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In Brief

How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy?
 How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy? 1024 783 Abbie Miller
By: Abbie Miller

New study shows essential role of RNA methlytransferase-mediated m6A modification in regulating heart development. Traditional research to understand the origins of congenital heart disease have focused on understanding how genetic mutations may cause heart problems. Now, a team at Nationwide Children’s Hospital is exploring a new way to understand congenital heart disease (CHD). “How the…

Relative Adrenal Insufficiency Observed Among Patients With High-Risk Neuroblastoma During Treatment
 Relative Adrenal Insufficiency Observed Among Patients With High-Risk Neuroblastoma During Treatment 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

A subset of patients with high-risk neuroblastoma (NBL) and primary adrenal tumors develop an adrenal insufficiency (AI)-like phenotype during treatment. “We noticed that some of the patients with neuroblastoma had less hypotension when we added hydrocortisone while they were getting dinutuximab therapy. So, we said, I wonder if that has anything to do with the…

Treating Severe Pediatric Kidney Disease with Simultaneous Bilateral Native Nephrectomy
 Treating Severe Pediatric Kidney Disease with Simultaneous Bilateral Native Nephrectomy 480 320 Abbie Miller
By: Abbie Miller

A 15-year review of indications, approaches and outcomes A recent study published in Pediatric Transplantation and led by Christina B. Ching, MD, pediatric urologist in the Department of Pediatric Urology at Nationwide Children’s Hospital, offers valuable insights into a very rare clinical procedure: simultaneous bilateral native nephrectomies, or the removal of both kidneys at the…

By the Book: Guiding Teens Through Inpatient Psychiatric Stays
 By the Book: Guiding Teens Through Inpatient Psychiatric Stays 1024 555 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new patient guidebook provides evidence-based resources to engage adolescents in their recovery throughout and after their hospital stay. Inpatient admissions for child and adolescent psychiatry patients typically occur due to a psychiatric crisis. At Nationwide Children’s Hospital, children stay an average of eight days before transitioning to outpatient care. While in the hospital, they…

Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention
 Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention 1024 683 Pam Georgiana
By: Pam Georgiana

Research offers promising solutions for urinary tract infection treatment and antibiotic resistance. Urinary tract infections affect millions of people and can contribute to significant morbidity. Research into innate immunity mechanisms has shown great promise for improving urinary tract infection prevention and treatment strategies, especially in populations at high risk, such as patients with insulin resistance.…

Genetic Variation Contributing to Nephrotic Syndrome
 Genetic Variation Contributing to Nephrotic Syndrome 1024 683 Abbie Miller
By: Abbie Miller

Genetic variants in CR1 have significantly different population-specific frequencies and are linked with focal segmental glomerulosclerosis (FSGS) – the leading cause of nephrotic syndrome. Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome — a kidney disorder that causes proteins to leak into the urine causing a variety of complications. FSGS has an…

Preventing Pediatric Suicide Through Systems-Level Collaboration
 Preventing Pediatric Suicide Through Systems-Level Collaboration 1024 576 Pam Georgiana
By: Pam Georgiana

How primary care, schools and communities are working together to address pediatric suicide rates through early intervention and collaborative care. Suicide is the second leading cause of death for youth aged 10 to 24 in the United States, and rates have been steadily rising across the country since 2007. Since the COVID-19 pandemic, the issue…

Depression is the New Predictor of Diabetes Control in Teens
 Depression is the New Predictor of Diabetes Control in Teens 1024 683 Pam Georgiana
By: Pam Georgiana

A new study reveals that depressive symptoms, not diabetes-specific stress, forecast long-term glycemic outcomes in adolescents with type 1 diabetes. Managing type 1 diabetes is challenging at any age, but for adolescents, the burden can be especially overwhelming. Previous cross-sectional studies have shown a link between diabetes-specific emotional distress, or the frustration and stress related…

Novel Viral Vector Manufacturing Approach Could Improve Safety of Gene Therapy
 Novel Viral Vector Manufacturing Approach Could Improve Safety of Gene Therapy 1024 683 Lauren Dembeck
By: Lauren Dembeck

