Monthly Archives :

September 2021

Long-Term Follow-up Study Shows Cannabidiol is Safe and Effective for Lennox-Gastaut Syndrome
Long-Term Follow-up Study Shows Cannabidiol is Safe and Effective for Lennox-Gastaut Syndrome 695 473 Mary Bates, PhD
Black and white environmental portrait of Dr. Anup Patel standing in the hospital in his lab coat with his hand in his pocket

Long-term treatment with highly purified plant-based CBD shows continued seizure reduction and no new side effects. The results of a long-term open-label extension trial of plant-derived, highly purified cannabidiol (CBD) show the treatment is effective and safe long term for patients with Lennox-Gastaut syndrome. The treatment had a similar safety profile as in the original…

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A Novel FUS/ETV4 Fusion and Other Rare FET/ETS Fusion Proteins Are Bona Fide Ewing Sarcoma
A Novel FUS/ETV4 Fusion and Other Rare FET/ETS Fusion Proteins Are Bona Fide Ewing Sarcoma 1024 575 Jessica Nye, PhD

Researchers conduct a molecular comparison between the established EWS/FLI translocation with rarer FET/ETS fusions, broadly supporting the inclusion of FET/ETS chimeric proteins in Ewing Sarcoma diagnosis and treatment.   Ewing sarcoma, most commonly caused by a chromosomal translocation of the amino-terminal domain of EWSR1 with the transcription factor FLI (EWS/FLI), presents as an aggressive pediatric…

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Targeted Muscle Reinnervation for Amputees Offers Chance at Less Pain, More Prosthetic Options
Targeted Muscle Reinnervation for Amputees Offers Chance at Less Pain, More Prosthetic Options 1024 684 Katie Brind'Amour, PhD, MS, CHES

The innovative procedure pioneered by surgeons at The Ohio State University and Nationwide Children’s Hospital reduces postoperative pain and enables control of bioprosthetics.   What started as Department of Defense-funded research in adult amputees at The Ohio State University Medical Center about 6 years ago has morphed into standard of care treatment for children undergoing…

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Ask A Specialist: Management of Labial Adhesions in Prepubertal Girls
Ask A Specialist: Management of Labial Adhesions in Prepubertal Girls 1024 680 Geri Hewitt, MD

What is the appropriate management of asymptomatic and symptomatic labial adhesions in a prepubertal girl? The management of labial adhesions has really evolved over time. The most important thing is to make sure you have the correct diagnosis and it’s not some other problem with the vagina opening. Labial adhesions are isolated (not associated with…

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What Pediatricians Should Know about Long COVID
What Pediatricians Should Know about Long COVID 1024 683 Octavio Ramilo, MD

More than 4 million children have tested positive for SARS-CoV-2 in the United States. According to the American Academy of Pediatrics, long-term effects from COVID-19 can be significant, regardless of initial disease severity. Medical providers across the nation, including here at Nationwide Children’s Hospital, are seeing an increase in cases of what is being called…

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Ask A Specialist: When Should Patients With Molluscum Contagiosum Be Referred to Dermatology?
Ask A Specialist: When Should Patients With Molluscum Contagiosum Be Referred to Dermatology? 1024 575 Patricia Witman, MD
Toddler playing with toys

What are the current treatment recommendations for moderate to severe molluscum, and when would you suggest referring to a dermatologist? Molluscum contagiosum is an infection caused by a virus that typically results in benign, mild skin disease characterized by lesions (Mollusca) that are small, raised and usually white, pink or flesh colored with a dimple…

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The Impact of Genomic Medicine: Carter’s Story
The Impact of Genomic Medicine: Carter’s Story 1024 685 Natalie Wilson

In 2013, at just 1 year old, Carter Daggett was diagnosed with a rare brain tumor. Now, in 2021, at 8 years old, he celebrated three years cancer free — thanks to his clinical teams and cutting-edge research by the team at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital.…

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Identifying Early Urinary Biomarkers of Kidney Damage in Type 1 Diabetes
Identifying Early Urinary Biomarkers of Kidney Damage in Type 1 Diabetes 1024 575 Mary Bates, PhD

Markers of renal tubule injury and oxidative stress indicate diabetic nephropathy before microalbuminuria. Diabetic nephropathy is a common complication of type 1 diabetes. Traditionally, measurement of microalbuminuria is used to screen children with diabetes for diabetic nephropathy. However, evidence suggests that damage to the kidneys may begin soon after diagnosis, much earlier than microalbuminuria can…

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Alarming Upward Trend in Black Youth Suicide From 2003 to 2017
Alarming Upward Trend in Black Youth Suicide From 2003 to 2017 1024 683 Lauren Dembeck
Sad black teenage girl

Prioritization of research aimed at identifying specific risk and protective factors associated with Black youth suicidal behavior is needed. In the United States, the rates of suicide and suicidal behavior among youth, children and adolescents 5-17 years of age, have been steadily increasing over the last decade, and Black youth, 5-12 years, are approximately two…

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Probiotic Treatment Promotes Neurodevelopment After Experimental Necrotizing Enterocolitis
Probiotic Treatment Promotes Neurodevelopment After Experimental Necrotizing Enterocolitis 777 640 Lauren Dembeck
B&W image of Dr. Gail Besner posing for a photo in her lab coat

A single dose of a novel live probiotic therapeutic protects the rodent brain during early development and the effects persist into adolescence. Researchers at Nationwide Children’s Hospital have demonstrated that when given in a biofilm state, probiotic Lactobacillus reuteri prevents the detrimental neurodevelopmental sequalae of experimental necrotizing enterocolitis (NEC).1 The findings, published in Brain, Behavior…

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Featured Researcher — Jennifer Muszynski, MD, MPH, FCCM
Featured Researcher — Jennifer Muszynski, MD, MPH, FCCM 150 150 Natalie Wilson

Jennifer Muszynski, MD, MPH, FCCM, a physician in the Division of Critical Care Medicine at Nationwide Children’s Hospital and an associate director of its fellowship program, is a principal investigator in the Center for Clinical and Translational Research in the Abigail Wexner Research Institute at Nationwide Children’s. Dr. Muszynski’s research focuses on understanding how receiving…

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Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival
Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival 150 150 Mary Bates, PhD

Most infants with established BPD referred to Nationwide’s BPD Center improve and survive, despite the severity of their illness. In a new study, researchers analyzed the in-hospital outcomes for preterm infants with established bronchopulmonary dysplasia (BPD) referred to Nationwide Children’s Comprehensive Center for BPD. They found that despite the high degree of illness severity in…

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Postoperative Care for Benign Ovarian Neoplasms
Postoperative Care for Benign Ovarian Neoplasms 150 150 Mary Bates, PhD

Study suggests no benefit from routine imaging and supports symptomatic imaging for postoperative management of benign ovarian neoplasms. In a new study, researchers at Nationwide Children’s Hospital led a collaboration with eight children’s hospitals examining the follow-up care and subsequent outcomes of pediatric patients after surgery for a benign ovarian neoplasm to develop evidence-based recommendations…

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Administering NK Cells Post-Transplant Improves Relapse in Myeloid Malignancies
Administering NK Cells Post-Transplant Improves Relapse in Myeloid Malignancies 150 150 Mary Bates, PhD

A Phase I/II clinical trial demonstrates donor-derived NK cells are safe and effective at decreasing relapse and increasing survival in adults with myeloid malignancies. Haploidentical stem-cell transplantation can be a successful treatment for patients with myeloid malignancies, but relapse remains a common risk. Natural killer (NK) cells are a subset of lymphocytes capable of recognizing…

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