Teens on the Road

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Learning in Real Time to Overcome COVID-19 and MIS-C

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Patient-Derived Stem Cells Are Changing the Trajectory of CHD Research

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Reconsidering Screening in Primary Care

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Therapy With Double-Bright Natural Killer Cell Infusions Increases Response Rates Among Frail Patients With Acute Myeloid Leukemia
 Therapy With Double-Bright Natural Killer Cell Infusions Increases Response Rates Among Frail Patients With Acute Myeloid Leukemia 969 533 Jessica Nye, PhD
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A case series of 13 patients with relapsed/refractory acute myeloid leukemia (AML) finds that a novel approach using repeated infusions of cultured natural killer (NK) cells increases overall and complete response rates. NK cells are lymphocytes – white blood cell components of the innate…

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Repeated Injury to Stem Cells Could be a Significant Contributor to Chronic Lung Disease
 Repeated Injury to Stem Cells Could be a Significant Contributor to Chronic Lung Disease 1024 575 Abbie Roth
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A series of experiments shows that biological aging of tracheobronchial stem cells could drive the development of chronic lung disease. In a recent publication in STEM CELLS Translational Medicine (SCTM), researchers showed that repeated injury to epithelial cells in the airway caused biological aging…

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Treating Intrauterine Opioid Exposure in Infants Born Preterm
 Treating Intrauterine Opioid Exposure in Infants Born Preterm 1024 575 Deborah L. Ungerleider, MD, FAAP
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We need a protocol to evaluate and treat neonatal abstinence syndrome in preterm infants. Neonatal abstinence syndrome (NAS) occurs when infants who are exposed to opioids in utero develop withdrawal signs and symptoms after birth.1 According to past studies, NAS occurs in 55% to…

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A Patient-Centered Medical Home for Pediatric Inflammatory Bowel Disease
 A Patient-Centered Medical Home for Pediatric Inflammatory Bowel Disease 1024 683 Mary Bates, PhD
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The Center for Pediatric and Adolescent IBD serves as a case study for comprehensive, multidisciplinary care. In a new paper published in Inflammatory Bowel Disease, researchers from Nationwide Children’s describe the multidisciplinary care model at the Center for Pediatric and Adolescent Inflammatory Bowel Disease…

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Standardizing Training in Pediatric Cardiac Critical Care
 Standardizing Training in Pediatric Cardiac Critical Care 150 150 Mary Bates, PhD
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In a new report, a taskforce of experts presented their recommendations to standardize training in pediatric cardiac critical care. The authors hope the report is a first step toward more oversight of training and certification in the field. The field of pediatric cardiac critical…

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Validity of the WISC-V Intelligence Testing in Children With Autism Spectrum Disorder
 Validity of the WISC-V Intelligence Testing in Children With Autism Spectrum Disorder 1024 575 Mary Bates, PhD
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Evaluating thinking and reasoning abilities for children with autism using conventional intelligence tests can be done, but with some caution. The Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) is one of the most widely used intelligence tests for children. However, little is known…

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Codetection of Respiratory Bacteria in Infants With RSV Infection Associated With Worse Outcomes
 Codetection of Respiratory Bacteria in Infants With RSV Infection Associated With Worse Outcomes 1024 575 Lauren Dembeck
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The interaction between the bacteria and respiratory syncytial virus (RSV) appears to be synergistic. Researchers are now working to understand the underlying biological mechanisms. Researchers at Nationwide Children’s Hospital have discovered that codetection of Haemophilus influenzae and Streptococcus pneumoniae in the upper respiratory tract…

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Building Momentum for School-Based Health Care
 Building Momentum for School-Based Health Care 150 150 Mary Kay Irwin, EdD
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Pediatric health care and the United States educational system share similar goals, even if they don’t quite use the same words to describe them. Health care professionals often say they want optimal wellness for children, so they can thrive throughout their lives. Schools want…

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Additional Ventures: Investing in Congenital Heart Disease Research to Advance Care
 Additional Ventures: Investing in Congenital Heart Disease Research to Advance Care 150 150 Natalie Wilson
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Additional Ventures is a purpose-driven nonprofit that has developed the Single Ventricle Research Fund (SVRF), an annual research award program dedicated to accelerating research and improving care for people with single ventricle heart defects. The fund supports investigators through multi-year, high-impact grants focused on…

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How Patient-Derived Stem Cells are Changing the Trajectory of Congenital Heart Disease Research
 How Patient-Derived Stem Cells are Changing the Trajectory of Congenital Heart Disease Research 1024 683 Katie Brind'Amour, PhD, MS, CHES
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Small blood samples — and the patient-specific, induced pluripotent stem cells (iPSCs) they enable — turn into valuable research material for understanding congenital cardiovascular disorders, especially when united with modern genome sequencing and editing, animal models and three dimensional tissue growth technologies. Patient-derived induced…

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Teens on the Road: How Technology, Policy and Parents Influence Driving Safety
 Teens on the Road: How Technology, Policy and Parents Influence Driving Safety 1024 633 Abbie Roth
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Traffic crashes are a leading cause of death in the United States. For teens, the stakes are especially high.