New AAV proviral plasmid for vector manufacturing has potential to increase patient safety and make gene therapies more affordable, researchers say. Gene therapy is one of the most exciting frontiers in modern medicine, offering potential cures for previously devastating or fatal disorders, such as spinal muscular atrophy and aromatic L-amino acid decarboxylase deficiency. Adeno-associated virus…

Enhancing Pediatric Suicide Risk Detection: Effective Screening, Pathways and Care
 Enhancing Pediatric Suicide Risk Detection: Effective Screening, Pathways and Care 1024 683 Madison Storm
By: Madison Storm

Youth suicide is a leading cause of death in the United States. Most youth who die by suicide have no mental illness diagnosis and have visited a health care provider within a year prior to their death. In fact, 40% of those youth visited a health care provider within one month prior.   “The data…

6 Key Insights for Understanding Pediatric Pulmonary Hypertension
 6 Key Insights for Understanding Pediatric Pulmonary Hypertension 1024 575 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s pulmonary hypertension expert offers insights into the condition. Sarah P. Cohen, MD, physician in the Division of Pulmonary, Sleep Medicine and Cystic Fibrosis at Nationwide Children’s and assistant professor of Pediatrics at The Ohio State University, recently shared six essential insights for understanding pulmonary hypertension, a rare yet serious condition characterized by abnormally…

Unique Cellular Trajectories Result in Reduced Cardiomyocyte Proliferation Capacities in Single Ventricle Disease
 Unique Cellular Trajectories Result in Reduced Cardiomyocyte Proliferation Capacities in Single Ventricle Disease 1024 537 Jessica Nye, PhD
By: Jessica Nye, PhD

Cellular trajectories deviate early in hypoplastic left heart syndrome (HLHS) and hypoplastic right heart syndrome (HRHS) development. Hypoplastic left and right heart syndromes are two rare and distinct single ventricle heart defects which are the most severe subtypes of congenital heart disease, usually requiring prompt surgical intervention after birth. “Clinically, there are large differences between…

Evaluating the Mental Health Impact of a Promising New Treatment for Cystic Fibrosis
 Evaluating the Mental Health Impact of a Promising New Treatment for Cystic Fibrosis 706 470 Pam Georgiana
By: Pam Georgiana

Insights from Nationwide Children’s study on how Trikafta affects children with cystic fibrosis. In response to the promising clinical benefits of elexacaftor/tezacaftor/ivacaftor (Trikafta) in adults with cystic fibrosis, a team in Nationwide Children’s Hospital Cystic Fibrosis Clinic recently investigated the effects of the drug in pediatric patients. Kimberly Pasley, PsyD, mental health coordinator in the…

Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders
 Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders 1024 683 Lauren Dembeck
By: Lauren Dembeck

Nationwide Children’s researchers create first-ever stem cell lines for rare genitourinary conditions. Induced pluripotent stem cells (iPSCs) have revolutionized medical research by providing powerful tools to study disease mechanisms, especially in rare genetic conditions. These versatile cells, derived directly from patients that have the condition, offer unprecedented opportunities to uncover the underlying genetic and cellular…

Understanding Treatment Outcomes in Pediatric Bipolar Disorder
 Understanding Treatment Outcomes in Pediatric Bipolar Disorder 1024 575 Pam Georgiana
By: Pam Georgiana
Teen girl with backpack

New study compares minimally adequate behavioral health treatments and clinical outcomes. Pediatric bipolar disorder, which affects approximately 3.9% of youth globally, is the fourth leading cause of years of life lost due to disability and premature death for young people between the ages of 10 and 24. Effective treatment is critical to reduce these risks and…

Why Do Some Children Have Worse Outcomes After Moderate to Severe Traumatic Brain Injury?
 Why Do Some Children Have Worse Outcomes After Moderate to Severe Traumatic Brain Injury? 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Children had reduced white matter structural connectivity after moderate to severe traumatic brain injury (TBI) relative to children with complicated-mild TBI (cmTBI) or orthopedic injury (OI). This reduced connectivity may explain some disparities in behavioral outcomes. Children and adolescents who experience a TBI are at risk for psychological and behavioral morbidities. “We find that kids…

Understanding Relationships Among Responsive Parenting, Internalizing in Children and Emotionality
 Understanding Relationships Among Responsive Parenting, Internalizing in Children and Emotionality 1024 576 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

