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Biofilms In Respiratory Infections and Beyond: A Review
 Biofilms In Respiratory Infections and Beyond: A Review 150 150 Emily Siebenmorgen
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Researchers from Nationwide Children’s recently published a landmark piece in Frontiers in Cellular and Infection Microbiology reviewing everything known about biofilm aggregates and their role in respiratory tract infections to date. Biofilms create sticky situations for several diseases. These microbial communities are formed when bacterial cells stick to each other and attach themselves to a…

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The Impact and Implications of Interferons Against RSV
 The Impact and Implications of Interferons Against RSV 1024 575 Emily Siebenmorgen
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Illustration of lungs on blue silhouette of upper chest on black background

Specific cytokines play a key role in minimizing disease severity Respiratory syncytial virus (RSV) shares many symptoms with other respiratory viruses like the common cold or the flu, but it represents the number one cause of hospitalization in infants worldwide. Despite being a large burden on the health care system, there are currently few preventative…

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How Quality Improvement Can Expand Insulin Pump Use and More
 How Quality Improvement Can Expand Insulin Pump Use and More 150 150 Mary Bates, PhD
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A Q&A with Don Buckingham about the T1D Exchange Quality Improvement Collaborative Don Buckingham, MBOE, CPHQ, CSSBB, joined Nationwide Children’s Center for Clinical Excellence as a quality strategist eight years ago. In a Q&A, he shares how he leveraged his background in industry and business services improvement in projects for the T1D Exchange Quality Improvement…

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Understanding Eosinophilic Esophagitis
 Understanding Eosinophilic Esophagitis 150 150 Emily Siebenmorgen
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Recent PediaCast CME episode from Mike Patrick, MD, shares important information about diagnosing and treating eosinophilic esophagitis. Eosinophilic esophagitis, or EOE, may not be the first condition providers think of when a patient presents with upper abdominal pain or dysphagia. EOE incidence has increased 30 times since its discovery in the 1990s, but overlapping symptoms…

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The New Book on Youth Suicide Prevention
 The New Book on Youth Suicide Prevention 150 150 John Ackerman, PhD and Lisa Horowitz, PhD, MPH
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Our new open access Springer Series book helps close the gap between the latest research in youth suicide prevention and how to make an impact in our communities.  Youth suicide is a public health crisis. It is the second leading cause of death among youth aged 10-17 in the United States, according to data from…

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American Academy of Pediatrics Updates Guidelines for the Management of Neonatal Hyperbilirubinemia
 American Academy of Pediatrics Updates Guidelines for the Management of Neonatal Hyperbilirubinemia 1024 737 Emily Siebenmorgen
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person in scrubs holding a baby

Nationwide Children’s physicians collaborate on updates to testing, treatment and follow-up recommendations for preventing hazardous hyperbilirubinemia and possible brain damage. The American Academy of Pediatrics’ (AAP) recommendations for managing hyperbilirubinemia in infants 35 gestational weeks and older are among its most accessed sets of clinical practice guidelines. A team led by Alex Kemper, MD, MPH,…

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Is There a Role for D-Mannose, Cranberry or Probiotics in Preventing Pediatric UTIs?
 Is There a Role for D-Mannose, Cranberry or Probiotics in Preventing Pediatric UTIs? 1024 683 Deborah L. Ungerleider, MD, FAAP
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Alternatives for prophylaxis of UTIs in children may help reduce antibiotic overuse. Preventing urinary tract infections (UTIs) in children is important, as multiple UTIs can lead to scarring of the kidneys, which can then lead to hypertension or end-stage renal disease.1 UTIs in children are generally treated with antibiotics, which are sometimes also used for…

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Factors Modulating Parenting Stress in Families of Children with Autism Spectrum Disorder
 Factors Modulating Parenting Stress in Families of Children with Autism Spectrum Disorder 1024 575 Mary Bates, PhD
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Parent and child holding hands

Parenting self-efficacy and family resources impact the relationship between behavior problems in children with autism spectrum disorder and parenting stress. Children with autism spectrum disorder (ASD) often exhibit co-occurring conditions that may increase parenting stress. These include externalizing behaviors, such as tantrums and disruptive behaviors, and internalizing issues, such as anxiety and depression. One factor…

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Fertility Navigators Support Important Consultations in Pediatric Settings
 Fertility Navigators Support Important Consultations in Pediatric Settings 150 150 Mary Bates, PhD
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At Nationwide Children’s, hiring a full-time fertility navigator increased access to fertility care among pediatric patients. With advances in chemotherapy and radiation, more children are surviving cancer and entering adulthood. However, a potential consequence of such treatments is fertility impairment, which can affect about 15% of female and 50% of male childhood cancer survivors. Although…

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Cardiopulmonary Rehabilitation Post-COVID: Could Your Patient Benefit?
 Cardiopulmonary Rehabilitation Post-COVID: Could Your Patient Benefit? 1024 728 Abbie Miller
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The road to recovery from COVID-19, the disease caused by SARS-CoV-2, is not always smooth, short or straight. For adults and children, long COVID, a condition where symptoms such as fatigue, headache and decreased respiratory function persist after the virus has “cleared” the body, can add increased stress and hardship. Additionally, even mild cases of…

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NASPGHAN: New Guidance for Surgical Procedure Selection in Pediatric Chronic Pancreatitis
 NASPGHAN: New Guidance for Surgical Procedure Selection in Pediatric Chronic Pancreatitis 899 450 Katie Brind'Amour, PhD, MS, CHES
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Informed, multispecialty decision-making is essential to give children with chronic pancreatitis the best chance for long-term pain relief and improved quality of life, according to new guidance issued by the North American Society for Pediatric Gastroenterology, Hepatology & Nutrition.   Chronic pancreatitis has long been an underappreciated and underrecognized condition in children. Now, a NASPGHAN…

