Monthly Archives :

November 2017

Cysteamine Appears to Help Clear Antibiotic-Resistant Bacteria from Cells of Patients With Cystic Fibrosis
Cysteamine Appears to Help Clear Antibiotic-Resistant Bacteria from Cells of Patients With Cystic Fibrosis 150 150 Kevin Mayhood

The drug could help eradicate members of the B. cepacia complex and other bacteria in CF. Physicians and researchers from Nationwide Children’s Hospital have found that the drug cysteamine protects cells of patients with cystic fibrosis (CF) against a group of disease-causing and multi-drug resistant microorganisms — members of the Burkholderia cepacia bacterial complex — in several…

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Building Heart Valves From Extracellular Matrix
Building Heart Valves From Extracellular Matrix 150 150 Abbie Roth

Physicians at Nationwide Children’s Hospital describe the use of an extracellular matrix cylindar valve in the mitral position. At The Heart Center at Nationwide Children’s, Patrick McConnell, MD, a pediatric cardiothoracic surgeon, is using an alternative to the traditional cadaveric, mechanical or biological replacement valve. In a recent case report published in Echocardiography, Dr. McConnell and his colleagues describe the…

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Considerations for Integrating Behavioral Health and Primary Care
Considerations for Integrating Behavioral Health and Primary Care 150 150 Cody Hostutler, PhD

As increasing numbers of pediatric patients require behavioral health care, primary care providers look to integrate behavioral health providers in their practice. You know the story. It’s the middle of a busy Friday afternoon, you just finished up an adolescent well-visit, your hand is on the door and you hear, “Doc, one more question?” The…

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Care Bundles Can Reduce Hospital-Acquired Pressure Injuries
Care Bundles Can Reduce Hospital-Acquired Pressure Injuries 150 150 Brianne Moore

Reliable implementation of care bundles reduces the number of serious hospital-acquired pressure injuries Hospital-acquired pressure injuries (PI) are a significant cause of preventable harm that can increase hospitalization costs and length of stay. Up to 27 percent of pediatric intensive care unit (PICU) patients and up to 23 percent of neonatal intensive care unit (NICU)…

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Two Classes of GGAA-Microsatellites in a Ewing Sarcoma Context
Two Classes of GGAA-Microsatellites in a Ewing Sarcoma Context 150 150 Abbie Roth

Characterization of GGAA-microsatellites provides insight in the role of noncoding DNA in cancer susceptibility and therapeutic development. In a study published in PLOS ONE, researchers describe two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma. Ewing sarcoma is the second most common pediatric bone malignancy. It is initiated by chromosomal…

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Phase 1 Study Shows Promise of Gene Replacement Therapy for Spinal Muscular Atrophy Type 1
Phase 1 Study Shows Promise of Gene Replacement Therapy for Spinal Muscular Atrophy Type 1 1024 575 Abbie Roth

The phase 1 clinical study shows that gene therapy extends survival of patients and supports achievement of milestones previously unseen in the natural course of the disease. A one-time intravenous infusion of the high dose of gene therapy extended the survival of patients with spinal muscular atrophy type 1 (SMA1), according to a study published in…

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