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Microsurgery for Acute Flaccid Myelitis: Personalized Approach Leads to Remarkable Recoveries
 Microsurgery for Acute Flaccid Myelitis: Personalized Approach Leads to Remarkable Recoveries 1024 440 Lauren Dembeck
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Children from around the world are coming to Nationwide Children’s for specialized care for AFM with lower extremity involvement. Dr. Amy Moore invented many of the procedures that are leading to remarkable recoveries for these patients. After an ordinary cold, most people continue with…

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2021 Bright Futures/AAP Recommendations for Preventive Pediatric Health Care (Periodicity Schedule) in color showing all of the screenings recommended across 34 patient visits through a patient's twenty-second birthday
Reconsidering Screening in Primary Care
 Reconsidering Screening in Primary Care 1024 683 Jeb Phillips
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Screenings are an important part of preventive care, but the growing list of recommendations is daunting. How do we prioritize the limited time we have with patients and families? There are 32 well-child primary care visits recommended by the American Academy of Pediatrics in…

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Learning in Real Time to Overcome COVID-19 and MIS-C
 Learning in Real Time to Overcome COVID-19 and MIS-C 1024 491 Natalie Wilson
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When multisystem inflammatory syndrome in children (MIS-C) emerged in May 2020, the new condition made headlines. Although rare, MIS-C can appear in kids about a month after they’ve recovered from infections with SARS-CoV-2, the virus that causes COVID-19 — even if they haven’t felt…

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Close up color photo of little boy holding hands on his belly
Lubiprostone Found to be Safe, as Effective as Placebo in Children With Constipation
 Lubiprostone Found to be Safe, as Effective as Placebo in Children With Constipation 1024 680 Mary Bates, PhD
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The medication, FDA-approved for adults, may benefit older pediatric patients with less of a behavioral component to their constipation. Pediatric functional constipation, though common, remains challenging to treat. Lubiprostone is a medication approved by the U.S. Food and Drug Administration (FDA) for the treatment…

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Distinct Transcriptional Regulatory Domain Identified in Ewing Sarcoma Fusion Protein
 Distinct Transcriptional Regulatory Domain Identified in Ewing Sarcoma Fusion Protein 1024 1024 Lauren Dembeck
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A better understanding of a newly defined region in the fusion protein that causes Ewing sarcoma may lead to novel approaches for therapeutic targeting. Ewing sarcoma is an aggressive pediatric bone cancer defined by the presence of a single genetic abnormality: a chromosomal translocation.…

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Impulsivity, Not Inattention, Predicts Externalizing Disorders
 Impulsivity, Not Inattention, Predicts Externalizing Disorders 1024 683 Natalie Wilson
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Without early intervention, children with hyperactive-impulsive symptoms of attention-deficit/hyperactivity disorder may be vulnerable to developing other externalizing behavior disorders. Contributing to a small but growing body of litera­ture evaluating trait impulsivity theory, a team of researchers led by Mary A. Fristad, PhD, ABPP, director…

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Risk for Serious Complications From Vaccine-Preventable Infections After Hematopoietic Cell Transplant
 Risk for Serious Complications From Vaccine-Preventable Infections After Hematopoietic Cell Transplant 1024 683 Katie Brind'Amour, PhD, MS, CHES
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Clinician-scientists reveal the burden of vaccine-preventable infections among children post-transplant, when immunity is low and risk is high. When a hematopoietic cell transplant (HCT) recipient at Nationwide Children’s Hospital was diagnosed with a vaccine-preventable infection (VPI), treating clinicians decided to evaluate the burden of…

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How Policy Can Influence Distracted Driving
 How Policy Can Influence Distracted Driving 150 150 Laura Dattner
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To combat the risks of using a cellphone while driving, states have implemented a variety of laws. As of July 2021, 21 of 50 states have implemented comprehensive hands-free cellphone laws (i.e., comprehensive handheld cellphone bans), which prohibit almost all handheld cellphone use including…

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Kidney and Urinary Tract Protein Demonstrates Antimicrobial Activity
 Kidney and Urinary Tract Protein Demonstrates Antimicrobial Activity 1024 683 Lauren Dembeck
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A little-studied peptide found in the urinary tract is a potential biomarker for urinary tract infection risk and could be developed into a novel therapeutic against drug-resistant bacteria.  Researchers at Nationwide Children’s Hospital have demonstrated that an understudied protein expressed in the human kidney…

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Nurse caring for infant in Neonatal Intensive Care Unit (NICU)
Is Tracheostomy Tube Placement in Preemies Safe?
 Is Tracheostomy Tube Placement in Preemies Safe? 1024 575 Mary Bates, PhD
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The procedure is safe and effective in newborns requiring high ventilator pressures. Tracheostomy tube placement is a common procedure performed for premature infants requiring respiratory assistance. Compared to an endotracheal tube, placement of a tracheostomy tube is thought to allow the infant more opportunities…

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Featured Researcher — Rodney Britt, PhD
 Featured Researcher — Rodney Britt, PhD 150 150 Natalie Wilson
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Rodney D. Britt Jr., PhD, is a principal investigator in the Center for Perinatal Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital and an assistant professor of Pediatrics at The Ohio State University. Dr. Britt earned his bachelor’s degree in Chemistry…

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Black and white environmental portrait of Dr. Anup Patel standing in the hospital in his lab coat with his hand in his pocket
Long-Term Follow-up Study Shows Cannabidiol is Safe and Effective for Lennox-Gastaut Syndrome
 Long-Term Follow-up Study Shows Cannabidiol is Safe and Effective for Lennox-Gastaut Syndrome 695 473 Mary Bates, PhD
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Long-term treatment with highly purified plant-based CBD shows continued seizure reduction and no new side effects. The results of a long-term open-label extension trial of plant-derived, highly purified cannabidiol (CBD) show the treatment is effective and safe long term for patients with Lennox-Gastaut syndrome.…

