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Universal Donor CAR NK Cells: A New Platform Technology for Cancer

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Updated Small Baby Care Guidelines Reflect 20 Years of Work Toward Improved Outcomes
 Updated Small Baby Care Guidelines Reflect 20 Years of Work Toward Improved Outcomes 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Thorough management guidelines for babies born before 27 weeks’ gestation join the program’s long list of accomplishments in improving survival and standardizing care for this vulnerable population. As the Small Baby Program at Nationwide Children’s Hospital celebrates its 20th anniversary, it is also releasing…

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Breaking New Ground in Cancer Immunotherapy
 Breaking New Ground in Cancer Immunotherapy 1024 683 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s researchers develop a scalable, targeted approach to overcoming cancer’s toughest challenges. Despite significant advances in treatments, cancer remains one of the leading causes of death globally. Traditional therapies, while improving patient outcomes, still have limitations — such as the need for frequent…

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Leveraging Technology and Partnerships to Transform Pediatric Orthopedic Care
 Leveraging Technology and Partnerships to Transform Pediatric Orthopedic Care 1024 683 Erin Gregory
By: Erin Gregory

An interview with Allen A. Kadado, MD, director of the Nationwide Children’s Hospital Center for Orthopedic Innovation, director of the Nationwide Children’s Pediatric Orthopedic Residency Program At Nationwide Children’s Hospital, the Department of Orthopedics drives pediatric health care innovation through collaborations that bridge clinical…

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More Than One REMEDY for Genetic Disorders
 More Than One REMEDY for Genetic Disorders 1024 768 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

How a new approach to correcting heterozygous mutations and other novel techniques for gene editing are transforming the potential to combat disease The field of gene therapy has had some astounding success in recent years — much of which emerged from labs at Nationwide…

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Innovative Highchair Design Revolutionizes Pediatric Care: A Collaborative Journey From Concept to Prototype
 Innovative Highchair Design Revolutionizes Pediatric Care: A Collaborative Journey From Concept to Prototype 1024 683 Madison Storm
By: Madison Storm

Highchairs are common in homes with babies and toddlers, as well as in places such as hospitals and restaurants where young children are fed. In hospitals, they are mainly used in pediatric care for infants, toddlers and children undergoing treatment or recovery. Highchairs provide…

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Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery?
 Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery? 1024 732 Lauren Dembeck
By: Lauren Dembeck

Kidney stones in children are on the rise, and many of these children miss critical post-op follow-ups. What prevents them from returning, and how can we help? Since 2000, kidney stone cases in the U.S. pediatric population have risen by 6–10% annually, leading to…

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Illustration of lungs on blue silhouette of upper chest on black background
What’s New in Pulmonary Care for Children With Sickle Cell Disease?
 What’s New in Pulmonary Care for Children With Sickle Cell Disease? 1024 575 Erin Gregory
By: Erin Gregory

A recent publication reviews the impact of pulmonary complications on children and youth with sickle cell disease (SCD) and offers suggestions to improve outcomes. Pulmonary complications are a leading cause of morbidity and mortality in children with sickle cell disease (SCD), yet they remain…

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Pivotal New Research Fuels Possibilities for Aggressive Pediatric Brain Cancer
 Pivotal New Research Fuels Possibilities for Aggressive Pediatric Brain Cancer 1024 414 Wendy Margolin
By: Wendy Margolin

A new umbrella trial of molecularly driven therapies for high-grade gliomas (HGG) and diffuse intrinsic pontine glioma (DIPG) aims to improve quality of live and extend survival rates for these aggressive tumors. The diagnosis of high-grade glioma (HGG), a type of aggressive, malignant brain…

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CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies
 CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies 1024 649 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital created fratricide-resistant and metabolically-enhanced chimeric antigen receptor (CAR) natural killer (NK) and T cells that have cytotoxic effects on many hematologic tumors. “One of the problems that we usually have with blood cancers is making effective therapies using immune…

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Meet Karen Texter, MD, Director of Fetal Echocardiography at Nationwide Children’s
 Meet Karen Texter, MD, Director of Fetal Echocardiography at Nationwide Children’s 1024 691 Abbie Miller
By: Abbie Miller

