization
 Cultivating Culture in a High-Growth, High-Performance Organization 700 407 Catherine Krawczeski, MD
By: Catherine Krawczeski, MD

Catherine Krawczeski, MD, chief medical officer and physician-in-chief at Nationwide Children’s shares her thoughts on how to drive a positive, collaborative culture while pursuing academic and clinical excellence. When you walk through the doors of Nationwide Children’s Hospital, you can feel it: the energy,…

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Making Universal Donor CAR NK Cells
 Making Universal Donor CAR NK Cells 1024 320 Abbie Miller
By: Abbie Miller

This article appeared in the 2025 Fall/Winter print issue. Download the issue here.   Image credit: Nationwide Children’s Read the Full Article: Universal Donor CAR NK Cells: A New Platform Technology for Cancer About the authorAuthorArticles by the Author Abbie MillerAbbie (Roth) Miller, MS, MWC,…

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Intravenous (IV) chemotherapy or Cell therapy treatment bag surrounded by cancer cells, fighting the disease
Universal Donor CAR NK Cells: A New Platform Technology for Cancer
 Universal Donor CAR NK Cells: A New Platform Technology for Cancer 1024 559 Abbie Miller
By: Abbie Miller

A first-in-human study of universal donor CAR NK cells for acute myeloid leukemia could pave a path for a new approach to treating cancer If you ask Dean Lee, MD, PhD, the new first-in-human trial to evaluate universal donor chimeric antigen receptor (CAR) natural…

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Close-up of nicotine pouches in a plastic container on a dark background, illustrating smokeless tobacco alternatives and nicotine addiction and poisoning risks.
New Study Finds Sharp Increase in Nicotine Pouch Ingestions Among Young Children
 New Study Finds Sharp Increase in Nicotine Pouch Ingestions Among Young Children 1024 683 Laura Dattner
By: Laura Dattner

Experts urge stronger regulations, a ban on flavors for all nicotine products and secure at-home storage to help prevent nicotine ingestions. A new study reveals that ingestions of nicotine pouches by young children in the United States have surged in recent years. Researchers at…

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Pediatric patient at a follow-up appointment after in-office ear tube insertion, with a doctor examining the child’s ear while the mother provides support.
From the Operating Room to the Clinic: A New Protocol for Ear Tube Surgery
 From the Operating Room to the Clinic: A New Protocol for Ear Tube Surgery 675 450 Alaina London
By: Alaina London

Nationwide Children’s Hospital is one of the only pediatric hospitals to offer in-office ear tubes as an established choice in their standard of care.  In the United States, bilateral myringotomy/ tympanostomy tube insertion (BTI), also known as ear tube surgery, is the most performed…

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Young pediatrician examining a little African-American girl at hospital. Health care, people concept
Primary Care Clinicians’ Comfort Level With Childhood Mental Health Medications
 Primary Care Clinicians’ Comfort Level With Childhood Mental Health Medications 1024 683 Shannon Caldwell
By: Shannon Caldwell

A recent survey of primary care clinicians revealed opportunities to improve mental health care for kids. Each year, 20% of children are diagnosed with a mental health condition, and an estimated $247 billion are spent on the treatment and management of childhood mental health…

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Pregnant woman smiling and holding her belly while awaiting a fetal echocardiogram to check her baby’s heart health during pregnancy.
Assessing the Clinical Utility of a Fetal Echocardiogram When a Sibling Has Congenital Heart Disease
 Assessing the Clinical Utility of a Fetal Echocardiogram When a Sibling Has Congenital Heart Disease 1024 695 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

A fetal echocardiogram when a sibling has congenital heart disease may not be clinically necessary if the fetus has a normal second-trimester level II ultrasound. A retrospective study led by Kacy Taylor, MSAH, RDCS, FASE, concluded that critical congenital heart disease (CHD) was not…

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Teenage girl having stomach ache, young woman health care provider examining her.
Beyond the Bedside: Nurses Conducting Research to Transform Pediatric Outcomes
 Beyond the Bedside: Nurses Conducting Research to Transform Pediatric Outcomes 1024 683 Madison Storm
By: Madison Storm

Nurses are vital to clinical research – supporting and conducting it. At Nationwide Children’s Hospital, nurse scientists are dedicated to advancing prevention, diagnosis and treatment of pediatric health conditions.   Nurses at Nationwide Children’s Hospital have long been recognized for their compassionate care and clinical…

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Premature baby receiving respiratory support through a nasal cannula in a neonatal intensive care unit, monitored and cared for by a health care provider.
Mode of Respiratory Support at 36 Weeks Predicts Weaning Timeline for Infants With Severe Bronchopulmonary Dysplasia
 Mode of Respiratory Support at 36 Weeks Predicts Weaning Timeline for Infants With Severe Bronchopulmonary Dysplasia 1024 683 Lauren Dembeck
By: Lauren Dembeck

Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, and its incidence is rising due to advances in neonatal care that have improved survival for extremely premature infants. Respiratory support is a cornerstone of management for these patients, yet the expected timeline…

