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Mary Bates, PhD

A Noncardiomyocyte Signaling Pathway in Early Heart Development
A Noncardiomyocyte Signaling Pathway in Early Heart Development 1024 670 Mary Bates, PhD

Study demonstrates role for endocardial cells in myocardial trabeculation. A new study in Nature Communications from researchers at Nationwide Children’s Hospital provides novel insights into a signaling pathway that regulates the developing myocardium during early heart development. The findings have implications for understanding congenital heart disease and myocardial regeneration. This research was led by Deqiang…

Outcomes of Colonic Pull-Through for Patients With Cloacal Exstrophy: Is it Really Helping Kids?
Outcomes of Colonic Pull-Through for Patients With Cloacal Exstrophy: Is it Really Helping Kids? 1024 683 Mary Bates, PhD

Collaborative study reveals infrequent utilization of the procedure and identifies factors correlated with success. Cloacal exstrophy is a rare grouping of congenital anorectal malformations. Although once nearly uniformly fatal, survival has increased significantly, and with it, the focus on long-term outcomes. In the last 15 years, a reconstructive surgery known as colonic pull-through has been…

How Does Thickened Formula Affect Reflux in Infants?
How Does Thickened Formula Affect Reflux in Infants? 1024 683 Mary Bates, PhD

Infants in the neonatal intensive care unit with suspected gastroesophageal reflux disease (GERD) are often fed formula with added rice cereal or other thickeners, despite limited evidence of its efficacy or long-term consequences. Additionally, the consequences of thickened feeds are not well-studied, says Sudarshan Jadcherla, MD, a principal investigator at the Center for Perinatal Research…

Infliximab Biosimilars Improve Growth Outcomes in Children With Inflammatory Bowel Disease
Infliximab Biosimilars Improve Growth Outcomes in Children With Inflammatory Bowel Disease 1024 683 Mary Bates, PhD

Treatment with either the infliximab originator or a biosimilar improves clinical and growth outcomes. In a new study, researchers at Nationwide Children’s Hospital report that children with inflammatory bowel disease showed similar growth and clinical outcomes whether they were treated with the infliximab originator or a biosimilar agent. The results add to the growing literature…

What Features Make Virtual Reality Effective in Pain Management?
What Features Make Virtual Reality Effective in Pain Management? 934 401 Mary Bates, PhD

Game realism, fun and engagement all impact pain perception during burn dressing changes. Researchers from Nationwide Children’s Hospital show that three key features of a virtual reality intervention (game realism, fun and engagement) influence self-reported pain scores during burn dressing changes. The findings provide insight into the potential mechanisms through which virtual reality affects pain…

Modulator Therapy Improves Chronic Sinus Disease in Individuals with Cystic Fibrosis
Modulator Therapy Improves Chronic Sinus Disease in Individuals with Cystic Fibrosis 1024 683 Mary Bates, PhD

Following 1 year of therapy, patients showed improved sinus CT metrics and clinical outcomes. Over the last decade, the development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs has revolutionized the treatment of cystic fibrosis (CF). The most widely used modulator is the triple combination elexacaftor-tezacaftor-ivacaftor (ETI), which is approved for people with CF…

Higher Respiratory Severity Scores Associated with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension Risk
Higher Respiratory Severity Scores Associated with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension Risk 1024 683 Mary Bates, PhD

The RSS score is noninvasive and may be clinically useful for risk stratification in extremely preterm infants. Researchers at Nationwide Children’s report that elevations in the respiratory severity score were correlated with an increased risk of bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants. This study identifies a pragmatic clinical risk score that can be measured…

Implanted Hemodynamic Monitoring in Patients With Fontan Circulation
Implanted Hemodynamic Monitoring in Patients With Fontan Circulation 150 150 Mary Bates, PhD

Pulmonary artery pressures obtained with the CardioMEMSTM system may be clinically useful. In a new study, researchers from The Ohio State University and Nationwide Children’s Hospital report on the use of invasive implanted hemodynamic monitoring (IHM) in patients with Fontan circulation. The findings suggest that IHM pressures in these patients are more closely associated with…

Researchers Create a Stem Cell Line to Study Alagille Syndrome
Researchers Create a Stem Cell Line to Study Alagille Syndrome 1024 683 Mary Bates, PhD

