Monthly Archives :

August 2022

Profiling the Tumor Microenvironment Offers New Insight for Hard-to-Treat Tumors
Profiling the Tumor Microenvironment Offers New Insight for Hard-to-Treat Tumors 1024 269 Katie Brind'Amour, PhD, MS, CHES

A multi-faceted approach to precision medicine may allow clinicians to gain a better understanding of cancer and the complex ecosystem in which it resides. The field of precision medicine has evolved in leaps and bounds in the past two decades. Genomic profiling tools that were once cost-prohibitive and slow are now reasonably affordable and fast…

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Examining Pediatric Injury-Related Emergency Department Vistis During the COVID-19 Pandemic
Examining Pediatric Injury-Related Emergency Department Vistis During the COVID-19 Pandemic 480 320 JoAnna Pendergrass, DVM

During the first year of the COVID-19 pandemic, the frequency of pediatric injury-related visits to the emergency department decreased, while injury severity increased. The COVID-19 pandemic caused disruptions not only on a global scale but also for individuals, particularly children. Pandemic-related closures of school and extracurricular activities significantly impacted the daily routines of children and…

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New Disorder of Copper Metabolism Identified, Caused by Variants in CTR1 Gene
New Disorder of Copper Metabolism Identified, Caused by Variants in CTR1 Gene 1024 575 Abbie Roth

A novel missense mutation in identical twins leads to discovery and definition of new inherited disorder of brain copper metabolism. Copper is essential for many cellular functions, including cellular respiration, antioxidant defense, neurotransmitter biosynthesis and neuropeptide amidation, among others. Until recently, only two inborn errors of copper metabolism were well established. Both are rare. Wilson’s…

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Featured Researcher — Allison Bradbury, MS, PhD
Featured Researcher — Allison Bradbury, MS, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES

Allison Bradbury, MS, PhD, is an accomplished principal investigator in the Center for Gene Therapy at Nationwide Children’s Hospital, but her introduction to medical research and the field of rare neurologic diseases wasn’t at school — it was in her great uncle’s garage, when his work as a veterinary pathologist led him to identify an inherited…

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How are Depression, Diabetes Distress and Glycemic Control Related in Adolescents With Type 2 Diabetes?
How are Depression, Diabetes Distress and Glycemic Control Related in Adolescents With Type 2 Diabetes? 150 150 Mary Bates, PhD

For adolescents with T2D, obesity and attempts at weight loss may contribute more to depression and diabetes distress than the demands of diabetes management. Diabetes distress is a negative emotional response to living with diabetes, a life-threatening illness that requires chronic, demanding, self-management. It is frequently mistaken for depression and the two are interrelated. Previous…

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