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February 2017

ANH Preserves Platelet Count and Function Regardless of Storage Method and Time
ANH Preserves Platelet Count and Function Regardless of Storage Method and Time 150 150 Kevin Mayhood

Length of storage during cardiac surgeries appears to have no detrimental effects on blood. Across the United States, transfusions are standard in cardiac operating rooms, but at Nationwide Children’s Hospital, a practice geared toward limiting blood transfusion has been established and finely honed. According to a recent study from The Heart Center at Nationwide Children’s, more than…

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How a QI Project Dramatically Increased Pediatric Survival After Cardiopulmonary Arrest
How a QI Project Dramatically Increased Pediatric Survival After Cardiopulmonary Arrest 150 150 Jeb Phillips

A survival rate of 37-48 percent among young heart surgery patients who experience code events is the norm. A multidisciplinary review process helped achieve an 81 percent rate at Nationwide Children’s Hospital. Survival rates have remained stubbornly low for young heart surgery patients who experience cardiopulmonary arrest; critical care literature reports that fewer than 50…

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There’s No Place Like Home (Depending on Which State You Live In…..)
There’s No Place Like Home (Depending on Which State You Live In…..) 150 150 Kelly Kelleher, MD, MPH

Researchers find wide variation in how federal entitlement and benefit programs are implemented from state to state. Over the past five decades, the health of America’s children has improved considerably. Unfortunately, those improvements were not evenly distributed. Most American children are healthy and have promising futures. Children in poverty, on the other hand, infrequently move…

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Two Investigational Antitumor Agents Work Better Together Against MPNST and Neuroblastoma
Two Investigational Antitumor Agents Work Better Together Against MPNST and Neuroblastoma 150 150 Abbie Roth

The synergistic effects of a kinase inhibitor and an oncolytic herpes virus show promise for difficult-to-treat neuroblastomas and malignant peripheral nerve sheath tumors. Two investigational agents, Aurora A kinase inhibitor (alisertib) and HSV1716, a virus derived from HSV-1 and attenuated by the deletion of RL1, have shown some antitumor efficacy in early clinical trials as…

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