The patient-derived iPSCs have a mutation affecting the Notch signaling pathway. Researchers at Nationwide Children’s have developed an induced pluripotent stem cell (iPSC) line derived from a patient with Alagille syndrome, a multisystem genetic disease. Like the majority of patients with Alagille syndrome, the stem cells have a pathogenic mutation in the JAG1 gene, part…

Rural-Urban Differences in Social and Emotional Protective Factors
Rural-Urban Differences in Social and Emotional Protective Factors 1024 683 Mary Bates, PhD

Efforts to improve child health and flourishing should consider communities’ unique sources of support. Children living in rural areas experience well-documented health and health care disparities compared to those living in urban areas. Protective factors, such as social connectedness and social engagement, also vary by geography, yet their contribution to differences in child health is…

What Other Screening Tests Should be Administered to Celiac Disease Patients?
What Other Screening Tests Should be Administered to Celiac Disease Patients? 1024 575 Mary Bates, PhD

Eliminating some labs may reduce costs without impacting quality of patient care. Researchers from Nationwide Children’s Hospital found that several screening laboratory tests currently recommended for pediatric patients newly diagnosed with celiac disease are infrequently abnormal. In a new study published in the Journal of Pediatrics, they suggest a more streamlined approach to decrease the…

What Treatment is Best for Preventing Kidney Complications in STEC Infections?
What Treatment is Best for Preventing Kidney Complications in STEC Infections? 150 150 Mary Bates, PhD

Nationwide Children’s Hospital is participating in a multicenter trial to determine the optimal way to treat children with high-risk STEC infections. Shiga toxin-producing E. coli (STEC) infections can lead to systemic disease affecting multiple organ systems, including the kidneys. Up to 20% of children infected by high-risk STEC develop hemolytic uremic syndrome (HUS), a devastating…

Modulator Therapy Improves Lives of Patients With Cystic Fibrosis With Severe Lung Disease
Modulator Therapy Improves Lives of Patients With Cystic Fibrosis With Severe Lung Disease 150 150 Mary Bates, PhD

Patients receiving ETI on a compassionate use basis experienced substantial clinical improvement. The development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs, most recently elexacaftor/tezacaftor/ivacaftor (ETI), has transformed the treatment of patients with cystic fibrosis. A new study from researchers at Nationwide Children’s Hospital shows that ETI therapy has the potential to change even…

Outcomes After Surgical Interventions for Abusive Head Trauma
Outcomes After Surgical Interventions for Abusive Head Trauma 1024 683 Mary Bates, PhD

Study suggests that most children can make clinically meaningful recoveries after neurosurgical intervention. Abusive head trauma (AHT) is a leading cause of injury and death in children under 5 years, according to the Centers for Disease Control and Prevention (CDC), yet the scientific literature on neurosurgical intervention for this population is mixed. Given the range…

Combined Pediatric-Adult Anticoagulation Program Exceeds Goals
Combined Pediatric-Adult Anticoagulation Program Exceeds Goals 1024 580 Mary Bates, PhD

The program achieved excellent quality of anticoagulation therapy in children and adults. The goal of most anticoagulation programs is to improve the care of adult patients on warfarin therapy, specifically by treating and preventing thromboembolic events while minimizing bleeding risk. In a new study, researchers from Nationwide Children’s Hospital report excellent outcomes for a combined…

Associations Between Blood-Based and Biochemical Markers of Inflammation and Body Mass
Associations Between Blood-Based and Biochemical Markers of Inflammation and Body Mass 1024 575 Mary Bates, PhD

Blood-based markers of inflammation increased with increasing body mass in healthy adolescents. The chronic inflammatory disease atherosclerosis has its origins in childhood and adolescence; however, there are currently no simple methods to easily identify at-risk adolescents.  In a new study, researchers at Nationwide Children’s Hospital explored the relationships between blood-based and biochemical markers of inflammation…

Increasing Use of Pharmacologic Clot Prevention Among Adolescents with Sickle Cell Disease
Increasing Use of Pharmacologic Clot Prevention Among Adolescents with Sickle Cell Disease 1024 580 Mary Bates, PhD

Growing interest in preventing thrombosis and approval of direct oral anticoagulants may be driving a shift to pharmacologic thromboprophylaxis. In a new study, researchers from Nationwide Children’s Hospital assessed the use of thromboprophylaxis in adolescent patients with sickle cell disease over the last decade. Sickle cell disease (SCD) increases the risk of venous thromboembolism (VTE).…

