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Universal Donor CAR NK Cells: A New Platform Technology for Cancer

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Eric Youngstrom, PhD
Norms, Needs and New Frontiers in Pediatric Mental Health
 Norms, Needs and New Frontiers in Pediatric Mental Health 1024 683 Madison Storm
By: Madison Storm

 An interview with Eric Youngstrom, PhD, director of the Institute for Mental and Behavioral Health Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. At Nationwide Children’s Hospital, the Institute for Mental and Behavioral Health Research (IMBHR) is driving discovery through improved…

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Understanding the Rising Suicide Risk Among Black Youth
 Understanding the Rising Suicide Risk Among Black Youth 1024 576 Alaina Doklovic
By: Alaina Doklovic

A new large-scale Medicaid study sheds light on complex factors driving risk and the protective factors that may help save lives. Suicide rates among Black youth (children, adolescents and young adults) have risen sharply in recent years, surpassing those of other racial and ethnic…

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Featured Researcher: Brian Becknell, MD, PhD
 Featured Researcher: Brian Becknell, MD, PhD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Urinary tract infections (UTIs) are among the most common bacterial infections in children worldwide, according to the Journal of Pediatric Urology. Did you know that UTIs can be associated with congenital anomalies, which may cause permanent renal scarring in certain children, resulting in long-term…

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Registry Data Provide Insight Into Ultra-Rare Pediatric Tenosynovial Giant Cell Tumors
 Registry Data Provide Insight Into Ultra-Rare Pediatric Tenosynovial Giant Cell Tumors 1024 473 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

At A Glance Tenosynovial giant cell tumor (TGCT) is a rare condition that affects joints, mostly in adults but sometimes in children. New research using an international patient registry shows that children often wait more than a year for the correct diagnosis because symptoms…

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Blood Sample in test tube
Filling a Critical Gap in Relapsed Sarcoma Treatment
 Filling a Critical Gap in Relapsed Sarcoma Treatment 1024 683 Pam Georgiana
By: Pam Georgiana

A first-in-sarcoma trial at Nationwide Children’s Hospital tests universal-donor NK cells with chemotherapy to address poor survival rates.   The five-year overall survival rate for children and young adults with relapsed bone or soft tissue sarcomas is between 17 and 26%. For Bhuvana A. Setty, MD, pediatric hematologist…

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Baby Bryson laughing at a check up following treatment for SMA.
Nationwide Children’s Hospital Completes One of the World’s First Prenatal Treatments for Spinal Muscular Atrophy
 Nationwide Children’s Hospital Completes One of the World’s First Prenatal Treatments for Spinal Muscular Atrophy 1024 600 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Investigational third-trimester, transplacental “bridging” therapy with risdiplam — followed by rapid postnatal treatment — aims to protect motor neurons during a critical window before and immediately after birth.  When Stacy Auker found out she was pregnant with her third child, she knew a diagnosis of spinal muscular atrophy (SMA) was…

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Selective Steroid Use After Kasai Portoenterostomy Improves Outcomes in Biliary Atresia
 Selective Steroid Use After Kasai Portoenterostomy Improves Outcomes in Biliary Atresia 1024 683 Pam Georgiana
By: Pam Georgiana

Postoperative protocol is associated with improved bile drainage and higher native liver survival without increased short-term risk. A new study published in the Journal of Pediatric Gastroenterology and Nutrition provides evidence that a selective, marker-guided approach to postoperative steroid use improves outcomes for infants…

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Study Shows Younger Children Experience Persistent Symptoms Following Concussion
 Study Shows Younger Children Experience Persistent Symptoms Following Concussion 1024 540 Abbie Miller and Katelyn Scott
By: Abbie Miller and Katelyn Scott

Nearly 30% of children younger than 6 years who had a concussion during the study had prolonged symptoms, which can affect learning and behavior later in childhood. When people typically think of concussion, the first type of patient that comes to mind is a…

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artistic representation of a kidney cross section
A New Candidate Therapeutic Target and Biomarker for Idiopathic Nephrotic Syndrome
 A New Candidate Therapeutic Target and Biomarker for Idiopathic Nephrotic Syndrome 1024 561 Abbie Miller
By: Abbie Miller

New data provides evidence for the role of endothelium in idiopathic nephrotic syndrome pathogenesis.

