Inside the Science of Pediatric Lung Disease

A Special Section
Read the Articles

Speeding Up Science With Patient-Derived Xenografts

Read the Article

Meeting the Challenge of Clinical Trial Recruitment and Retention

Find Out More

Cultivating Culture in a High-Growth, High-Performance Organization

Read More

Don't Miss an Update: Subscribe to Our Newsletters

Subscribe Now
Close
Enter your
text here
Featured Researcher: Laura Chavez, PhD, MPH
 Featured Researcher: Laura Chavez, PhD, MPH 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Improving access to health care for all, regardless of age, race, gender and socioeconomic background, is essential for numerous health and economic reasons — especially for children. It’s vital to understand and prevent health disparities from impacting children to ensure the best outcomes for…

read more
Study Explores Impact of Duffy Null Phenotype on Neutrophil Count and Hydroxyurea Dosing in Children With Sickle Cell Disease
 Study Explores Impact of Duffy Null Phenotype on Neutrophil Count and Hydroxyurea Dosing in Children With Sickle Cell Disease 1024 683 Lauren Dembeck
By: Lauren Dembeck

Children with sickle cell disease and the Duffy null phenotype may have lower measured neutrophil counts, but new research suggests that there are opportunities to optimize hydroxyurea regardless of Duffy null status. Sickle cell disease (SCD) primarily affects individuals of minority populations and can…

read more
Close up color photo of little boy holding hands on his belly
Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms
 Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms 1024 680 Pam Georgiana
By: Pam Georgiana

A retrospective analysis of the clinical correlation between gastric emptying scintigraphy and antroduodenal manometry in pediatric patients with upper GI symptoms. Children with persistent nausea, vomiting or abdominal pain often undergo extensive testing to evaluate for underlying etiologies such as pediatric intestinal pseudo-obstruction, rumination…

read more
Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms
 Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms 480 320 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new model accurately identifies neonates at risk of acute kidney injury (AKI) — and the factors physicians should address to prevent it — offering the first AKI prediction tool specific to this vulnerable population. Acute kidney injury (AKI) is common and irreversible, making…

read more
Black baby smiling up at his mother
Studying the Clinical Progression of Congenital Hypopituitarism
 Studying the Clinical Progression of Congenital Hypopituitarism 1024 683 Pam Georgiana
By: Pam Georgiana

New research reveals the clinical progression and evolution of pituitary hormone deficiencies in the first 3 years of life. In a recent retrospective study published in Clinical Endocrinology, Jennifer M. Ladd, MD, MSc, pediatric physician in the Division of Endocrinology and associate program director…

read more
Black-and-white photograph of a very small infant wrapped in blankets and resting in an adult’s arms. The infant is wearing a hat and has medical tubing attached to the face. One hand is raised near the face while the adult’s hand supports the infant’s body. The image is closely cropped, focusing on the infant and the protective hold of the adult in a hospital setting.
High Rates of Readmission and Airway Complications Found in Tracheostomy-Dependent Infants With BPD
 High Rates of Readmission and Airway Complications Found in Tracheostomy-Dependent Infants With BPD 1024 575 Lauren Dembeck
By: Lauren Dembeck

While tracheostomy can be lifesaving for infants with severe bronchopulmonary dysplasia, new data highlights the risks and outcomes that families and providers must be prepared to face. Infants with bronchopulmonary dysplasia (BPD), the most common morbidity of prematurity, often require long-term respiratory support. Severe…

read more
small baby with nose canula
Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants
 Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants 1024 575 Jessica Nye, PhD
By: Jessica Nye, PhD

A positive first hip ultrasound (HUS) is highly predictive of having developmental dysplasia of the hip (DDH) among preterm infants, according to results of a study published in the American Journal of Perinatology. “In term babies, more is known about the accuracy of ultrasounds…

read more
Photo of a toddler playing with toys
Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network
 Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network 1024 575 Erin Gregory
By: Erin Gregory

In their recent publication, Boosting Autism Screening and Referrals with EHR-Integrated Tools at Well-Child Visits, Elizabeth W. Barnhardt, DO, MAEd, developmental-behavioral pediatrician at Nationwide Children’s Hospital and faculty member at The Ohio State University College of Medicine, and her team describe a quality improvement…

read more
physicians in white coats looking at a tablet
Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1
 Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1 1024 683 Pam Georgiana
By: Pam Georgiana

Pilot study supports the use of sleep questionnaires to identify underrecognized symptoms in children and adults with DM1. Myotonic Dystrophy Type 1 (DM1) is a genetic, multisystemic neuromuscular disorder that affects skeletal muscle, cardiac function, the endocrine system and the central nervous system. In…

read more
Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer
 Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer 1024 683 Pam Georgiana
By: Pam Georgiana