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A Novel FUS/ETV4 Fusion and Other Rare FET/ETS Fusion Proteins Are Bona Fide Ewing Sarcoma
 A Novel FUS/ETV4 Fusion and Other Rare FET/ETS Fusion Proteins Are Bona Fide Ewing Sarcoma 1024 575 Jessica Nye, PhD
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Researchers conduct a molecular comparison between the established EWS/FLI translocation with rarer FET/ETS fusions, broadly supporting the inclusion of FET/ETS chimeric proteins in Ewing Sarcoma diagnosis and treatment.   Ewing sarcoma, most commonly caused by a chromosomal translocation of the amino-terminal domain of EWSR1…

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Targeted Muscle Reinnervation for Amputees Offers Chance at Less Pain, More Prosthetic Options
 Targeted Muscle Reinnervation for Amputees Offers Chance at Less Pain, More Prosthetic Options 1024 684 Katie Brind'Amour, PhD, MS, CHES
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The innovative procedure pioneered by surgeons at The Ohio State University and Nationwide Children’s Hospital reduces postoperative pain and enables control of bioprosthetics.   What started as Department of Defense-funded research in adult amputees at The Ohio State University Medical Center about 6 years…

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Practical Tips for Clinicians to Support Transgender and Gender-Diverse Youth
 Practical Tips for Clinicians to Support Transgender and Gender-Diverse Youth 1024 683 Katie Brind'Amour, PhD, MS, CHES
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Experts share advice for family medicine and other practitioners hoping to learn more about supporting transgender and gender-diverse patients. Although gender identity-related health topics have made it into mainstream media in recent months, their lack of discussion in many clinician education programs has left…

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Ask A Specialist: Management of Labial Adhesions in Prepubertal Girls
 Ask A Specialist: Management of Labial Adhesions in Prepubertal Girls 1024 680 Geri Hewitt, MD
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What is the appropriate management of asymptomatic and symptomatic labial adhesions in a prepubertal girl? The management of labial adhesions has really evolved over time. The most important thing is to make sure you have the correct diagnosis and it’s not some other problem…

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What Pediatricians Should Know about Long COVID
 What Pediatricians Should Know about Long COVID 1024 683 Octavio Ramilo, MD
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More than 4 million children have tested positive for SARS-CoV-2 in the United States. According to the American Academy of Pediatrics, long-term effects from COVID-19 can be significant, regardless of initial disease severity. Medical providers across the nation, including here at Nationwide Children’s Hospital,…

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Ask A Specialist: When Should Patients With Molluscum Contagiosum Be Referred to Dermatology?
 Ask A Specialist: When Should Patients With Molluscum Contagiosum Be Referred to Dermatology? 1024 575 Patricia Witman, MD
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What are the current treatment recommendations for moderate to severe molluscum, and when would you suggest referring to a dermatologist? Molluscum contagiosum is an infection caused by a virus that typically results in benign, mild skin disease characterized by lesions (Mollusca) that are small,…

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The Impact of Genomic Medicine: Carter’s Story
 The Impact of Genomic Medicine: Carter’s Story 1024 685 Natalie Wilson
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In 2013, at just 1 year old, Carter Daggett was diagnosed with a rare brain tumor. Now, in 2021, at 8 years old, he celebrated three years cancer free — thanks to his clinical teams and cutting-edge research by the team at the Steve…

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Identifying Early Urinary Biomarkers of Kidney Damage in Type 1 Diabetes
 Identifying Early Urinary Biomarkers of Kidney Damage in Type 1 Diabetes 1024 575 Mary Bates, PhD
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Markers of renal tubule injury and oxidative stress indicate diabetic nephropathy before microalbuminuria. Diabetic nephropathy is a common complication of type 1 diabetes. Traditionally, measurement of microalbuminuria is used to screen children with diabetes for diabetic nephropathy. However, evidence suggests that damage to the…

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Alarming Upward Trend in Black Youth Suicide From 2003 to 2017
 Alarming Upward Trend in Black Youth Suicide From 2003 to 2017 1024 683 Lauren Dembeck
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Prioritization of research aimed at identifying specific risk and protective factors associated with Black youth suicidal behavior is needed. In the United States, the rates of suicide and suicidal behavior among youth, children and adolescents 5-17 years of age, have been steadily increasing over…

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B&W image of Dr. Gail Besner posing for a photo in her lab coat
Probiotic Treatment Promotes Neurodevelopment After Experimental Necrotizing Enterocolitis
 Probiotic Treatment Promotes Neurodevelopment After Experimental Necrotizing Enterocolitis 777 640 Lauren Dembeck
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A single dose of a novel live probiotic therapeutic protects the rodent brain during early development and the effects persist into adolescence. Researchers at Nationwide Children’s Hospital have demonstrated that when given in a biofilm state, probiotic Lactobacillus reuteri prevents the detrimental neurodevelopmental sequalae…

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Featured Researcher — Jennifer Muszynski, MD, MPH, FCCM
 Featured Researcher — Jennifer Muszynski, MD, MPH, FCCM 150 150 Natalie Wilson
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Jennifer Muszynski, MD, MPH, FCCM, a physician in the Division of Critical Care Medicine at Nationwide Children’s Hospital and an associate director of its fellowship program, is a principal investigator in the Center for Clinical and Translational Research in the Abigail Wexner Research Institute…

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Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival
 Specialized Treatment for Severe Bronchopulmonary Dysplasia Increases Survival 150 150 Mary Bates, PhD
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Most infants with established BPD referred to Nationwide’s BPD Center improve and survive, despite the severity of their illness. In a new study, researchers analyzed the in-hospital outcomes for preterm infants with established bronchopulmonary dysplasia (BPD) referred to Nationwide Children’s Comprehensive Center for BPD.…

