Fetus in utero receiving valvuloplasty
Tissue Engineering and Fetal Medicine: A New Frontier for Congenital Heart Disease
Tissue Engineering and Fetal Medicine: A New Frontier for Congenital Heart Disease 1024 575 Abbie Miller

Procedures that utilize cardiac catheterization to improve fetal heart development are often successful, but they are not without risk. And even if they can successfully prevent the development of single ventricle disease, there is always ongoing heart valve disease (HVD). HVD may not be…

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Susceptibility to and Use of E-cigarettes and Marijuana Is Common Among Adolescents With Congenital Heart Disease
Susceptibility to and Use of E-cigarettes and Marijuana Is Common Among Adolescents With Congenital Heart Disease 1024 575 Lauren Dembeck

Adolescents with congenital heart disease (CHD) are subject to disease-related stressors, such as attending medical appointments and undergoing medical procedures. They have elevated risk for cardiovascular and cognitive complications, which may be exacerbated by the use of e-cigarettes and marijuana. To inform prevention strategies…

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What Pediatricians Need to Know About Lymphedema in Pediatrics
What Pediatricians Need to Know About Lymphedema in Pediatrics 150 150 Abbie Miller

Lymphedema is chronic, progressive swelling caused by maldevelopment or disruption of the lymphatic system. Typically, patients present with an asymmetric swelling of an arm or leg that progressively worsens. Min-Jeong Cho, MD, a microsurgeon and assistant professor at The Ohio State University and Nationwide…

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Toddler playing with toys
Investigating Caregiver Disclosure of Pediatric Urologic Surgery
Investigating Caregiver Disclosure of Pediatric Urologic Surgery 1024 575 Mary Bates, PhD

A survey reveals most caregivers plan to disclose urologic surgery to their child but would like more guidance from providers. Some pediatric urologic surgeries are performed early in childhood and with short-term follow-up. When children have surgery before the age of memory formation, it…

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Evolution of the Youth Crisis Stabilization Unit
Evolution of the Youth Crisis Stabilization Unit 1024 538 Mary Bates, PhD

An alternative to inpatient hospitalization for youth experiencing a mental health crisis and their families sees success at Nationwide Children’s.   The Youth Crisis Stabilization Unit (YCSU) is an inpatient psychiatric setting at Nationwide Children’s for children and adolescents experiencing a mental health crisis.…

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Deep Brain Stimulation Ameliorates Symptoms of Genetic Movement Disorder
Deep Brain Stimulation Ameliorates Symptoms of Genetic Movement Disorder 150 150 Mary Bates, PhD

First report of DBS for management of tremor in a treatment-resistant AIFM1-related disorder.   In a new case series, researchers from Nationwide Children’s report using deep brain stimulation (DBS) to help manage tremor due to a genetic movement disorder in two brothers. The report,…

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Social Needs Associated with Postpartum Depression
Social Needs Associated with Postpartum Depression 1024 683 Mary Bates, PhD

Screening for social needs at pediatric well-checks may help identify vulnerable mothers. In a new study, researchers from Nationwide Children’s found a significant relationship between self-reported social needs and postpartum depression symptoms of mothers screened in pediatric primary care clinics. The findings suggest that…

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Comprehensive Care Model and Integrated Sickle Cell Disease-Pulmonary Clinic Improves Access and Outcomes
Comprehensive Care Model and Integrated Sickle Cell Disease-Pulmonary Clinic Improves Access and Outcomes 1024 683 Jessica Nye, PhD

A comprehensive care model which incorporates pulmonology services in the sickle cell disease (SCD) clinic aims to reduce access barriers and improve outcomes.   “Our sickle cell clinic at Nationwide Children’s Hospital used to see patients just for their comprehensive [sickle cell] care. One…

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Featured Researcher — Meisam Naeimi Kararoudi, DVM, PhD
Featured Researcher — Meisam Naeimi Kararoudi, DVM, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES

Meisam Naeimi Kararoudi, DVM, PhD, director of the CRISPR/Gene Editing Core and principal investigator in the Center for Childhood Cancer Research at Nationwide Children’s, has taken a winding, international road to his current role at Nationwide Children’s Hospital. From his native Iran to Italy,…

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Shorter Course of Antibiotics for Early Onset Sepsis as Safe as Longer Course
Shorter Course of Antibiotics for Early Onset Sepsis as Safe as Longer Course 150 150 Jessica Nye, PhD

Discontinuing empirical antibiotic therapy for early-onset sepsis (EOS) at 24 hours had a similar safety profile as the standard 48-hour treatment course. “In the neonatal intensive care unit (NICU), we have data to show that each additional day of unnecessary antibiotics leads to adverse…