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Real-Life Impact of ETI Therapy in Cystic Fibrosis: Insights From a Large Treatment Center
 Real-Life Impact of ETI Therapy in Cystic Fibrosis: Insights From a Large Treatment Center 706 470 Pam Georgiana
By: Pam Georgiana

Greater clinical gains observed in patients with severe lung disease, regardless of genotype. A recent prospective observational study led by Shahid I. Sheikh, MD, pediatric pulmonologist at Nationwide Children’s Hospital and professor of Pediatrics at The Ohio State University College of Medicine, offers insights…

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Pediatric Restless Legs Syndrome: More Common (and Impactful) Than You Might Think
 Pediatric Restless Legs Syndrome: More Common (and Impactful) Than You Might Think 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

This underdiagnosed condition is more than just a bedtime annoyance — it may reflect nutrient deficiencies and have major impacts on daytime behavior. Restless legs syndrome (RLS) affects 2-4% of school-aged children, with symptoms that can significantly impact sleep quality, family relationships and daytime…

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Featured Expert: Anna J. Kerlek, MD
 Featured Expert: Anna J. Kerlek, MD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Anna J. Kerlek, MD, is a physician specializing in child and adolescent psychiatry at Nationwide Children’s Hospital and is an Associate Professor at The Ohio State University College of Medicine. The Division of Behavioral Health at Nationwide Children’s is the largest of its kind…

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Featured Researcher: Laura Chavez, PhD, MPH
 Featured Researcher: Laura Chavez, PhD, MPH 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Improving access to health care for all, regardless of age, race, gender and socioeconomic background, is essential for numerous health and economic reasons — especially for children. It’s vital to understand and prevent health disparities from impacting children to ensure the best outcomes for…

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Study Explores Impact of Duffy Null Phenotype on Neutrophil Count and Hydroxyurea Dosing in Children With Sickle Cell Disease
 Study Explores Impact of Duffy Null Phenotype on Neutrophil Count and Hydroxyurea Dosing in Children With Sickle Cell Disease 1024 683 Lauren Dembeck
By: Lauren Dembeck

Children with sickle cell disease and the Duffy null phenotype may have lower measured neutrophil counts, but new research suggests that there are opportunities to optimize hydroxyurea regardless of Duffy null status. Sickle cell disease (SCD) primarily affects individuals of minority populations and can…

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Close up color photo of little boy holding hands on his belly
Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms
 Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms 1024 680 Pam Georgiana
By: Pam Georgiana

A retrospective analysis of the clinical correlation between gastric emptying scintigraphy and antroduodenal manometry in pediatric patients with upper GI symptoms. Children with persistent nausea, vomiting or abdominal pain often undergo extensive testing to evaluate for underlying etiologies such as pediatric intestinal pseudo-obstruction, rumination…

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Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms
 Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms 480 320 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new model accurately identifies neonates at risk of acute kidney injury (AKI) — and the factors physicians should address to prevent it — offering the first AKI prediction tool specific to this vulnerable population. Acute kidney injury (AKI) is common and irreversible, making…

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Black baby smiling up at his mother
Studying the Clinical Progression of Congenital Hypopituitarism
 Studying the Clinical Progression of Congenital Hypopituitarism 1024 683 Pam Georgiana
By: Pam Georgiana

New research reveals the clinical progression and evolution of pituitary hormone deficiencies in the first 3 years of life. In a recent retrospective study published in Clinical Endocrinology, Jennifer M. Ladd, MD, MSc, pediatric physician in the Division of Endocrinology and associate program director…

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Black-and-white photograph of a very small infant wrapped in blankets and resting in an adult’s arms. The infant is wearing a hat and has medical tubing attached to the face. One hand is raised near the face while the adult’s hand supports the infant’s body. The image is closely cropped, focusing on the infant and the protective hold of the adult in a hospital setting.
High Rates of Readmission and Airway Complications Found in Tracheostomy-Dependent Infants With BPD
 High Rates of Readmission and Airway Complications Found in Tracheostomy-Dependent Infants With BPD 1024 575 Lauren Dembeck
By: Lauren Dembeck

While tracheostomy can be lifesaving for infants with severe bronchopulmonary dysplasia, new data highlights the risks and outcomes that families and providers must be prepared to face. Infants with bronchopulmonary dysplasia (BPD), the most common morbidity of prematurity, often require long-term respiratory support. Severe…

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small baby with nose canula
Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants
 Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants 1024 575 Jessica Nye, PhD
By: Jessica Nye, PhD

A positive first hip ultrasound (HUS) is highly predictive of having developmental dysplasia of the hip (DDH) among preterm infants, according to results of a study published in the American Journal of Perinatology. “In term babies, more is known about the accuracy of ultrasounds…

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Photo of a toddler playing with toys
Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network
 Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network 1024 575 Erin Gregory
By: Erin Gregory

In their recent publication, Boosting Autism Screening and Referrals with EHR-Integrated Tools at Well-Child Visits, Elizabeth W. Barnhardt, DO, MAEd, developmental-behavioral pediatrician at Nationwide Children’s Hospital and faculty member at The Ohio State University College of Medicine, and her team describe a quality improvement…

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