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In Brief

Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1
 Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1 1024 683 Pam Georgiana
By: Pam Georgiana
physicians in white coats looking at a tablet

Pilot study supports the use of sleep questionnaires to identify underrecognized symptoms in children and adults with DM1. Myotonic Dystrophy Type 1 (DM1) is a genetic, multisystemic neuromuscular disorder that affects skeletal muscle, cardiac function, the endocrine system and the central nervous system. In addition to myotonia (the inability to relax muscles) and progressive muscle…

Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer
 Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer 1024 683 Pam Georgiana
By: Pam Georgiana

 A pilot study shows promise in enhancing shared decision-making and patient satisfaction through family-centered support. Fertility preservation is a critical yet underutilized aspect of cancer care for adolescent males. Despite being a medically low-risk and effective option, only a minority of young patients attempt sperm banking. Barriers exist at both the system and individual/family levels,…

National Study Reveals Gaps in Antidepressant Treatment Quality for Youth
 National Study Reveals Gaps in Antidepressant Treatment Quality for Youth 1024 683 Pam Georgiana
By: Pam Georgiana

Findings highlight critical disparities and opportunities to improve care. A national study led by Cynthia A. Fontanella, PhD, principal investigator in the Center for Suicide Prevention and Research in the Abigail Wexner Research Institute at Nationwide Children’s Hospital and professor of Psychiatry and Behavioral Health at the Ohio State University, finds that many young people…

How One Role is Improving Emergency Department Wait Times
 How One Role is Improving Emergency Department Wait Times 150 150 Alaina Doklovic
By: Alaina Doklovic

In any emergency department (ED), many people work behind the scenes to keep things running smoothly so patients receive the care they need, when they need it. At Nationwide Children’s Hospital, one behind-the-scenes position is making a big impact: the triage coordinator. “The role of triage coordinator and the way it works is unique here…

Understanding Long-Term Outcomes for Children With Anorectal Malformation
 Understanding Long-Term Outcomes for Children With Anorectal Malformation 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Researchers finally have high-quality data about the trajectory of continence outcomes — and key predictors for quality of life — across childhood for children with anorectal malformations. For many parents of children with an anorectal malformation (ARM), the primary goal is for the child to be “clean and dry” — able to manage bowel movements…

Cystic Fibrosis: Screening, Diagnosis and Therapy
 Cystic Fibrosis: Screening, Diagnosis and Therapy 150 150 Pam Georgiana
By: Pam Georgiana

Since the implementation of universal newborn screening for cystic fibrosis in all states by 2010, the expectation has been that every child with cystic fibrosis would be identified early and benefit from life-extending treatments. The reality, however, is more complex. “Because of the complexities of the genetic causes of cystic fibrosis and significant variations in…

ACMG Issues Primer on Regulation of Laboratory-Developed Tests
 ACMG Issues Primer on Regulation of Laboratory-Developed Tests 1024 683 Lauren Dembeck
By: Lauren Dembeck

The new statement, co-authored by a Nationwide Children’s laboratory geneticist, outlines how lab-developed tests are regulated and offers patient-centered recommendations for modernizing oversight. Laboratory-developed tests (LDTs) are validated testing protocols developed by certified clinical laboratories for patient care and play an essential role in diagnosing and guiding treatment for many conditions that affect pediatric patients.…

Don’t Oversize Your Tissue-Engineered Vascular Grafts: Insights for the Translation of New Surgical Technologies
 Don’t Oversize Your Tissue-Engineered Vascular Grafts: Insights for the Translation of New Surgical Technologies 1024 683 Abbie Miller
By: Abbie Miller

Study shows that adoption of a tissue engineered vascular graft technology currently in clinical trials would require a shift in surgical approach. Tissue engineered vascular grafts (TEVGs) are designed to overcome two important problems associated with synthetic conduits used in surgeries for children with congenital heart disease (CHD): the lack of growth potential and the…

A New Path to Relief: Gastrostomy Tubes Offer Treatment for Children With Autism and Chronic Constipation
 A New Path to Relief: Gastrostomy Tubes Offer Treatment for Children With Autism and Chronic Constipation 1024 680 Pam Georgiana
By: Pam Georgiana
Close up color photo of little boy holding hands on his belly

