Optimizing Prenatal and Neonatal Care for Infants With Treatable Rare Diseases

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Unraveling the Genetic Mystery Behind a Rare Pediatric Disease

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New National “Vital Signs” to Measure Population-wide Pediatric Health

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Advancing Genomics-Driven Precision Medicine in the NICU
 Advancing Genomics-Driven Precision Medicine in the NICU 1024 683 Natalie Wilson
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According to the Children’s Hospitals Neonatal Consortium, as many as half of newborns hospitalized in level IV neonatal intensive care units (NICUs) due to critical illness have an underlying genetic condition. Most don’t get their diagnosis for months or even years. However, clinical assays,…

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Beyond the Wow Factor: Artificial Intelligence in Pediatrics
 Beyond the Wow Factor: Artificial Intelligence in Pediatrics 1024 576 Katie Brind'Amour, PhD, MS, CHES
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What promise do AI and machine learning hold for pediatrics, and how can their potential flourish while still safeguarding children’s health and privacy? Machine learning (ML) and artificial intelligence (AI) have exploded across the worlds of marketing and commerce in recent years. Streaming services…

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Going Viral: The AAV Approach to Curing Cancer
 Going Viral: The AAV Approach to Curing Cancer 1024 256 Emily Siebenmorgen
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According to Timothy Cripe, MD, PhD, chief of the Division of Hematology and Oncology at Nationwide Children’s Hospital, it’s an incredible time to be working on cancer treatment – and now, targeted cancer prevention. “There’s so much going on in the cancer world these…

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Placing Value on a Pediatric Surgeon’s Academic Work
 Placing Value on a Pediatric Surgeon’s Academic Work 1024 683 Mary Bates, PhD
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The addition of an academic RVU system to an existing work RVU-based incentivization plan boosted academic productivity in the Department of Pediatric Surgery at Nationwide Children’s Hospital. At many institutions, physicians and surgeons are compensated using a productivity formula based on work relative value…

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Role of Myeoloid-Derived Suppressor Cells in Septic Shock Immunoparalysis
 Role of Myeoloid-Derived Suppressor Cells in Septic Shock Immunoparalysis 1024 683 Mary Bates, PhD
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New study is the first to describe increased myeloid-derived suppressors cells in children with septic shock. In children with septic shock, the immune system initiates a systemic inflammatory response and a nearly concurrent compensatory anti-inflammatory response. When severe, this anti-inflammatory response is termed “immunoparalysis”…

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Micro-dystrophin: A Small Gene With Big Promise
 Micro-dystrophin: A Small Gene With Big Promise 1024 632 Abbie Miller
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SRP-9001 for Duchenne muscular dystrophy supplies a functional dystrophin gene via AAVrh74 gene therapy. In 1969, Jerry Mendell, MD, was working at the National Institute of Neurological Disorders and Stroke (NINDS) when he saw his first patient with Duchenne muscular dystrophy (DMD). DMD, a…

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Implementation of a COVID-19 Monoclonal Antibody Program
 Implementation of a COVID-19 Monoclonal Antibody Program 150 150 Lauren Dembeck
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Researchers provide guidance on risk stratification and offer subspecialists and community practitioners a streamlined approach to treating patients at greater risk for severe COVID-19. The COVID-19 pandemic necessitated the development of therapeutic approaches to combat the SAR-CoV-2 virus. In late 2020, monoclonal antibody therapies…

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Preterm Birth Increases Health Vulnerabilities of Babies With Down Syndrome
 Preterm Birth Increases Health Vulnerabilities of Babies With Down Syndrome 1024 624 JoAnna Pendergrass, DVM
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Babies with Down syndrome who are born preterm have higher prenatal morbidity and mortality rates than those in babies with Down syndrome born at term, suggesting pediatricians can lower their risk threshold for certain screenings or interventions. Compared with age-matched neonates without Down syndrome,…

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Improving the Diagnosis and Treatment of Iron Deficiency and Anemia in Children With Inflammatory Bowel Disease
 Improving the Diagnosis and Treatment of Iron Deficiency and Anemia in Children With Inflammatory Bowel Disease 150 150 Lauren Dembeck
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Iron deficiency with and without anemia is under-recognized and under-treated in children with inflammatory bowel disease.   Anemia is the most common extr-aintestinal manifestation of inflammatory bowel disease (IBD), which includes conditions such as Crohn’s disease and ulcerative colitis, and iron deficiency is the…

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Intraoperative Evaluation of Penile Blood Flow During Bladder Exstrophy
 Intraoperative Evaluation of Penile Blood Flow During Bladder Exstrophy 150 150 Mary Bates, PhD
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Laser angiography technology allows for real-time measurements of penile perfusion during exstrophy repair operations. In a new pilot study, researchers from the Pediatric Urology Midwest Alliance (PUMA) demonstrated that intraoperative laser angiography is a safe and easy method to evaluate penile perfusion during bladder…