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Postoperative Care for Benign Ovarian Neoplasms
 Postoperative Care for Benign Ovarian Neoplasms 150 150 Mary Bates, PhD
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Study suggests no benefit from routine imaging and supports symptomatic imaging for postoperative management of benign ovarian neoplasms. In a new study, researchers at Nationwide Children’s Hospital led a collaboration with eight children’s hospitals examining the follow-up care and subsequent outcomes of pediatric patients…

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Administering NK Cells Post-Transplant Improves Relapse in Myeloid Malignancies
 Administering NK Cells Post-Transplant Improves Relapse in Myeloid Malignancies 150 150 Mary Bates, PhD
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A Phase I/II clinical trial demonstrates donor-derived NK cells are safe and effective at decreasing relapse and increasing survival in adults with myeloid malignancies. Haploidentical stem-cell transplantation can be a successful treatment for patients with myeloid malignancies, but relapse remains a common risk. Natural…

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Stent Implantations Are an Option for Small Patients
 Stent Implantations Are an Option for Small Patients 1024 670 Mary Bates, PhD
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Stents that can be dilated to adult size are safe and effective for the treatment of coarctation of the aorta in young patients. Studies have demonstrated stent implantation is more effective and safer than balloon angioplasty for the treatment of coarctation of the aorta…

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Smiling boy outside
Video Game-Based Therapy Makes Cardiopulmonary Rehabilitation Program More Patient-Centric
 Video Game-Based Therapy Makes Cardiopulmonary Rehabilitation Program More Patient-Centric 1024 683 Katie Brind'Amour, PhD, MS, CHES
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Patients can benefit from traditional therapeutic services as well as engaging, updated approaches to improve lung capacity and fitness.  The Cardiopulmonary Rehabilitation Program at Nationwide Children’s Hospital, launched in 2005 after a year-long pilot, has long offered services for patients to improve their ability…

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Two Novel Biomarkers for Urinary Tract Infection Diagnosis Identified
 Two Novel Biomarkers for Urinary Tract Infection Diagnosis Identified 1024 575 Mary Bates, PhD
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Study identifies two proteins that are elevated in children with UTIs compared to those with culture-negative pyuria. In a new study from Nationwide Children’s, researchers identified two novel biomarkers that could be developed to further fine tune the diagnosis of urinary tract infection (UTI)…

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Illustration showing the precise pattern of a biofilm - a perfect, 3D matrix
When Dismantling Bacterial Biofilms, the First Line of Defense Comes From Within
 When Dismantling Bacterial Biofilms, the First Line of Defense Comes From Within 1024 575 Natalie Wilson
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Researchers identified the mechanism behind the anti-biofilm properties of a protein found in all vertebrates. Too little of this protein allows disease-causing bacteria protected by biofilms to spread, while too much can lead to septic shock. Could a molecule of this protein be engineered…

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Unraveling the Role of Pioneer Factors in Childhood Cancer
 Unraveling the Role of Pioneer Factors in Childhood Cancer 150 150 Abbie Roth
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New study implicates PAX3-FOXO1, an oncogenic driver of rhabdomyosarcoma, as a chimeric pioneer factor. Transcription factors are proteins that read the DNA sequences and can direct the transcription of that sequence into mRNA for translation into a protein. Transcription can become deregulated in cancer.…

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Top-down view of heart valves
Cylinder Mitral Valve Construct is a Safe and Durable Alternative for Young Patients
 Cylinder Mitral Valve Construct is a Safe and Durable Alternative for Young Patients 1024 752 Mary Bates, PhD
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The new technique could potentially reduce the number of lifetime surgeries required by these patients, researchers say. In a new study, researchers from Nationwide Children’s Hospital report that pediatric patients who underwent cylinder mitral valve construct, a new technique for replacing the mitral valve,…

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Featured Researcher — Leena Nahata, MD
 Featured Researcher — Leena Nahata, MD 150 150 Natalie Wilson
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Pediatric endocrinologist Leena Nahata, MD, is the founder and medical director of the Fertility and Reproductive Health Program at Nationwide Children’s Hospital and a principal investigator in the Center for Biobehavioral Health at the Abigail Wexner Research Institute at Nationwide Children’s. Although fertility-related decisions…

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Robotic Surgery Is Here to Stay
 Robotic Surgery Is Here to Stay 150 150 Abbie Roth
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A recent publication describes increases in the use of robotic surgery in children’s hospitals across the country.  The use of robotic surgery in tertiary children’s hospitals has been on the rise since the 2000s. In a recent publication, researchers from Nationwide Children’s Hospital sought…

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Molecular Toolset: Real-Time Screening for SARS-CoV-2 Variants
 Molecular Toolset: Real-Time Screening for SARS-CoV-2 Variants 1024 683 Lauren Dembeck
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Tracking variants of concern or interest is critical to inform public health decisions and to ensure patients receive the best available COVID-19 treatments for SARS-CoV-2 infections. Researchers at Nationwide Children’s Hospital and The Ohio State University (OSU) have developed a set of mutation-specific tests…

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EVALI and MIS-C: Overlapping Diagnoses
 EVALI and MIS-C: Overlapping Diagnoses 1024 575 Mary Bates, PhD
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Taking a thorough history can differentiate these similarly presenting conditions. In a new report, researchers from Nationwide Children’s Hospital describe six patients admitted to the hospital with concerns for MIS-C who were later diagnosed with EVALI. The researchers discuss the factors that led them…

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The 5,000 Babies Project: Screening Newborns for Early Diagnosis of Developmental Delay
 The 5,000 Babies Project: Screening Newborns for Early Diagnosis of Developmental Delay 150 150 Lauren Dembeck
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Democratizing health care requires equal access to early identification of infant neurodevelopmental disorders.  Delayed diagnosis of disorders that involve developmental delays, such as cerebral palsy, can lead to lifelong disability. Yet not all families have access to health care facilities employing highly trained specialists…