A groundbreaking study reveals how a low-risk intervention dramatically improves quality of life. Children with autism spectrum disorder often struggle with chronic constipation due to behavioral, sensory and dietary challenges. Uncontrolled constipation can cause poor school functioning, eating challenges and sleeping issues. In many cases, due to oral sensory issues, children with autism cannot reliably…

How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy?
 How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy? 1024 783 Abbie Miller
By: Abbie Miller

New study shows essential role of RNA methlytransferase-mediated m6A modification in regulating heart development. Traditional research to understand the origins of congenital heart disease have focused on understanding how genetic mutations may cause heart problems. Now, a team at Nationwide Children’s Hospital is exploring a new way to understand congenital heart disease (CHD). “How the…

Relative Adrenal Insufficiency Observed Among Patients With High-Risk Neuroblastoma During Treatment
 Relative Adrenal Insufficiency Observed Among Patients With High-Risk Neuroblastoma During Treatment 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

A subset of patients with high-risk neuroblastoma (NBL) and primary adrenal tumors develop an adrenal insufficiency (AI)-like phenotype during treatment. “We noticed that some of the patients with neuroblastoma had less hypotension when we added hydrocortisone while they were getting dinutuximab therapy. So, we said, I wonder if that has anything to do with the…

Treating Severe Pediatric Kidney Disease with Simultaneous Bilateral Native Nephrectomy
 Treating Severe Pediatric Kidney Disease with Simultaneous Bilateral Native Nephrectomy 480 320 Pam Georgiana
By: Pam Georgiana

A 15-year review of indications, approaches and outcomes. A recent study published in Pediatric Transplantation and led by Christina B. Ching, MD, pediatric urologist in the Department of Pediatric Urology at Nationwide Children’s Hospital, offers valuable insights into a very rare clinical procedure: simultaneous bilateral native nephrectomies, or the removal of both kidneys at the…

By the Book: Guiding Teens Through Inpatient Psychiatric Stays
 By the Book: Guiding Teens Through Inpatient Psychiatric Stays 1024 555 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new patient guidebook provides evidence-based resources to engage adolescents in their recovery throughout and after their hospital stay. Inpatient admissions for child and adolescent psychiatry patients typically occur due to a psychiatric crisis. At Nationwide Children’s Hospital, children stay an average of eight days before transitioning to outpatient care. While in the hospital, they…

Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention
 Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention 1024 683 Pam Georgiana
By: Pam Georgiana

Research offers promising solutions for urinary tract infection treatment and antibiotic resistance. Urinary tract infections affect millions of people and can contribute to significant morbidity. Research into innate immunity mechanisms has shown great promise for improving urinary tract infection prevention and treatment strategies, especially in populations at high risk, such as patients with insulin resistance.…

Genetic Variation Contributing to Nephrotic Syndrome
 Genetic Variation Contributing to Nephrotic Syndrome 1024 683 Abbie Miller
By: Abbie Miller

Genetic variants in CR1 have significantly different population-specific frequencies and are linked with focal segmental glomerulosclerosis (FSGS) – the leading cause of nephrotic syndrome. Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome — a kidney disorder that causes proteins to leak into the urine causing a variety of complications. FSGS has an…

Preventing Pediatric Suicide Through Systems-Level Collaboration
 Preventing Pediatric Suicide Through Systems-Level Collaboration 1024 576 Pam Georgiana
By: Pam Georgiana

How primary care, schools and communities are working together to address pediatric suicide rates through early intervention and collaborative care. Suicide is the second leading cause of death for youth aged 10 to 24 in the United States, and rates have been steadily rising across the country since 2007. Since the COVID-19 pandemic, the issue…

Depression is the New Predictor of Diabetes Control in Teens
 Depression is the New Predictor of Diabetes Control in Teens 1024 683 Pam Georgiana
By: Pam Georgiana
Diabetic girl with an insulin pump connected to her leg

A new study reveals that depressive symptoms, not diabetes-specific stress, forecast long-term glycemic outcomes in adolescents with type 1 diabetes. Managing type 1 diabetes is challenging at any age, but for adolescents, the burden can be especially overwhelming. Previous cross-sectional studies have shown a link between diabetes-specific emotional distress, or the frustration and stress related…

