Monthly Archives :

April 2021

Unraveling Intractable Functional Constipation: Manometries Are Still the Gold Standard
Unraveling Intractable Functional Constipation: Manometries Are Still the Gold Standard 1024 680 Natalie Wilson
Close up color photo of little boy holding hands on his belly

Cine-MRI recordings can’t replace colonic manometries when assessing motility among children with functional constipation, but they may offer additional information. And conducting both MRIs and manometries simultaneously is feasible. While functional constipation (FC) is common in childhood, and most children who experience it respond well to behavioral interventions or treatment with laxatives, some children continue…

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Indicators of Blood Clot Potential Directly Relate to Nephrotic Syndrome Severity
Indicators of Blood Clot Potential Directly Relate to Nephrotic Syndrome Severity 150 150 Katie Brind'Amour, PhD, MS, CHES

Researchers in the NEPTUNE network and collaborators at Nationwide Children’s Hospital have confirmed their preclinical studies demonstrating a direct correlation between the severity of disease and prothrombotic biomarkers in patients with nephrotic syndrome. Nephrotic syndrome (NS) dramatically increases the risk of a life-threatening blood clot, but until recently, clinicians have had no reasonable biomarker to…

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How Can We Make Child Health Equitable?
How Can We Make Child Health Equitable? 550 350 Jeb Phillips, Abbie Roth and Natalie Wilson

Researchers in the Center for Child Health Equity and Outcomes Research at Nationwide Children’s Hospital are tackling this question by identifying health disparities and uncovering exactly how social drivers of health impact outcomes. “Health equity means that everyone has a fair and just opportunity to be as healthy as possible.” That’s how the Robert Wood…

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The First Opioid-Prescribing Guidelines for Children Who Require Surgery
The First Opioid-Prescribing Guidelines for Children Who Require Surgery 1024 573 Lauren Dembeck

Providers should recognize the risks of opioids, maximize nonopioid regimens, and educate families appropriately. The first opioid-prescribing guidelines to address the unique needs of children who require surgery have been published by an expert panel in JAMA Surgery. The new guidelines aim to help health care professionals caring for children and adolescents in the perioperative…

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A New Kind of Rectal Diversion in Classic Bladder Exstrophy
A New Kind of Rectal Diversion in Classic Bladder Exstrophy 1024 754 Jeb Phillips

  This article appeared in the Spring/Summer 2021 print issue. Download the full issue.   Medical illustrations by Mandy Root-Thompson for Nationwide Children’s Hospital Source: V. Rama Jayanthi, chief of Urology at Nationwide Children’s Hospital To learn more about the procedure and it’s applications, read A Surprising Approach to Classic Bladder Exstrophy.

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A Surprising Approach to Classic Bladder Exstrophy
A Surprising Approach to Classic Bladder Exstrophy 1024 754 Jeb Phillips

A procedure developed at Nationwide Children’s Hospital comes with possible risks but can have a huge impact on quality of life. It’s become clearer over the last two years that a “good outcome” for children born with classic bladder exstrophy is in the eye of the beholder. One of the best outcomes, nearly everyone would…

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Targeting DIPG: The Most Puzzling of Pediatric Brain Tumors
Targeting DIPG: The Most Puzzling of Pediatric Brain Tumors 1024 629 Katie Brind'Amour, PhD, MS, CHES

Survival has dramatically improved for numerous pediatric cancers over the last several decades, with a notable and very deadly exception: diffuse intrinsic pontine glioma (DIPG). Now, a community of researchers and clinician-scientists have set the stage for a renewed — and better-armed — assault against this beast of a brain tumor. The past 50 years…

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Lessons Learned Through a Global Pandemic
Lessons Learned Through a Global Pandemic 1024 683 Lauren Bakaletz, PhD
Lauren Bakaletz, PhD