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More Than a Building: Why Our Expanded Research Facilities Matter for Kids Everywhere
More Than a Building: Why Our Expanded Research Facilities Matter for Kids Everywhere 1024 624 Dennis Durbin, MD, MSCE

At Nationwide Children’s Hospital, we proudly acknowledge the significant role research has in improving patient care and overall child heath. The integration of research and clinical care is at the heart of the hospital’s strategic plan — a $3.3 billion investment over the next…

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How Language-Processing Technology Could Transform Medical Practice, Research and Patient Participation
How Language-Processing Technology Could Transform Medical Practice, Research and Patient Participation 150 150 Katie Brind'Amour, PhD, MS, CHES

Recent revolutions in researchers’ ability to process natural language sources, such as clinic visit notes, transcripts or medical diaries, could dramatically expand opportunities to improve health care and prevention health outreach.   Natural Language Processing (NLP) is a subfield of computer science and artificial…

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Advancing Genomics-Driven Precision Medicine in the NICU
Advancing Genomics-Driven Precision Medicine in the NICU 1024 683 Natalie Wilson

According to the Children’s Hospitals Neonatal Consortium, as many as half of newborns hospitalized in level IV neonatal intensive care units (NICUs) due to critical illness have an underlying genetic condition. Most don’t get their diagnosis for months or even years. However, clinical assays,…

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Beyond the Wow Factor: Artificial Intelligence in Pediatrics
Beyond the Wow Factor: Artificial Intelligence in Pediatrics 1024 576 Katie Brind'Amour, PhD, MS, CHES

What promise do AI and machine learning hold for pediatrics, and how can their potential flourish while still safeguarding children’s health and privacy? Machine learning (ML) and artificial intelligence (AI) have exploded across the worlds of marketing and commerce in recent years. Streaming services…

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Going Viral: The AAV Approach to Curing Cancer
Going Viral: The AAV Approach to Curing Cancer 1024 256 Emily Siebenmorgen

According to Timothy Cripe, MD, PhD, chief of the Division of Hematology and Oncology at Nationwide Children’s Hospital, it’s an incredible time to be working on cancer treatment – and now, targeted cancer prevention. “There’s so much going on in the cancer world these…

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Placing Value on a Pediatric Surgeon’s Academic Work
Placing Value on a Pediatric Surgeon’s Academic Work 1024 683 Mary Bates, PhD

The addition of an academic RVU system to an existing work RVU-based incentivization plan boosted academic productivity in the Department of Pediatric Surgery at Nationwide Children’s Hospital. At many institutions, physicians and surgeons are compensated using a productivity formula based on work relative value…

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Role of Myeoloid-Derived Suppressor Cells in Septic Shock Immunoparalysis
Role of Myeoloid-Derived Suppressor Cells in Septic Shock Immunoparalysis 1024 683 Mary Bates, PhD

New study is the first to describe increased myeloid-derived suppressors cells in children with septic shock. In children with septic shock, the immune system initiates a systemic inflammatory response and a nearly concurrent compensatory anti-inflammatory response. When severe, this anti-inflammatory response is termed “immunoparalysis”…

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Micro-dystrophin: A Small Gene With Big Promise
Micro-dystrophin: A Small Gene With Big Promise 1024 632 Abbie Miller

SRP-9001 for Duchenne muscular dystrophy supplies a functional dystrophin gene via AAVrh74 gene therapy. In 1969, Jerry Mendell, MD, was working at the National Institute of Neurological Disorders and Stroke (NINDS) when he saw his first patient with Duchenne muscular dystrophy (DMD). DMD, a…

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Implementation of a COVID-19 Monoclonal Antibody Program
Implementation of a COVID-19 Monoclonal Antibody Program 150 150 Lauren Dembeck

Researchers provide guidance on risk stratification and offer subspecialists and community practitioners a streamlined approach to treating patients at greater risk for severe COVID-19. The COVID-19 pandemic necessitated the development of therapeutic approaches to combat the SAR-CoV-2 virus. In late 2020, monoclonal antibody therapies…

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Preterm Birth Increases Health Vulnerabilities of Babies With Down Syndrome
Preterm Birth Increases Health Vulnerabilities of Babies With Down Syndrome 1024 624 JoAnna Pendergrass, DVM

Babies with Down syndrome who are born preterm have higher prenatal morbidity and mortality rates than those in babies with Down syndrome born at term, suggesting pediatricians can lower their risk threshold for certain screenings or interventions. Compared with age-matched neonates without Down syndrome,…

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