Inside the Science of Pediatric Lung Disease

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Baby in a NICU bed with nasal canula. Swaddled in white blanket with health care worker's hand gently resting on the baby.
Planning Starts During Pregnancy for the Fastest Genome Sequencing in the NICU
 Planning Starts During Pregnancy for the Fastest Genome Sequencing in the NICU 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Genome sequencing (GS) has become standard for babies with congenital anomalies in the neonatal intensive care unit (NICU) at Nationwide Children’s.   To ensure that clinicians have access to genomic results as soon as possible, GS coordination is moving to the gestational period for…

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test tube of blood held in gloved hands
International Framework Establishes Path Toward Risk-Adapted Osteosarcoma Treatment
 International Framework Establishes Path Toward Risk-Adapted Osteosarcoma Treatment 1024 575 Lauren Dembeck
By: Lauren Dembeck

A new international framework prioritizes molecular classifiers that could enable risk-adapted, biologically informed treatment for children, adolescents, and young adults with osteosarcoma.   Despite substantial advances in understanding osteosarcoma biology, treatment has remained largely unchanged for more than four decades. An international working group…

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MRA Brain or Magnetic resonance angiography (MRI) of Vessel in the brain sagittal view for evaluate them stenosis
Study Supports Use of Flow-Diverting Stent for Complex Brain Aneurysms in Children
 Study Supports Use of Flow-Diverting Stent for Complex Brain Aneurysms in Children 1024 531 Lauren Dembeck
By: Lauren Dembeck

New research suggests that a minimally invasive flow-diversion device approved for adults may offer a safe and effective treatment option for children with complex brain aneurysms. Pediatric intracranial aneurysms are rare, but when they occur, they can be among the most challenging cerebrovascular conditions…

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Baby in a NICU bed with nasal canula. Swaddled in white blanket with health care worker's hand gently resting on the baby.
Improving Neonatal X-Ray Quality Through Standardization
 Improving Neonatal X-Ray Quality Through Standardization 1024 683 Pam Georgiana
By: Pam Georgiana

Pre-X-ray Safety CHECK reduces repeat imaging, radiation exposure and diagnostic variability in the NICU. Portable radiographs are necessary for diagnosing disease and evaluating position of medical devices in neonatal intensive care units (NICUs). However, repeat imaging due to poor-quality radiographs exposes vulnerable infants to…

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Caucasian adolescent girl paying attention to the road and listening to her instructor. Teenage girl driving during her test to get a driver's license
Technology and Parent Engagement Reduce Risky Driving in Teens With Traffic Violations
 Technology and Parent Engagement Reduce Risky Driving in Teens With Traffic Violations 1024 683 Pam Georgiana
By: Pam Georgiana

Randomized clinical trial assesses whether driving feedback technology, parent communication training or a combination reduces risky driving in teenagers with traffic violations. Motor vehicle crashes are a leading cause of death for adolescents in the United States. Teen drivers who receive traffic citations represent…

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Genetic Testing Reshapes Care for Children With Kidney Disease
 Genetic Testing Reshapes Care for Children With Kidney Disease 1024 683 Lauren Dembeck
By: Lauren Dembeck

As more genetic causes of pediatric kidney disease are identified, clinicians are increasingly using genetic testing not only to diagnose disease, but also to guide treatment and improve long-term outcomes. For many children with kidney disease, the path to diagnosis can be long and…

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Get to Know the Neuroimmunology Clinic: Q&A With Kelsey Poisson, MD
 Get to Know the Neuroimmunology Clinic: Q&A With Kelsey Poisson, MD 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Dr. Poisson answers questions about the importance of specialized neuroimmunology care and what the Nationwide Children’s Neuroimmunology Clinic offers its patients. The Neuroimmunology Clinic at Nationwide Children’s Hospital offers patients with complex neuroimmune disorders a one-stop shop for multidisciplinary care. By integrating visits with…

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Close up of gloved doctor's hands injecting vaccine medicine into a syringe - stock image
Phase I Glioblastoma Cancer Vaccine Trial Shows Promise for Patients and Novel Vaccine Platform
 Phase I Glioblastoma Cancer Vaccine Trial Shows Promise for Patients and Novel Vaccine Platform 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Early results suggest extended survival and the potential to manufacture customized vaccines that target up to 40 patient-specific neoantigens. Glioblastoma is the most common primary central nervous system cancer in adults. Highly heterogenous from patient to patient and even within a single tumor, it…

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Antonio Cabrera, MD, wearing white coat and tie standing in hospital hallway
First AHA Scientific Statement Establishes Framework for Pediatric Acute Heart Failure Care
 First AHA Scientific Statement Establishes Framework for Pediatric Acute Heart Failure Care 1024 683 Pam Georgiana
By: Pam Georgiana

New guidance outlines a stepwise approach to early recognition, stabilization and long-term management.   A new scientific statement from the American Heart Association provides the first comprehensive framework for evaluating and managing children with acute decompensated heart failure (ADHF). ADHF is a high-risk condition…

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Nationwide Children’s Specialty Pharmacy Expands Access to Life-Changing Care
 Nationwide Children’s Specialty Pharmacy Expands Access to Life-Changing Care 1024 683 Alaina Doklovic
By: Alaina Doklovic

Nationwide Children’s Specialty Pharmacy is helping more patients access life-changing medications faster. What began as a focused effort to better serve patients with cystic fibrosis (CF) has grown into a comprehensive Specialty Pharmacy program supporting patients across more than 11 disease states at Nationwide…

