Biofilms: The Good, the Bad & the Groundbreaking

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Approaching Uncertainty in Medicine With a Growth Mindset

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From Scan to Plan: Making Virtual Surgical Planning the Standard of Care for Ortho-oncology Operations

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Lessons Learned: From First Gen Student to Chief Scientific Officer

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Empowering Therapists With Better Tools

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Proteinuria Reduction in Nephrotic Syndrome Without Suppressing the Immune System
 Proteinuria Reduction in Nephrotic Syndrome Without Suppressing the Immune System 375 280 Mary Bates, PhD
By: Mary Bates, PhD

Study suggests a distinct, non-immunosuppressive mechanism of action for drugs that ameliorate proteinuria in an NS model. Nephrotic syndrome (NS) is a leading cause of chronic kidney disease in children and adults. NS is characterized by dysregulation of the kidneys’ glomerular filtering units, resulting…

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Optimizing Outpatient Epilepsy Care With Digital Seizure Action Plans
 Optimizing Outpatient Epilepsy Care With Digital Seizure Action Plans 1024 683 Pam Georgiana
By: Pam Georgiana

Customized seizure action plans enhance care and family use. Many schools and caregivers require families of children with epilepsy to provide a written seizure action plan (SAP) signed by their primary care provider. The Epilepsy Foundation provides a printable PDF form to fill out,…

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Meet David Axelson, MD, Chief of Psychiatry and Behavioral Health
 Meet David Axelson, MD, Chief of Psychiatry and Behavioral Health 1024 647 Shannon Caldwell
By: Shannon Caldwell

Dr. Axelson and his team have achieved amazing things in the last decade, from more than doubling the volume of patients served to establishing a new research institute for mental and behavioral health, and they’re not slowing down. We recently sat down to talk…

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Weighing the Risk of Blood Clots With Reward of Less Pain
 Weighing the Risk of Blood Clots With Reward of Less Pain 1024 683 Pam Georgiana
By: Pam Georgiana

For people with sickle cell disease who menstruate, hormonal contraception can be effective against SCD-related pain, but it also raises the risk of thrombosis.   As people with sickle cell disease (SCD) transition into their reproductive years, health care providers are increasingly focused on…

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What Primary Care Providers Need to Know About Precocious Puberty
 What Primary Care Providers Need to Know About Precocious Puberty 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

PCPs are the first line of defense in recognizing and referring possible cases of precocious puberty to endocrinologists for formal diagnosis and treatment. Precocious puberty — signs of the onset of puberty before the age of 8 in girls and 9 in boys —…

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Illustration of NK Cells, T Cells, other immune cells floating across white background
Shedding Light on Immune Responses in Children With Acute Asthma Exacerbations
 Shedding Light on Immune Responses in Children With Acute Asthma Exacerbations 969 533 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

The innate immune system is upregulated in children hospitalized with acute asthma exacerbations, signaling a need for therapies that target innate immune pathways to help control acute asthma flare-ups more effectively.  Asthma affects more than 6 million children in the United States, yet little…

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Treating Obesity With GLP-1s — Finding the Way Forward
 Treating Obesity With GLP-1s — Finding the Way Forward 150 150 Abbie Miller
By: Abbie Miller

Using lessons learned from medicating mental and behavioral health conditions, Stephen Cook, MD, offers suggestions about how medications approved for adolescents with obesity should become part of care.   For most of the time in Western medicine, people have treated obesity like a choice…

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Approaching Uncertainty in Medicine With a Growth Mindset
 Approaching Uncertainty in Medicine With a Growth Mindset 1024 531 Abbie Miller
By: Abbie Miller

In baseball, a really good batting average is .333 — which means the batter hits the ball and gets to first base a third of the time. That also means they miss —they fail — two-thirds of the time. Medical providers are expected to…

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Tissue-Engineered Vascular Grafts Resist Calcification
 Tissue-Engineered Vascular Grafts Resist Calcification 968 1024 Abbie Miller
By: Abbie Miller

Dystrophic calcification is the biggest reason for prosthetic biomaterial failure. Compared to expanded poly(tetrafluoroethylene) (PTFE) grafts, tissue-engineered vascular grafts (TEVGs) exhibited superior durability, including reduced late-term calcification, according to a study published in Nature Communications. “All of the biomaterials we routinely use for cardiovascular…

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CSPINE Injury Prediction Rule Could Decrease Radiographic Imaging Exposure in Children
 CSPINE Injury Prediction Rule Could Decrease Radiographic Imaging Exposure in Children 1024 675 Katelyn Scott
By: Katelyn Scott