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Ask a Specialist: When Should Primary Care Providers Refer Dental Injuries to the Emergency Department?
 Ask a Specialist: When Should Primary Care Providers Refer Dental Injuries to the Emergency Department? 150 150 Ehsan N. Azadani, DDS, MS
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An expert reveals the most common red flag dental injuries that should be referred to the ED and what precautions PCPs can take before sending the child.   The most time-sensitive dental injury is the avulsion of a permanent tooth; that is, when the…

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physicians in white coats looking at a tablet
Using Machine Learning in the Electronic Medical Record to Save Lives
 Using Machine Learning in the Electronic Medical Record to Save Lives 1024 683 Abbie Miller
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The deterioration risk index identifies patients at risk for deterioration and poor outcomes, triggering the care team to act before a crisis happens. In a report published in Pediatric Critical Care Medicine, a team from Nationwide Children’s Hospital describes a machine learning tool for…

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Toddler playing with toys
Improving Outcomes for Infants and Children With Congenital Hypothyroidism
 Improving Outcomes for Infants and Children With Congenital Hypothyroidism 1024 575 Mary Bates, PhD
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A quality improvement project identifies high-risk patients and ensures they receive necessary care.   Congenital hypothyroidism (CH) is one of the most common preventable causes of intellectual disability. In the United States and many other countries, newborns are tested a 24-72 hours after birth…

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conceptual art of DNA
High-Risk Genotype Impacts Kidney Disease Trajectory
 High-Risk Genotype Impacts Kidney Disease Trajectory 1024 575 Mary Bates, PhD
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Patients with focal segmental glomerulosclerosis that possess two variations in the APOL1 gene experience more rapid progression of kidney disease. In a new study, researchers from Nationwide Children’s and other institutions quantified the relationship between a high-risk genotype and kidney disease progression in patients…

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Youth Suicide and Attempted Suicide Reported to Poison Control Centers Increased During the COVID-19 Pandemic
 Youth Suicide and Attempted Suicide Reported to Poison Control Centers Increased During the COVID-19 Pandemic 150 150 Laura Dattner
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A recent study evaluated trends of suspected suicides and suicide attempts among children 6-19 years old reported to United States poison centers. A recent study published in Journal of Medical Toxicology from the Center for Injury Research and Policy and Central Ohio Poison Center…

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smiling baby being held up by an adult
Reducing Opioid Prescriptions for Common Pediatric Urologic Procedures
 Reducing Opioid Prescriptions for Common Pediatric Urologic Procedures 1024 682 JoAnna Pendergrass, DVM
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To address the national opioid epidemic, clinician-scientists developed a quality improvement initiative to achieve significant, long-term reductions in opioid prescriptions after common pediatric urologic procedures.   Opioids are commonly prescribed for pediatric urologic procedures. However, studies have reported a troubling practice of overprescribing opioids…

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Nephrology Education Ripe With Opportunities to Improve Health Equity
 Nephrology Education Ripe With Opportunities to Improve Health Equity 1024 575 Katie Brind'Amour, PhD, MS, CHES
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The Health Care Justice Committee of the American Society of Nephrology has released recommendations for incorporating anti-racism and social justice concepts into education and mentoring with the goal of improving health equity.   In 2020, leaders in the American Society of Nephrology (ASN) reached…

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Multidisciplinary Treatment Is Effective for Patients With Rumination Syndrome
 Multidisciplinary Treatment Is Effective for Patients With Rumination Syndrome 150 150 Jessica Nye, PhD
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Tiered, multidisciplinary behavioral treatment is effective at improving symptoms of rumination syndrome (RS) among children and adolescents, even in the outpatient setting.   Children with RS present with repeated, effortless regurgitation of undigested food. Although limited data about treatment are available, previous studies have…

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Featured Researcher — Eric Nelson, PhD
 Featured Researcher — Eric Nelson, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES
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Eric Nelson, PhD, is a principal investigator in the Center for Biobehavioral Health in the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital. His work centers around how the brain develops, particularly during adolescence, as well as how it changes (or doesn’t) during…

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Pediatric Obesity Can Be Treated Safely and Effectively
 Pediatric Obesity Can Be Treated Safely and Effectively 1024 575 Abbie Miller
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New guidelines from the American Academy of Pediatrics emphasize evidence for safe, effective treatment of pediatric obesity for long-term benefit of children and adolescents.   More than 14.4 million U.S. children and adolescents have obesity, making it one of the most common chronic conditions…

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