Research

The True History of the Nuremberg Code: Leo Alexander’s Blueprint Uncovered
The True History of the Nuremberg Code: Leo Alexander’s Blueprint Uncovered 150 150 Abbie Roth

An investigation of Duke University’s Medical Center’s Archives boxes labeled “Alexander’s Papers” reveals a document containing six principles, which were included nearly word-for-word in the Nuremberg Code.  At the end of the famous Doctors’ Trial, the trial of Nazi doctors for their crimes and treatment of people who were identified as “research participants,” Judge Sebring…

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Novel Compound Shows Promise for Treating Nephrotic Syndrome
Novel Compound Shows Promise for Treating Nephrotic Syndrome 1024 575 Mary Bates, PhD

PPARγ selective modulator appear to be more efficacious in reducing proteinuria and comorbidities, and has fewer side effects than a traditional PPARγ agonist in a preclinical model of nephrotic syndrome. Nephrotic syndrome, characterized by high proteinuria, is one of the most common forms of glomerular disease. It is typically associated with edema, hypercholesterolemia, hypoalbuminemia, systemic…

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Hydroxyurea Dose and Adherence Affect Hematologic Outcomes in Children With Sickle Cell Anemia
Hydroxyurea Dose and Adherence Affect Hematologic Outcomes in Children With Sickle Cell Anemia 1024 683 JoAnna Pendergrass, DVM

Optimal hydroxyurea dosing and medication adherence can improve hematologic outcomes for children with sickle cell anemia.   For pediatric patients with sickle cell anemia, hydroxyurea is highly effective at reducing disease complications. However, it can be challenging for these patients to take hydroxyurea for the long term. “There are many barriers to medication adherence in…

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Nafcillin is a Safe Alternative to Vancomycin for Empirical Treatment of Late-Onset Sepsis Among Infants in the NICU
Nafcillin is a Safe Alternative to Vancomycin for Empirical Treatment of Late-Onset Sepsis Among Infants in the NICU 1024 681 Mary Bates, PhD
sleeping infant

Guidelines to reduce vancomycin use at three Ohio NICUs did not impact mortality rate. In 2014, the Neonatal Antimicrobial Stewardship Program at Nationwide Children’s Hospital recommended nafcillin rather than vancomycin for empirical therapy of possible late-onset sepsis in infants without a history of methicillin-resistant Staphylococcus aureus (MRSA) infection or colonization. In a new study, researchers…

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A More Efficient Method for Diagnosing Electrical Status Epilepticus in Sleep?
A More Efficient Method for Diagnosing Electrical Status Epilepticus in Sleep? 375 280 Mary Bates, PhD

Calculating the spike-wave index of the EEG of just the first 100 seconds of sleep is enough for diagnosis. Electrical status epilepticus in sleep (ESES) is an electrographic pattern in which epileptiform activity is dramatically activated by sleep. The ESES pattern is a key electrographic feature in several pediatric seizure disorders that vary in severity.…

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When Functional Outcomes Are Achieved Post-Op, Do Patients and Families Care About Scarring?
When Functional Outcomes Are Achieved Post-Op, Do Patients and Families Care About Scarring? 1024 683 Abbie Roth

A recent editorial from Dr. Daniel DaJusta questions whether cosmetic concerns after surgery are primarily driven by surgeons, patients or parents. It is widely accepted that having a smaller, neater or less visible scar following surgery is a preferable cosmetic outcome to a large, ragged or highly visible scar. This is supported anecdotally by surgeons,…

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Is 3D Anorectal Manometry Preferable to Traditional Anorectal Manometry in Children With Functional Constipation?
Is 3D Anorectal Manometry Preferable to Traditional Anorectal Manometry in Children With Functional Constipation? 1024 680 Mary Bates, PhD
Close up color photo of little boy holding hands on his belly

Study finds 3D-ARM is less comfortable and does not provide additional information compared to traditional ARM.   In a recent pilot study, researchers from Nationwide Children’s compared outcomes and patient experience of a new three-dimensional (3D) anorectal manometry (ARM) technique compared to regular ARM in children with functional constipation. They found that the use of…

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When Every Week Matters: Advancing a Treatment to the Clinic
When Every Week Matters: Advancing a Treatment to the Clinic 1024 491 Natalie Wilson
Illustrations of clock faces at different times and angles

Researchers and regulatory experts bring a potential new therapy for a deadly neurodegenerative disease from IND application to clinical trial enrollment in a matter of weeks, setting a new standard in translating therapies from bench to bedside. In October 2021, the Office of Research Regulatory Affairs (ORRA) at Nationwide Children’s Hospital submitted an Investigational New…

