Monthly Archives :

October 2023

Is Dextranomer/Hyaluronic Acid an Effective Bladder Neck Bulking Agent for Patients with Persistent Incontinence Following Bladder Neck Reconstruction?
Is Dextranomer/Hyaluronic Acid an Effective Bladder Neck Bulking Agent for Patients with Persistent Incontinence Following Bladder Neck Reconstruction? 1024 575
Dr. Jayanthi standing in OR

Urinary incontinence caused by bladder neck incompetence is common in children diagnosed with neurogenic bladder. Many patients undergo surgery to increase bladder outlet resistance to incontinence, but some still experience it even after surgery. Endoscopic injection of bulking agents has previously been utilized and studied for use in the bladder neck as follow-up treatment for…

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Modulator Therapy Improves Lives of Patients With Cystic Fibrosis With Severe Lung Disease
Modulator Therapy Improves Lives of Patients With Cystic Fibrosis With Severe Lung Disease 150 150 Mary Bates, PhD

Patients receiving ETI on a compassionate use basis experienced substantial clinical improvement. The development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs, most recently elexacaftor/tezacaftor/ivacaftor (ETI), has transformed the treatment of patients with cystic fibrosis. A new study from researchers at Nationwide Children’s Hospital shows that ETI therapy has the potential to change even…

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Outcomes After Surgical Interventions for Abusive Head Trauma
Outcomes After Surgical Interventions for Abusive Head Trauma 1024 683 Mary Bates, PhD

Study suggests that most children can make clinically meaningful recoveries after neurosurgical intervention. Abusive head trauma (AHT) is a leading cause of injury and death in children under 5 years, according to the Centers for Disease Control and Prevention (CDC), yet the scientific literature on neurosurgical intervention for this population is mixed. Given the range…

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Expanding Access to Genomic Testing in Level IV Neonatal Intensive Care Units
Expanding Access to Genomic Testing in Level IV Neonatal Intensive Care Units 1024 575
conceptual art of DNA

Recent study identifies variations in availability and highlights opportunities to improve access to genomic testing in the United States and Canada. In the Nationwide Children’s Hospital neonatal intensive care unit, patients needing rapid genome sequencing can get it on demand without administrative approval. However, that is not the case in all level IV neonatal intensive…

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Congenital Heart Disease and Extracardiac Phenotypes Associated With Novel Pathogenic Variant in GATA6
Congenital Heart Disease and Extracardiac Phenotypes Associated With Novel Pathogenic Variant in GATA6 1024 575 Jessica Nye, PhD

A study published in Pediatric Research describes a novel pathogenic variant in the gene GATA binding protein 6 (GATA6) associated with congenital heart disease (CHD), diabetes mellitus and necrotizing enterocolitis.   GATA is a family of transcription factors that encode zinc finger DNA binding proteins which are critical regulators during organogenesis. Pathogenic variants in three…

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Enhancing Intestinal Rehabilitation Workflow with Disease-Specific Documentation Tools
Enhancing Intestinal Rehabilitation Workflow with Disease-Specific Documentation Tools 150 150

Structured data entry not only reduces the amount of time physicians are spending in the electronic health record but also opens the door for new research. A recent study published in JAMA Pediatrics by Nationwide Children’s Hospital’s Ethan Mezoff, MD, Jennifer Lee, MD, and team has shed light on a promising solution to improve the…

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Treating Pediatric Melanoma: Ultrasound Surveillance vs. Completion Lymph Node Dissection for Sentinel Node Positive Patients
Treating Pediatric Melanoma: Ultrasound Surveillance vs. Completion Lymph Node Dissection for Sentinel Node Positive Patients 1024 683

Treatments for pediatric melanoma are usually based on adult studies, but increasing recognition of the differences between pediatric and adult melanoma could change that. Pediatric melanoma is rare in the United States. The Skin Cancer Foundation reports that about 400 children under 20 years old are diagnosed with melanoma each year in the United States.…

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Novel Cause of Brain Mosaicism and Focal Epilepsy Identified
Novel Cause of Brain Mosaicism and Focal Epilepsy Identified 1024 575 Abbie Miller

In Nature Genetics, researchers report a novel mechanism for the origin of brain chromosomal mosaicism and link brain mosaic chromosome 1q gain to a distinct clinical phenotype.   In most people, every cell in their body contains the same genetic information. However, sometimes people can have two or more genetically different sets of cells. This…

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Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model
Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model 898 504 Abbie Miller

Biofilm formulation of Limosilactobacillus reuteri protects against necrotizing enterocolitis in piglet model.  Necrotizing enterocolitis (NEC) is a debilitating and deadly condition affecting infants born preterm. In NEC cases, intestinal tissues become inflamed, and in severe cases, there is ischemia and death of the involved intestines. Treatment for NEC often involves surgery to remove the dying…

