Optimizing Prenatal and Neonatal Care for Infants With Treatable Rare Diseases

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Unraveling the Genetic Mystery Behind a Rare Pediatric Disease

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New National “Vital Signs” to Measure Population-wide Pediatric Health

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Loss of RNase 6 Increases Susceptibility to Upper Urinary Tract Infections, Model Shows
 Loss of RNase 6 Increases Susceptibility to Upper Urinary Tract Infections, Model Shows 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The latest in a robust series of studies confirms an important role for RNase 6 in deterring infections of the ureters and kidneys.   Research teams at the Abigail Wexner Research Institute at Nationwide Children’s Hospital have long been studying a superfamily of ribonucleases…

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Do Text Messages Help Youth at Risk For Suicide Feel Supported After Discharge?
 Do Text Messages Help Youth at Risk For Suicide Feel Supported After Discharge? 1024 683 Katelyn Scott
By: Katelyn Scott

Nationwide Children’s is the first pediatric hospital to implement Caring Contacts approach within its Zero Suicide initiative. The initial study period shows high enrollment and satisfaction with the program. Youth who receive care for suicidal thoughts and behaviors need extra support as they transition…

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Surgical Repair of Cloacal Malformation Does Not Worsen Bladder Function
 Surgical Repair of Cloacal Malformation Does Not Worsen Bladder Function 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

The complexity of the malformation, more than the surgical approach, determines post-operative urodynamics. Approximately 90% of girls with cloacal malformation exhibit some degree of bladder dysfunction. While associated conditions can impact bladder dynamics, the complex surgery required to repair cloacal malformation has also been…

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Has the Next Generation of Gene Therapy Arrived?
 Has the Next Generation of Gene Therapy Arrived? 1024 683 Wendy Margolin
By: Wendy Margolin

Researchers crack the code to deliver dual gene therapy in preclinical studies – with promises of wider applications. In a gene therapy breakthrough, a Nationwide Children’s Hospital researcher has successfully used an adeno-associated virus (AAV) to introduce two genes into cells with a single…

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Uncovering the Alarming Rise in Death by Suicide Among Preteens
 Uncovering the Alarming Rise in Death by Suicide Among Preteens 1024 657 Pam Georgiana
By: Pam Georgiana

Data from a new study implies that gender and race/ethnicity play a role in increasing suicide rates. Youth suicide is a significant public health concern. When the National Institute of Mental Health convened a research roundtable series to address the rising rates of death…

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Enhancing School Readiness for Children with Critical Congenital Heart Disease: Insights and Strategies for Health Care Clinicians
 Enhancing School Readiness for Children with Critical Congenital Heart Disease: Insights and Strategies for Health Care Clinicians 1024 664 Erin Gregory
By: Erin Gregory

A recent publication in Pediatric Cardiology explores the complexities of school readiness among children with critical congenital heart disease (CCHD) compared to their peers. The study hypothesizes that children with CCHD will face more significant difficulties in school readiness, linked to specific medical risk factors associated…

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Sacral Nerve Stimulation Improves Symptoms and Quality of Life in Children With Defecation Disorders
 Sacral Nerve Stimulation Improves Symptoms and Quality of Life in Children With Defecation Disorders 1024 656 Mary Bates, PhD
By: Mary Bates, PhD

A new study narrows down the patients who may benefit the most from the treatment. In a large prospective study, researchers from Nationwide Children’s Hospital found that sacral nerve stimulation can lead to significant and long-lasting improvements in fecal continence and quality of life…

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Can Artificial Intelligence (AI) Improve Access to Social Resources for Better Patient Outcomes?
 Can Artificial Intelligence (AI) Improve Access to Social Resources for Better Patient Outcomes? 1024 540 Pam Georgiana
By: Pam Georgiana

A recent study tests the ability of the DAPHNE© Chatbot to do just that. Health care providers and organizations recognize the impact of social factors on health and are increasingly addressing social determinants to improve health outcomes and equity. However, integrating social care into…

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Molly Fuchs, MD
Long-Term Bladder Management and Continence in Girls With Cloacal Malformation
 Long-Term Bladder Management and Continence in Girls With Cloacal Malformation 1024 683 Pam Georgiana
By: Pam Georgiana

New insights on outcomes and quality of life from Nationwide Children’s comprehensive study of pediatric patients. Over the last decade, surgical innovation has revolutionized the treatment of cloacal malformation, a congenital anomaly affecting the development of the gastrointestinal, urinary and reproductive systems in girls.…

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Rethinking Male Bias in Pediatric Growth Hormone Deficiency
 Rethinking Male Bias in Pediatric Growth Hormone Deficiency 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Although males have historically been over-represented in pediatric growth hormone deficiency (GHD) cases, this predominance does not hold true across various classifications of GHD.   Referrals for short-stature evaluations are common in pediatric endocrinology despite the rarity of growth hormone deficiency (GHD). Historically, boys…