As a microbiologist and vaccinologist, I spend nearly every day thinking about viruses and bacteria and the diseases they cause, as well as how to best prevent them from doing so. While in graduate school, we were taught about the great ‘flu’ pandemic of 1918 that infected one-third of the world’s population and killed 20-50…

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Understanding Immune Responses to Build a Better Vaccine
Understanding Immune Responses to Build a Better Vaccine 1024 606 Abbie Roth

Researchers have used studies of respiratory syncytial virus and infant immune responses to develop a promising vaccine candidate. Respiratory syncytial virus (RSV) is an incredibly common yet potentially deadly pathogen. Almost everyone becomes infected with RSV during their first three years of life, but for certain populations — infants and elderly or immunocompromised people —…

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Pediatricians Offer Valuable Oral Health Services for the Very Young, Before and Throughout Pandemic
Pediatricians Offer Valuable Oral Health Services for the Very Young, Before and Throughout Pandemic 1024 680 Katie Brind'Amour, PhD, MS, CHES
toddler brushing teeth

Medical professionals see very young children much more frequently during the first several years of life than dentists, and many states’ Medicaid programs have seized the opportunity to reimburse pediatricians for preventive oral care, such as fluoride application and oral hygiene education. Despite reimbursement options and national guidelines recommending dental care begin by age 1,…

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Even Severe Asthma Can Improve if Guidelines Are Followed
Even Severe Asthma Can Improve if Guidelines Are Followed 1024 683 Mary Bates, PhD

Patients treated with adequate medications and asthma family education can significantly improve irrespective of asthma severity. Severe asthma accounts for 5-8% of patients with asthma, but this group is more challenging to treat and is responsible for up to 40% of total asthma-care expenses. The majority of patients with severe asthma have difficult-to-treat asthma (in…

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Global Study Highlights Antibiotic Overuse in the NICU
Global Study Highlights Antibiotic Overuse in the NICU 1024 683 Abbie Roth
Baby in NICU

Antimicrobial stewardship programs were associated with lower antibiotic use, regardless of the country’s income level. Excessive antibiotic use among infants born preterm in the newborn intensive care unit (NICU) is associated with poor patient outcomes, such as sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia and others, and contributes to the emergence of multi-drug resistant microbes. A new…

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Can Neurocognitive Functioning Tests Help Predict Future Suicide Attempts?
Can Neurocognitive Functioning Tests Help Predict Future Suicide Attempts? 1024 683 Mary Bates, PhD
Sad black teenage girl

Researchers identify sex-specific deficits in measures of working memory and affective processing associated with suicidal behavior in youth with depression. To prevent youth suicide, researchers are working to identify factors associated with suicide attempts in adolescents at elevated risk for suicidal behavior. In a new study, researchers from Nationwide Children’s examined neurocognitive functioning in suicidal…

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Lower Traffic Volumes During COVID-19 Shut-Downs Lead to Fewer Injuries
Lower Traffic Volumes During COVID-19 Shut-Downs Lead to Fewer Injuries 1024 683 Laura Dattner
Teen driving a car

To minimize transmission of COVID-19, in spring 2020, most U.S. states passed policies promoting social distancing through stay-at-home orders prohibiting non-essential travel. While vehicle-miles traveled in the United States decreased by 41% in April 2020 compared to 2019, the effect of this mobility decrease on motor vehicle crashes (MVCs) is poorly understood. Motao (Matt) Zhu,…

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Innovative Biostatistical Methodology for Causal Evaluation of Medical Treatments
Innovative Biostatistical Methodology for Causal Evaluation of Medical Treatments 150 150 Laura Dattner

Medical records are readily available nowadays, but using medical records to evaluate medical treatments is full of challenges. Henry Xiang, MD, MPH, PhD, professor of medicine and principal investigator in the Center for Injury Research and Policy, collaborated with biostatisticians from The Ohio State University College of Public Health to develop a novel statistical method…

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Introducing a New SARS-CoV-2 Vaccine Candidate
Introducing a New SARS-CoV-2 Vaccine Candidate 1024 512 Abbie Roth
coronavirus

