Monthly Archives :

July 2017

How to Advocate for Patients with Legislators
How to Advocate for Patients with Legislators 150 150 Steve Allen, MD

Perhaps more this year than any other in recent memory, the health care community has come together against a proposed piece of federal legislation. While opposition to the American Health Care Act/Better Care Reconciliation Act has been particularly urgent, hospitals and medical associations regularly engage in government advocacy work. At Nationwide Children’s Hospital, for example,…

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Different Patterns of Executive Function Deficits in Different Pediatric Brain Disorders
Different Patterns of Executive Function Deficits in Different Pediatric Brain Disorders 150 150 Mary Bates, PhD

Clinical implications include specialized testing for deficits in executive function as these may not be apparent at a routine exam. A large group of researchers, including many from Nationwide Children’s Hospital, recently looked at whether children with different brain disorders show diverse patterns of strengths and weaknesses in executive functions. Children with traumatic brain injuries…

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Immune Profiling Leads to Implications for Immunotherapy for NF1-Associated Tumors
Immune Profiling Leads to Implications for Immunotherapy for NF1-Associated Tumors 150 150 Abbie Roth

Profiling reveals histologic subtype distinctions and heterogeneity of neurofibromatosis type 1-associated tumors. Neurofibromatosis type 1 (NF1) — an autosomal dominant disorder affecting approximately one in every 3,500 people — results in dysfunctional neurofibromin, a protein expressed throughout the body and involved in the RAS signaling pathway. Virtually all patients with NF1 develop benign peripheral nerve…

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Hepatitis E Persists and Self-Limits Due to Novel Mechanism, Study Finds
Hepatitis E Persists and Self-Limits Due to Novel Mechanism, Study Finds 150 150 Brianne Moore

A team of researchers finds that Hepatitis E behaves uniquely compared other hepatitis viruses and hopes to pave the way for future investigation. Hepatitis E virus (HEV) is one of five known human hepatitis viruses and infects approximately 20 million people annually. HEV causes significant morbidity and mortality around the world, causing acute hepatitis in…

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Combining Immunotherapies Effective Against Mouse Model of Cancer
Combining Immunotherapies Effective Against Mouse Model of Cancer 150 150 Mary Bates, PhD

Recent study results suggest that combining virotherapy and PD-1 blockades may be more effective than either approach alone. Rhabdomyosarcoma, a cancer made up of cells that normally develop into skeletal muscles, is the most common soft tissue cancer in children. If it is detected early and localized in certain areas, rhabdomyosarcoma is usually curable with…

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