A new study offers insights in the complex interplay among negative emotionality, internalizing problems and parental responsivity in very young children. Positive responsive parenting can benefit children aged 3 to 5 years with internalizing problems, especially those with average to high levels of negative emotionality, according to recent research led by Amanda Thompson, PhD, a…

Postpartum Depression Linked to Increased Use of Acute Infant Care
 Postpartum Depression Linked to Increased Use of Acute Infant Care 1024 569 Alaina Doklovic
By: Alaina Doklovic

Study results highlight the importance of primary care in infant and maternal support. In a recent study published in Academic Pediatrics, researchers found a link between postpartum depression in mothers and the infants’ use of acute care, which includes emergency department or urgent care visits. Postpartum depression (PPD) is often unrecognized and undertreated. Frequently mistaken…

Direct Breastfeeding of Mother’s Own Milk Benefits Preterm Infants
 Direct Breastfeeding of Mother’s Own Milk Benefits Preterm Infants 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Despite benefits, new study finds low rates of breastfeeding among preterm infants discharged from the NICU. Mother’s own milk (MOM) and direct breastfeeding (DBF) are associated with numerous health and development advantages, especially for preterm infants. However, the rates of MOM feeding and DBF among infants admitted to neonatal intensive care units (NICUs) are low,…

Bridging the Gap: Aligning Aspirations with Workforce Reality in Pediatric Endocrinology
 Bridging the Gap: Aligning Aspirations with Workforce Reality in Pediatric Endocrinology 1024 683 Pam Georgiana
By: Pam Georgiana

Recent survey reveals a mismatch in career expectations and realities, calling for enhanced mentorship and policy reform. Pediatric endocrinology, like many pediatric subspecialities, is struggling to sustain an adequate workforce. When Leena Nahata, MD, served on the Research Affairs Committee of the Pediatric Endocrine Society in 2024, a topic of interest for the upcoming annual…

Transforming Medical Training: Perspectives on Competency-Based Education
 Transforming Medical Training: Perspectives on Competency-Based Education 1024 557 Madison Storm
By: Madison Storm

The alternative approach would move away from traditional time-based education to a more flexible, competency-focused approach. Imagine a world where medical education is tailored to each student’s pace and learning style, ensuring every graduate is fully competent in real-world clinical settings. A recent perspective piece, published in Current Problems in Pediatric and Adolescent Health Care,…

Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention
 Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention 1024 602 Pam Georgiana
By: Pam Georgiana

Research offers promising solutions for urinary tract infection treatment and antibiotic resistance. Urinary tract infections affect millions of people and can contribute to significant morbidity. Research into innate immunity mechanisms has shown great promise for improving urinary tract infection prevention and treatment strategies, especially in populations at high risk, such as patients with insulin resistance.…

Genomics Testing in the Neonatal Intensive Care Unit: Reducing Variability, Improving Utility
 Genomics Testing in the Neonatal Intensive Care Unit: Reducing Variability, Improving Utility 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Genomics testing of infants in the neonatal intensive care unit (NICU) has the potential to improve care, but process improvement efforts require consideration of major differences in hospital resources. Babies with genetic conditions make up a significant number of the infants in pediatric and neonatal intensive care units (NICUs), but knowing which babies are sick…

After Concussion: Monitor Sleep and Limit Daytime Naps for Faster Recovery
 After Concussion: Monitor Sleep and Limit Daytime Naps for Faster Recovery 1024 540 Laura Dattner
By: Laura Dattner

A new study reinforces the importance of sleep for concussion recovery and supports recommendations for quality nighttime sleep with limited naps. Researchers have found that when it comes to concussion recovery, sleep matters. In a study published in British Journal of Sports Medicine, researchers from Nationwide Children’s Hospital found that limiting daytime sleep and getting…

Eat, Sleep, Console: Reducing NICU Admissions of Infants With Prenatal Opioid Exposure
 Eat, Sleep, Console: Reducing NICU Admissions of Infants With Prenatal Opioid Exposure 1024 575 Lauren Dembeck
By: Lauren Dembeck