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Optimizing the Body’s Natural Cancer Killers
Optimizing the Body’s Natural Cancer Killers 1024 649 Katie Brind'Amour, PhD, MS, CHES

Recent advances in the expansion and production of natural killer cells offers pediatric patients new hope for remission after high-risk cancer diagnoses. Natural killer (NK) cells are the innate immune system’s first line of defense for viral infections. Although these white blood cells don’t have the antigen-specific “memory” that characterizes T cells or the antibody-producing…

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How Does Allergic Disease Protect Against Developing Asthma After Viral Infection?
How Does Allergic Disease Protect Against Developing Asthma After Viral Infection? 1024 523 Mary Bates, PhD

Neutrophils and IL-4 are critical in preventing post-viral airway disease in mice with pre-existing allergic disease. In a new study, researchers from Nationwide Children’s Hospital show that in a mouse mode simulating human respiratory viral infection, pre-existing allergic disease prevents the development of asthma following viral infection. Further experiments revealed that this protection against post-viral…

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Moving Emergency Medicine Research Forward
Moving Emergency Medicine Research Forward 1024 614 Abbie Roth

Utilizing exception from informed consent studies and a national network of emergency medicine experts, clinician-scientists are advancing research to uncover best practices and improve care. Exception from informed consent (EFIC) is a special rule set utilized by the U.S. Food and Drug Administration (FDA) to support research in emergency situations. The word exception is particularly…

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Improving Racial Diversity and Equity in Clinical Trials
Improving Racial Diversity and Equity in Clinical Trials 1024 511 Jeb Phillips

There is now broad consensus across medicine that clinical trials must be more representative of minority populations. How can that be achieved? Last year, a group of Nationwide Children’s Hospital neonatologists published an unusually pointed critique of racial and ethnic representation in neonatal clinical trials in the Journal of Perinatology. They wrote that the lack…

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Engineered Viruses Help the Immune System Target Cancer Cells
Engineered Viruses Help the Immune System Target Cancer Cells 1024 623 Lauren Dembeck

The seemingly unlikely “partnership” leads to strong antitumor responses in pediatric tumor models. A recent study from researchers at Nationwide Children’s Hospital, published in the Journal for Immuno Therapy of Cancer, describes how a type of viroimmunotherapy activates the immune system to preferentially target tumor cells. “Pediatric tumor typically lack neoantigens – new proteins that…

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SARS-CoV-2 RNA in the Blood is Associated With Worse Outcomes in Kids
SARS-CoV-2 RNA in the Blood is Associated With Worse Outcomes in Kids 1024 575 Katie Brind'Amour, PhD, MS, CHES

Researchers have identified a risk factor for more severe illness in children with COVID-19: detectable levels of SARS-CoV-2 RNA circulating in the blood. Children with detectable SARS-CoV-2 RNA in the blood, called RNAemia, were more likely to require oxygen and be admitted to the intensive care unit than children with COVID-19 who did not have…

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Featured Researcher — Diana Thomas, MD, PhD
Featured Researcher — Diana Thomas, MD, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES

Diana Thomas, MD, PhD, joined the Biopathology Center (BPC) at Nationwide Children’s Hospital as its pathology operations director in 2021. Since then, she has been busy supporting research protocol development and the receipt, processing, banking and distribution of biospecimens for clinical and research investigators around the world. As a biorepository for some of the largest…

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Perceptions About Type 2 Diabetes Differ Among Adolescent Patients, Parents and Physicians
Perceptions About Type 2 Diabetes Differ Among Adolescent Patients, Parents and Physicians 1024 683 JoAnna Pendergrass, DVM

Differing perceptions about type 2 diabetes among teens, parents and physicians can create barriers to diagnosing and managing the disease.   Type 2 diabetes (T2D) is becoming increasingly prevalent in adolescents, with a median age of diagnosis of 13.5 years in the pediatric population. Managing pediatric T2D is challenging, given that traditional medical and non-medical…

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Which Surgical Approach for Catheterizable Channels in Bowel and Bladder Management Is Best?
Which Surgical Approach for Catheterizable Channels in Bowel and Bladder Management Is Best? 150 150 Jessica Nye, PhD

Specific patient characteristics, such as appendix size, may help guide clinicians when deciding which surgical approach to use for patients in need of catheterizable channels for bladder and bowel management. Many patients with neurologic disorders experience urinary and fecal incontinence. The appendix or the transverse ileal tube can be repurposed as a catheterizable channel to…