Karen Texter, MD, is a pediatric cardiologist and director of Fetal Echocardiography at Nationwide Children’s. Her clinical and research interests include echocardiography in congenital and acquired heart disease and fetal cardiology. What inspired you to pursue a career in pediatric cardiology? How did you…

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Featured Researcher – Eric Sribnick
 Featured Researcher – Eric Sribnick 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

When children experience a traumatic brain injury (TBI) as well as significant injuries elsewhere in the body—such as a liver or spleen laceration or a broken bone—they face a substantially increased risk of subsequent infection. Research suggests this may stem from a sort of…

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Linaclotide: A New Option For Chronic Pediatric Constipation
 Linaclotide: A New Option For Chronic Pediatric Constipation 1024 668 Pam Georgiana
By: Pam Georgiana

Phase 3 Trial at Nationwide Children’s Supports Safety and Efficacy in Children Aged 6–17. Constipation, a common issue for children, can be a source of prolonged struggle and distress for young patients and their families. Despite many treatments being available, some children continue to…

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What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s
 What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s 1024 683 Erin Gregory
By: Erin Gregory

GLP-1 receptor agonists such as Ozempic (semaglutide) offer new opportunities for managing pediatric diabetes and obesity. These medications target insulin resistance and related comorbidities, but their use raises questions about safety, access and ethical considerations. In the following interview, Leena Mamilly, MD, and Rohan…

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Real-Time Arrhythmia Detection in Adults With Fontan Palliation
 Real-Time Arrhythmia Detection in Adults With Fontan Palliation 1024 683 Pam Georgiana
By: Pam Georgiana

Evaluating the Utility and Accuracy of Patient-Driven Wearable EKG Monitoring Devices Patient-driven diagnostic wearables, such as personal EKG devices, are popular among adults interested in heart health. However, little is known about the accuracy of these devices for adults with congenital heart disease. “Research…

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How Accurate is Pediatric Bipolar Disorder Testing?
 How Accurate is Pediatric Bipolar Disorder Testing? 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Symptom-based bipolar disorder tests accurately diagnose pediatric bipolar disorder, with parent-reported tests being among the most accurate. According to a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of bipolar disorder index tests, parent-reported tests are more accurate than self- or teacher-reported…

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Improving Pediatric Clinical Trials by Incorporating Parent Input
 Improving Pediatric Clinical Trials by Incorporating Parent Input 1024 681 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A Parent Council in an ongoing pediatric stroke rehabilitation trial provides important insights into how parent involvement can inform and enrich the research process. While the need for diverse and inclusive clinical trial populations has been acknowledged for the last few decades, the value…

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Treatment for Substance Use Disorder in the Synthetic Opioid Era
 Treatment for Substance Use Disorder in the Synthetic Opioid Era 1024 683 Alaina Doklovic
By: Alaina Doklovic

Medications for opioid use disorder (MOUD) is the recommended first line treatment for adolescents with opioid use disorder (OUD), the chronic use of opioids and/or synthetic opioids that causes clinically significant distress or impairment. Buprenorphine is the most accessible medication for MOUD. Studies show…

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Introducing the Fourth Wave of the Drug Epidemic
 Introducing the Fourth Wave of the Drug Epidemic 1024 575 Alaina Doklovic
By: Alaina Doklovic

Drug overdoses and poisoning are the third leading cause of pediatric death. In recent years, there has been a dramatic increase in the number of fentanyl-related overdoses, with 15-19 year olds being the most affected. In the Ohio illicit drug supply, as shared by…

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Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are
 Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are 1024 768 Alaina Doklovic
By: Alaina Doklovic

According to the U.S. Department of Health and Human Services, fewer than 10% of adolescents with a substance use disorder receive care. Of those 10%, many are not ready to engage in treatment. They are often brought in by a parent or guardian. Harm…

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Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research
 Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research 1024 537 Abbie Miller
By: Abbie Miller

The ECMO Repository at Nationwide Children’s Hospital is the first and larges of its kind in children’s hospitals in the United States. In December 2014, The Heart Center and Center for Cardiovascular Research at Nationwide Children’s Hospital launched an initiative to prospectively collect biologic…

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