Focusing on non-pharmacological care, emphasizing mother-baby bonding, and natural infant behaviors may keep infants out of the NICU, but other barriers may limit implementation. Infants exposed to opioids in utero may experience withdrawal symptoms after birth, which can vary in severity depending on many factors, such as length of exposure and type of opioid. In…

Updated Small Baby Care Guidelines Reflect 20 Years of Work Toward Improved Outcomes
 Updated Small Baby Care Guidelines Reflect 20 Years of Work Toward Improved Outcomes 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Thorough management guidelines for babies born before 27 weeks’ gestation join the program’s long list of accomplishments in improving survival and standardizing care for this vulnerable population. As the Small Baby Program at Nationwide Children’s Hospital celebrates its 20th anniversary, it is also releasing its latest set of care guidelines for their tiny patients. Divided…

Breaking New Ground in Cancer Immunotherapy
 Breaking New Ground in Cancer Immunotherapy 1024 683 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s researchers develop a scalable, targeted approach to overcoming cancer’s toughest challenges. Despite significant advances in treatments, cancer remains one of the leading causes of death globally. Traditional therapies, while improving patient outcomes, still have limitations — such as the need for frequent dosing, complex and costly manufacturing and severe side effects. These challenges…

Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery?
 Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery? 1024 732 Lauren Dembeck
By: Lauren Dembeck

Kidney stones in children are on the rise, and many of these children miss critical post-op follow-ups. What prevents them from returning, and how can we help? Since 2000, kidney stone cases in the U.S. pediatric population have risen by 6–10% annually, leading to a corresponding increase in surgical interventions. Alarmingly, nearly half of pediatric…

CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies
 CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies 1024 649 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital created fratricide-resistant and metabolically-enhanced chimeric antigen receptor (CAR) natural killer (NK) and T cells that have cytotoxic effects on many hematologic tumors. “One of the problems that we usually have with blood cancers is making effective therapies using immune cells, because the immune cells then recognize themselves as a threat…

Linaclotide: A New Option For Chronic Pediatric Constipation
 Linaclotide: A New Option For Chronic Pediatric Constipation 1024 668 Pam Georgiana
By: Pam Georgiana

Phase 3 Trial at Nationwide Children’s Supports Safety and Efficacy in Children Aged 6–17. Constipation, a common issue for children, can be a source of prolonged struggle and distress for young patients and their families. Despite many treatments being available, some children continue to battle with this condition for years. There is a lack of…

What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s
 What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s 1024 683 Erin Gregory
By: Erin Gregory

GLP-1 receptor agonists such as Ozempic (semaglutide) offer new opportunities for managing pediatric diabetes and obesity. These medications target insulin resistance and related comorbidities, but their use raises questions about safety, access and ethical considerations. In the following interview, Leena Mamilly, MD, and Rohan K. Henry, MD, pediatric endocrinology experts at Nationwide Children’s Hospital, explore…

Real-Time Arrhythmia Detection in Adults With Fontan Palliation
 Real-Time Arrhythmia Detection in Adults With Fontan Palliation 1024 683 Pam Georgiana
By: Pam Georgiana

Evaluating the Utility and Accuracy of Patient-Driven Wearable EKG Monitoring Devices Patient-driven diagnostic wearables, such as personal EKG devices, are popular among adults interested in heart health. However, little is known about the accuracy of these devices for adults with congenital heart disease. “Research supports smartphone-based heart monitors for detecting normal rhythms and atrial fibrillation…

How Accurate is Pediatric Bipolar Disorder Testing?
 How Accurate is Pediatric Bipolar Disorder Testing? 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Symptom-based bipolar disorder tests accurately diagnose pediatric bipolar disorder, with parent-reported tests being among the most accurate. According to a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of bipolar disorder index tests, parent-reported tests are more accurate than self- or teacher-reported tests. The analysis, led by Cristian Alcaíno, a doctoral candidate at…

Improving Pediatric Clinical Trials by Incorporating Parent Input
 Improving Pediatric Clinical Trials by Incorporating Parent Input 1024 681 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A Parent Council in an ongoing pediatric stroke rehabilitation trial provides important insights into how parent involvement can inform and enrich the research process. While the need for diverse and inclusive clinical trial populations has been acknowledged for the last few decades, the value of input into trial design from the patient (and in pediatrics,…