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Improving Identification of Neonatal Acute Kidney Injury in the NICU
Improving Identification of Neonatal Acute Kidney Injury in the NICU 1024 575 Mary Bates, PhD

Approaches at three different institutions all resulted in improved identification and care of acute kidney injury in newborns. In a new study, researchers describe three different approaches to standardizing the identification and care of acute kidney injury (AKI) in the neonatal intensive care unit (NICU), including the approach taken at Nationwide Children’s. They report that…

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COVID-19 and Neurologic Manifestations in Children
COVID-19 and Neurologic Manifestations in Children 1024 512 Marlina Lovett, MD
coronavirus

Just weeks after SARS-CoV-2 was identified, global consortiums were formed to combat the pandemic. Health care providers and scientists worked together to learn how SARS-CoV-2 impacted the body, to share information, to generate hypotheses and to develop treatment approaches. The Global Consortium Study of Neurologic Dysfunction in COVID-19 (GCS-NeuroCOVID) was designed to provide insight into…

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What Psychosocial Interventions Are Well Established for the Treatment of Bipolar Disorder in Youth?
What Psychosocial Interventions Are Well Established for the Treatment of Bipolar Disorder in Youth? 150 150 Lauren Dembeck

Clinical psychology researchers at Nationwide Children’s Hospital recently published a comprehensive review of evidence-based psychosocial treatments for bipolar disorder in youth.  Bipolar spectrum disorders (BPSDs) are chronic, recurrent conditions characterized by episodic mood disturbance alternating between periods of depression and (hypo)mania. These conditions are associated with considerable impairment, reduced quality of life, high rates of…

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The Success of an EMR-Based Health-Related Social Needs Screen in Pediatrics
The Success of an EMR-Based Health-Related Social Needs Screen in Pediatrics 1024 683 Deborah L. Ungerleider, MD, FAAP

Standardized universal HRSN screening with an EMR system and follow-up by social work consults can be successful and contribute to reducing health disparities.   Health-related social needs (HRSNs), sometimes referred to as social determinants of health (SODH), are the risk factors of food insecurity, lack of stable housing and poverty, all of which can play…

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Stress Increases Systemic Inflammation and Anxiety in Mouse Model of IBD
Stress Increases Systemic Inflammation and Anxiety in Mouse Model of IBD 1024 606 Mary Bates, PhD

Exposure to stress did not induce a relapse in colitis in the mice. In a new study, researchers at Nationwide Children’s Hospital and the Abigail Wexner Research Institute tested whether exposure to stress would lead to flares of intestinal inflammation in a mouse model of inflammatory bowel disease. They found stress did not exacerbate colitis…

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Practical, At-Home Parasacral Nerve Stimulation for Overactive Bladder in Children
Practical, At-Home Parasacral Nerve Stimulation for Overactive Bladder in Children 150 150 Mary Bates, PhD

A new regimen for parasacral transcutaneous electrical nerve stimulation (TENS) is manageable and results in subjective improvements, though objective improvements were modest. In a new study, researchers from Nationwide Children’s evaluated the effectiveness of a practical, at-home regimen of parasacral transcutaneous electrical nerve stimulation (TENS) for children with overactive bladder. Parasacral TENS involves electrical stimulation…

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Featured Researcher — Tracy Bedrosian, PhD
Featured Researcher — Tracy Bedrosian, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES

Tracy Bedrosian, PhD, is a principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine and a specialist in brain mosaicism and neurodevelopment working to uncover the impact that localized mutations in brain cells have on epilepsy symptoms, autism and other neurodevelopmental diseases. She collaborates with neurologists and other experts in the Steve…

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First Multicenter, Prospective Study of Surgical Approach and Short-term Outcomes in Patients Undergoing Total Pancreatectomy With Islet Autotransplantation
First Multicenter, Prospective Study of Surgical Approach and Short-term Outcomes in Patients Undergoing Total Pancreatectomy With Islet Autotransplantation 150 150 Lauren Dembeck

The goal of the prospective study is to critically evaluate current clinical practices to determine which should be adopted or abandoned. It will also provide an opportunity to evaluate patients’ quality of life after total pancreatectomy with islet autotransplantation.   For children and adults with debilitating pancreatitis that fails to respond to medical and endoscopic…