Novel Viral Vector Manufacturing Approach Could Improve Safety of Gene Therapy
 Novel Viral Vector Manufacturing Approach Could Improve Safety of Gene Therapy 1024 683 Lauren Dembeck
By: Lauren Dembeck

New AAV proviral plasmid for vector manufacturing has potential to increase patient safety and make gene therapies more affordable, researchers say. Gene therapy is one of the most exciting frontiers in modern medicine, offering potential cures for previously devastating or fatal disorders, such as spinal muscular atrophy and aromatic L-amino acid decarboxylase deficiency. Adeno-associated virus…

Enhancing Pediatric Suicide Risk Detection: Effective Screening, Pathways and Care
 Enhancing Pediatric Suicide Risk Detection: Effective Screening, Pathways and Care 1024 683 Madison Storm
By: Madison Storm

Youth suicide is a leading cause of death in the United States. Most youth who die by suicide have no mental illness diagnosis and have visited a health care provider within a year prior to their death. In fact, 40% of those youth visited a health care provider within one month prior.   “The data…

6 Key Insights for Understanding Pediatric Pulmonary Hypertension
 6 Key Insights for Understanding Pediatric Pulmonary Hypertension 1024 575 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s pulmonary hypertension expert offers insights into the condition. Sarah P. Cohen, MD, physician in the Division of Pulmonary, Sleep Medicine and Cystic Fibrosis at Nationwide Children’s and assistant professor of Pediatrics at The Ohio State University, recently shared six essential insights for understanding pulmonary hypertension, a rare yet serious condition characterized by abnormally…

Unique Cellular Trajectories Result in Reduced Cardiomyocyte Proliferation Capacities in Single Ventricle Disease
 Unique Cellular Trajectories Result in Reduced Cardiomyocyte Proliferation Capacities in Single Ventricle Disease 1024 537 Jessica Nye, PhD
By: Jessica Nye, PhD

Cellular trajectories deviate early in hypoplastic left heart syndrome (HLHS) and hypoplastic right heart syndrome (HRHS) development. Hypoplastic left and right heart syndromes are two rare and distinct single ventricle heart defects which are the most severe subtypes of congenital heart disease, usually requiring prompt surgical intervention after birth. “Clinically, there are large differences between…

Evaluating the Mental Health Impact of a Promising New Treatment for Cystic Fibrosis
 Evaluating the Mental Health Impact of a Promising New Treatment for Cystic Fibrosis 706 470 Pam Georgiana
By: Pam Georgiana

Insights from Nationwide Children’s study on how Trikafta affects children with cystic fibrosis. In response to the promising clinical benefits of elexacaftor/tezacaftor/ivacaftor (Trikafta) in adults with cystic fibrosis, a team in Nationwide Children’s Hospital Cystic Fibrosis Clinic recently investigated the effects of the drug in pediatric patients. Kimberly Pasley, PsyD, mental health coordinator in the…

Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders
 Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders 1024 683 Lauren Dembeck
By: Lauren Dembeck

Nationwide Children’s researchers create first-ever stem cell lines for rare genitourinary conditions. Induced pluripotent stem cells (iPSCs) have revolutionized medical research by providing powerful tools to study disease mechanisms, especially in rare genetic conditions. These versatile cells, derived directly from patients that have the condition, offer unprecedented opportunities to uncover the underlying genetic and cellular…

Understanding Treatment Outcomes in Pediatric Bipolar Disorder
 Understanding Treatment Outcomes in Pediatric Bipolar Disorder 1024 575 Pam Georgiana
By: Pam Georgiana
Teen girl with backpack

New study compares minimally adequate behavioral health treatments and clinical outcomes. Pediatric bipolar disorder, which affects approximately 3.9% of youth globally, is the fourth leading cause of years of life lost due to disability and premature death for young people between the ages of 10 and 24. Effective treatment is critical to reduce these risks and…