Treatment for Substance Use Disorder in the Synthetic Opioid Era
 Treatment for Substance Use Disorder in the Synthetic Opioid Era 1024 683 Alaina Doklovic
By: Alaina Doklovic

Medications for opioid use disorder (MOUD) is the recommended first line treatment for adolescents with opioid use disorder (OUD), the chronic use of opioids and/or synthetic opioids that causes clinically significant distress or impairment. Buprenorphine is the most accessible medication for MOUD. Studies show long-term use of buprenorphine decreases opioid use, reduces overdose risk and…

Introducing the Fourth Wave of the Drug Epidemic
 Introducing the Fourth Wave of the Drug Epidemic 1024 575 Alaina Doklovic
By: Alaina Doklovic

Drug overdoses and poisoning are the third leading cause of pediatric death. In recent years, there has been a dramatic increase in the number of fentanyl-related overdoses, with 15-19 year olds being the most affected. In the Ohio illicit drug supply, as shared by the Ohio Narcotics Intelligence Center (ONIC), the emerging drugs, known as…

Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are
 Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are 1024 768 Alaina Doklovic
By: Alaina Doklovic

According to the U.S. Department of Health and Human Services, fewer than 10% of adolescents with a substance use disorder receive care. Of those 10%, many are not ready to engage in treatment. They are often brought in by a parent or guardian. Harm reduction is an opportunity to engage all adolescents, whether they are…

Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research
 Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research 1024 537 Abbie Miller
By: Abbie Miller

The ECMO Repository at Nationwide Children’s Hospital is the first and larges of its kind in children’s hospitals in the United States. In December 2014, The Heart Center and Center for Cardiovascular Research at Nationwide Children’s Hospital launched an initiative to prospectively collect biologic samples from pediatric patients undergoing extracorporeal membrane oxygenation (ECMO) – a…

Bridging the Fertility Awareness Gap in Adolescents With PCOS
 Bridging the Fertility Awareness Gap in Adolescents With PCOS 1024 683 Pam Georgiana
By: Pam Georgiana

Assessing knowledge, concerns and quality of life to inform early clinical counseling While polycystic ovary syndrome (PCOS) is common in adolescent females, little is known about how the potential for long-term complications like infertility affect young patients’ well-being. Research with adult PCOS patients has found links between fertility challenges and diminished psychosocial well-being. However, there…

A Novel EEG Evaluation Method for Children With Infantile Spasms
 A Novel EEG Evaluation Method for Children With Infantile Spasms 1024 677 Lauren Dembeck
By: Lauren Dembeck

Clinician-researchers have developed a rapid training program to learn the BASED score, a novel EEG evaluation method. The easily accessible training program allows clinicians to reliably determine the response to treatment. Infantile epileptic spasms syndrome is a severe form of early childhood epilepsy. Onset typically occurs in infants 4 to 8 months old and is…

The Nurse Perception of Infant Condition (NPIC) Scale: A Tool for NICU Nurses to Evaluate Neonatal Well-being
 The Nurse Perception of Infant Condition (NPIC) Scale: A Tool for NICU Nurses to Evaluate Neonatal Well-being 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD
Baby in NICU

Investigators from Nationwide Children’s Hospital developed a tool for nurses to use when assessing a neonate’s wellbeing, called the Nurse Perception of Infant Condition (NPIC) Scale. “For neonates, it was hard to find a scale that was relevant and would allow us to measure anything for research,” says Christine A. Fortney, PhD, RN, FPCN, FAAN,…

Establishing Meaningful Clinical Outcome Measures for Gastrointestinal Symptoms in Cystic Fibrosis
 Establishing Meaningful Clinical Outcome Measures for Gastrointestinal Symptoms in Cystic Fibrosis 1024 683 Lauren Dembeck
By: Lauren Dembeck

Understanding the minimal clinically important differences of PROMs is crucial in interpreting results in clinical trials. Patient-reported outcome measures (PROMs) are a set of standardized questions that directly assess the patient’s perspective of their symptoms and quality of life to better understand their experience with a disease or treatment. PROMs support patient-centered care and are…