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Researchers Classify High-Risk Variants in Lamin A/C Cardiac Disease Using Machine Learning
Researchers Classify High-Risk Variants in Lamin A/C Cardiac Disease Using Machine Learning 1024 575 Lauren Dembeck
conceptual art of DNA

A recent study from researchers at Nationwide Children’s Hospital, published in Heart Rhythm, describes how a LMNA variant of unknown significance was identified as high-risk using family histories, genomic analysis and machine learning. “Genetic variants in LMNA are well known to cause a spectrum of clinical disease — referred to as laminopathies — particularly cardiomyopathy,…

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Exploring the RNA Cargo of Extracellular Vesicles in Malignant Pediatric Brain Tumors
Exploring the RNA Cargo of Extracellular Vesicles in Malignant Pediatric Brain Tumors 150 150 JoAnna Pendergrass, DVM

The RNA cargo within the extracellular vesicles of medulloblastoma and diffuse infiltrative pontine glioma can provide valuable insight into diagnosing and treating these malignant pediatric brain tumors. Recent studies have shed light on extracellular vesicles’ ability to use their cargo, which includes small noncoding RNA (ncRNA), to facilitate cell-to-cell communication. Extracellular vesicles (EVs) derived from…

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The Importance of Body Composition in Cystic Fibrosis
The Importance of Body Composition in Cystic Fibrosis 150 150 Mary Bates, PhD

Lean mass deficits are common in pediatric patients with cystic fibrosis and associated with impaired lung and bone health. Now, experts are calling for increased use of body composition measurements in clinical care.  In cystic fibrosis — a multisystem disorder characterized by progressive lung disease, pancreatic insufficiency, malabsorption and malnutrition — nutrition status is correlated with…

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Could a Sequence-Specific Splice Switching Oligonucleotide and Antibody Therapy Combination Successfully Treat Rhabdomyosarcoma?
Could a Sequence-Specific Splice Switching Oligonucleotide and Antibody Therapy Combination Successfully Treat Rhabdomyosarcoma? 1024 683 Jessica Nye, PhD

Blocking alternative splicing may be a viable therapeutic intervention strategy for reducing tumor growth in rhabdomyosarcoma (RMS).   RMS is the most common pediatric soft tissue sarcoma and is associated with poor prognosis, a high rate of metastasis and recurrence. RMS tumors overexpress insulin growth factor (IGF)-2, making the IGF pathway a potential interventional target.…

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Study Supports Virotherapy as a Potential Treatment for Brain Tumors
Study Supports Virotherapy as a Potential Treatment for Brain Tumors 1024 575 Nationwide Children's

A new study provides additional evidence of the efficacy of virotherapy for glioblastoma, the deadliest type of brain tumor. The research findings, published in Clinical Cancer Research, indicate that an oncolytic herpes simplex virus, G207, appears to boost immune response and that this is associated with better overall survival for patients with glioblastoma. The study,…

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Physical Activity Intervention May Benefit Adolescents With Congenital Heart Defects
Physical Activity Intervention May Benefit Adolescents With Congenital Heart Defects 1024 684 Mary Bates, PhD
teen girl using cell phone

A lifestyle intervention delivered via videoconference increased physical activity in the least active participants. In a new pilot study, researchers from Nationwide Children’s evaluated the efficacy of the Congenital Heart Disease Physical Activity Lifestyle (CHD-PAL) intervention for high school-aged adolescents with congenital heart defects. The results demonstrate the intervention is feasible and acceptable, and preliminary…

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Postoperative Management of Flexor Tendon Injuries in Children
Postoperative Management of Flexor Tendon Injuries in Children 150 150 Mary Bates, PhD

One month of immobilization followed by a modified Duran protocol leads to good outcomes. Pediatric flexor tendon injuries can be challenging due to children’s smaller anatomy and possible treatment nonadherence. In adults, immediate to early active motion for flexor tendon repairs has become standard, as prolonged postoperative immobilization can lead to adhesion formation and joint…

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Pediatric Bone Density Measures Require Adjusted Scoring for Accurate Interpretation
Pediatric Bone Density Measures Require Adjusted Scoring for Accurate Interpretation 1024 575 Katie Brind'Amour, PhD, MS, CHES

Understanding the limits of pediatric bone densitometry reports can make results more useful for clinical decision making. Dual-energy X-ray absorptiometry, or DXA, is the standard scan used to assess bone mineral density (BMD) in children. It uses very little radiation and has extensive normative data from pediatric populations, to which a child’s results can be…