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Young adult using a finger-prick device to check blood sugar levels while holding a glucose meter, standing at a kitchen counter with a small medical kit nearby.
Advancing Care for Youth-Onset Type 2 Diabetes, an Urgent and Evolving Public Health Issue
 Advancing Care for Youth-Onset Type 2 Diabetes, an Urgent and Evolving Public Health Issue 1024 589 Madison Storm
By: Madison Storm

Type 2 diabetes was once considered an adult-only condition, but today, that paradigm has shifted dramatically. Pediatric endocrinologists are caring for a growing and increasingly complex population of young patients with type 2 diabetes, underscoring the urgency of effective care.  “Youth-onset type 2 diabetes…

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Featured Researcher: Thomas Lynch, PhD
 Featured Researcher: Thomas Lynch, PhD 150 150 Gina Vitale, PTA
By: Gina Vitale, PTA

Studying human lung development and diseases at the cellular level, such as cystic fibrosis, asthma and lung transplantation, may improve their treatment protocols. Research involving the submucosal glands, tiny disease defenders in the airways, could be the key to unlocking disease prevention or cures.…

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a woman makes inhalation to a child at home. brings the nebulizer mask to his face. inhales the vapor of the medication. the girl is breathing through a mask
Identifying Low-Risk Children With Intermittent Asthma
 Identifying Low-Risk Children With Intermittent Asthma 1024 683 Pam Georgiana
By: Pam Georgiana

Research suggests opportunities to refine treatment guidelines and reduce unnecessary medication use. In the medical community, there is an ongoing debate over the Global Initiative for Asthma guidelines, which discourage the use of short-acting beta-agonists (SABAs) alone, in patients with mild asthma. Instead, the…

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Fast Brain MRI Demonstrates High Diagnostic Value for Pediatric Neurologic Emergencies
 Fast Brain MRI Demonstrates High Diagnostic Value for Pediatric Neurologic Emergencies 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Fast brain MRI is a radiation-sparing technique that has demonstrated value as a screening tool for generalized emergent neurologic conditions in the pediatric emergency setting.   A recent retrospective study led by Nathaniel Forman, MD, a former pediatric emergency medicine fellow at Nationwide Children’s…

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person in blue scrubs holding a baby, cropped so focus is on the baby
A Balancing Act: Early Versus Late Renal and Bladder Ultrasound After a First Febrile Urinary Tract Infection
 A Balancing Act: Early Versus Late Renal and Bladder Ultrasound After a First Febrile Urinary Tract Infection 1024 634 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Performing a renal and bladder ultrasound less than 24 hours after a first febrile urinary tract infection increases the likelihood of detecting non-clinically relevant, transient inflammatory changes.   A retrospective study conducted at Nationwide Children’s and four other academic pediatric hospitals reported that a…

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Teen sitting curled up on a couch, looking out a bright window, appearing thoughtful or pensive.
The Future of Bipolar Disorder Management: Beyond the Clinic and Into the Community
 The Future of Bipolar Disorder Management: Beyond the Clinic and Into the Community 1024 683 Abbie Miller
By: Abbie Miller

A new, state-of-the-field publication lays out tools and evidence for building community-based systems of care for youth with bipolar. Individuals with bipolar disorders, a set of mental health conditions characterized by fluctuations in mood with periods of depression and mania, spend far more time…

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Photo of Christina Ching, MD, wearing a white lab coat, smiling at the camera in a lab.
New Mechanism Identified in Urinary Tract Infection Host Defense
 New Mechanism Identified in Urinary Tract Infection Host Defense 1024 683 Pam Georgiana
By: Pam Georgiana

IL-6 promotes urothelial expulsion of intracellular bacteria, limiting recurrence risk. A recent study published in the Journal of Innate Immunity provides new insights into how the body actively defends against urinary tract infections (UTIs). Led by Christina B. Ching, MD, principal investigator of the…

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Ryan Goodwin, MD, MBA, standing in a hallway with a teal wall. He is wearing a blue shirt and black suit pants and jacket.
Meet Ryan Goodwin, MD: Advancing Pediatric Spine Care at Nationwide Children’s
 Meet Ryan Goodwin, MD: Advancing Pediatric Spine Care at Nationwide Children’s 1024 683 Alaina Doklovic
By: Alaina Doklovic

Nationwide Children’s Hospital recently welcomed pediatric orthopedic and spine surgeon Ryan Goodwin, MD, new director of the Center for Comprehensive Spine Care. With more than two decades of experience and a passion for innovation in scoliosis treatment, Dr. Goodwin brings both expertise and new…

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Close-up digital illustration of a DNA strand against a blue background.
Health Systems Face Growing Gap in Cell and Gene Therapy Implementation
 Health Systems Face Growing Gap in Cell and Gene Therapy Implementation 1024 768 Pam Georgiana
By: Pam Georgiana

New manuscript outlines practical strategies to address safety, operational and financial challenges. As cell and gene therapies (CGTs) are increasingly incorporated into standard clinical care, health systems face a widening operational gap. An invited manuscript published in Transfusion outlines the challenge and presents a…

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Graphic illustration of kidneys and bladder organ visualization. Healthcare concept background with medical icons.
Why Immune Balance Matters in UTI Susceptibility
 Why Immune Balance Matters in UTI Susceptibility 1024 459 Pam Georgiana
By: Pam Georgiana

New research identifies PTEN as a main regulator of bladder immunity and suggests potential non-antibiotic prevention strategies. Urinary tract infections (UTIs) remain among the most common bacterial infections in clinical practice, contributing to significant morbidity and raising concerns about antibiotic resistance. While known risk…

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