Inside the Science of Pediatric Lung Disease

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Speeding Up Science With Patient-Derived Xenografts

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Upset confused Black woman holding cellphone having problem with mobile phone, frustrated angry mixed race girl reading bad news in message looking at smartphone annoyed by spam or missed call
Effectiveness and Adoption of a Mental Health Crisis App
 Effectiveness and Adoption of a Mental Health Crisis App 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Youth who used a statewide mental health crisis app in Utah reported significant declines in the intensity of their presenting concerns and were generally satisfied with the app. Youth who used SafeUT, a statewide crisis app in Utah, reported experiencing significant decreases in the…

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microscopy image of podocytes, a type of cell found in the kidney, stained with blue and fluorescent yellow. small red dots mark the cell
Lowering Thrombin Levels Offers a Double Benefit in Glomerular Disease Model
 Lowering Thrombin Levels Offers a Double Benefit in Glomerular Disease Model 1024 410 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Preclinical studies suggest that reducing levels of the clotting enzyme may simultaneously reduce kidney damage and lower risk of blood clots. Preclinical research in an in vivo model now confirms what Bryce Kerlin, MD, and his team first proposed in a publication 8 years…

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Illustration of research and healthcare symbols, including gears, a clipboard with a checklist and medical cross, a magnifying glass, a lab flask, and green icons with a check mark, an X, and a question mark.
Meeting the Challenge of Clinical Trial Recruitment and Retention
 Meeting the Challenge of Clinical Trial Recruitment and Retention 1024 483 Lynn Dosky
By: Lynn Dosky

Participant recruitment and retention strategies are crucial features of any successful clinical study design. In fact, an article published in the Journal of Clinical and Translational Science noted, “up to 85% of clinical trials fail to recruit or retain a sufficient sample size, leading…

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cropped microscopy image of lungs tissue with tumors
Speeding Up Science With Patient-Derived Xenografts
 Speeding Up Science With Patient-Derived Xenografts 1024 483 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A perfect storm of advanced technologies and scientific collaboration opens doors to rapid progress in pediatric oncology research. The world of pediatric cancer research faces the challenges of small patient numbers, increased ethical considerations, limited funding and poorly classified diseases. In some ways, these…

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Ashley Fernandes, MD, PhD, wearing a white coat with a Nationwide Children's logo, standing in front of a blurred hospital interior background
Professionalism in Pediatric Medicine: Why We Must Get It Right
 Professionalism in Pediatric Medicine: Why We Must Get It Right 1024 580 Ashley Fernandes, MD, PhD
By: Ashley Fernandes, MD, PhD

A talented junior attending physician on a high acuity service is impatient on rounds and visibly irritated by nursing concerns, making trainees and team members uncomfortable and anxious about speaking up. A senior medical researcher pushes the limits on deadlines for important grants and…

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abstract art of magnifying glass over DNA strand
Genetic Evaluation Practices for Neonates With Congenital Heart Disease
 Genetic Evaluation Practices for Neonates With Congenital Heart Disease 1024 614 Pam Georgiana
By: Pam Georgiana

Multi-institutional survey reveals wide variation in cardiac testing and care. Advances in genomic medicine have significantly improved the understanding of congenital heart disease etiology. However, the integration of genetic evaluation into neonatal cardiac critical care remains inconsistent. A recent multi-institutional study, led by Amee…

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Neurosurgeon Albert Isaacs posed in the operating room, looking at the camera.
Early Temporization Linked to Better Early Development in Premature Infants With Posthemorrhagic Hydrocephalus
 Early Temporization Linked to Better Early Development in Premature Infants With Posthemorrhagic Hydrocephalus 864 576 Nationwide Children's
By: Nationwide Children's

A new HCRN study led by Nationwide Children’s links early temporary cerebral spinal fluid diversion and timely shunt conversion to better early development in preterm infants with posthemorrhagic hydrocephalus. A new Hydrocephalus Clinical Research Network (HCRN) study, published in Journal of Neurosurgery: Pediatrics, suggests…

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Finding the Unexpected: Pulmonary Sclerosing Pneumocytoma in a Pediatric Patient
 Finding the Unexpected: Pulmonary Sclerosing Pneumocytoma in a Pediatric Patient 1024 575 Pam Georgiana
By: Pam Georgiana

A case study demonstrates the need for a structured evaluation and consideration of genetic risk factors in rare pediatric tumors. Primary lung tumors in children are rare and present diagnostic uncertainty. A recent case study published in Pediatric Pulmonology highlights the evaluation and management…

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Genome Database Analysis Suggests Cystic Fibrosis is More Globally Distributed Than Previously Believed
 Genome Database Analysis Suggests Cystic Fibrosis is More Globally Distributed Than Previously Believed 1024 768 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Despite lower CF incidence in non-European populations, total CF births in Asia, Africa and South America likely equal or surpass those in North America and Europe. Cystic fibrosis (CF) has long been viewed as a disease that primarily affects people of European descent. Even…

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In Sight: Targeted Muscle Reinnervation
 In Sight: Targeted Muscle Reinnervation 150 150 Abbie Miller
By: Abbie Miller

Amputation in pediatrics is often a result of traumatic injury or cancers, such as osteosarcoma. At Nationwide Children’s, Thomas Scharschmidt, MD, director of the Orthopedic Oncology Program, is a leader in limb salvage surgery and targeted muscle reinnervation.  Targeted muscle reinnervation (TMR) is a…