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Featured Researcher: Katherine E Miller, PhD
 Featured Researcher: Katherine E Miller, PhD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

The battle against pediatric cancer is being waged within research facilities globally. In December 2025, five institutions, including Nationwide Children’s Hospital, were awarded a combined total of $5 million in grants from the Ohio Department of Children and Youth to support various research studies.…

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Behavioral Intervention Program for Children With Autism Spectrum Disorder Undergoing Epilepsy Evaluation: Increasing Phase 1 Monitoring Rates
 Behavioral Intervention Program for Children With Autism Spectrum Disorder Undergoing Epilepsy Evaluation: Increasing Phase 1 Monitoring Rates 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

A behavioral intervention program that started as a quality improvement project evolved to a new standard of care — increasing access and compliance with Phase 1 monitoring for children with intractable epilepsy and autism spectrum disorder. A recent study led by Mary Wojnaroski, PhD,…

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Cardiometabolic Screening Gaps in Pediatric Congenital Heart Disease
 Cardiometabolic Screening Gaps in Pediatric Congenital Heart Disease 1024 683 Pam Georgiana
By: Pam Georgiana

Retrospective review reveals inconsistent HbA1c screening in eligible patients. Pediatric cardiology has achieved remarkable gains in survival for children with congenital heart disease. However, as more patients reach adolescence and adulthood, they are at risk for experiencing acquired cardiovascular and cardiometabolic conditions such as…

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Advancing Surgical Care for Pediatric Hip Dysplasia
 Advancing Surgical Care for Pediatric Hip Dysplasia 1024 575 Pam Georgiana
By: Pam Georgiana

A novel technique demonstrates safety, stability and reduced casting needs. For children with developmental dysplasia of the hip, open reduction surgery reliably restores the hip to the socket. However, recurrent instability, iatrogenic complications, residual dysplasia and prolonged casting can limit favorable outcomes. To improve…

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Long-Term Kidney Complications Are Common Among Pediatric and Young Adult Cancer Survivors
 Long-Term Kidney Complications Are Common Among Pediatric and Young Adult Cancer Survivors 1024 683 Pam Georgiana
By: Pam Georgiana

Study reveals the need for improved surveillance and updated survivorship guidelines. As pediatric cancer survival rates continue to climb, focus is shifting to enhancing the long-term health of survivors. While treatments have become more precise, their delayed effects are not yet fully understood. A…

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Watchful Waiting: The New Recommendation for Most Preterm Infants With PDA
 Watchful Waiting: The New Recommendation for Most Preterm Infants With PDA 1024 683 Abbie Miller
By: Abbie Miller

A study published in JAMA found that treating patent ductus arteriosus with medication did not help with disease management but was associated with higher mortality.   A new study from the Neonatal Research Network, published in JAMA, found that treating patent ductus arteriosus (PDA)…

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Setting the Stage the Next Era of Gene Therapy for Ultrarare Disease
 Setting the Stage the Next Era of Gene Therapy for Ultrarare Disease 1024 576 Abbie Miller
By: Abbie Miller

Researchers at Nationwide Children’s Hospital recently administered a novel gene therapy targeting SLC6A1, advancing precision medicine for children who previously could not be treated. Maxwell, age 8, made history this fall, when he received a bespoke gene therapy targeting his ultrarare disease. This wasn’t…

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3 Things to Know About Glomerular Disease
 3 Things to Know About Glomerular Disease 1024 683 Gina Vitale, PTA
By: Gina Vitale, PTA

Gabriel Cara Fuentes, MD, PhD, offers insights for physicians regarding pediatric glomerular disease treatment and referral. Gabriel Cara Fuentes, MD, PhD, a pediatric nephrologist and principal investigator at the Kidney and Urinary Tract Research Center at Nationwide Children’s Hospital, is focused on a translational…

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Young boy turned sideways in front of a dark background, with dark lighting and an illustration of his brain appearing in front of the side of his head
Expanding the Evidence for Cannabidiol in Focal Epilepsy
 Expanding the Evidence for Cannabidiol in Focal Epilepsy 1024 575 Pam Georgiana
By: Pam Georgiana

A multicenter study led by Nationwide Children’s Hospital demonstrates long-term efficacy and safety of Epidiolex® for treatment-resistant seizures. As global use of cannabidiol for seizure management increases, most research has targeted generalized epilepsy. This leaves a major evidence gap for patients with focal seizures…

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As Suicide Increases in Preteens, Investigators Expand Research into Causes and Prevention
 As Suicide Increases in Preteens, Investigators Expand Research into Causes and Prevention 1024 576 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

By tracking trends in suicide over time, researchers identify critical new directions for suicide prevention work. Last year, a study published in JAMA Network Open by researchers at Nationwide Children’s Hospital and collaborating institutions reported that suicide among preteens (children ages 8-12) had increased…

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Bringing Behavioral Health Into the Medical Home
 Bringing Behavioral Health Into the Medical Home 1024 683 Pam Georgiana
By: Pam Georgiana

Scaling integrated care across community pediatrics increases access to and utilization of mental health care. When a teenage patient shared feelings of anxiety and depression during a routine wellness visit, the pediatrician immediately called in the behavioral health clinician down the hall. Within minutes,…

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