Ensuring Vulnerable Babies Receive the Benefits of Human Milk
Ensuring Vulnerable Babies Receive the Benefits of Human Milk 1024 575 Mary Bates, PhD
small baby with nose canula

A QI project increases human milk consumption among newborns hospitalized with congenital heart disease. The American Academy of Pediatrics and the World Health Organization recommend human milk for infants because of its important health benefits. However, most newborns with congenital heart disease (CHD) are separated from their mothers shortly after birth and admitted to a…

User Experiences With Subcutaneous Depot Medroxyprogesterone Acetate
User Experiences With Subcutaneous Depot Medroxyprogesterone Acetate 1024 683 Mary Bates, PhD
Girl sitting on a bench with her phone smiling.

Survey reveals high satisfaction among adolescents and young adults using subcutaneous DMPA Depot medroxyprogesterone acetate (DMPA) is a progestin-only injectable contraceptive that is used as birth control method and in the treatment of heavy or painful menstrual periods, endometriosis, and for menstrual suppression. DMPA can be injected intramuscularly or subcutaneously, with no difference in effectiveness…

Diagnosing and Treating Cubital Tunnel Syndrome in Adolescents
Diagnosing and Treating Cubital Tunnel Syndrome in Adolescents 1024 575 Mary Bates, PhD
Julie Samora, MD

Surgery leads to improved outcomes in pediatric patients with symptoms of cubital tunnel syndrome, even when electrodiagnostic studies are negative. In a new study, researchers from Nationwide Children’s Hospital demonstrate that pediatric patients who underwent surgical decompression for cubital tunnel syndrome achieved good resolution of their symptoms, regardless of whether their electrodiagnostic findings were positive…

Counseling Families of Patients with Hypoplastic Left Heart Syndrome
Counseling Families of Patients with Hypoplastic Left Heart Syndrome 150 150 Mary Bates, PhD

A new survey investigates how palliation strategies have changed in the last ten years. Approximately ten years ago, researchers at Nationwide Children’s Hospital surveyed pediatric cardiac providers regarding initial counseling for families of patients with hypoplastic left heart syndrome (HLHS). Given the evolution of options and outcomes since that time, the team recently queried providers…

Fertility Concerns in Boys and Men With Sickle Cell Disease
Fertility Concerns in Boys and Men With Sickle Cell Disease 1024 575 Mary Bates, PhD
Color photo of Black father holding infant on shoulder in front of nursery background with clouds on the wall

Sickle cell disease and its treatments may impact fertility, but more research is needed to help counsel this population. Sickle cell disease (SCD) affects approximately 100,000 Americans, most of whom belong to underserved, minority populations. Advances in disease-modifying therapies, such as hydroxyurea, have led to better clinical outcomes. However, as more individuals with SCD survive…

Assessing Respiratory Stability in Infants Hospitalized with Bronchopulmonary Dysplasia
Assessing Respiratory Stability in Infants Hospitalized with Bronchopulmonary Dysplasia 1024 683 Mary Bates, PhD

The Behavioral Signs of Respiratory Instability Scale is a valid, reliable measure of respiratory status and developmental ability. In a new study, researchers at Nationwide Children’s evaluated the Behavioral Signs of Respiratory Instability (BSRI) Scale, which was developed as an objective measure of developmental capacity of infants with severe forms of bronchopulmonary dysplasia (BPD). The…

Home Infusions of Infliximab for Inflammatory Bowel Disease
Home Infusions of Infliximab for Inflammatory Bowel Disease 1024 683 Mary Bates, PhD

With a standardized care approach, home infusions may be an effective alternative to hospital-based infusions. Pediatric inflammatory bowel disease (IBD) is often treated with infusions of infliximab in a hospital setting. However, these can be costly and present time and travel barriers to patients and their families. Due to these considerations and recent insurance mandates,…

What Drives Nephrotic Syndrome Hypercoagulopathy?
What Drives Nephrotic Syndrome Hypercoagulopathy? 150 150 Mary Bates, PhD

Antithrombin deficiency does not play a major mechanistic role in the increased clotting risk of nephrotic syndrome, according to a new study. Patients with nephrotic syndrome are at risk for life-threatening venous thromboembolism complications. This risk is thought to be driven by an acquired hypercoagulopathy, or excessive blood clotting. Although the mechanisms underlying this hypercoagulopathy…