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Dr. Joan Han standing in a white coat in a hospital setting
Hot Topics in Endocrinology: A conversation with Joan Han, MD, Division Chief of Endocrinology at Nationwide Children’s
 Hot Topics in Endocrinology: A conversation with Joan Han, MD, Division Chief of Endocrinology at Nationwide Children’s 1024 605 Pam Georgiana
By: Pam Georgiana

Joan C. Han, MD, became chief of the Division of Endocrinology at Nationwide Children’s Hospital in January 2026. She is a nationally recognized physician-scientist in pediatric obesity and metabolic disease. In this Q&A, Dr. Han discusses the most pressing issues in pediatric endocrinology and…

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The Growing Use of Robotics in General Pediatric Surgical Procedures
 The Growing Use of Robotics in General Pediatric Surgical Procedures 1024 683 Lauren Dembeck
By: Lauren Dembeck

Pediatric surgeons are increasingly turning to robotic technology for the delivery of safe and enhanced minimally invasive surgical approaches for younger children. Over the past two decades, the use of minimally invasive surgery (MIS) techniques for both laparoscopic and thoracoscopic surgery have been widely…

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Q&A With Cory Criss, MD: Advancing Pediatric Care Through Innovation
 Q&A With Cory Criss, MD: Advancing Pediatric Care Through Innovation 150 150 Alaina Doklovic
By: Alaina Doklovic

Cory Criss, MD, is a pediatric surgeon at Nationwide Children’s Hospital and the founder and director of the Innovation Center. He also serves as the chief operating officer and co-principal investigator of the Midwest Pediatric Device Consortium (MPDC), a multi-million-dollar FDA funded initiative accelerating…

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Portrait of Alexander Bishop, DPhil, standing in a hospital lobby and smiling, wearing a navy blazer and light blue shirt.
From Biology to Bedside: How the Center for Childhood Cancer Research Is Shaping What Comes Next
 From Biology to Bedside: How the Center for Childhood Cancer Research Is Shaping What Comes Next 1024 627 Madison Storm
By: Madison Storm

An interview with Alexander Bishop, DPhil, director of the Center for Childhood Cancer Research, principal investigator and Richard J. Solove Endowed Chair in Cancer Clinical Developmental Therapeutics at Nationwide Children’s Hospital. At Nationwide Children’s Hospital, the mission of the Center for Childhood Cancer Research…

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Illustration of a heart showing the Fontan surgery
Tissue Engineered Vascular Grafts: A Breakthrough for Children With Heart Defects
 Tissue Engineered Vascular Grafts: A Breakthrough for Children With Heart Defects 968 1024 Abbie Miller
By: Abbie Miller

An innovation 30 years in the making is poised to change the way children with single ventricle disease experience life after a Fontan procedure. Children with single ventricle disease are often described as having “half a heart.” What this really means is that one…

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DNA Methylation-Based Diagnostics: Refining Diagnosis for the Most Complex Pediatric Brain Tumors
 DNA Methylation-Based Diagnostics: Refining Diagnosis for the Most Complex Pediatric Brain Tumors 1024 783 Lauren Dembeck
By: Lauren Dembeck

Developed at Nationwide Children’s, the MACDADI classifier is compatible with next-generation methylation arrays and quickly delivers more accurate tumor diagnoses, offering a clinically validated alternative to outdated and unregulated methylation classifiers. Diagnosing central nervous system (CNS) tumors in children is among the most challenging…

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Dr. Zarife Sahenk, MD, PhD
One Gene, Big Impact: The Science Behind a New Therapy for Brain and Muscle Health
 One Gene, Big Impact: The Science Behind a New Therapy for Brain and Muscle Health 1024 683 Madison Storm
By: Madison Storm

A promising new gene therapy developed at Nationwide Children’s Hospital is offering hope for new patients with neurodegenerative and muscle disorders. Led by Zarife Sahenk, MD, PhD, a neurologist, principal investigator in the Jerry R. Mendell Center for Gene Therapy and director of Clinical…

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Startups Update: Where Are They Now?
 Startups Update: Where Are They Now? 1024 683 Madison Storm
By: Madison Storm

From cutting-edge gene therapies to transformative medical devices, startups are redefining what’s possible in-patient care and technology. Born from pioneering research and nurtured through strategic collaborations, startups are tackling critical challenges—from neonatal care to oncology and rare genetic disorders—while advancing toward commercialization. Supported by…

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Newborn baby with nasal canula oxygen support receiving care in a neonatal intensive care unit (NICU) at a hospital, resting while monitored by medical staff.
Shorter Antibiotic Courses Appear Safe for Uncomplicated Gram-Negative Bloodstream Infections in the NICU
 Shorter Antibiotic Courses Appear Safe for Uncomplicated Gram-Negative Bloodstream Infections in the NICU 1024 602 Pam Georgiana
By: Pam Georgiana

Neonatology and pediatric pharmacy partner to advance antibiotic stewardship. For years, Pablo J. Sánchez, MD, principal investigator in the Center for Perinatal Research in the Abigail Wexner Research Institute at Nationwide Children’s Hospital, observed that approximately 7 days of antibiotic therapy appeared sufficient for…

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Eric Youngstrom, PhD
Norms, Needs and New Frontiers in Pediatric Mental Health
 Norms, Needs and New Frontiers in Pediatric Mental Health 1024 683 Madison Storm
By: Madison Storm

 An interview with Eric Youngstrom, PhD, director of the Institute for Mental and Behavioral Health Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. At Nationwide Children’s Hospital, the Institute for Mental and Behavioral Health Research (IMBHR) is driving discovery through improved…

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