Why Do Some Children Have Worse Outcomes After Moderate to Severe Traumatic Brain Injury?
 Why Do Some Children Have Worse Outcomes After Moderate to Severe Traumatic Brain Injury? 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Children had reduced white matter structural connectivity after moderate to severe traumatic brain injury (TBI) relative to children with complicated-mild TBI (cmTBI) or orthopedic injury (OI). This reduced connectivity may explain some disparities in behavioral outcomes. Children and adolescents who experience a TBI are at risk for psychological and behavioral morbidities. “We find that kids…

Understanding Relationships Among Responsive Parenting, Internalizing in Children and Emotionality
 Understanding Relationships Among Responsive Parenting, Internalizing in Children and Emotionality 1024 576 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

A new study offers insights in the complex interplay among negative emotionality, internalizing problems and parental responsivity in very young children. Positive responsive parenting can benefit children aged 3 to 5 years with internalizing problems, especially those with average to high levels of negative emotionality, according to recent research led by Amanda Thompson, PhD, a…

Postpartum Depression Linked to Increased Use of Acute Infant Care
 Postpartum Depression Linked to Increased Use of Acute Infant Care 1024 569 Alaina Doklovic
By: Alaina Doklovic

Study results highlight the importance of primary care in infant and maternal support. In a recent study published in Academic Pediatrics, researchers found a link between postpartum depression in mothers and the infants’ use of acute care, which includes emergency department or urgent care visits. Postpartum depression (PPD) is often unrecognized and undertreated. Frequently mistaken…

Direct Breastfeeding of Mother’s Own Milk Benefits Preterm Infants
 Direct Breastfeeding of Mother’s Own Milk Benefits Preterm Infants 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Despite benefits, new study finds low rates of breastfeeding among preterm infants discharged from the NICU. Mother’s own milk (MOM) and direct breastfeeding (DBF) are associated with numerous health and development advantages, especially for preterm infants. However, the rates of MOM feeding and DBF among infants admitted to neonatal intensive care units (NICUs) are low,…

Bridging the Gap: Aligning Aspirations with Workforce Reality in Pediatric Endocrinology
 Bridging the Gap: Aligning Aspirations with Workforce Reality in Pediatric Endocrinology 1024 683 Pam Georgiana
By: Pam Georgiana

Recent survey reveals a mismatch in career expectations and realities, calling for enhanced mentorship and policy reform. Pediatric endocrinology, like many pediatric subspecialities, is struggling to sustain an adequate workforce. When Leena Nahata, MD, served on the Research Affairs Committee of the Pediatric Endocrine Society in 2024, a topic of interest for the upcoming annual…

Transforming Medical Training: Perspectives on Competency-Based Education
 Transforming Medical Training: Perspectives on Competency-Based Education 1024 557 Madison Storm
By: Madison Storm

The alternative approach would move away from traditional time-based education to a more flexible, competency-focused approach. Imagine a world where medical education is tailored to each student’s pace and learning style, ensuring every graduate is fully competent in real-world clinical settings. A recent perspective piece, published in Current Problems in Pediatric and Adolescent Health Care,…

Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention
 Harnessing the Power of Antimicrobial Peptides: A New Frontier in Infection Prevention 1024 602 Pam Georgiana
By: Pam Georgiana

Research offers promising solutions for urinary tract infection treatment and antibiotic resistance. Urinary tract infections affect millions of people and can contribute to significant morbidity. Research into innate immunity mechanisms has shown great promise for improving urinary tract infection prevention and treatment strategies, especially in populations at high risk, such as patients with insulin resistance.…

Genomics Testing in the Neonatal Intensive Care Unit: Reducing Variability, Improving Utility
 Genomics Testing in the Neonatal Intensive Care Unit: Reducing Variability, Improving Utility 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Genomics testing of infants in the neonatal intensive care unit (NICU) has the potential to improve care, but process improvement efforts require consideration of major differences in hospital resources. Babies with genetic conditions make up a significant number of the infants in pediatric and neonatal intensive care units (NICUs), but knowing which babies are sick…

After Concussion: Monitor Sleep and Limit Daytime Naps for Faster Recovery
 After Concussion: Monitor Sleep and Limit Daytime Naps for Faster Recovery 1024 540 Laura Dattner
By: Laura Dattner

