Clinical Genomics: From Research to Reality

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Single Ventricle, Many Research Angles

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Setting the Standard for Cloacal Malformation Management

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Who Do You Trust?

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Studying the Environment’s Impact on Pediatric Health Outcomes

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New Trial Aims to Boost Kids’ Immune Systems to Fight Neuroblastoma
 New Trial Aims to Boost Kids’ Immune Systems to Fight Neuroblastoma 1024 558 Lauren Dembeck
By: Lauren Dembeck

A new cellular therapy approach could improve outcomes and ease the treatment burden for patients and families. Neuroblastoma is rare, with only 700 to 800 new cases diagnosed in the United States each year, but it is the most common extracranial solid tumor in…

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How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy?
 How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy? 1024 783 Abbie Miller
By: Abbie Miller

New study shows essential role of RNA methlytransferase-mediated m6A modification in regulating heart development. Traditional research to understand the origins of congenital heart disease have focused on understanding how genetic mutations may cause heart problems. Now, a team at Nationwide Children’s Hospital is exploring…

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Relative Adrenal Insufficiency Observed Among Patients With High-Risk Neuroblastoma During Treatment
 Relative Adrenal Insufficiency Observed Among Patients With High-Risk Neuroblastoma During Treatment 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

A subset of patients with high-risk neuroblastoma (NBL) and primary adrenal tumors develop an adrenal insufficiency (AI)-like phenotype during treatment. “We noticed that some of the patients with neuroblastoma had less hypotension when we added hydrocortisone while they were getting dinutuximab therapy. So, we…

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Treating Severe Pediatric Kidney Disease with Simultaneous Bilateral Native Nephrectomy
 Treating Severe Pediatric Kidney Disease with Simultaneous Bilateral Native Nephrectomy 480 320 Abbie Miller
By: Abbie Miller

A 15-year review of indications, approaches and outcomes A recent study published in Pediatric Transplantation and led by Christina B. Ching, MD, pediatric urologist in the Department of Pediatric Urology at Nationwide Children’s Hospital, offers valuable insights into a very rare clinical procedure: simultaneous…

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By the Book: Guiding Teens Through Inpatient Psychiatric Stays
 By the Book: Guiding Teens Through Inpatient Psychiatric Stays 1024 555 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new patient guidebook provides evidence-based resources to engage adolescents in their recovery throughout and after their hospital stay. Inpatient admissions for child and adolescent psychiatry patients typically occur due to a psychiatric crisis. At Nationwide Children’s Hospital, children stay an average of eight…

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Featured Researcher – Mattina Davenport, PhD
 Featured Researcher – Mattina Davenport, PhD 150 150 Gina Vitale
By: Gina Vitale

What happens when a passion for law and social advocacy intersects with science and mentorship? The result is a remarkable research scientist driven to improve pediatric health equity and access, eager to lead the next generation of scientists. Meet Mattina A. Davenport, PhD. She’s…

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Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention
 Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention 1024 683 Pam Georgiana
By: Pam Georgiana

Research offers promising solutions for urinary tract infection treatment and antibiotic resistance. Urinary tract infections affect millions of people and can contribute to significant morbidity. Research into innate immunity mechanisms has shown great promise for improving urinary tract infection prevention and treatment strategies, especially…

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Genetic Variation Contributing to Nephrotic Syndrome
 Genetic Variation Contributing to Nephrotic Syndrome 1024 683 Abbie Miller
By: Abbie Miller

Genetic variants in CR1 have significantly different population-specific frequencies and are linked with focal segmental glomerulosclerosis (FSGS) – the leading cause of nephrotic syndrome. Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome — a kidney disorder that causes proteins to leak…

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Preventing Pediatric Suicide Through Systems-Level Collaboration
 Preventing Pediatric Suicide Through Systems-Level Collaboration 1024 576 Pam Georgiana
By: Pam Georgiana

How primary care, schools and communities are working together to address pediatric suicide rates through early intervention and collaborative care. Suicide is the second leading cause of death for youth aged 10 to 24 in the United States, and rates have been steadily rising…

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Depression is the New Predictor of Diabetes Control in Teens
 Depression is the New Predictor of Diabetes Control in Teens 1024 683 Pam Georgiana
By: Pam Georgiana

A new study reveals that depressive symptoms, not diabetes-specific stress, forecast long-term glycemic outcomes in adolescents with type 1 diabetes. Managing type 1 diabetes is challenging at any age, but for adolescents, the burden can be especially overwhelming. Previous cross-sectional studies have shown a…