Is Growth Hormone Replacement Safe Following Central Nervous System Tumors?
Is Growth Hormone Replacement Safe Following Central Nervous System Tumors? 1024 683 Mary Bates, PhD

Research suggests the benefits of growth hormone therapy outweigh the risks for pediatric cancer survivors. In a new review paper, researchers from Nationwide Children’s Hospital evaluated the risks and benefits associated with administering growth hormone to pediatric patients after diagnosis of a central nervous system tumor. The authors conclude that the therapy has many important…

An Alternative Method for Diagnosing Central Adrenal Insufficiency in Newborns
An Alternative Method for Diagnosing Central Adrenal Insufficiency in Newborns 1024 683 Mary Bates, PhD
Baby in NICU

Researchers evaluate the utility of random cortisol levels to diagnose adrenal insufficiency. In infants with central adrenal insufficiency, adrenocorticotropic hormone (ACTH) fails to signal to the adrenal gland, leading to decreased cortisol levels. It is a potentially life-threatening condition requiring urgent diagnosis and treatment. Diagnosing central adrenal insufficiency typically involves a low-dose synthetic ACTH (cosyntropin)…

Investigating Caregiver Disclosure of Pediatric Urologic Surgery
Investigating Caregiver Disclosure of Pediatric Urologic Surgery 1024 575 Mary Bates, PhD
Toddler playing with toys

A survey reveals most caregivers plan to disclose urologic surgery to their child but would like more guidance from providers. Some pediatric urologic surgeries are performed early in childhood and with short-term follow-up. When children have surgery before the age of memory formation, it is up to their caregiver to disclose this surgery to them.…

Evolution of the Youth Crisis Stabilization Unit
Evolution of the Youth Crisis Stabilization Unit 1024 538 Mary Bates, PhD

An alternative to inpatient hospitalization for youth experiencing a mental health crisis and their families sees success at Nationwide Children’s.   The Youth Crisis Stabilization Unit (YCSU) is an inpatient psychiatric setting at Nationwide Children’s for children and adolescents experiencing a mental health crisis. Over the last 12 years, the YCSU has grown from a…

Deep Brain Stimulation Ameliorates Symptoms of Genetic Movement Disorder
Deep Brain Stimulation Ameliorates Symptoms of Genetic Movement Disorder 150 150 Mary Bates, PhD

First report of DBS for management of tremor in a treatment-resistant AIFM1-related disorder.   In a new case series, researchers from Nationwide Children’s report using deep brain stimulation (DBS) to help manage tremor due to a genetic movement disorder in two brothers. The report, published in the journal Pediatric Neurology, suggests DBS may be useful…

Social Needs Associated with Postpartum Depression
Social Needs Associated with Postpartum Depression 1024 683 Mary Bates, PhD

Screening for social needs at pediatric well-checks may help identify vulnerable mothers. In a new study, researchers from Nationwide Children’s found a significant relationship between self-reported social needs and postpartum depression symptoms of mothers screened in pediatric primary care clinics. The findings suggest that social needs could be targeted concurrently in future interventions addressing postpartum…

Placing Value on a Pediatric Surgeon’s Academic Work
Placing Value on a Pediatric Surgeon’s Academic Work 1024 683 Mary Bates, PhD

The addition of an academic RVU system to an existing work RVU-based incentivization plan boosted academic productivity in the Department of Pediatric Surgery at Nationwide Children’s Hospital. At many institutions, physicians and surgeons are compensated using a productivity formula based on work relative value units (wRVUs). wRVUs commonly quantify clinical work, practice expenses and professional…

Role of Myeoloid-Derived Suppressor Cells in Septic Shock Immunoparalysis
Role of Myeoloid-Derived Suppressor Cells in Septic Shock Immunoparalysis 1024 683 Mary Bates, PhD

New study is the first to describe increased myeloid-derived suppressors cells in children with septic shock. In children with septic shock, the immune system initiates a systemic inflammatory response and a nearly concurrent compensatory anti-inflammatory response. When severe, this anti-inflammatory response is termed “immunoparalysis” and is associated with increased risk of infections and death. Researchers…

Intraoperative Evaluation of Penile Blood Flow During Bladder Exstrophy
Intraoperative Evaluation of Penile Blood Flow During Bladder Exstrophy 150 150 Mary Bates, PhD