A new study reinforces the importance of sleep for concussion recovery and supports recommendations for quality nighttime sleep with limited naps. Researchers have found that when it comes to concussion recovery, sleep matters. In a study published in British Journal of Sports Medicine, researchers from Nationwide Children’s Hospital found that limiting daytime sleep and getting…

Eat, Sleep, Console: Reducing NICU Admissions of Infants With Prenatal Opioid Exposure
 Eat, Sleep, Console: Reducing NICU Admissions of Infants With Prenatal Opioid Exposure 1024 575 Lauren Dembeck
By: Lauren Dembeck

Focusing on non-pharmacological care, emphasizing mother-baby bonding, and natural infant behaviors may keep infants out of the NICU, but other barriers may limit implementation. Infants exposed to opioids in utero may experience withdrawal symptoms after birth, which can vary in severity depending on many factors, such as length of exposure and type of opioid. In…

Updated Small Baby Care Guidelines Reflect 20 Years of Work Toward Improved Outcomes
 Updated Small Baby Care Guidelines Reflect 20 Years of Work Toward Improved Outcomes 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Thorough management guidelines for babies born before 27 weeks’ gestation join the program’s long list of accomplishments in improving survival and standardizing care for this vulnerable population. As the Small Baby Program at Nationwide Children’s Hospital celebrates its 20th anniversary, it is also releasing its latest set of care guidelines for their tiny patients. Divided…

Breaking New Ground in Cancer Immunotherapy
 Breaking New Ground in Cancer Immunotherapy 1024 683 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s researchers develop a scalable, targeted approach to overcoming cancer’s toughest challenges. Despite significant advances in treatments, cancer remains one of the leading causes of death globally. Traditional therapies, while improving patient outcomes, still have limitations — such as the need for frequent dosing, complex and costly manufacturing and severe side effects. These challenges…

Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery?
 Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery? 1024 732 Lauren Dembeck
By: Lauren Dembeck

Kidney stones in children are on the rise, and many of these children miss critical post-op follow-ups. What prevents them from returning, and how can we help? Since 2000, kidney stone cases in the U.S. pediatric population have risen by 6–10% annually, leading to a corresponding increase in surgical interventions. Alarmingly, nearly half of pediatric…

CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies
 CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies 1024 649 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital created fratricide-resistant and metabolically-enhanced chimeric antigen receptor (CAR) natural killer (NK) and T cells that have cytotoxic effects on many hematologic tumors. “One of the problems that we usually have with blood cancers is making effective therapies using immune cells, because the immune cells then recognize themselves as a threat…

Linaclotide: A New Option For Chronic Pediatric Constipation
 Linaclotide: A New Option For Chronic Pediatric Constipation 1024 668 Pam Georgiana
By: Pam Georgiana

Phase 3 Trial at Nationwide Children’s Supports Safety and Efficacy in Children Aged 6–17. Constipation, a common issue for children, can be a source of prolonged struggle and distress for young patients and their families. Despite many treatments being available, some children continue to battle with this condition for years. There is a lack of…

What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s
 What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s 1024 683 Erin Gregory
By: Erin Gregory

GLP-1 receptor agonists such as Ozempic (semaglutide) offer new opportunities for managing pediatric diabetes and obesity. These medications target insulin resistance and related comorbidities, but their use raises questions about safety, access and ethical considerations. In the following interview, Leena Mamilly, MD, and Rohan K. Henry, MD, pediatric endocrinology experts at Nationwide Children’s Hospital, explore…

Real-Time Arrhythmia Detection in Adults With Fontan Palliation
 Real-Time Arrhythmia Detection in Adults With Fontan Palliation 1024 683 Pam Georgiana
By: Pam Georgiana

Evaluating the Utility and Accuracy of Patient-Driven Wearable EKG Monitoring Devices Patient-driven diagnostic wearables, such as personal EKG devices, are popular among adults interested in heart health. However, little is known about the accuracy of these devices for adults with congenital heart disease. “Research supports smartphone-based heart monitors for detecting normal rhythms and atrial fibrillation…

