Better Asthma Outcomes: A Systems-Level Approach

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Universal Donor CAR NK Cells: A New Platform Technology for Cancer

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Prematurity Increases Morbidity and Mortality Risk in Preterm Neonates with Down Syndrome in the NICU
 Prematurity Increases Morbidity and Mortality Risk in Preterm Neonates with Down Syndrome in the NICU 1024 624 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

  Premature neonates with Down syndrome who are admitted to the neonatal intensive care unit experience higher rates of health complications and an increased mortality risk.   A retrospective study led by Emily Messick, DO, at Nationwide Children’s Hospital, reported the increased risk of…

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Molly Fuchs, MD
Rethinking Routine Kidney Ultrasounds in Children With Mild Anorectal Malformations
 Rethinking Routine Kidney Ultrasounds in Children With Mild Anorectal Malformations 1024 683 Lauren Dembeck
By: Lauren Dembeck

  Annual scans rarely identify new kidney concerns in symptom-free children. Children born with anorectal malformations (ARMs), a group of congenital conditions affecting the anus and rectum, are routinely screened for kidney abnormalities because of the association between ARM and urinary tract anomalies. The…

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Featured Researcher: Diana Zepeda-Orozco, MD
 Featured Researcher: Diana Zepeda-Orozco, MD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Diana Zepeda-Orozco, MD, is a principal investigator in the Kidney and Urinary Tract Research Center within the Abigail Wexner Research Institute, an attending physician and the associate division chief of research for the Division of Pediatric Nephrology and Hypertension, and an associate professor of…

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Challenges in Medication Titration in Children with Heart Failure
 Challenges in Medication Titration in Children with Heart Failure 1024 537 Pam Georgiana
By: Pam Georgiana

Beyond the guidelines: implementing consensus-based care for complex patients. Pediatric heart failure is a complex clinical diagnosis, with a growing body of evidence to suggest there are critical differences between pediatric and adult heart failure. In a recent review published in JHLT Open, Jessie…

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Defining Urinary Tract Infection: Why Standardization Matters for Research and Care
 Defining Urinary Tract Infection: Why Standardization Matters for Research and Care 1024 683 Pam Georgiana
By: Pam Georgiana

Urinary tract infections (UTIs) are one of the most common bacterial infections worldwide, affecting an estimated 150 million people annually and costing more than $5 billion in the United States alone. However, despite their prevalence, there is still no universally accepted definition of what…

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What Clinicians Need to Know About RSV Prevention
 What Clinicians Need to Know About RSV Prevention 1024 609 Jason Newland, MD, MEd
By: Jason Newland, MD, MEd

Respiratory syncytial virus (RSV) infects the nose, throat and lungs, causing mild cold-like symptoms (upper respiratory infection) for most children and adults. However, in high-risk populations, including infants, children with chronic conditions, and older adults, it can be quite severe — ultimately leading to…

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Nationwide Children’s Team Builds Award-Winning AI Tool to Drive Mental Health Research
 Nationwide Children’s Team Builds Award-Winning AI Tool to Drive Mental Health Research 1024 502 Abbie Miller
By: Abbie Miller

DREAM project wins the 2025 Gartner Eye on Innovation Mid-Size Enterprise Award in the Americas region. In recognition of its innovative application of technology to address critical health care challenges, the Office of Data Sciences was selected as the winner for the prestigious 2025…

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Color image of enteral complete liquid nutritional products of several brands
Food-Based Tube Feeding: Balancing Parental Demand With Pediatric Nutrition Science
 Food-Based Tube Feeding: Balancing Parental Demand With Pediatric Nutrition Science 1024 575 Pam Georgiana
By: Pam Georgiana

New research from Nationwide Children’s reveals significant differences in nutrient adequacy across commercial food-based formulas. In the last two decades, enteral nutrition has undergone a significant transformation. Fifteen to 20 years ago, pediatric patients requiring gastrostomy tube feeding had only one option: synthetic, cow…

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Guiding the Treatment of Ballistic Fractures: A New Report Offers Education and Support for Orthopedic Surgeons
 Guiding the Treatment of Ballistic Fractures: A New Report Offers Education and Support for Orthopedic Surgeons 1024 620 Alaina Doklovic
By: Alaina Doklovic

Despite firearm injury incidence and severity in children, no guidelines for orthopedic surgeons existed – until now. Firearm-related injury is the leading cause of death in the United States among children and adolescents aged 1 to 19. Despite this alarming statistic, there were no…

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Parents’ Perceptions Highlight Gaps in Supporting Children with Epilepsy in School
 Parents’ Perceptions Highlight Gaps in Supporting Children with Epilepsy in School 1024 579 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Discussions with parents of children with epilepsy revealed concerning gaps in school-based seizure education and care, underscoring the need for better lines of communication between medical teams, school personnel, and the children’s families.   A qualitative study led by Mary Kay Irwin, EdD, and…

