Acute Kidney Injury After Comprehensive Stage Two Palliation in Infants With Hypoplastic Left Heart Syndrome
Acute Kidney Injury After Comprehensive Stage Two Palliation in Infants With Hypoplastic Left Heart Syndrome 150 150 JoAnna Pendergrass, DVM

Infants with hypoplastic left heart syndrome who undergo the Hybrid pathway palliation commonly develop acute kidney injury after the comprehensive stage 2 procedure and may require advanced medical therapy.   In a recent Cardiology in the Young publication, Andrew Yates, MD, associate medical director…

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Innovations in Pediatric Nephrology and Urology: Spotlight on Congenital Urinary Tract Obstruction
Innovations in Pediatric Nephrology and Urology: Spotlight on Congenital Urinary Tract Obstruction 150 150 Erin Gregory

Congenital urinary tract obstruction poses significant challenges for pediatric patients, compelling innovative approaches in urology. Nationwide Children’s Hospital pioneers research in this field, focusing on understanding the complexities of urinary tract conditions. Two labs within the Kidney and Urinary Tract Center at Nationwide Children’s…

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Legislation Associated With Reduction in Amount of Opioids Prescribed at Discharge
Legislation Associated With Reduction in Amount of Opioids Prescribed at Discharge 1024 681 Laura Dattner

Study shows a decrease after the 2017 Ohio Prescription Opioid Cap Law went into effect. The Ohio Opioid Cap Law, enacted on August 31, 2017, limited the total dose and duration of opioids that could be prescribed for minors. The anticipated benefit of cap laws…

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Novel Treatment Ameliorates Proteinuria and Dyslipidemia in a Model of Noninflammatory Glomerular Disease
Novel Treatment Ameliorates Proteinuria and Dyslipidemia in a Model of Noninflammatory Glomerular Disease 150 150 Lauren Dembeck

Idiopathic nephrotic syndrome — characterized by proteinuria, hypoalbuminemia, dyslipidemia, and edema — is one of the most common pediatric glomerular diseases. Glucocorticoids are first-line treatment, followed by calcineurin inhibitors for steroid-resistant disease; however, currently available calcineurin inhibitors can have numerous side effects, including dyslipidemia,…

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illustrated cross section of islets from pancreas
The Endocrinologists’ Role in Caring for TPIAT Patients
The Endocrinologists’ Role in Caring for TPIAT Patients 1024 500 Lauren Dembeck

Children with recurrent acute or chronic pancreatitis often suffer debilitating pain and may endure an impaired quality of life. They may be frequently admitted to the hospital, disrupting their daily routines and activities. Patients may undergo medical and endoscopic interventions for both diagnostic and…

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Increasing the Donor Pool for Young Children Waiting for Heart Transplants
Increasing the Donor Pool for Young Children Waiting for Heart Transplants 150 150 Pam Georgiana

The one-year survival rate following a pediatric heart transplant is over 90%, However, waitlist mortality in the United States for children remains high at 17%. Young and highly sensitized children typically experience longer waitlist times for a heart transplant, which increases their waitlist mortality.…

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Implanted Hemodynamic Monitoring in Patients With Fontan Circulation
Implanted Hemodynamic Monitoring in Patients With Fontan Circulation 150 150 Mary Bates, PhD

Pulmonary artery pressures obtained with the CardioMEMSTM system may be clinically useful. In a new study, researchers from The Ohio State University and Nationwide Children’s Hospital report on the use of invasive implanted hemodynamic monitoring (IHM) in patients with Fontan circulation. The findings suggest…

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Changing the Landscape of Blood Disorder Treatments: A Long Time Coming
Changing the Landscape of Blood Disorder Treatments: A Long Time Coming 1024 574 Alaina Doklovic

New therapies, from virus-mediated gene therapy to CRISPR-based treatments, are poised to change the clinical landscape of blood disorder treatments and outcomes.   For more than two decades experts have been searching for curative therapies for blood disorders. They have invested time, money and…

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conceptual art of DNA
Researchers Create Public Database of Nearly 40,000 Control Samples for Genetic Association Studies
Researchers Create Public Database of Nearly 40,000 Control Samples for Genetic Association Studies 1024 575 Lauren Dembeck

Genetic association studies provide powerful means of discovering relationships between genetic variants and disease risk. However, these studies require enrolling very large numbers of individuals with the disease (cases) and healthy individuals (controls) as well as collecting genetic data for all of those participants…

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New Zebrafish Pipeline Enables Functional Evaluation of Novel, Rare, Fusion-Oncogenes in vivo
New Zebrafish Pipeline Enables Functional Evaluation of Novel, Rare, Fusion-Oncogenes in vivo 1024 683 Jessica Nye, PhD