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Increasing Same-Day Amoxicillin Graded Dose Challenges
Increasing Same-Day Amoxicillin Graded Dose Challenges 1024 683 JoAnna Pendergrass, DVM

A quality improvement initiative overcomes several barriers to de-labeling penicillin allergies. In a study published in The Journal of Allergy and Clinical Immunology: In Practice, a research team led by Margaret Redmond, MD, a pediatric allergist at Nationwide Children’s Hospital, reported on a quality improvement (QI) initiative that sustainably increased rates of same-day amoxicillin graded…

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Building Hope, Recovery, and Life Beyond Substance Use Disorder
Building Hope, Recovery, and Life Beyond Substance Use Disorder 1024 702 Abbie Miller

Five years ago, Pediatrics Nationwide dedicated its fall issue to a comprehensive look at the effects of the opioid crisis on children and families. At that time, Sarah Parker was working hard to stay sober, recovering from the very crisis holding the nation’s attention. Parker grew up in Chillicothe, Ohio, halfway between Portsmouth, Ohio, the…

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Whole Child, Whole Family Care
Whole Child, Whole Family Care 150 150 Abbie Miller and Jeb Phillips

Meeting the needs of children and caregivers with evidence-based programming and intentional support for access. Parenting a young child can be tough in the best circumstances. But when you overlay poverty, inequity, and concerns about employment and education on top of it, parenting a young child can feel overwhelming. Whitney Raglin Bignall, PhD, has dedicated…

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Tissue Engineered Trachea: State of the Research
Tissue Engineered Trachea: State of the Research 150 150 Lauren Dembeck

The promise of tissue-engineered trachea grafts is moving closer to the clinic, as recent preclinical studies have shown successful implantation and neovascularization. Breathing is an essential biological function that provides our bodies with the oxygen necessary for survival. However, most of us rarely think about the biological structures that make it possible. The trachea, commonly…

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Caring for Incarcerated Children
Caring for Incarcerated Children 1024 537 Jeb Phillips

Young people in juvenile detention centers need health care. In fact, decades of studies show they most often need it more urgently than their peers who are not involved in the justice system – nearly 70% of “confined youth” have an unmet health care need (2010 study). So it makes some sense that “urgent care”…

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Preventing Accidental Ingestion of Marijuana
Preventing Accidental Ingestion of Marijuana 1024 683 Abbie Miller

If you are a child, and you find a bag of fruit snacks — you don’t eat just one piece. The THC/marijuana products on the market today have an average of 10-20 mg in one serving. That’s one square of a chocolate bar, one gummy (which looks like a fruit snack) or one chip. “THC…

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User Experiences with Subcutaneous DMPA
User Experiences with Subcutaneous DMPA 1024 683

Survey reveals high satisfaction among adolescents and young adults using subcutaneous DMPA. Depot medroxyprogesterone acetate (DMPA) is a progestin-only injectable contraceptive that is used as a birth control method and in the treatment of heavy or painful menstrual periods, endometriosis, and for menstrual suppression. DMPA can be injected intramuscularly or subcutaneously, with no difference in…

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Should You Offer Fentanyl Test Strips in Your Office?
Should You Offer Fentanyl Test Strips in Your Office? 150 150 Abbie Miller

Harm reduction approaches support the use of fentanyl test strips for individuals who are taking illicit substances but want to avoid fentanyl. Nichole Michaels, PhD, a principal investigator in the Center for Injury Research and Policy at Nationwide Children’s, is conducting two studies about the efficacy of offering and educating about fentanyl testing among adults.…

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Combined Pediatric-Adult Anticoagulation Program Exceeds Goals
Combined Pediatric-Adult Anticoagulation Program Exceeds Goals 1024 580 Mary Bates, PhD

The program achieved excellent quality of anticoagulation therapy in children and adults. The goal of most anticoagulation programs is to improve the care of adult patients on warfarin therapy, specifically by treating and preventing thromboembolic events while minimizing bleeding risk. In a new study, researchers from Nationwide Children’s Hospital report excellent outcomes for a combined…

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Growing Clinical Research at Nationwide Children’s With Cynthia Gerhardt, PhD
Growing Clinical Research at Nationwide Children’s With Cynthia Gerhardt, PhD 1024 683 and Natalie Wilson

Dr. Gerhardt was appointed Chief Clinical Research Officer at Nationwide Children’s Hospital in April 2023. With integrating clinical care and research at the heart of the hospital’s strategic plan, she has big plans for ensuring our clinical research infrastructure continues to grow and evolve to support the best bench-to-bedside-and-back science for best outcomes. Learn more…

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Literature Review: Coping Through Narrative Medicine
Literature Review: Coping Through Narrative Medicine 1024 555 Natalie Wilson

Engaging with others’ stories helps prevent burnout among pediatric residents. A recent publication in Annals of Medicine shows pediatric residents practicing narrative medicine reported sustained improvements in their perceived levels of stress, self-compassion, empathy, mindfulness, burnout and resilience. This marks the first study to demonstrate the value of a narrative medicine intervention in promoting lasting…