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An Alarming Connection Between Justice System Involvement and Child Health
 An Alarming Connection Between Justice System Involvement and Child Health 1024 575 Jeb Phillips
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A first-of-its kind study finds that while only 2% of patients at a large children’s hospital are identified with likely personal or family involvement in the justice system, they account for large proportions of some troubling diagnoses. Research over the last decade has shown…

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5 Things to Know About Vertebral Body Tethering for Scoliosis
 5 Things to Know About Vertebral Body Tethering for Scoliosis 150 150 Allan C. Beebe, MD and Crystal D. Seilhamer, FNP
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As the surgical approach to scoliosis grows in popularity, understanding the pros, cons and contraindications becomes increasingly important. At the Center for Comprehensive Spine Care in the Department of Orthopedics at Nationwide Children’s Hospital, patients and providers are increasingly asking about vertebral body tethering…

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Improving Suicide Prevention by Examining Characteristics and Precipitating Circumstances Among Children Aged 5 to 11 Years
 Improving Suicide Prevention by Examining Characteristics and Precipitating Circumstances Among Children Aged 5 to 11 Years 150 150 Natalie Wilson
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Suicides among children aged 11 or younger are on the rise. In response to this trend and a call to action by the National Institute of Mental Health task force on child suicide research, researchers have identified common themes across coroner’s and police reports…

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Diabetes Distress Associated With Poor Glycemic Control in Adolescents With Diabetes
 Diabetes Distress Associated With Poor Glycemic Control in Adolescents With Diabetes 1024 683 Mary Bates, PhD
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Screening for diabetes distress, in addition to depression, could benefit adolescents with diabetes. Adolescents with type 1 diabetes are more likely to experience depression than their peers without diabetes, and symptoms of depression can directly impact adherence to diabetes care. Thus, both the American…

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Lawnmower Injuries in Children Are Limb-Threatening and Avoidable
 Lawnmower Injuries in Children Are Limb-Threatening and Avoidable 1024 683 Ibrahim Khansa, MD
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During the warm months, lawnmowers are a ubiquitous sight in American lawns. Unfortunately, more than 9,000 children are injured by lawnmowers every year in the United States. In a recent study, published in the Journal of Plastic, Reconstructive and Aesthetic Surgery – Open, our…

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Occurrence and Cost of Infections After Heart Transplant
 Occurrence and Cost of Infections After Heart Transplant 150 150 Mary Bates, PhD
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Researchers identify risk factors, long-term outcomes of vaccine-preventable infections following heart transplantation in pediatric patients. Recently, a study using the Pediatric Health Information System (PHIS) database found that one in six pediatric solid organ transplant recipients were hospitalized with respiratory syncytial virus (RSV) or…

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Providing Education and PrEP for Teens at Risk for HIV
 Providing Education and PrEP for Teens at Risk for HIV 1024 683 Abbie Roth
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In a recent PediaCast CME, Mike Patrick, MD, and Megan Brundrett, MD, share important information about offering PrEP and HIV-related education in your primary care practice. Listen to the Full Episode About 20% of new cases of HIV, the virus that causes Acquired Immunodeficiency…

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Unique Approach Helps Child Neurology Residents Improve Communication Skills
 Unique Approach Helps Child Neurology Residents Improve Communication Skills 150 150 Natalie Wilson
By:

More than 75% of residents said the opportunity to receive direct feedback from standardized patients, faculty and peers during simulated patient encounters was a valuable addition to their medical education. Teaching residents how to be sensitive, supportive, clear and thorough as they communicate complex…

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teen girl using cell phone
Self-Administered Electronic Assessment Tool Helps Clinicians Screen for Pediatric Bleeding Disorders
 Self-Administered Electronic Assessment Tool Helps Clinicians Screen for Pediatric Bleeding Disorders 1024 684 JoAnna Pendergrass, DVM
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An electronic self-administered bleeding assessment tool is a time-saving measure to comprehensively evaluate a pediatric patient’s bleeding symptoms. Bleeding assessment tools (BATs), originally developed as research tools, are used clinically to comprehensively evaluate a patient’s bleeding symptoms. Along with clinical judgement, “BATs are used…

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Does Twinkle Artifact on Ultrasound Indicate a Kidney Stone in Pediatric Patients?
 Does Twinkle Artifact on Ultrasound Indicate a Kidney Stone in Pediatric Patients? 150 150 Abbie Roth
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The presence of twinkle artifact on ultrasound is a useful, though imperfect, tool for diagnosing kidney stones in children. For pediatric patients, ultrasound is the recommended imaging modality used to diagnose kidney stones. Several findings are used to identify stones on ultrasound, including the…

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Featured Researcher — Genevieve Kendall, PhD
 Featured Researcher — Genevieve Kendall, PhD 150 150 Natalie Wilson
By:

Genevieve Kendall, PhD, is a principal investigator in the Center for Childhood Cancer and Blood Diseases and an assistant professor of Pediatrics at The Ohio State University College of Medicine. Dr. Kendall and her lab focus on developing basic and translational models of pediatric…

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Young boy turned sideways in front of a dark background, with dark lighting and an illustration of his brain appearing in front of the side of his head
Understanding the Social Neural Network
 Understanding the Social Neural Network 1024 575 Natalie Wilson
By:

Neuroimaging of participants with and without epilepsy allows researchers to explore the neural networks associated with social skills. Epilepsy is a chronic brain disease characterized by neural network dysfunction and seizures. According to the Centers for Disease Control (CDC), 470,000 children in the United…