Laser angiography technology allows for real-time measurements of penile perfusion during exstrophy repair operations. In a new pilot study, researchers from the Pediatric Urology Midwest Alliance (PUMA) demonstrated that intraoperative laser angiography is a safe and easy method to evaluate penile perfusion during bladder exstrophy closure. The optimal technique for repair of bladder exstrophy in…

Improving Outcomes for Infants and Children With Congenital Hypothyroidism
Improving Outcomes for Infants and Children With Congenital Hypothyroidism 1024 575 Mary Bates, PhD
Toddler playing with toys

A quality improvement project identifies high-risk patients and ensures they receive necessary care.   Congenital hypothyroidism (CH) is one of the most common preventable causes of intellectual disability. In the United States and many other countries, newborns are tested a 24-72 hours after birth for CH as part of standard screening tests. This condition must…

High-Risk Genotype Impacts Kidney Disease Trajectory
High-Risk Genotype Impacts Kidney Disease Trajectory 1024 575 Mary Bates, PhD
conceptual art of DNA

Patients with focal segmental glomerulosclerosis that possess two variations in the APOL1 gene experience more rapid progression of kidney disease. In a new study, researchers from Nationwide Children’s and other institutions quantified the relationship between a high-risk genotype and kidney disease progression in patients with focal segmental glomerulosclerosis (FSGS). The researchers leveraged data from the…

5 Things Neonatologists Should Know About Vitamin K Deficiency
5 Things Neonatologists Should Know About Vitamin K Deficiency 1024 683 Mary Bates, PhD

Vitamin K prophylaxis is safe and effective. Why are more parents refusing it, and what can be done? In a new perspective paper in the Journal of Perinatology, researchers from Nationwide Children’s say that vitamin K prophylaxis is an essential component of newborn care and yet, parental refusal of the intervention is on the rise.…

The PROMISE Program Reduces Cardiac Arrests in High-Risk Patients
The PROMISE Program Reduces Cardiac Arrests in High-Risk Patients 600 400 Mary Bates, PhD

This proactive quality improvement initiative improved outcomes for high-risk pediatric cardiology patients undergoing cardiac intervention. Faculty within The Heart Center at Nationwide Children’s recently initiated proactive risk mitigation strategies to reduce post-procedural cardiac arrests in high-risk congenital heart patients. In a new paper, the team used quality improvement methodology to show that their efforts resulted…

Using 3D Motion Capture Technology to Improve Outcomes
Using 3D Motion Capture Technology to Improve Outcomes 150 150 Mary Bates, PhD

  Kirsten Tulchin-Francis, PhD Kirsten Tulchin-Francis, PhD, joined Nationwide Children’s in March 2022 as director of orthopedic research and director of the Honda Center for Gait Analysis and Mobility Enhancement. In a Q&A, she discusses how she uses motion capture technology to improve outcomes for pediatric patients. What is your area of expertise? I have…

Virtual Support for Educating Parents of Newborns with Sickle Cell Trait
Virtual Support for Educating Parents of Newborns with Sickle Cell Trait 1024 681 Mary Bates, PhD
Black couple with newborn

A supplementary videoconferencing program engages parents and reduces worry about sickle cell trait status. Nearly 3 million people in the U.S. have sickle cell trait (SCT), in which they inherit one sickle cell gene and one normal gene. Individuals with SCT are usually asymptomatic; however, two parents with SCT have a 25% chance of having…

Fertility-Related Care for Girls With Turner Syndrome
Fertility-Related Care for Girls With Turner Syndrome 150 150 Mary Bates, PhD

Recent survey of providers shows fertility counseling and referrals are delivered inconsistently in this population. Researchers from Nationwide Children’s recently assessed practices surrounding fertility-related care among clinical providers who treat girls with Turner syndrome. They found that fertility counseling and referral rates remain inconsistent and identified common barriers to fertility care in this population. Turner…

New Insights into the Role of the NOTCH1 Gene in Congenital Heart Defects
New Insights into the Role of the NOTCH1 Gene in Congenital Heart Defects 150 150 Mary Bates, PhD

Experiments in human cells identify how mutations in the NOTCH1 gene impact cardiac cell differentiation and proliferation. A new study published in Circulation Research provides novel insights into how mutations in the NOTCH1 gene may lead to abnormal differentiation and proliferation of cardiomyocytes and contribute to ventricular hypoplasia and other structural anomalies found in congenital…