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Short- and Long-Term Kidney Issues in Children Treated for Leukemia
Short- and Long-Term Kidney Issues in Children Treated for Leukemia 720 480 Mary Bates, PhD

While outcomes for childhood acute lymphoblastic leukemia (ALL) have improved, researchers are finding long-term effects on kidney function that require monitoring. In a new study published recently in Pediatric Nephrology, researchers from Nationwide Children’s report the incidence of hypertension and kidney issues in pediatric patients diagnosed with acute lymphoblastic leukemia over a recent nine-year period.…

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Epilepsy Centers in United States Expand in Size and Specialized Testing Services with Accreditation
Epilepsy Centers in United States Expand in Size and Specialized Testing Services with Accreditation 150 150 Rebecca Cybulski

Recent data is used to analyze characteristics of accredited epilepsy centers across the United States, including testing, treatment and outcomes for drug resistant epilepsy patients. New research from the Abigail Wexner Research Institute at Nationwide Children’s Hospital has found that as a result of the increased number of accredited epilepsy centers in the United States, drug-resistant epilepsy…

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What is “Normal” Thyroid Functioning in Preterm Infants?
What is “Normal” Thyroid Functioning in Preterm Infants? 1024 683 Mary Bates, PhD
Baby in NICU

Study provides one of the largest samples of thyroid values in preterm infants to establish reference intervals. Preterm infants are born with an immature hypothalamic-pituitary-thyroid axis, putting them at risk for hypothyroidism from a delayed rise in thyroid-stimulating hormone (TSH). Currently in the United States, the thyroid function of all infants is evaluated within the…

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Exploring Dopamine Genotype as a Moderator of the Effect of Parental Behavior on Children’s Self-Control
Exploring Dopamine Genotype as a Moderator of the Effect of Parental Behavior on Children’s Self-Control 150 150 Daphne Vrantsidis, PhD

Did you know developmental psychologists have found the secret to life success? It’s not eating your vegetables or doing your homework or anything else your parents or teachers told you growing up. It’s how long you waited to eat a marshmallow when you were 4 years old. Delaying gratification — waiting 5 minutes to eat…

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First In Human
First In Human 150 150 Abbie Roth

The Heart Center at Nationwide Children’s Hospital has a long history of helping to bring innovations from the lab to the patient. The latest, the Autus Valve, aims to improve care and outcomes for children with pulmonary valve disease. In December 2021, Mark Galantowicz, MD, cardiothoracic surgeon and director of The Heart Center at Nationwide…

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How the Antimicrobial Protein RNase 7 Helps Prevent Urinary Tract Infections
How the Antimicrobial Protein RNase 7 Helps Prevent Urinary Tract Infections 1024 683 Mary Bates, PhD

Researchers identify genetic variation associated with severe and recurrent UTIs. A new study adds to the growing body of evidence suggesting the antimicrobial protein RNase 7 plays an important role in preventing urinary tract infections (UTIs). The findings, published in The Journal of Clinical Investigation, suggest genetic variations in the RNase 7 gene may increase…

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Novel Digital Storybook Intervention Aims to Support Children With Hearing Loss
Novel Digital Storybook Intervention Aims to Support Children With Hearing Loss 1024 683 Abbie Roth

Hear Me Read, invented and developed at Nationwide Children’s Hospital, is now being validated in a prospective clinical trial. For children who are deaf or hard of hearing, access to sound via hearing aids and cochlear implants and intensive speech therapy with highly trained verbal therapists are important parts of developing speech and literacy. “Children…

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NCHart-1 a New Approach to Estimating Total Body Surface Area Burn Percentages
NCHart-1 a New Approach to Estimating Total Body Surface Area Burn Percentages 150 150 Abbie Roth

The new chart reduces math errors, improving accuracy for better outcomes. When a child has a burn injury, immediate care is essential. Fluid administration and treatment resources needed are decisions made in the field by emergency medical technicians (EMTs) and paramedics. Both decisions hinge on what percent of the child’s skin has burns. This number…

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After Lung Transplantation for Cystic Fibrosis, Migration of Stem Cells May Lead to Chimeric Phenotype
After Lung Transplantation for Cystic Fibrosis, Migration of Stem Cells May Lead to Chimeric Phenotype 1024 575 Jessica Nye, PhD
Illustration of lungs on blue silhouette of upper chest on black background

Lung transplantation (LTx) for cystic fibrosis (CF) may trigger bidirectional, long-distance migration of tissue specific stem cells (TSC), causing a chimeric phenotype which could have implications for host defense capabilities. CF is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene and is characterized by progressive chronic obstructive lung disease which can lead…