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Nurse caring for infant in Neonatal Intensive Care Unit (NICU)
Bronchopulmonary Dysplasia: Characterizing the Chronic Lung Disease of Prematurity
 Bronchopulmonary Dysplasia: Characterizing the Chronic Lung Disease of Prematurity 1024 575 Lauren Dembeck
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  Precise definitions and/or classifications of bronchopulmonary dysplasia are needed to optimize outcomes. Researchers at Nationwide Children’s Hospital are continuing to help refine the definition of severe bronchopulmonary dysplasia (sBPD). In a recent study, members of the BPD Collaborative demonstrated that preterm infants with…

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small baby with nose canula
Diuretic Therapy in Preterm Infants With Acute Kidney Injury Is Common: Should It Be?
 Diuretic Therapy in Preterm Infants With Acute Kidney Injury Is Common: Should It Be? 1024 575 Lauren Dembeck
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Lack of efficacy and safety data on diuretic therapy in the critically ill infants is cause for concern. Researchers at Nationwide Children’s Hospital are beginning to fill in the gaps. Despite the common use of diuretic therapy in preterm infants with acute kidney injury,…

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Chronic Pediatric Pancreatitis and (No) Persistent Belly Pain
 Chronic Pediatric Pancreatitis and (No) Persistent Belly Pain 1024 575 Katie Brind'Amour, PhD, MS, CHES
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Underlying — even silent — chronic pancreatitis can be at play in children without previous acute pancreatitis episodes, including among children with little or no reported pain. Pancreatitis in children is rare (about 3-13 per 100,000 people per year), but diagnosis is increasing, at…

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Understanding Black Youth Suicide: Steps Toward Prevention
 Understanding Black Youth Suicide: Steps Toward Prevention 1024 596 Abbie Roth
By:

To understand the how and why of rising rates of Black youth suicide, researchers call for a ‘Ground Zero’ approach. In December 2019, the Congressional Black Caucus released the statement “Ring the Alarm: The Crisis of Black Youth Suicide in America.” The statement focused…

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Dehumanizing Language in the Health Care System Harms Children With Incarcerated Family Members
 Dehumanizing Language in the Health Care System Harms Children With Incarcerated Family Members 1024 683 Rosemary Martoma, MD and Kelly Kelleher, MD, MPH
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Dehumanizing Language Causes Harm Labels and language matter. Language has the power to condemn or redeem, and words reflect our values and beliefs as clinicians, scholars, and members of the community.” – Bedell et al., Humanity: Person-First Language in Correctional Health Epidemiology, American Journal…

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Using Virtual Reality Games to Reduce Dressing Change Pain in Pediatric Burn Patients
 Using Virtual Reality Games to Reduce Dressing Change Pain in Pediatric Burn Patients 934 401 JoAnna Pendergrass, DVM
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Smartphone-based virtual reality games can reduce dressing change pain for pediatric patients receiving outpatient burn treatment. According to the American Burn Association, burn injuries affect approximately 250,000 children in the United States each year. The pain associated with burn injuries extends beyond the injury…

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“Left Behind Again:” Rural Children Enrolled in Medicaid Use Home Health Services Far Less Than Urban Children
 “Left Behind Again:” Rural Children Enrolled in Medicaid Use Home Health Services Far Less Than Urban Children 1024 575 Jeb Phillips
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Data from a pediatric accountable care organization is allowing physicians and researchers to explore the rural-urban health care gap. While it’s long been clear that children in rural areas have reduced access to some kinds of health care services compared to their urban peers,…

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Close up color photo of little boy holding hands on his belly
Study Highlights Relationship Between SI Gene and Chronic, Idiopathic Loose Stool in Some Children
 Study Highlights Relationship Between SI Gene and Chronic, Idiopathic Loose Stool in Some Children 1024 680 Abbie Roth
By:

Researchers conducted one of the largest prospective, multicenter trials in pediatrics looking at the connection between SI variants and common gastrointestinal symptoms. The SI gene codes for the sucrase-isomaltase enzyme, which is expressed in the intestinal brush border. This enzyme is important to the…

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She for She: Supporting Women in Orthopaedics
 She for She: Supporting Women in Orthopaedics 1024 575 Julie Samora, MD, PhD
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Julie Balch Samora, MD, PhD, MPH, an orthopaedic surgeon at Nationwide Children’s Hospital and the hospital’s associate medical director for quality, is the 2021 President of the Ruth Jackson Orthopaedic Society – the leading international organization championing women in orthopaedics. This column was adapted…

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Featured Researcher — Mingtao Zhao, DVM, PhD
 Featured Researcher — Mingtao Zhao, DVM, PhD 150 150 Natalie Wilson
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Mingtao Zhao, DVM, PhD, is a principal investigator in the Center for Cardiovascular Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. He is also an assistant professor of Pediatrics at The Ohio State University College of Medicine. Dr. Zhao’s research aims…

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Leaving No Stone Unturned: Nationwide Children’s Joins Children’s Oncology Group Pediatric Early Phase Clinical Trial Network
 Leaving No Stone Unturned: Nationwide Children’s Joins Children’s Oncology Group Pediatric Early Phase Clinical Trial Network 1024 683 Natalie Wilson
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The Children’s Oncology Group (COG), the world’s largest and most recognized pediatric cancer research collaborative, recently selected Nationwide Children’s Hospital to join its Pediatric Early Phase Clinical Trial Network (PEP-CTN) through a peer review process. The COG PEP-CTN is a re-iteration of the COG…

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9 Facts About the COVID-19 Vaccine
 9 Facts About the COVID-19 Vaccine 1024 683 Abbie Roth
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COVID-19 is a disease caused by the SARS-CoV-2 virus. In the United States, three vaccines are approved for emergency use, those produced by Pfizer, Moderna and Johnson & Johnson (J&J). These vaccines dramatically reduce your risk of getting severely ill or dying from COVID-19.…