Black Youth Experience Disparities in Care for First-Episode Psychosis in Ohio
 Black Youth Experience Disparities in Care for First-Episode Psychosis in Ohio 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Black youth enrolled in Medicaid were more likely to experience a first-episode psychosis (FEP) event and be diagnosed with schizophrenia spectrum disorder but less likely to receive key early intervention services than White youth.   “It’s been known for a long time, especially in the United States, that Black individuals specifically face racial disparities when…

Childhood-Onset Rumination Syndrome: Insights from 15 Years of Research
 Childhood-Onset Rumination Syndrome: Insights from 15 Years of Research 1024 680 Pam Georgiana
By: Pam Georgiana
Close up color photo of little boy holding hands on his belly

Education is needed to improve diagnostic timelines and treatment outcomes for pediatric patients. Childhood-onset rumination syndrome presents significant diagnostic challenges, even for gastroenterologists. Physicians often misdiagnose the symptoms as gastroesophageal reflux disease. Initial treatments frequently fail, leading to delays in accurate diagnosis. Patients can experience symptoms for 2 to 3 years before receiving an accurate…

Exploring Pediatric Diffuse Alveolar Hemorrhage: Causes and Outcomes
 Exploring Pediatric Diffuse Alveolar Hemorrhage: Causes and Outcomes 1024 575 Erin Gregory
By: Erin Gregory
Illustration of lungs on blue silhouette of upper chest on black background

In a groundbreaking study published in Pediatric Pulmonology, Sarah P. Cohen, MD, MS, and Katelyn Krivchenia, MD — both from Nationwide Children’s Hospital — along with their team investigate diffuse alveolar hemorrhage (DAH) in children, a rare but life-threatening condition involving bleeding into the lungs. The study unveils the complex interplay of causes and outcomes associated…

Pediatric Obstructive Sleep Apnea Diagnosis and Treatment: What You Need to Know
 Pediatric Obstructive Sleep Apnea Diagnosis and Treatment: What You Need to Know 1024 575 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM
Color image of young boy asleep in bed

Pediatric obstructive sleep apnea, a common condition in children, is definitively diagnosed with sleep studies and can be treated through various modalities, depending on disease severity. Obstructive sleep apnea (OSA) is a disorder characterized by snoring, gas exchange abnormalities and disrupted sleep, with near-complete airway blockage. Affecting approximately 1% to 4% of preschool children, with…

How Does Cannabis Use During Pregnancy Affect Children?
 How Does Cannabis Use During Pregnancy Affect Children? 1024 683 Katelyn Scott
By: Katelyn Scott

A recent study shows that prenatal exposure to cannabis is associated with poorer thinking skills and behaviors.  In a study published in JAMA Pediatrics, researchers found prenatal cannabis exposure was associated in early childhood with poorer thinking skills and behaviors such as impulse control, paying attention and planning ability, and more aggressive behavior, all of…

Advancing Care for Infants with Hypoplastic Left Heart Syndrome: New Insights into Maternal and Community Health Factors
 Advancing Care for Infants with Hypoplastic Left Heart Syndrome: New Insights into Maternal and Community Health Factors 1024 537 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s Heart Center explores the impact of maternal and social determinants of health on congenital heart disease. While maternal-fetal environment factors are known to impact outcomes in babies who receive the traditional Norwood surgery to treat hypoplastic left heart syndrome (HLHS), there is little research on how the maternal-fetal environment affects outcomes after the…

Subclinical Herpes Simplex Virus in Neonates: What to Do?
 Subclinical Herpes Simplex Virus in Neonates: What to Do? 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Neonates can test positive for HSV without having visible lesions or other classic symptoms, leaving clinical uncertainty regarding appropriate antiviral treatment and testing protocols. Researchers at Nationwide Children’s Hospital have shared data on a sample of 17 neonates who tested positive for herpes simplex virus (HSV) at mucosal sites, without any mucosal lesions, positive blood…

What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections?
 What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections? 1024 575 Pam Georgiana
By: Pam Georgiana

Two studies reveal how impaired insulin receptors compromise immunity in people with diabetes. While excess glucose in the urine is often thought to be the main factor behind urinary tract infections in people with diabetes, two recent studies led by Laura L. Schwartz, PhD, principal investigator in the Kidney and Urinary Tract Center at Nationwide…