The new vaccine candidate takes advantage of the long and successful history of the measles vaccine. A team of researchers from The Ohio State University and Nationwide Children’s have built a novel vaccine candidate against SARS-CoV-2. The candidate, published in Proceedings of the National Academy of Sciences (PNAS), used the measles vaccine as a vector…

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Getting Children and Families Outside With PlayStreets
Getting Children and Families Outside With PlayStreets 1024 683 Tiwana Henderson

A PlayStreet initiative in 2019 from Healthy Neighborhoods Healthy Families helped more than 350 South Side residents get outside and play – safely. Research has found that children who play outside are more physically active and have stronger social skills that those who do not. Unfortunately, low-income neighborhoods with high rates of crime and lack…

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Calls to Poison Centers About High-Powered Magnets Increased by 444% After Ban Lifts
Calls to Poison Centers About High-Powered Magnets Increased by 444% After Ban Lifts 1024 521 Laura Dattner
cube made of ball magnets in the palm of a hand

High-powered magnets are small, shiny and made from powerful rare earth metals. Since they started showing up in children’s toys in the early 2000s and then later in desk sets in 2009, high-powered magnets have caused thousands of injuries and are considered to be among the most dangerous ingestion hazards in children. When more than one…

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Featured Researcher — Tendy Chiang, MD, FACS
Featured Researcher — Tendy Chiang, MD, FACS 150 150 Natalie Wilson

​​​​​​​Tendy Chiang, MD, FACS is a principal investigator in the Center for Regenerative Medicine at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. His work focuses on understanding how airway tissue repairs and regenerates itself and using that information to design tissue-engineered trachea. Tissue engineering is the process of seeding cells on a biodegradable scaffold or support…

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Long-Term Treatment of Pediatric Chronic Inflammatory Demyelinating Polyneuropathy with Pulse Oral Corticosteroid Therapy
Long-Term Treatment of Pediatric Chronic Inflammatory Demyelinating Polyneuropathy with Pulse Oral Corticosteroid Therapy 150 150 JoAnna Pendergrass, DVM

Pediatric patients with chronic inflammatory demyelinating polyneuropathy can benefit from the safety and effectiveness of long-term pulse oral corticosteroid therapy. Chronic inflammatory demyelinating polyneuropathy (CIDP) affects the peripheral nervous system in children, causing weakness, sensory loss and depressed tendon reflexes. Pediatric patients with this rare, immune-mediated disease often undergo years of immunomodulatory therapy, with the…

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Girls’ Perineal Microbiomes Change Over Development, After Urinary Tract Infection
Girls’ Perineal Microbiomes Change Over Development, After Urinary Tract Infection 150 150 Mary Bates, PhD

Next-generation sequencing reveals different flora associated with developmental milestones in girls, as well as disruptions in patients with a history of urinary tract infection. In a new pilot study, researchers from Nationwide Children’s Hospital evaluated the microbiomes of girls at specific developmental timepoints. They found shifts in the perineal microbiome corresponding with important developmental milestones,…

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Targeting FSHD With Designed Antisense RNAs
Targeting FSHD With Designed Antisense RNAs 1024 683 Abbie Roth

Researchers describe small nuclear RNA antisense expression cassettes as a way to silence the DUX4 gene underlying facioscapulohumeral muscular dystrophy. Facioscapulohumeral muscular dystrophy (FSHD) arises from genetic and epigenetic changes that result in expression of the DUX4 gene in muscle. DUX4 is a developmental gene that is normally off in healthy muscle.  When expressed in…

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Immersive Virtual Reality-Based Training Improves Empathy Among Health Care Providers
Immersive Virtual Reality-Based Training Improves Empathy Among Health Care Providers 414 224 Lauren Dembeck