 A pilot study shows promise in enhancing shared decision-making and patient satisfaction through family-centered support. Fertility preservation is a critical yet underutilized aspect of cancer care for adolescent males. Despite being a medically low-risk and effective option, only a minority of young patients attempt…

read more
Transforming the Approach to Cancer Epigenomic Studies
 Transforming the Approach to Cancer Epigenomic Studies 1024 764 Abbie Miller
By: Abbie Miller

Two new publications from the Center for Childhood Cancer Research at Nationwide Children’s offer a new platform technology and proof of concept that illuminates the role of a known gene fusion driving rhabdomyosarcoma.  Synergy is an important part of scientific endeavors, and people, teams…

read more
National Study Reveals Gaps in Antidepressant Treatment Quality for Youth
 National Study Reveals Gaps in Antidepressant Treatment Quality for Youth 1024 683 Pam Georgiana
By: Pam Georgiana

Findings highlight critical disparities and opportunities to improve care. A national study led by Cynthia A. Fontanella, PhD, principal investigator in the Center for Suicide Prevention and Research in the Abigail Wexner Research Institute at Nationwide Children’s Hospital and professor of Psychiatry and Behavioral…

read more
Featured Researcher: Mykyta Artomov, PhD
 Featured Researcher: Mykyta Artomov, PhD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Bioinformatics combines the natural sciences and information technology. This rapidly developing field has become an essential piece of genomic medicine, which is currently experiencing unprecedented scientific progress in understanding inherited susceptibilities for many diseases – identification of disease risk genes, pathways and affected cell…

read more
Neurosurgeon Albert Isaacs posed in the operating room, looking at the camera.
Meet Our Expert: Albert Isaacs, MD, PhD, Neurosurgeon and Genomic Scientist
 Meet Our Expert: Albert Isaacs, MD, PhD, Neurosurgeon and Genomic Scientist 864 576 Lauren Dembeck
By: Lauren Dembeck

Albert Isaacs, MD, PhD, is a pediatric neurosurgeon at Nationwide Children’s Hospital and an assistant professor of Neurological Surgery at The Ohio State University College of Medicine. His research focuses on uncovering the molecular and immunologic drivers of neonatal hydrocephalus, with the goal of…

read more
How One Role is Improving Emergency Department Wait Times
 How One Role is Improving Emergency Department Wait Times 150 150 Alaina Doklovic
By: Alaina Doklovic

In any emergency department (ED), many people work behind the scenes to keep things running smoothly so patients receive the care they need, when they need it. At Nationwide Children’s Hospital, one behind-the-scenes position is making a big impact: the triage coordinator. “The role…

read more
Understanding Long-Term Outcomes for Children With Anorectal Malformation
 Understanding Long-Term Outcomes for Children With Anorectal Malformation 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Researchers finally have high-quality data about the trajectory of continence outcomes — and key predictors for quality of life — across childhood for children with anorectal malformations. For many parents of children with an anorectal malformation (ARM), the primary goal is for the child…

read more
Cystic Fibrosis: Screening, Diagnosis and Therapy
 Cystic Fibrosis: Screening, Diagnosis and Therapy 150 150 Pam Georgiana
By: Pam Georgiana

Since the implementation of universal newborn screening for cystic fibrosis in all states by 2010, the expectation has been that every child with cystic fibrosis would be identified early and benefit from life-extending treatments. The reality, however, is more complex. “Because of the complexities…

read more
close up of a researcher with blue gloves inject liquid into vials.
ACMG Issues Primer on Regulation of Laboratory-Developed Tests
 ACMG Issues Primer on Regulation of Laboratory-Developed Tests 1024 683 Lauren Dembeck
By: Lauren Dembeck

The new statement, co-authored by a Nationwide Children’s laboratory geneticist, outlines how lab-developed tests are regulated and offers patient-centered recommendations for modernizing oversight. Laboratory-developed tests (LDTs) are validated testing protocols developed by certified clinical laboratories for patient care and play an essential role in…

read more
Forging the Future of Sarcoma Care and Research
 Forging the Future of Sarcoma Care and Research 150 150 Nationwide Children's
By: Nationwide Children's

Precision Medicine for Children With Sarcoma At age 7, Will was diagnosed with an osteosarcoma after breaking his leg while visiting his grandmother in Pennsylvania. Scans of the injury revealed that Will’s broken leg was likely caused by a tumor. Hundreds of miles from…

read more
Featured Researcher – Ryan Roberts, MD, PhD
 Featured Researcher – Ryan Roberts, MD, PhD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Ryan D. Roberts, MD, PhD, is a physician in the Division of Hematology and Oncology at Nationwide Children’s Hospital and a principal investigator for the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. He is a member of…

read more