Turning Evidence Into Advocacy

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A New Therapeutic Era for Sickle Cell Disease

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A Blueprint for Better Care: The Constant Drive for Quality Improvement in Primary Care

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Iron Deficiency Begins Before Anemia

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Dr. Ashley Jackson wearing a white lab coat, purple gloves, leaning over a microscope in a lab and smiling at the camera
Pioneering Investigations in Renal Urothelium: Q & A With Ashley R. Jackson, PhD
 Pioneering Investigations in Renal Urothelium: Q & A With Ashley R. Jackson, PhD 1012 1024 Gina Vitale, PTA
By: Gina Vitale, PTA

Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and kidney failure. Nationwide Children’s Hospital nephrologists, urologists and researchers combine efforts to investigate how the kidney responds to obstruction and how that response might inform new approaches to treatment…

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Dr. Alvin J. Freeman, MD
In-Line Lipase Cartridge Associated With Growth Improvements in Young Children Receiving Enteral Nutrition
 In-Line Lipase Cartridge Associated With Growth Improvements in Young Children Receiving Enteral Nutrition 1024 683 Lauren Dembeck
By: Lauren Dembeck

Real-world data suggest that an in-line lipase cartridge may help improve weight and nutritional status in young children with fat malabsorption who require enteral feeding. Young children with fat malabsorption who received enteral formula through an in-line lipase cartridge showed significant improvements in weight…

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Facility image of the Big Lots Behavioral Health Pavillion at Nationwide Children's Hospital
Supporting Adolescents With ADHD in Achieving Academic and Life Success
 Supporting Adolescents With ADHD in Achieving Academic and Life Success 1024 538 Pam Georgiana
By: Pam Georgiana

Research at Nationwide Children’s Hospital focuses on improving ADHD assessment, treatment and coordination between clinical care and schools. Steven W. Evans, PhD is a principal investigator in the Institute for Mental and Behavioral Health Research at Nationwide Children’s Hospital and a professor of Psychiatry…

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Medical illustration of the digestive tract with a section of the colon highlighted in red and a magnified inset depicting cancer cells.
Colorectal Cancer in Adolescents Often Diagnosed at Advanced Stages
 Colorectal Cancer in Adolescents Often Diagnosed at Advanced Stages 1024 559 Abbie Miller
By: Abbie Miller

Multi-institutional study highlights diagnostic delays, aggressive disease and the need to consider colorectal cancer when concerning symptoms persist. Although colorectal cancer remains rare in children and adolescents, its incidence is increasing — and many young patients are diagnosed only after the disease has reached…

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New Consensus Guidance Addresses Antithrombotic Management in Infants With Congenital Heart Disease
 New Consensus Guidance Addresses Antithrombotic Management in Infants With Congenital Heart Disease 1024 670 Lauren Dembeck
By: Lauren Dembeck

New AATS consensus recommendations aim to reduce variation in antithrombotic testing, treatment, and monitoring for neonates and infants undergoing cardiac interventions. Antithrombotic management around cardiac procedures can be particularly challenging in neonates and infants, whose hemostatic systems differ from those of older children and…

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New Single-Cell Immune Atlas Offers a Framework for Studying the Developing Immune System
 New Single-Cell Immune Atlas Offers a Framework for Studying the Developing Immune System 150 150 Abbie Miller and Mykyta Artomov, PhD
By: Abbie Miller and Mykyta Artomov, PhD

Collaboration between research teams at Nationwide Children’s Hospital, Washington University in St. Louis, and King’s College London has created a large-scale single-cell map of the human immune system that could provide an important framework for studying how immunity develops throughout life. Their findings are…

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Fertility Knowledge Gaps Continue Into Adulthood for People With Sickle Cell Disease
 Fertility Knowledge Gaps Continue Into Adulthood for People With Sickle Cell Disease 1024 683 Pam Georgiana
By: Pam Georgiana

Study findings support earlier, ongoing fertility education and counseling beginning in pediatric care. Sickle cell disease and its treatments can affect reproductive health, yet new research suggests patients may still have significant knowledge gaps about infertility when they reach adulthood. In a study published…

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MRI scans of a brain
MRI Study Points to Glymphatic System Changes in Pediatric Demyelinating Disorders
 MRI Study Points to Glymphatic System Changes in Pediatric Demyelinating Disorders 1024 445 Pam Georgiana
By: Pam Georgiana

Findings could help researchers understand how brain changes evolve over the course of disease. Relatively little is known about the brain’s glymphatic system. Researchers know that it helps remove waste products from the brain, but they are still learning how this recently discovered system…

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close up of gloved hands in a surgical field holding surgical instruments
Blood-Sparing Heart Surgery With Cardio-pulmonary Bypass: Limiting the Use of Blood Products for Repair of Congenital Heart Disease
 Blood-Sparing Heart Surgery With Cardio-pulmonary Bypass: Limiting the Use of Blood Products for Repair of Congenital Heart Disease 432 351 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

More than two decades of work suggest that not only can complicated cardiac surgeries be done without blood transfusions but the outcomes are likely just as good as the traditional approach. For the multidisciplinary team of clinicians at Nationwide Children’s, blood transfusion and cardio-pulmonary…