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Making (Lots of) NK Cells
 Making (Lots of) NK Cells 1024 649 Katie Brind'Amour, PhD, MS, CHES
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When Dean Lee, MD, PhD, joined Nationwide Children’s and The Ohio  State University Comprehensive Cancer Center in 2016, the institutions gave him leadership of a joint program: the Cellular Therapy and Cancer Immunology Program (CTCI), which serves to develop research efforts into clinical care for both pediatric and adult patients. The CTCI team has worked…

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How the Antimicrobial Protein RNase 7 Helps Prevent Urinary Tract Infections
 How the Antimicrobial Protein RNase 7 Helps Prevent Urinary Tract Infections 1024 683 Mary Bates, PhD
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Researchers identify genetic variation associated with severe and recurrent UTIs. A new study adds to the growing body of evidence suggesting the antimicrobial protein RNase 7 plays an important role in preventing urinary tract infections (UTIs). The findings, published in The Journal of Clinical Investigation, suggest genetic variations in the RNase 7 gene may increase…

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Growing Opportunities for Tissue Engineering
 Growing Opportunities for Tissue Engineering 150 150 Katie Brind'Amour, PhD, MS, CHES
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A new system removes much of the expense and technical challenges surrounding cell seeding of tissue-engineered vascular grafts, making the technology more accessible to patients everywhere. One of the key challenges in congenital heart surgery is that current grafts used to correct heart defects are not living grafts—they don’t grow with the patient or function…

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What Pediatricians Should Know about Long COVID
 What Pediatricians Should Know about Long COVID 1024 683 Octavio Ramilo, MD
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More than 4 million children have tested positive for SARS-CoV-2 in the United States. According to the American Academy of Pediatrics, long-term effects from COVID-19 can be significant, regardless of initial disease severity. Medical providers across the nation, including here at Nationwide Children’s Hospital, are seeing an increase in cases of what is being called…

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Alarming Upward Trend in Black Youth Suicide From 2003 to 2017
 Alarming Upward Trend in Black Youth Suicide From 2003 to 2017 1024 683 Lauren Dembeck
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Sad black teenage girl

Prioritization of research aimed at identifying specific risk and protective factors associated with Black youth suicidal behavior is needed. In the United States, the rates of suicide and suicidal behavior among youth, children and adolescents 5-17 years of age, have been steadily increasing over the last decade, and Black youth, 5-12 years, are approximately two…

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Cylinder Mitral Valve Construct is a Safe and Durable Alternative for Young Patients
 Cylinder Mitral Valve Construct is a Safe and Durable Alternative for Young Patients 1024 752 Mary Bates, PhD
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Top-down view of heart valves

The new technique could potentially reduce the number of lifetime surgeries required by these patients, researchers say. In a new study, researchers from Nationwide Children’s Hospital report that pediatric patients who underwent cylinder mitral valve construct, a new technique for replacing the mitral valve, had improved left ventricular function over time. In addition, there were…

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Self-Administered Electronic Assessment Tool Helps Clinicians Screen for Pediatric Bleeding Disorders
 Self-Administered Electronic Assessment Tool Helps Clinicians Screen for Pediatric Bleeding Disorders 1024 684 JoAnna Pendergrass, DVM
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teen girl using cell phone

An electronic self-administered bleeding assessment tool is a time-saving measure to comprehensively evaluate a pediatric patient’s bleeding symptoms. Bleeding assessment tools (BATs), originally developed as research tools, are used clinically to comprehensively evaluate a patient’s bleeding symptoms. Along with clinical judgement, “BATs are used to discriminate between patients who do and do not have a…

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Using Virtual Reality Games to Reduce Dressing Change Pain in Pediatric Burn Patients
 Using Virtual Reality Games to Reduce Dressing Change Pain in Pediatric Burn Patients 934 401 JoAnna Pendergrass, DVM
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Smartphone-based virtual reality games can reduce dressing change pain for pediatric patients receiving outpatient burn treatment. According to the American Burn Association, burn injuries affect approximately 250,000 children in the United States each year. The pain associated with burn injuries extends beyond the injury itself; there is also significant pain from dressing changes, which can…

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How Can We Make Child Health Equitable?
 How Can We Make Child Health Equitable? 550 350 Jeb Phillips, Abbie Miller and Natalie Wilson
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Researchers in the Center for Child Health Equity and Outcomes Research at Nationwide Children’s Hospital are tackling this question by identifying health disparities and uncovering exactly how social drivers of health impact outcomes. “Health equity means that everyone has a fair and just opportunity to be as healthy as possible.” That’s how the Robert Wood…

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Targeting FSHD With Designed Antisense RNAs
 Targeting FSHD With Designed Antisense RNAs 1024 683 Abbie Miller
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Researchers describe small nuclear RNA antisense expression cassettes as a way to silence the DUX4 gene underlying facioscapulohumeral muscular dystrophy. Facioscapulohumeral muscular dystrophy (FSHD) arises from genetic and epigenetic changes that result in expression of the DUX4 gene in muscle. DUX4 is a developmental gene that is normally off in healthy muscle.  When expressed in…

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How to Make a Viral Vector
 How to Make a Viral Vector 150 150 Abbie Miller
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The Research Institute at Nationwide Children’s Hospital is the home to a current Good Manufacturing Practices (cGMP) Clinical Manufacturing Facility (CMF) that operates according to FDA cGMP Guidelines to ensure the safety of manufactured biologic products. The Space The CMF is a 9000-sq-ft space, including a 7500-sq-ft clean room suite with ISO Class 5/7/8 spaces…

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