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silhouette girl portrait
Closing the Treatment Gap: Opioid Use Disorder Medications in Adolescents and Young Adults
 Closing the Treatment Gap: Opioid Use Disorder Medications in Adolescents and Young Adults 1024 683 Pam Georgiana
By: Pam Georgiana

Findings from the PROUD trial highlight the need for youth-centered prescription strategies in primary care. Adolescents and young adults are far less likely than older adults to receive evidence-based medications for opioid use disorder (OUD), even though buprenorphine and extended-release naltrexone are recommended treatments.…

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Advances in the Care of Patients With Chest Wall Deformities
 Advances in the Care of Patients With Chest Wall Deformities 1024 683 Sara Mansfield, MD
By: Sara Mansfield, MD

Every year Nationwide Children’s Hospital sees several hundred children and adolescents with chest wall deformities. Common Chest Wall Conditions Two of the most common chest wall diagnoses are pectus excavatum (sunken chest) and pectus carinatum (pigeon chest).  These conditions can cause a variety of…

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LaCrosse Virus: What You Need to Know
 LaCrosse Virus: What You Need to Know 1024 586 Christopher Ouellette, MD
By: Christopher Ouellette, MD

La Crosse virus (LACV) is a mosquito-borne illness primarily found in the upper Midwest, Mid-Atlantic, and southeastern United States. This virus is spread mostly through the bite of the eastern treehole mosquito, Aedes triseriatus, and over the past 20+ years, more cases have been…

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Virtual Reality Training Model Aims to Transform Workplace Safety in Health Care
 Virtual Reality Training Model Aims to Transform Workplace Safety in Health Care 1024 683 Madison Storm
By: Madison Storm

A virtual reality (VR) training module developed at Nationwide Children’s Hospital, called DEFUSE, which stands for De-escalate Effectively, Foster Understanding, Safeguard Environments, is setting a new standard for workplace violence prevention in health care settings. Funded by the Ohio Bureau of Workers’ Compensation, the…

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Post-Ictal Rhythmic Thalamic Activity in the Central Media Nucleus May Play a Role in Seizure Termination in Drug-Resistant Epilepsy
 Post-Ictal Rhythmic Thalamic Activity in the Central Media Nucleus May Play a Role in Seizure Termination in Drug-Resistant Epilepsy 1024 677 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital are the first to describe post-ictal rhythmic thalamic activity (PIRTA) in the central media nucleus (CMN) during focal onset seizure. “When this paper was published, it was a period where understanding the role of the center of the thalamus…

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Device for monitoring glucose placed on girl's arm
Choosing a Continuous Glucose Monitor After TPIAT: When Research Directly Impacts Clinical Practice
 Choosing a Continuous Glucose Monitor After TPIAT: When Research Directly Impacts Clinical Practice 1024 683 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s study highlights hydroxyurea interference with Dexcom, but not with Libre, and the clinical implications for glycemic management. Total pancreatectomy with islet autotransplantation (TPIAT) is the definitive surgical treatment for acute recurrent and chronic pancreatitis. Nationwide Children’s Hospital is one of the very…

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Advancing Pediatric Behavioral Health: Care, Research and Prevention
 Advancing Pediatric Behavioral Health: Care, Research and Prevention 150 150 Nationwide Children's
By: Nationwide Children's

Meet David Axelson, MD, Chief of Psychiatry and Behavioral Health Dr. Axelson and his team have achieved amazing things in the last decade, from more than doubling the volume of patients served to establishing a new research institute for mental and behavioral health, and…

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Norms, Needs and New Frontiers in Pediatric Mental Health
 Norms, Needs and New Frontiers in Pediatric Mental Health 1024 683 Madison Storm
By: Madison Storm

An interview with Eric Youngstrom, PhD, director of the Institute for Mental and Behavioral Health Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital.   At Nationwide Children’s Hospital, the Institute for Mental and Behavioral Research (IMBHR) is driving discovery through improved…

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How Useful Are Large Language Models for Caregivers of Pediatric Cancer Patients?
 How Useful Are Large Language Models for Caregivers of Pediatric Cancer Patients? 1024 502 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

These powerful informational tools for caregivers of pediatric cancer patients vary in areas such as readability and source credibility, highlighting the need to carefully consider their clinical utility. A recent study led by Emre Sezgin, PhD, and Micah Skeens, PhD, APRN, FAAN, CPNP-PC, at…

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Smiling child wearing a blue bike helmet and vest while riding outdoors on a sunny day, promoting bicycle safety and healthy outdoor activities for kids.
Better Asthma Outcomes: A Systems-Level Approach
 Better Asthma Outcomes: A Systems-Level Approach 1024 422 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A dedicated team of experts embraced sweeping tactics to reduce asthma-related emergency department visits by 33% and inpatient length of stay by 0.9 days. This is how they did it. It started with a conversation about the data: Why are kids with asthma the…

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