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Novel Viral Vector Manufacturing Approach Could Improve Safety of Gene Therapy
 Novel Viral Vector Manufacturing Approach Could Improve Safety of Gene Therapy 1024 683 Lauren Dembeck
By: Lauren Dembeck

New AAV proviral plasmid for vector manufacturing has potential to increase patient safety and make gene therapies more affordable, researchers say. Gene therapy is one of the most exciting frontiers in modern medicine, offering potential cures for previously devastating or fatal disorders, such as…

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A Simple Intervention With Great Potential
 A Simple Intervention With Great Potential 1024 585 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

If the CORD-CHD Study meets even a single endpoint, it will represent one of the simplest and most accessible improvements in congenital heart disease management in recent history. The concept is elegant in its simplicity: delay clamping the umbilical cord for a minute or…

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Enhancing Pediatric Suicide Risk Detection: Effective Screening, Pathways and Care
 Enhancing Pediatric Suicide Risk Detection: Effective Screening, Pathways and Care 1024 683 Madison Storm
By: Madison Storm

Youth suicide is a leading cause of death in the United States. Most youth who die by suicide have no mental illness diagnosis and have visited a health care provider within a year prior to their death. In fact, 40% of those youth visited…

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6 Key Insights for Understanding Pediatric Pulmonary Hypertension
 6 Key Insights for Understanding Pediatric Pulmonary Hypertension 1024 575 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s pulmonary hypertension expert offers insights into the condition. Sarah P. Cohen, MD, physician in the Division of Pulmonary, Sleep Medicine and Cystic Fibrosis at Nationwide Children’s and assistant professor of Pediatrics at The Ohio State University, recently shared six essential insights for…

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Unique Cellular Trajectories Result in Reduced Cardiomyocyte Proliferation Capacities in Single Ventricle Disease
 Unique Cellular Trajectories Result in Reduced Cardiomyocyte Proliferation Capacities in Single Ventricle Disease 1024 537 Jessica Nye, PhD
By: Jessica Nye, PhD

Cellular trajectories deviate early in hypoplastic left heart syndrome (HLHS) and hypoplastic right heart syndrome (HRHS) development. Hypoplastic left and right heart syndromes are two rare and distinct single ventricle heart defects which are the most severe subtypes of congenital heart disease, usually requiring…

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Evaluating the Mental Health Impact of a Promising New Treatment for Cystic Fibrosis
 Evaluating the Mental Health Impact of a Promising New Treatment for Cystic Fibrosis 706 470 Pam Georgiana
By: Pam Georgiana

Insights from Nationwide Children’s study on how Trikafta affects children with cystic fibrosis. In response to the promising clinical benefits of elexacaftor/tezacaftor/ivacaftor (Trikafta) in adults with cystic fibrosis, a team in Nationwide Children’s Hospital Cystic Fibrosis Clinic recently investigated the effects of the drug…

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Featured Researcher – Nizar Y. Saad, PhD
 Featured Researcher – Nizar Y. Saad, PhD 150 150 Gina Vitale
By: Gina Vitale

Not all genetic diseases are inherited; however, they are all the result of DNA mutations or flaws. Genetic research and gene therapy are integral in finding cures or helpful treatments for diseases such as muscular dystrophy. At the Abigail Wexner Research Institute (AWRI) at…

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Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders
 Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders 1024 683 Lauren Dembeck
By: Lauren Dembeck

Nationwide Children’s researchers create first-ever stem cell lines for rare genitourinary conditions. Induced pluripotent stem cells (iPSCs) have revolutionized medical research by providing powerful tools to study disease mechanisms, especially in rare genetic conditions. These versatile cells, derived directly from patients that have the…

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Teen girl with backpack
Understanding Treatment Outcomes in Pediatric Bipolar Disorder
 Understanding Treatment Outcomes in Pediatric Bipolar Disorder 1024 575 Pam Georgiana
By: Pam Georgiana

New study compares minimally adequate behavioral health treatments and clinical outcomes. Pediatric bipolar disorder, which affects approximately 3.9% of youth globally, is the fourth leading cause of years of life lost due to disability and premature death for young people between the ages of…

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Why Do Some Children Have Worse Outcomes After Moderate to Severe Traumatic Brain Injury?
 Why Do Some Children Have Worse Outcomes After Moderate to Severe Traumatic Brain Injury? 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Children had reduced white matter structural connectivity after moderate to severe traumatic brain injury (TBI) relative to children with complicated-mild TBI (cmTBI) or orthopedic injury (OI). This reduced connectivity may explain some disparities in behavioral outcomes. Children and adolescents who experience a TBI are…

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