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Post-concussion Screen Time: Amount and Type Matter for Recovery
 Post-concussion Screen Time: Amount and Type Matter for Recovery 1024 661 Laura Dattner
By: Laura Dattner

A new study found that moderate screen time may speed recovery in youth with concussion. In a study published in British Journal of Sports Medicine, researchers found that about 141 minutes of screen time each day for the first three days following concussion was associated…

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Decorative gold bar and circles on a white background
A New Therapeutic Era for Sickle Cell Disease
 A New Therapeutic Era for Sickle Cell Disease 1024 320 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Transformative therapies, coupled with novel approaches to supportive care, provide increasing hope for a normal life. For more than 100 years, progress in sickle cell disease (SCD) treatment has been slow. Its mainstay treatment, hydroxyurea, approved about 30 years ago, is a repurposed cancer…

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King Robinson - a young patient at Nationwide Children's - smiling and standing next to a window inside the hospital
Therapy Fit for a King
 Therapy Fit for a King 1024 588 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Marsha Marshall decided to raise King Robinson when he was just a baby at the request of his mother, Tameka Robinson, who was suffering from complications of sickle cell disease. It wasn’t long before King was diagnosed as well. For a woman in her…

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A girl in a bright pink shirt smiles while sitting beside a large hospital window and looking outside.
Turning Evidence Into Advocacy
 Turning Evidence Into Advocacy 1024 574 Abbie Miller
By: Abbie Miller

The healthcare community is increasingly recognizing their role in shaping policy, leveraging front-line experience, injury data and research. In June 2024, 11-year-old Avery Russell was playing at a friend’s house when she was viciously attacked by two dogs. What happened that day changed her…

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Stronger Together: The Unique Power of the Ohio Children’s Hospital Association
 Stronger Together: The Unique Power of the Ohio Children’s Hospital Association 595 212 Abbie Miller
By: Abbie Miller

The Ohio Children’s Hospital Association (OCHA) was formed 40 years ago when the CEOs of Ohio’s six children’s hospitals got together to address a new methodology for reimbursement that did not take into consideration pediatric conditions and acuity. “Ohio’s children’s hospitals are safety net…

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A smiling girl sits on a table at a doctor's office. A smiling female doctor is checking the girl's ear.
A Blueprint for Better Care: The Constant Drive for Quality Improvement in Primary Care
 A Blueprint for Better Care: The Constant Drive for Quality Improvement in Primary Care 1024 683 Alaina London
By: Alaina London

A culture of quality improvement at Nationwide Children’s Hospital has become the model of care for children across the country. Every day, thousands of children walk through the doors of Nationwide Children’s Primary Care Centers for well visits, follow-up care, acute illness and so…

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Beyond the Clinic: Bipolar Disorder Care Where Kids Live, Learn and Grow
 Beyond the Clinic: Bipolar Disorder Care Where Kids Live, Learn and Grow 1024 320 Madison Storm
By: Madison Storm

For many children and adolescents with bipolar disorder, care begins in a crisis: severe mood symptoms, suicidality or hospitalization. They are evaluated in an emergency department or admitted for inpatient care. Stabilization is an immediate priority. But what happens next? A new state-of-the-field review…

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teenage patient and doctor talking in an exam room
Iron Deficiency Begins Before Anemia
 Iron Deficiency Begins Before Anemia 1024 683 Amanda E. Jacobson-Kelly, MD, MSc
By: Amanda E. Jacobson-Kelly, MD, MSc

Why Pediatricians Should Recognize and Treat Iron Deficiency Before Anemia Develops For generations, pediatricians have been taught to think about iron deficiency in the context of anemia. We routinely screen infants for anemia and, when hemoglobin is low, diagnose and treat iron deficiency. If…

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Doctor in a white coat holding a clipboard pad and fill medical history list with silver pen.
Delays and Disparities in Uptake of Effective Antiseizure Medications
 Delays and Disparities in Uptake of Effective Antiseizure Medications 1024 562 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

National prescribing trends suggest many children may receive suboptimal epilepsy therapy. In the wake of landmark trials (SANAD II) firmly supporting the use of lamotrigine for focal and valproate for generalized epilepsy, neurologists at Nationwide Children’s expected these drugs would be increasingly prescribed. Instead,…

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Newborn baby in an incubator at the NICU
Evaluating Adherence and Safety Outcomes for Neonatal UTI Diagnosis and Treatment
 Evaluating Adherence and Safety Outcomes for Neonatal UTI Diagnosis and Treatment 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Neonates are at increased risk for developing urinary tract infections, yet a knowledge gap exists regarding defining, diagnosing and treating them in the NICU. A study across seven Nationwide Children’s neonatal intensive care units (NICUs) reported 80% adherence to diagnostic criteria for urinary tract…

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Graphic is titled Prevalence of Depression in Youth. It shows 3 pie graphs depicting 3% School-aged Children, 20% Adolescents, and 18% Young Adults
Depression Medication Adherence Varies Among Medicaid Youth
 Depression Medication Adherence Varies Among Medicaid Youth 1024 270 Lynn Dosky
By: Lynn Dosky

Poor medication adherence increases risk of persistent depression, suicide and self-harm. A national study of nearly 200,000 Medicaid- enrolled youth ages 9 to 24 found major gaps in the quality of antidepressant treatment and adherence for a new major depressive episode. Researchers analyzed Medicaid…

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