Monthly Archives :

September 2021

The Impact of Genomic Medicine: Carter’s Story
The Impact of Genomic Medicine: Carter’s Story 1024 685 Natalie Wilson

In 2013, at just 1 year old, Carter Daggett was diagnosed with a rare brain tumor. Now, in 2021, at 8 years old, he celebrated 3 years cancer free — thanks to his clinical teams and cutting-edge research by the team at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital.…

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Identifying Early Urinary Biomarkers of Kidney Damage in Type 1 Diabetes
Identifying Early Urinary Biomarkers of Kidney Damage in Type 1 Diabetes 1024 575 Mary Bates, PhD

Markers of renal tubule injury and oxidative stress indicate diabetic nephropathy before microalbuminuria. Diabetic nephropathy is a common complication of type 1 diabetes. Traditionally, measurement of microalbuminuria is used to screen children with diabetes for diabetic nephropathy. However, evidence suggests that damage to the kidneys may begin soon after diagnosis, much earlier than microalbuminuria can…

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Alarming Upward Trend in Black Youth Suicide From 2003 to 2017
Alarming Upward Trend in Black Youth Suicide From 2003 to 2017 1024 683 Lauren Dembeck
Sad black teenage girl

Prioritization of research aimed at identifying specific risk and protective factors associated with Black youth suicidal behavior is needed. In the United States, the rates of suicide and suicidal behavior among youth, children and adolescents 5-17 years of age, have been steadily increasing over the last decade, and Black youth, 5-12 years, are approximately two…

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Probiotic Treatment Promotes Neurodevelopment After Experimental Necrotizing Enterocolitis
Probiotic Treatment Promotes Neurodevelopment After Experimental Necrotizing Enterocolitis 777 640 Lauren Dembeck
B&W image of Dr. Gail Besner posing for a photo in her lab coat

A single dose of a novel live probiotic therapeutic protects the rodent brain during early development and the effects persist into adolescence. Researchers at Nationwide Children’s Hospital have demonstrated that when given in a biofilm state, probiotic Lactobacillus reuteri prevents the detrimental neurodevelopmental sequalae of experimental necrotizing enterocolitis (NEC).1 The findings, published in Brain, Behavior…

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Featured Researcher — Jennifer Muszynski, MD, MPH, FCCM
Featured Researcher — Jennifer Muszynski, MD, MPH, FCCM 150 150 Natalie Wilson

Jennifer Muszynski, MD, MPH, FCCM, a physician in the Division of Critical Care Medicine at Nationwide Children’s Hospital and an associate director of its fellowship program, is a principal investigator in the Center for Clinical and Translational Research in the Abigail Wexner Research Institute at Nationwide Children’s. Dr. Muszynski’s research focuses on understanding how receiving…

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Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival
Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival 150 150 Mary Bates, PhD

Most infants with established BPD referred to Nationwide’s BPD Center improve and survive, despite the severity of their illness. In a new study, researchers analyzed the in-hospital outcomes for preterm infants with established bronchopulmonary dysplasia (BPD) referred to Nationwide Children’s Comprehensive Center for BPD. They found that despite the high degree of illness severity in…

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Postoperative Care for Benign Ovarian Neoplasms
Postoperative Care for Benign Ovarian Neoplasms 150 150 Mary Bates, PhD

Study suggests no benefit from routine imaging and supports symptomatic imaging for postoperative management of benign ovarian neoplasms. In a new study, researchers at Nationwide Children’s Hospital led a collaboration with eight children’s hospitals examining the follow-up care and subsequent outcomes of pediatric patients after surgery for a benign ovarian neoplasm to develop evidence-based recommendations…

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Administering NK Cells Post-Transplant Improves Relapse in Myeloid Malignancies
Administering NK Cells Post-Transplant Improves Relapse in Myeloid Malignancies 150 150 Mary Bates, PhD

A Phase I/II clinical trial demonstrates donor-derived NK cells are safe and effective at decreasing relapse and increasing survival in adults with myeloid malignancies. Haploidentical stem-cell transplantation can be a successful treatment for patients with myeloid malignancies, but relapse remains a common risk. Natural killer (NK) cells are a subset of lymphocytes capable of recognizing…

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