Intrauterine Devices are a First-Line Option for Adolescents with Bleeding Disorders
Intrauterine Devices are a First-Line Option for Adolescents with Bleeding Disorders 150 150 Mary Bates, PhD

Among adolescents with heavy menstrual bleeding, study shows no difference in IUD expulsion rate between adolescents with bleeding disorders and those without. In a new study, researchers from Nationwide Children’s evaluated the use of intrauterine devices (IUDs) in two young women’s hematology clinics. They found that young women with bleeding disorders did not experience a…

How Quality Improvement Can Expand Insulin Pump Use and More
How Quality Improvement Can Expand Insulin Pump Use and More 150 150 Mary Bates, PhD

A Q&A with Don Buckingham about the T1D Exchange Quality Improvement Collaborative Don Buckingham, MBOE, CPHQ, CSSBB, joined Nationwide Children’s Center for Clinical Excellence as a quality strategist eight years ago. In a Q&A, he shares how he leveraged his background in industry and business services improvement in projects for the T1D Exchange Quality Improvement…

Development of Acute Kidney Injury as a Potential Biomarker of Necrotizing Enterocolitis in Preterm Infants
Development of Acute Kidney Injury as a Potential Biomarker of Necrotizing Enterocolitis in Preterm Infants 1024 683 Mary Bates, PhD

Regular measurement of serum creatinine levels could help identify necrotizing enterocolitis sooner. Researchers at Nationwide Children’s neonatal intensive care unit (NICU) evaluated serum creatinine levels and the development of acute kidney injury as a potential biomarker of necrotizing enterocolitis in preterm infants. The retrospective chart review showed that acute kidney injury is more prevalent in…

Integrating Behavioral Health and Primary Care Increases Access and Equity
Integrating Behavioral Health and Primary Care Increases Access and Equity 1024 683 Mary Bates, PhD

With mental health concerns on the rise, more primary care providers are integrating behavioral health services in their practices.  Despite increasing demand for behavioral health care, multiple barriers still exist that limit access for pediatric patients. In recent years, primary care settings across the country have responded by integrating mental health specialists into their practices.…

Predicting Response to Bronchodilators in Infants with Bronchopulmonary Dysplasia
Predicting Response to Bronchodilators in Infants with Bronchopulmonary Dysplasia 1024 683 Mary Bates, PhD

Study emphasizes importance of identifying those patients who will respond to treatment. Certain pulmonary function test parameters in newborns with bronchopulmonary dysplasia are associated with bronchodilator response, according to a new study from researchers at Nationwide Children’s Hospital. The team also found that responders had evidence of greater dysanaptic lung growth than nonresponders. Bronchodilators are…

Quality of Life in Pediatric Patients With Non-ambulatory Cerebral Palsy and Epilepsy
Quality of Life in Pediatric Patients With Non-ambulatory Cerebral Palsy and Epilepsy 600 400 Mary Bates, PhD

Study indicates that quality of life in young people with non-ambulatory cerebral palsy decreases with the use of more antiseizure medications. In a new study, researchers from Nationwide Children’s Hospital assessed the relationship between epilepsy-specific characteristics and proxy-reported health-related quality of life in children and young people with non-ambulatory cerebral palsy. The findings indicate that…

Factors Modulating Parenting Stress in Families of Children with Autism Spectrum Disorder
Factors Modulating Parenting Stress in Families of Children with Autism Spectrum Disorder 1024 575 Mary Bates, PhD
Parent and child holding hands

Parenting self-efficacy and family resources impact the relationship between behavior problems in children with autism spectrum disorder and parenting stress. Children with autism spectrum disorder (ASD) often exhibit co-occurring conditions that may increase parenting stress. These include externalizing behaviors, such as tantrums and disruptive behaviors, and internalizing issues, such as anxiety and depression. One factor…

Anal Sphincter Botox Injections for Children With Severe Constipation
Anal Sphincter Botox Injections for Children With Severe Constipation 1024 680 Mary Bates, PhD
Close up color photo of little boy holding hands on his belly

The treatment is safe and effective for many children with Hirschsprung disease and, to a lesser extent, functional constipation. In a new prospective study, researchers at Nationwide Children’s evaluated children with severe, refractory constipation treated with anal sphincter botulinum toxin (Botox) injection. They found the treatment can be effective in patients with both Hirschsprung disease…