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Associations Between Blood-Based and Biochemical Markers of Inflammation and Body Mass
Associations Between Blood-Based and Biochemical Markers of Inflammation and Body Mass 1024 575 Mary Bates, PhD

Blood-based markers of inflammation increased with increasing body mass in healthy adolescents. The chronic inflammatory disease atherosclerosis has its origins in childhood and adolescence; however, there are currently no simple methods to easily identify at-risk adolescents.  In a new study, researchers at Nationwide Children’s Hospital explored the relationships between blood-based and biochemical markers of inflammation…

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Increasing Use of Pharmacologic Clot Prevention Among Adolescents with Sickle Cell Disease
Increasing Use of Pharmacologic Clot Prevention Among Adolescents with Sickle Cell Disease 1024 580 Mary Bates, PhD

Growing interest in preventing thrombosis and approval of direct oral anticoagulants may be driving a shift to pharmacologic thromboprophylaxis. In a new study, researchers from Nationwide Children’s Hospital assessed the use of thromboprophylaxis in adolescent patients with sickle cell disease over the last decade. Sickle cell disease (SCD) increases the risk of venous thromboembolism (VTE).…

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Oncolytic Virus Immunotherapy Safe and Tolerable in Children With Relapsed or Refractory Solid Tumors
Oncolytic Virus Immunotherapy Safe and Tolerable in Children With Relapsed or Refractory Solid Tumors 1024 683 Lauren Dembeck

The overall survival rates for children with childhood cancers is now over 80%; however, for children with relapsed and refractory tumors, the survival rates remain low. “For example, children with relapsed or refractory neuroblastoma have a five-year survival of less than ten percent,” explains Keri A. Streby, MD, director of the Neuroblastoma Program in the…

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Recognizing the Benefits of Music and Massage Co-therapy in Pediatric Palliative Care
Recognizing the Benefits of Music and Massage Co-therapy in Pediatric Palliative Care 1024 680 JoAnna Pendergrass, DVM

For adolescent patients in home-based pediatric palliative care, co-treatment with music therapy and massage therapy benefits both the patients and their families. A case study recently published in Music & Medicine reported the benefits of co-treatment with music therapy and massage therapy for a patient in home-based pediatric palliative care. Complementary therapies, such as music…

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QI Initiative Reduces Emergency Room Visits for Functional Constipation
QI Initiative Reduces Emergency Room Visits for Functional Constipation 1024 683 Katie Brind'Amour, PhD, MS, CHES

Preliminary data from a large accountable care organization’s quality improvement efforts suggest advanced care visits dropped 27% in two years. Partners For Kids (PFK), the nation’s oldest and largest pediatric accountable care organization, launched a series of quality improvement (QI) projects targeting disease management strategies that could significantly impact healthcare utilization and outcomes for children…

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Racial Disparities in Healthcare Use Among Medicaid-Covered Children With Congenital Heart Disease
Racial Disparities in Healthcare Use Among Medicaid-Covered Children With Congenital Heart Disease 1024 683 Lauren Dembeck

In the United States, congenital heart disease is the most common birth anomaly, with almost 40,000 newborns diagnosed each year. As these children grow, they are at increased risk of developing cardiovascular complications. Thus, ensuring they receive recommended cardiology care is essential to their long-term health and well-being. Racial disparities in health outcomes have been…

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Ensuring Vulnerable Babies Receive the Benefits of Human Milk
Ensuring Vulnerable Babies Receive the Benefits of Human Milk 1024 575 Mary Bates, PhD
small baby with nose canula

A QI project increases human milk consumption among newborns hospitalized with congenital heart disease. The American Academy of Pediatrics and the World Health Organization recommend human milk for infants because of its important health benefits. However, most newborns with congenital heart disease (CHD) are separated from their mothers shortly after birth and admitted to a…

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Bridging Language Barriers to Advance Health Care Equity in Developmental Screenings
Bridging Language Barriers to Advance Health Care Equity in Developmental Screenings 1024 575

A QI project to utilize interpreters for screening questionnaires eliminated completion disparities between English speakers and people who prefer a language other than English.  In primary care pediatrics, there are several standard screenings for development delay in children younger than 30 months. Nationwide Children’s Hospital has a high rate of screening completion – over 90%.…

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5 Keys to Managing Iron Deficiency in Children Undergoing Intestinal Rehabilitation
5 Keys to Managing Iron Deficiency in Children Undergoing Intestinal Rehabilitation 150 150

A new position paper offers recommendations for the evaluation and management of iron deficiency in children undergoing intestinal rehabilitation. Iron deficiency is a prevalent concern among children with certain digestive problems, presenting various health challenges. A position paper from the NASPGHAN Intestinal Rehabilitation Special Interest Group, led by Ethan Mezoff, MD, a pediatric gastroenterologist at…

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