Inside the Science of Pediatric Lung Disease

A Special Section
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Speeding Up Science With Patient-Derived Xenografts

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Meeting the Challenge of Clinical Trial Recruitment and Retention

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Photo of Christina Ching, MD, wearing a white lab coat, smiling at the camera in a lab.
New Mechanism Identified in Urinary Tract Infection Host Defense
 New Mechanism Identified in Urinary Tract Infection Host Defense 1024 683 Pam Georgiana
By: Pam Georgiana

IL-6 promotes urothelial expulsion of intracellular bacteria, limiting recurrence risk. A recent study published in the Journal of Innate Immunity provides new insights into how the body actively defends against urinary tract infections (UTIs). Led by Christina B. Ching, MD, principal investigator of the…

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Ryan Goodwin, MD, MBA, standing in a hallway with a teal wall. He is wearing a blue shirt and black suit pants and jacket.
Meet Ryan Goodwin, MD: Advancing Pediatric Spine Care at Nationwide Children’s
 Meet Ryan Goodwin, MD: Advancing Pediatric Spine Care at Nationwide Children’s 1024 683 Alaina Doklovic
By: Alaina Doklovic

Nationwide Children’s Hospital recently welcomed pediatric orthopedic and spine surgeon Ryan Goodwin, MD, new director of The Center for Comprehensive Spine Care. With more than two decades of experience and a passion for innovation in scoliosis treatment, Dr. Goodwin brings both expertise and new…

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Close-up digital illustration of a DNA strand against a blue background.
Health Systems Face Growing Gap in Cell and Gene Therapy Implementation
 Health Systems Face Growing Gap in Cell and Gene Therapy Implementation 1024 768 Pam Georgiana
By: Pam Georgiana

New manuscript outlines practical strategies to address safety, operational and financial challenges. As cell and gene therapies (CGTs) are increasingly incorporated into standard clinical care, health systems face a widening operational gap. An invited manuscript published in Transfusion outlines the challenge and presents a…

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Graphic illustration of kidneys and bladder organ visualization. Healthcare concept background with medical icons.
Why Immune Balance Matters in UTI Susceptibility
 Why Immune Balance Matters in UTI Susceptibility 1024 459 Pam Georgiana
By: Pam Georgiana

New research identifies PTEN as a main regulator of bladder immunity and suggests potential non-antibiotic prevention strategies. Urinary tract infections (UTIs) remain among the most common bacterial infections in clinical practice, contributing to significant morbidity and raising concerns about antibiotic resistance. While known risk…

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Photo of lone star tick on a leaf, the tick has a white dot on the center of its back
Testing for Alpha-gal Syndrome: Clinical Clarity for Primary Care
 Testing for Alpha-gal Syndrome: Clinical Clarity for Primary Care 1024 683 David Stukus, MD and William Long, MD
By: David Stukus, MD and William Long, MD

Alpha-gal syndrome (AGS) presents a unique diagnostic challenge for clinicians, often leading to unnecessary testing in patients with vague allergic symptoms or solely due to a history of a tick bite with no other symptoms. Understanding when — and when not — to order…

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A woman sitting on a couch reading a book with two young children, who smile and look at the pages together.
Closing the Kindergarten Readiness Gap With Direct Literacy Screening in Primary Care
 Closing the Kindergarten Readiness Gap With Direct Literacy Screening in Primary Care 1024 683 Madison Storm
By: Madison Storm

New research suggests direct literacy screening during pediatric well visits can complement traditional developmental surveillance and better support kindergarten readiness. Pediatricians have long relied on developmental screening tools during well-child visits to monitor whether children are meeting expected milestones prior to starting kindergarten. But…

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A girl with Down syndrome smiling
Parent-Practitioner Collaboration Sparks New, Multidisciplinary Approach to Down Syndrome Care
 Parent-Practitioner Collaboration Sparks New, Multidisciplinary Approach to Down Syndrome Care 1024 661 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

An enhanced, family-focused clinic at Nationwide Children’s Hospital now offers appointments with multiple specialists in a single-location, single-day clinic. Even before birth, Down syndrome is a condition that demands the attention of multiple medical specialties. From geneticists and neonatologists to the cardiologists who often…

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Enironmental portrait of Rama Jayanthi, MD, and Peter Cuckow, MB, BS, FRCS
The Kelly Procedure: A Groundbreaking Approach to Treating Bladder Exstrophy
 The Kelly Procedure: A Groundbreaking Approach to Treating Bladder Exstrophy 1024 683 Alaina Doklovic
By: Alaina Doklovic

The Kelly Procedure, part of a revolutionary two-step approach to treat bladder exstrophy, provides continence quicker, improves outcomes and shortens recovery. Bladder exstrophy is a rare and complex condition that occurs in approximately one in 10,000 to 50,000 births. With this condition, the bladder…

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Gene and Cell Therapy at Nationwide Children’s: Leading Discovery, Driving Care
 Gene and Cell Therapy at Nationwide Children’s: Leading Discovery, Driving Care 1024 572 Nationwide Children's
By: Nationwide Children's

Nationwide Children’s has been a pioneer in gene and cell therapy for more than 30 years. Since our first clinical trial in 1999, our team has only accelerated the pace of innovation, discovery and patient-centered care. On this page, you’ll find a collection of…

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simple cartoon illustration of lungs
Bronchopulmonary Dysplasia Care: Evidence-Based, Future Focused
 Bronchopulmonary Dysplasia Care: Evidence-Based, Future Focused 1024 448 Nationwide Children's
By: Nationwide Children's