How Accurate is Pediatric Bipolar Disorder Testing?
 How Accurate is Pediatric Bipolar Disorder Testing? 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Symptom-based bipolar disorder tests accurately diagnose pediatric bipolar disorder, with parent-reported tests being among the most accurate. According to a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of bipolar disorder index tests, parent-reported tests are more accurate than self- or teacher-reported tests. The analysis, led by Cristian Alcaíno, a doctoral candidate at…

Improving Pediatric Clinical Trials by Incorporating Parent Input
 Improving Pediatric Clinical Trials by Incorporating Parent Input 1024 681 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A Parent Council in an ongoing pediatric stroke rehabilitation trial provides important insights into how parent involvement can inform and enrich the research process. While the need for diverse and inclusive clinical trial populations has been acknowledged for the last few decades, the value of input into trial design from the patient (and in pediatrics,…

Treatment for Substance Use Disorder in the Synthetic Opioid Era
 Treatment for Substance Use Disorder in the Synthetic Opioid Era 1024 683 Alaina Doklovic
By: Alaina Doklovic

Medications for opioid use disorder (MOUD) is the recommended first line treatment for adolescents with opioid use disorder (OUD), the chronic use of opioids and/or synthetic opioids that causes clinically significant distress or impairment. Buprenorphine is the most accessible medication for MOUD. Studies show long-term use of buprenorphine decreases opioid use, reduces overdose risk and…

Introducing the Fourth Wave of the Drug Epidemic
 Introducing the Fourth Wave of the Drug Epidemic 1024 575 Alaina Doklovic
By: Alaina Doklovic

Drug overdoses and poisoning are the third leading cause of pediatric death. In recent years, there has been a dramatic increase in the number of fentanyl-related overdoses, with 15-19 year olds being the most affected. In the Ohio illicit drug supply, as shared by the Ohio Narcotics Intelligence Center (ONIC), the emerging drugs, known as…

Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are
 Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are 1024 768 Alaina Doklovic
By: Alaina Doklovic

According to the U.S. Department of Health and Human Services, fewer than 10% of adolescents with a substance use disorder receive care. Of those 10%, many are not ready to engage in treatment. They are often brought in by a parent or guardian. Harm reduction is an opportunity to engage all adolescents, whether they are…

Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research
 Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research 1024 537 Abbie Miller
By: Abbie Miller

The ECMO Repository at Nationwide Children’s Hospital is the first and larges of its kind in children’s hospitals in the United States. In December 2014, The Heart Center and Center for Cardiovascular Research at Nationwide Children’s Hospital launched an initiative to prospectively collect biologic samples from pediatric patients undergoing extracorporeal membrane oxygenation (ECMO) – a…

Bridging the Fertility Awareness Gap in Adolescents With PCOS
 Bridging the Fertility Awareness Gap in Adolescents With PCOS 1024 683 Pam Georgiana
By: Pam Georgiana

Assessing knowledge, concerns and quality of life to inform early clinical counseling While polycystic ovary syndrome (PCOS) is common in adolescent females, little is known about how the potential for long-term complications like infertility affect young patients’ well-being. Research with adult PCOS patients has found links between fertility challenges and diminished psychosocial well-being. However, there…

A Novel EEG Evaluation Method for Children With Infantile Spasms
 A Novel EEG Evaluation Method for Children With Infantile Spasms 1024 677 Lauren Dembeck
By: Lauren Dembeck

Clinician-researchers have developed a rapid training program to learn the BASED score, a novel EEG evaluation method. The easily accessible training program allows clinicians to reliably determine the response to treatment. Infantile epileptic spasms syndrome is a severe form of early childhood epilepsy. Onset typically occurs in infants 4 to 8 months old and is…

The Nurse Perception of Infant Condition (NPIC) Scale: A Tool for NICU Nurses to Evaluate Neonatal Well-being
 The Nurse Perception of Infant Condition (NPIC) Scale: A Tool for NICU Nurses to Evaluate Neonatal Well-being 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD
Baby in NICU

Investigators from Nationwide Children’s Hospital developed a tool for nurses to use when assessing a neonate’s wellbeing, called the Nurse Perception of Infant Condition (NPIC) Scale. “For neonates, it was hard to find a scale that was relevant and would allow us to measure anything for research,” says Christine A. Fortney, PhD, RN, FPCN, FAAN,…