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Is Surfactant Treatment at Birth Associated With Severe Bronchopulmonary Dysplasia?
 Is Surfactant Treatment at Birth Associated With Severe Bronchopulmonary Dysplasia? 1024 683 Pam Georgiana
By: Pam Georgiana

An observational study reviews a contemporary cohort of preterm infants. Recently, Leif D. Nelin, MD, division chief of neonatology at Nationwide Children’s and a professor of pediatrics at The Ohio State University College of Medicine, and a team of doctors in the Bronchopulmonary Dysplasia…

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Featured Researcher – Mark Peeples, PhD
 Featured Researcher – Mark Peeples, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Mark E. Peeples, PhD, is a principal investigator and member of the Center for Vaccines and Immunity at The Abigail Wexner Research Institute at Nationwide Children’s Hospital, and a professor of Pediatrics and of Molecular & Cellular Biochemistry at The Ohio State University College…

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Water Beads: Sensory Fun or Ticket to the Emergency Department?
 Water Beads: Sensory Fun or Ticket to the Emergency Department? 1024 683 Laura Dattner
By: Laura Dattner

Researchers find ED visits more than doubled from 2021 to 2022 and call for federal legislation and regulation to address this child hazard. Researchers from the Center for Injury Research and Policy and Central Ohio Poison Center at Nationwide Children’s Hospital have found more…

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Nationwide Children’s Researchers Awarded Funding to Carry Out Groundbreaking Research on Single Ventricle Heart Disease
 Nationwide Children’s Researchers Awarded Funding to Carry Out Groundbreaking Research on Single Ventricle Heart Disease 150 150 Madison Storm
By: Madison Storm

The American Heart Association (AHA) and Additional Ventures have announced funding for five teams of scientists for research on single ventricle heart disease. Four researchers from Nationwide Children’s Hospital were included in the grant awards, building off their ongoing work in regenerative medicine and…

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Evaluating Teaching Methods in Pulmonary Physiology
 Evaluating Teaching Methods in Pulmonary Physiology 1024 683 Pam Georgiana
By: Pam Georgiana

Does the flipped classroom or engaging lecture technique create better learning outcomes? In the Pediatric Pulmonary Physiology fellowship program at Nationwide Children’s, the flipped classroom approach was primarily used to teach pulmonary physiology. This necessary curriculum component can be challenging to teach and learn,…

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Supporting Tracheostomy Decision-Making for Families and Providers
 Supporting Tracheostomy Decision-Making for Families and Providers 1024 683 Abbie Miller
By: Abbie Miller

The Trach Scoring Tool, developed by BPD leaders at Nationwide Children’s Hospital, offers support for physicians and families. The decision of when to do a tracheostomy on an infant is difficult, to say the least, says Leif Nelin, MD, division chief of Neonatology at…

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How Common is the Duffy Null Polymorphism Among Children With Sickle Cell Disease? Does It Affect Treatment?
 How Common is the Duffy Null Polymorphism Among Children With Sickle Cell Disease? Does It Affect Treatment? 1024 683 Pam Georgiana
By: Pam Georgiana

Recent research shows that a commonly inherited polymorphism could impact outcomes. At a recent hematology team meeting, Susan E. Creary, MD, and colleagues found themselves discussing the Duffy null, a common genetic condition in which the Duffy antigen is not found on red blood…

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Extended Reality Offers New Ways to View Congenital Heart Disease
 Extended Reality Offers New Ways to View Congenital Heart Disease 1024 577 Mary Bates, PhD
By: Mary Bates, PhD

Researchers are evaluating the technology’s potential to improve clinical practice, trainee and family education, and patient outcomes. What if you could put on a headset and teleport inside a model of a patient’s beating heart? What if you could interact with that heart —…

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Dr. Jadcherla
Study Reveals New Use for GER Tool in Neonates: Swallowing Analysis
 Study Reveals New Use for GER Tool in Neonates: Swallowing Analysis 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Investigators have repurposed a simple test for gastroesophageal reflux (GER) disease to provide valuable insight into multiple swallowing abnormalities in newborn babies. A tool used to diagnose gastroesophageal reflux disease (GERD) in hospitalized neonates now has another use: characterizing swallowing abilities. The researchers at…

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Evaluating Caregiver Report of Developmental Delays in Young Children
 Evaluating Caregiver Report of Developmental Delays in Young Children 1024 681 Mary Bates, PhD
By: Mary Bates, PhD

Caregiver-report measures of cognitive skills correlate with direct assessments by clinicians. Researchers from Nationwide Children’s Hospital report that a standardized caregiver interview can effectively identify children at risk for cognitive developmental delays. The findings suggest that caregiver-report measures may be useful in assessing young…

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