Bronchopulmonary dysplasia (BPD), also known as chronic lung disease, causes long-term breathing problems for premature babies, often resulting in poor growth and development. The team at the Comprehensive Center for Bronchopulmonary Dysplasia at Nationwide Children’s saves babies from around the world with the most…

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Featured Researcher: Sarah A. Keim, PhD, MA, MS
 Featured Researcher: Sarah A. Keim, PhD, MA, MS 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Epidemiology studies and analyzes the who, what, where, when and why of disease. Applying this approach to studying children’s health is critically important, particularly given all the health challenges today’s children face. Children’s health needs are unique because they are still growing and developing.…

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Inside the Science of Pediatric Lung Disease: A Special Section
 Inside the Science of Pediatric Lung Disease: A Special Section 1024 624 Abbie Miller
By: Abbie Miller

A NOTE FROM THE EDITOR Our breath connects us with the moment, grounds us and has the power to calm our minds and bodies. But for millions of children, an easy breath is not guaranteed. Lung disease accounts for about a third of admissions…

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Two smiling young children sit side by side indoors, facing the camera, with a colorful blurred artwork in the background.
Beyond Modulators: Ensuring All Patients With Cystic Fibrosis Benefit From the Next Wave of Therapy
 Beyond Modulators: Ensuring All Patients With Cystic Fibrosis Benefit From the Next Wave of Therapy 1024 618 Lauren Dembeck
By: Lauren Dembeck

Before CFTR modulators transformed care, cystic fibrosis (CF) was defined by relentless daily treatment and progressive lung disease. Children grew up with thick airway secretions, chronic cough, recurrent pulmonary infections, and frequent hospitalizations. Maintaining weight was a constant struggle, and lung function typically declined…

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Blue-toned illustration showing lungs beside silhouettes of people across the lifespan, from a crawling baby and toddler to a child, adult, and older adult with a cane.
From Bronchopulmonary Dysplasia to Chronic Obstructive Pulmonary Disease: A Developmental Continuum
 From Bronchopulmonary Dysplasia to Chronic Obstructive Pulmonary Disease: A Developmental Continuum 1024 774 Yan Hu, PhD
By: Yan Hu, PhD

A Prolonged Window of Vulnerability Lung development is a highly orchestrated process that begins early in gestation and continues well into postnatal life. Following airway branching during the embryonic and pseudoglandular stages, distal lung maturation, including small airway and alveolar formation, extends through infancy…

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A close-up medical illustration of blood vessels showing normal round red blood cells flowing through the vessel, with a cluster of rigid, crescent-shaped sickle cells causing a blockage. White blood cells are also visible against the dark background.
Sickle Cell Lung Disease: Opportunities to Advance Care and Research
 Sickle Cell Lung Disease: Opportunities to Advance Care and Research 1024 575 Pam Georgiana
By: Pam Georgiana

A series of studies aims to close gaps by integrating immunology, microbiology and environmental health into clinical research.  For children with sickle cell disease, lung complications remain among the most serious and least predictable drivers of morbidity and mortality. Despite advances in supportive care…

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Newborn with bronchopulmonary dysplasia sleeping in a NICU crib, wrapped in a hospital blanket and receiving oxygen through a nasal cannula.
Bronchopulmonary Dysplasia Research: Innovating on All Fronts
 Bronchopulmonary Dysplasia Research: Innovating on All Fronts 1024 509 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

From understanding the disease at a molecular level to improving strategies for oxygen support after discharge, researchers are tackling bronchopulmonary dysplasia from all angles. The doctors in the Neonatal Intensive Care Unit at Nationwide Children’s Hospital care for more babies with bronchopulmonary dysplasia (BPD)…

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Microscopy image of a mouse heart sample colored with red and green fluorescent dye, and marked for single-cell sampling.
How Diabetes Rewires the Heart’s Smallest Vessels
 How Diabetes Rewires the Heart’s Smallest Vessels 1024 597 Lauren Dembeck
By: Lauren Dembeck

A landmark study uncovers how diabetes alters the heart at the cellular level. Cardiovascular disease is the leading cause of death in type 2 diabetes. While its effects on large arteries are well recognized, growing evidence suggests the earliest cardiovascular injury occurs in the…

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New Health Challenges in the Post-CFTR Modulator Era
 New Health Challenges in the Post-CFTR Modulator Era 1024 576 Lauren Dembeck
By: Lauren Dembeck

The remarkable progress in CF care has also revealed new challenges. As individuals with CF live longer, clinicians are seeing higher frequencies of complications and other down- stream health concerns that rarely emerged in the past and are now focused on aging-related diseases and…

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Newborn baby in an NICU bed with a nasogastric tube.
Precision Medicine Brings Clarity to Preterm Infant Reflux
 Precision Medicine Brings Clarity to Preterm Infant Reflux 1024 492 Alaina Doklovic
By: Alaina Doklovic

Sudarshan Jadcherla, MD, and team aim to distinguish normal reflux from GERD in preterm infants. Gastroesophageal reflux (GER) is common in preterm infants regardless of whether they are being fed formula or breast milk, often presenting as irritability, coughing or feeding difficulties. These symptoms…

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simple cartoon illustration of lungs
Decoding Pediatric Asthma: From Cells to Care
 Decoding Pediatric Asthma: From Cells to Care 1024 448 Madison Storm
By: Madison Storm

How clinician-scientist teams are mapping the molecular drivers of wheezing and asthma to guide smarter, faster and more personalized treatment. Asthma is one of the most common reasons children visit the Emergency Department (ED) at Nationwide Children’s Hospital. While frontline clinicians work quickly to…

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