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Surgical Management of Recurrent Patellar Instability in the Pediatric Population
 Surgical Management of Recurrent Patellar Instability in the Pediatric Population 1024 575 Mary Bates, PhD
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Medial patellofemoral ligament reconstruction via the quadriceps turndown technique is safe and effective in young patients. In a new study, researchers from Nationwide Children’s Hospital demonstrate the safety and efficacy of the quadriceps turndown technique for medial patellofemoral ligament reconstruction in pediatric and adolescent…

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sleeping infant
Antibodies to Spinal Muscular Atrophy Gene Therapy Vector May Dissipate, Allowing More Children to Receive Treatment
 Antibodies to Spinal Muscular Atrophy Gene Therapy Vector May Dissipate, Allowing More Children to Receive Treatment 1024 681 Katie Brind'Amour, PhD, MS, CHES
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A review of antibody titers for SMA patients revealed that levels may decrease with time, potentially enabling delayed dosing for children who otherwise might have been excluded from life-saving gene therapy. Adeno-associated viral (AAV) vectors are used to deliver gene therapies such as onasemnogene…

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Keeping in Touch: Renin-Producing Cells Require Cell Adhesion Molecule to Survive
 Keeping in Touch: Renin-Producing Cells Require Cell Adhesion Molecule to Survive 1024 575 Lauren Dembeck
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Uncovering the molecular mechanisms underlying the renin-angiotensin-aldosterone system may provide insights into the long-term effects of hypertension and antihypertensive medications.  As the main source of renin in the human body, juxtaglomerular (JG) cells are crucial for blood pressure and fluid-electrolyte homeostasis. However, these cells…

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The Sound of Silence: The Impact of “Silent” Genetic Variation in Health and Disease
 The Sound of Silence: The Impact of “Silent” Genetic Variation in Health and Disease 1024 575 Lauren Dembeck
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Despite widespread scientific interest in messenger RNA (mRNA) structure, its role in human health and disease remains poorly understood. Researchers at Nationwide Children’s Hospital have developed novel software and metrics to identify “silent” genetic variants that affect mRNA folding and may underlie rare genetic…

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Growth Hormone is Still Important Beyond the Growing Years
 Growth Hormone is Still Important Beyond the Growing Years 1024 683 Rohan Henry, MD, MS
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The History of Growth Hormone The first reported use of growth hormone (GH) as treatment for severe growth retardation occurred in the 1950s.1 Since that time, growth hormone’s importance in growth promotion has been clear. Its role in promoting normal metabolism even after growth…

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Illustration of heart, CAVD
Pediatric Acute Care Cardiology Collaborative: Shared Focus on Quality to Improve Outcomes and Family Experiences
 Pediatric Acute Care Cardiology Collaborative: Shared Focus on Quality to Improve Outcomes and Family Experiences 1024 575 Katie Brind'Amour, PhD, MS, CHES
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The PAC3 has released three recent studies describing care practices and outcomes across member institutions in an effort to drive improved care. Established in 2014 with the aim of improving acute care outcomes and experience among pediatric cardiology patients, families, clinicians and hospitals, the…

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Featured Researcher — Susan Creary, MD, MSc
 Featured Researcher — Susan Creary, MD, MSc 150 150 Natalie Wilson
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Susan Creary, MD, MSc, is a principal investigator in the Center for Child Health Equity and Outcomes Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, a physician in the Hematology, Oncology and Blood and Marrow Transplant (BMT) Clinic at Nationwide Children’s,…

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What is “Dry Drowning,” and How Do I Talk to Parents About It?
 What is “Dry Drowning,” and How Do I Talk to Parents About It? 1024 683 Daniel Scherzer, MD and Bema Bonsu, MD
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The concern about so called “dry drowning” (which is not an actual medical phrase; neither is “secondary drowning”) is based on the fear that a child can unexpectedly succumb to respiratory problems some unpredictable time after swimming. This fear has been exacerbated by media…

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Close up color photo of little boy holding hands on his belly
Unraveling Intractable Functional Constipation: Manometries Are Still the Gold Standard
 Unraveling Intractable Functional Constipation: Manometries Are Still the Gold Standard 1024 680 Natalie Wilson
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Cine-MRI recordings can’t replace colonic manometries when assessing motility among children with functional constipation, but they may offer additional information. And conducting both MRIs and manometries simultaneously is feasible. While functional constipation (FC) is common in childhood, and most children who experience it respond…

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Indicators of Blood Clot Potential Directly Relate to Nephrotic Syndrome Severity
 Indicators of Blood Clot Potential Directly Relate to Nephrotic Syndrome Severity 150 150 Katie Brind'Amour, PhD, MS, CHES
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Researchers in the NEPTUNE network and collaborators at Nationwide Children’s Hospital have confirmed their preclinical studies demonstrating a direct correlation between the severity of disease and prothrombotic biomarkers in patients with nephrotic syndrome. Nephrotic syndrome (NS) dramatically increases the risk of a life-threatening blood…

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How Can We Make Child Health Equitable?
 How Can We Make Child Health Equitable? 550 350 Jeb Phillips, Abbie Roth and Natalie Wilson
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Researchers in the Center for Child Health Equity and Outcomes Research at Nationwide Children’s Hospital are tackling this question by identifying health disparities and uncovering exactly how social drivers of health impact outcomes. “Health equity means that everyone has a fair and just opportunity…