An innovative method that uses a zebrafish model to rapidly study novel fusion-oncogenes in vivo has been developed by investigators at Nationwide Children’s Hospital.   Fusion oncogenes are frequently observed in pediatric cancers. These fusion oncogenes are typically caused by a chromosomal translocation that…

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Meet Toni Pearson, MD: Pediatric Movement Disorders Expert
Meet Toni Pearson, MD: Pediatric Movement Disorders Expert 150 150 Pam Georgiana

Toni S. Pearson, MD, joined Nationwide Children’s in 2022 as an attending pediatric neurologist and professor of pediatrics at The Ohio State University College of Medicine. She specializes in childhood movement disorders, such as dystonia, chorea, parkinsonism, ataxia, myoclonus, tremors, tics, and spasticity. Dr.…

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Interactions Between Invading Tumor and Lung Cells Permit Metastatic Lung Colonization of Osteosarcoma
Interactions Between Invading Tumor and Lung Cells Permit Metastatic Lung Colonization of Osteosarcoma 150 150 Lauren Dembeck

Survival signals elicited by lung tissue interactions promote osteosarcoma metastasis and represent a promising target for clinical trials in both human and canine patients.   Osteosarcoma, the most common primary tumor of bone, occurs predominantly in children, teens and young adults. Patient survival largely…

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Featured Researcher – Amrik Khalsa, MD
Featured Researcher – Amrik Khalsa, MD 150 150 Alaina Doklovic

Amrik Khalsa, MD, is a physician and principal investigator in the Center for Child Health Equity and Outcomes Research (CCHEOR) in the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital. He is dual medically trained and board certified in Internal Medicine and Pediatrics…

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Kids With Concussions Need Specialized Assessment and Care
Kids With Concussions Need Specialized Assessment and Care 1024 683 Sean Rose, MD

Learn why cutting-edge care and research specifically for children matters. The 2020 National Health Interview Survey reported that 6.8% of children experience symptoms of a concussion or brain injury in their lifetime. However, only 3.9% had received a diagnosis or treatment of a concussion…

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Transforming Treatment for Paratesticular Rhabdomyosarcoma in Adolescents through Robotics
Transforming Treatment for Paratesticular Rhabdomyosarcoma in Adolescents through Robotics 1024 683 Erin Gregory

Retroperitoneal lymph node dissection (RPLND) has been a crucial component of treating testicular and paratesticular cancers for over a century. Recent advancements in minimally invasive techniques, such as robotic-assisted methods, have expanded the applicability of RPLND, offering reduced morbidity and faster recovery. However, concerns…

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Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2
Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2 150 150 Lauren Dembeck

Tuberous sclerosis complex (TSC) is a devastating genetic disease that affects nearly 1 in every 5,500 newborns and approximately 2 million people worldwide. The disease is characterized by the formation of non-malignant tumors throughout multiple organs, including the kidney, lungs, eyes, and heart, but…

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What Are the Risk Factors for Recurrent Wheezing in Late Preterm Infants?
What Are the Risk Factors for Recurrent Wheezing in Late Preterm Infants? 1024 683 Pam Georgiana

A collaboration between a pulmonary medicine fellow and allergy and immunology expert identifies four risk factors associated with recurrent wheezing in these patients.   When Brooke R. Gustafson, MD, a member of the Section of Pediatric Pulmonary Medicine at Nationwide Children’s and an assistant…

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GERD Less Likely Cause of Irritability and Back Arching in Infants
GERD Less Likely Cause of Irritability and Back Arching in Infants 1024 683 Lauren Dembeck

In infants, frequent irritability and arching of the back can be concerning to parents and providers. These symptoms are often attributed to gastroesophageal reflux disease (GERD), a disease in which the lower esophageal sphincter does not close or opens at the wrong time. As…

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Ensuring All Children Have Access to Behavioral Health Care
Ensuring All Children Have Access to Behavioral Health Care 531 213 Pam Georgiana

New study reports the results of integrating psychologists into primary care clinics. Cody A. Hostutler, PhD, a psychologist in the Department of Pediatric Psychology and Neuropsychology at Nationwide Children’s, is concerned about the mental health of the children and adolescents visiting primary care centers.…

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Accelerating Pediatric Medical Device Innovation 
Accelerating Pediatric Medical Device Innovation  150 150 Erin Gregory

The Midwest Pediatric Device Consortium (MPDC) is a unique collective led by Nationwide Children’s Hospital and The Ohio State University, designed to facilitate the development, production, and distribution of pediatric medical devices. Comprising a diverse group of leaders in universities, healthcare systems, community organizations,…

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