A new study shows that implementing the rule can reduce CT scans by more than 50% without missing clinically significant injuries. While cervical spine injuries (CSI) are uncommon in children, they can be potentially devastating, resulting in quadriplegia — paralysis below the neck affecting…

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Patient Perspective: Living With Weight-Based Stigma
 Patient Perspective: Living With Weight-Based Stigma 1024 376 Alaina Doklovic
By: Alaina Doklovic

In 2019, 15-year-old Paige watched her father die from a disease that was consistently ignored, and his symptoms repeatedly blamed on his weight. He had stage 4 cancer by the time he was properly diagnosed. Shortly after his death, her mother had a 40-pound…

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Health-Related Quality of Life in Pediatric Cancer Survivors: Assessing the Impacts
 Health-Related Quality of Life in Pediatric Cancer Survivors: Assessing the Impacts 1024 683 Madison Storm
By: Madison Storm

Family factors have a significant impact on health-related quality of life. Childhood cancer is a life-changing diagnosis for children and their families. Children undergoing cancer treatment often experience impairment in health-related quality of life compared to children from healthy populations. The severity of impact…

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Weight-Based Stigma and Its Impact on Children With Obesity
 Weight-Based Stigma and Its Impact on Children With Obesity 1024 376 Alaina Doklovic
By: Alaina Doklovic

More children in the United States live with obesity than any other chronic condition. The obesity rate among U.S. children and teens has more than tripled since 1980, according to the Centers for Disease Control and Prevention (CDC). Although there are numerous efforts underway…

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Good Intentions but Low Adherence for Safe Sleep Guidelines
 Good Intentions but Low Adherence for Safe Sleep Guidelines 1024 585 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Although mothers are aware of the Safe Sleep Guidelines developed by the American Academy of Pediatrics, they frequently deviate from them to try to help their babies sleep better and longer. Research recently published in Pediatrics and conducted by Lara B. McKenzie, MA, PhD,…

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Virtual Surgical Planning for Musculoskeletal Oncology
 Virtual Surgical Planning for Musculoskeletal Oncology 150 150 Abbie Miller
By: Abbie Miller

CT of pelvis showing tumor MRI of pelvis showing tumor Step 1: Data acquisition: Computed tomography (CT) and magnetic resonance images (MRI) are obtained during the same visit with markers used to help align the scans to create the composite image. That composite is used…

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Biofilms: The Good, the Bad & the Groundbreaking
 Biofilms: The Good, the Bad & the Groundbreaking 1024 615 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Decades of research into the structure and function of bacterial biofilms have begun to pay off in the form of imminent clinical applications capable of harnessing both the protective and problematic aspects of this universal phenomenon. Imagine a hospital emergency department filled with patients…

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Delivering Implicit Bias Training for Health Care Providers – Via Smartphone
 Delivering Implicit Bias Training for Health Care Providers – Via Smartphone 1024 680 Jessica Nye, PhD
By: Jessica Nye, PhD

A Virtual and Augmented Reality Implicit Association Training (VARIAT) app developed by investigators from Nationwide Children’s Hospital and The Ohio State University leverages mobile technology to bring implicit bias training to the hands of Medicaid clinicians. Everyone has implicit biases that manifest as favorable…

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From Scan to Plan: Making Virtual Surgical Planning the Standard of Care for Ortho-oncology Operations
 From Scan to Plan: Making Virtual Surgical Planning the Standard of Care for Ortho-oncology Operations 1024 281 Abbie Miller
By: Abbie Miller

“We deal in rarities,” says Thomas Scharschmidt, MD, director of the Pediatric Orthopedic Oncology Program at Nationwide Children’s Hospital and professor of Orthopedics at The Ohio State University. “When you consider that across the entire U.S. population, we have between 2,500 and 3,000 cases…

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Lessons Learned: From First Gen Student to Chief Scientific Officer
 Lessons Learned: From First Gen Student to Chief Scientific Officer 1024 683 Nationwide Children's
By: Nationwide Children's

Joanne Turner, PhD, chief scientific officer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, shares what it’s like to go from first gen college student to academic leadership.    What inspired you to go to college and pursue a bachelor’s degree in…

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Empowering Therapists With Better Tools
 Empowering Therapists With Better Tools 1024 481 Wendy Margolin
By: Wendy Margolin

New research director sets out to improve mental and behavioral health care with assessments.  Providing mental or behavioral health care without simple, effective clinical assessment tools is like trying to lose weight without access to a bathroom scale, says Eric Youngstrom, PhD, the new…

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