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Featured Researcher — Amit Kapoor, PhD
Featured Researcher — Amit Kapoor, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES

Amit Kapoor, PhD, joined Nationwide Children’s Hospital as a principal investigator in the Center for Vaccines and Immunity and The Ohio State University as an associate professor of Pediatrics in 2015. Dr. Kapoor’s lab is working to understand the immunopathogenesis of several viral pathogens that infect humans and animals. His lab is developing new animal…

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Iron Deficiency and Fatigue Among Adolescents With Heavy Menstrual Bleeding
Iron Deficiency and Fatigue Among Adolescents With Heavy Menstrual Bleeding 1024 673 Mary Bates, PhD

Both iron deficiency and fatigue are common in adolescents with heavy menstrual bleeding and may not indicate presence of a bleeding disorder. In a new multicenter study of nearly 200 adolescents with heavy menstrual bleeding, researchers found a high prevalence of iron deficiency without concomitant anemia as well as a high prevalence of fatigue. The…

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Epilepsy Surgery Underutilized in Young Patients With Drug-Resistant Epilepsy
Epilepsy Surgery Underutilized in Young Patients With Drug-Resistant Epilepsy 1024 575 Katie Brind'Amour, PhD, MS, CHES
Color close up image of young baby girl looking at hanging toys

Research suggests that early surgical intervention can boost developmental outcomes and even cure young children with intractable epilepsy, but low referral rates and other barriers result in limited access for some. Early surgery for drug-resistant epilepsy (DRE) can improve quality of life by reducing or even eliminating seizures. DRE affects about one in every three…

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An Epigenetic Vulnerability for Rhabdomyosarcoma Among Children?
An Epigenetic Vulnerability for Rhabdomyosarcoma Among Children? 150 150 Jessica Nye, PhD

A deep classification of epigenetic machinery in rhabdomyosarcoma (RMS) tumors finds that the mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) complexes are essential for the stabilization of RMS.   A recent study, published in Nature Communications, by Ben Stanton, PhD, and colleagues focused on rhabdomyosarcoma (RMS), a lethal pediatric soft tissue malignancy. Fusion positive RMS (FP-RMS) has properties…

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4-Year Study Finds No Correlation Between Head Impacts and Cognitive Outcomes in Youth Tackle Football Players
4-Year Study Finds No Correlation Between Head Impacts and Cognitive Outcomes in Youth Tackle Football Players 1024 683 Lauren Dembeck

In the longest study of its kind, researchers studied individual players through 4 seasons of youth tackle football and found no correlation between the number or severity of head impacts and cognitive and behavioral outcomes.  When children are considering playing contact sports, parents/guardians and medical providers must weigh the risks and benefits. One of the…

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Right Care, Right Place, Right Time? Frequency and Duration of Boarding for Pediatric Mental Health Conditions at Acute Care Hospitals
Right Care, Right Place, Right Time? Frequency and Duration of Boarding for Pediatric Mental Health Conditions at Acute Care Hospitals 150 150 Lauren Dembeck

Mental health boarding durations significantly exceed standards by the Joint Commission, and youth receive minimal mental health services in these acute care settings. This study calls for increased awareness, dedicated resources and research to improve mental health care for youths in these settings. According to the results of a national survey conducted, in part by…

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Study Finds High Mortality Rates of Youths Previously Incarcerated in the Juvenile Legal System
Study Finds High Mortality Rates of Youths Previously Incarcerated in the Juvenile Legal System 1024 683 Rebecca Cybulski
silhouette girl portrait

Recent data links youth incarceration to early mortality by homicide, overdose and suicide. New research from the Abigail Wexner Research Institute at Nationwide Children’s Hospital finds that youth aged 11 to 21 years, who have been previously incarcerated in the juvenile legal system, are 5.9 times more likely than the general population to experience early mortality.…

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Polyethylene Glycol 3350 Does Not Lead to Behavior Changes in Animal Model
Polyethylene Glycol 3350 Does Not Lead to Behavior Changes in Animal Model 1024 683 Mary Bates, PhD

The laxative affected stool consistency and gut bacteria but did not alter anxiety-like behavior in mice. Polyethylene glycol 3350 (PEG3350) is a laxative commonly used to treat constipation in children. Over the years, the Food and Drug Administration has received some reports of neuropsychiatric symptoms in children administered PEG3350, including anxiety, aggression and obsessive-compulsive behaviors.…

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