A novel VR-based training program helps providers develop knowledge, skills, and attitudes to understand how social determinants of health affect patients and how to mitigate their effects. Researchers recently reported their novel virtual reality (VR)-based empathy training program, Making Professionals Able THrough Immersion (MPATHI), improved knowledge, skills, and attitudes of health care providers for care…

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How Important is Fasting for Pediatric Routine Cholesterol Screening?
How Important is Fasting for Pediatric Routine Cholesterol Screening? 1024 575 Andrew Tran, MD

A nonfasting lipid panel is a great first-line screening tool to use. While it is ideal to have a fasting lipid panel, this can be difficult to obtain in practice. For the purposes of screening, I think that it is much more important to go ahead and get the nonfasting lipid panel while the patient…

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No More Sitting in the Dark?
No More Sitting in the Dark? 1024 728 Laura Dattner

A new study from the Center for Injury Research and Policy, Sports Medicine and Emergency Medicine is the first to document objectively self-paced physical and cognitive activity post-concussion among youth. The results suggest they may be able to engage in physical and cognitive activity as soon as tolerated post-concussion. Clinical guidelines for managing concussion in…

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Modifying NK Cells With CRISPR/Cas9
Modifying NK Cells With CRISPR/Cas9 969 533 Mary Bates, PhD
Illustration of NK Cells, T Cells, other immune cells floating across white background

A proof-of-concept study shows success in modifying NK cells for multiple myeloma. In a new proof-of-concept study, researchers from Nationwide Children’s Hospital used CRISPR/Cas9 technology to genetically modify natural killer immune cells, which they then showed are able to address a recognized hurdle in immunotherapy of multiple myeloma. “It was an amazing feeling when we…

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Protecting an ‘Open Future:’ Improving Fertility Preservation Decision-Making for Young Males With Cancer
Protecting an ‘Open Future:’ Improving Fertility Preservation Decision-Making for Young Males With Cancer 1024 575 Katie Brind'Amour, PhD, MS, CHES
Color photo of Black father holding infant on shoulder in front of nursery background with clouds on the wall

Evidence from a new study highlights the importance of family-centered decision processes and clinician facilitation in improving fertility preservation uptake prior to cancer treatment. Numerous cancer treatments can reduce fertility or render some patients entirely infertile, but fertility preservation (FP) services have historically had low rates of uptake. When a young person is diagnosed with…

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A Quick and Reliable Method to Determine The Time to Full Weight Bearing in Patients Undergoing Intramedullary Limb Lengthening
A Quick and Reliable Method to Determine The Time to Full Weight Bearing in Patients Undergoing Intramedullary Limb Lengthening 1024 575 Lauren Dembeck

A new method to objectively measure bone healing may help the patient with an intramedullary lengthening nail make strides to full weight bearing status. Intramedullary limb lengthening is indicated for the treatment of limb length discrepancy and short stature. Traditionally, the procedure was done using external fixators, which must remain on the patient’s limb for…

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No Evidence Supporting Prophylactic Indomethacin Treatment for Most Preterm Infants
No Evidence Supporting Prophylactic Indomethacin Treatment for Most Preterm Infants 1024 575 Lauren Dembeck

Inconsistency among studies prompted researchers to take a closer look at the drug’s effects. Despite limited evidence supporting its use, prophylactic indomethacin treatment is often administered to very preterm infants within the first 24-hours after birth to reduce the risks of intraventricular hemorrhage and longer-term neonatal morbidities, such as bronchopulmonary dysplasia (BPD). Data from a…

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One Year Reflection: Behavioral Health Pavilion Adds to Industry-Leading Model of Care During Pandemic
One Year Reflection: Behavioral Health Pavilion Adds to Industry-Leading Model of Care During Pandemic 1024 538 Kaitlin Hall

The full impact of COVID-19 on children’s mental health likely won’t be known for some time. But even before the pandemic, pediatric mental health was in a national crisis, with one in five children living with a mental illness, and suicide the second leading cause of death for children 10 and older. That means the…

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