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The First Opioid-Prescribing Guidelines for Children Who Require Surgery
 The First Opioid-Prescribing Guidelines for Children Who Require Surgery 1024 573 Lauren Dembeck
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Providers should recognize the risks of opioids, maximize nonopioid regimens, and educate families appropriately. The first opioid-prescribing guidelines to address the unique needs of children who require surgery have been published by an expert panel in JAMA Surgery. The new guidelines aim to help…

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A New Kind of Rectal Diversion in Classic Bladder Exstrophy
 A New Kind of Rectal Diversion in Classic Bladder Exstrophy 1024 754 Jeb Phillips
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  This article appeared in the Spring/Summer 2021 print issue. Download the full issue.   Medical illustrations by Mandy Root-Thompson for Nationwide Children’s Hospital Source: V. Rama Jayanthi, chief of Urology at Nationwide Children’s Hospital To learn more about the procedure and it’s applications,…

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A Surprising Approach to Classic Bladder Exstrophy
 A Surprising Approach to Classic Bladder Exstrophy 1024 754 Jeb Phillips
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A procedure developed at Nationwide Children’s Hospital comes with possible risks but can have a huge impact on quality of life. It’s become clearer over the last two years that a “good outcome” for children born with classic bladder exstrophy is in the eye…

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Targeting DIPG: The Most Puzzling of Pediatric Brain Tumors
 Targeting DIPG: The Most Puzzling of Pediatric Brain Tumors 1024 629 Katie Brind'Amour, PhD, MS, CHES
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Survival has dramatically improved for numerous pediatric cancers over the last several decades, with a notable and very deadly exception: diffuse intrinsic pontine glioma (DIPG). Now, a community of researchers and clinician-scientists have set the stage for a renewed — and better-armed — assault…

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Lauren Bakaletz, PhD
Lessons Learned Through a Global Pandemic
 Lessons Learned Through a Global Pandemic 1024 683 Lauren Bakaletz, PhD
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As a microbiologist and vaccinologist, I spend nearly every day thinking about viruses and bacteria and the diseases they cause, as well as how to best prevent them from doing so. While in graduate school, we were taught about the great ‘flu’ pandemic of…

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Understanding Immune Responses to Build a Better Vaccine
 Understanding Immune Responses to Build a Better Vaccine 1024 606 Abbie Roth
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Researchers have used studies of respiratory syncytial virus and infant immune responses to develop a promising vaccine candidate. Respiratory syncytial virus (RSV) is an incredibly common yet potentially deadly pathogen. Almost everyone becomes infected with RSV during their first three years of life, but…

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toddler brushing teeth
Pediatricians Offer Valuable Oral Health Services for the Very Young, Before and Throughout Pandemic
 Pediatricians Offer Valuable Oral Health Services for the Very Young, Before and Throughout Pandemic 1024 680 Katie Brind'Amour, PhD, MS, CHES
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Medical professionals see very young children much more frequently during the first several years of life than dentists, and many states’ Medicaid programs have seized the opportunity to reimburse pediatricians for preventive oral care, such as fluoride application and oral hygiene education. Despite reimbursement…

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Even Severe Asthma Can Improve if Guidelines Are Followed
 Even Severe Asthma Can Improve if Guidelines Are Followed 1024 683 Mary Bates, PhD
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Patients treated with adequate medications and asthma family education can significantly improve irrespective of asthma severity. Severe asthma accounts for 5-8% of patients with asthma, but this group is more challenging to treat and is responsible for up to 40% of total asthma-care expenses.…

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Baby in NICU
Global Study Highlights Antibiotic Overuse in the NICU
 Global Study Highlights Antibiotic Overuse in the NICU 1024 683 Abbie Roth
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Antimicrobial stewardship programs were associated with lower antibiotic use, regardless of the country’s income level. Excessive antibiotic use among infants born preterm in the newborn intensive care unit (NICU) is associated with poor patient outcomes, such as sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia and others,…

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Sad black teenage girl
Can Neurocognitive Functioning Tests Help Predict Future Suicide Attempts?
 Can Neurocognitive Functioning Tests Help Predict Future Suicide Attempts? 1024 683 Mary Bates, PhD
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Researchers identify sex-specific deficits in measures of working memory and affective processing associated with suicidal behavior in youth with depression. To prevent youth suicide, researchers are working to identify factors associated with suicide attempts in adolescents at elevated risk for suicidal behavior. In a…

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Teen driving a car
Lower Traffic Volumes During COVID-19 Shut-Downs Lead to Fewer Injuries
 Lower Traffic Volumes During COVID-19 Shut-Downs Lead to Fewer Injuries 1024 683 Laura Dattner
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To minimize transmission of COVID-19, in spring 2020, most U.S. states passed policies promoting social distancing through stay-at-home orders prohibiting non-essential travel. While vehicle-miles traveled in the United States decreased by 41% in April 2020 compared to 2019, the effect of this mobility decrease…

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Innovative Biostatistical Methodology for Causal Evaluation of Medical Treatments
 Innovative Biostatistical Methodology for Causal Evaluation of Medical Treatments 150 150 Laura Dattner
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Medical records are readily available nowadays, but using medical records to evaluate medical treatments is full of challenges. Henry Xiang, MD, MPH, PhD, professor of medicine and principal investigator in the Center for Injury Research and Policy, collaborated with biostatisticians from The Ohio State…

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coronavirus
Introducing a New SARS-CoV-2 Vaccine Candidate
 Introducing a New SARS-CoV-2 Vaccine Candidate 1024 512 Abbie Roth
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The new vaccine candidate takes advantage of the long and successful history of the measles vaccine. A team of researchers from The Ohio State University and Nationwide Children’s have built a novel vaccine candidate against SARS-CoV-2. The candidate, published in Proceedings of the National…

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