Getting Children and Families Outside With PlayStreets
Getting Children and Families Outside With PlayStreets 1024 683 Tiwana Henderson

A PlayStreet initiative in 2019 from Healthy Neighborhoods Healthy Families helped more than 350 South Side residents get outside and play – safely. Research has found that children who play outside are more physically active and have stronger social skills that those who do…

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Calls to Poison Centers About High-Powered Magnets Increased by 444% After Ban Lifts
Calls to Poison Centers About High-Powered Magnets Increased by 444% After Ban Lifts 1024 521 Laura Dattner

High-powered magnets are small, shiny and made from powerful rare earth metals. Since they started showing up in children’s toys in the early 2000s and then later in desk sets in 2009, high-powered magnets have caused thousands of injuries and are considered to be among…

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Featured Researcher — Tendy Chiang, MD, FACS
Featured Researcher — Tendy Chiang, MD, FACS 150 150 Natalie Wilson

​​​​​​​Tendy Chiang, MD, FACS is a principal investigator in the Center for Regenerative Medicine at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. His work focuses on understanding how airway tissue repairs and regenerates itself and using that information to design tissue-engineered trachea. Tissue engineering is…

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Long-Term Treatment of Pediatric Chronic Inflammatory Demyelinating Polyneuropathy with Pulse Oral Corticosteroid Therapy
Long-Term Treatment of Pediatric Chronic Inflammatory Demyelinating Polyneuropathy with Pulse Oral Corticosteroid Therapy 150 150 JoAnna Pendergrass, DVM

Pediatric patients with chronic inflammatory demyelinating polyneuropathy can benefit from the safety and effectiveness of long-term pulse oral corticosteroid therapy. Chronic inflammatory demyelinating polyneuropathy (CIDP) affects the peripheral nervous system in children, causing weakness, sensory loss and depressed tendon reflexes. Pediatric patients with this…

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Girls’ Perineal Microbiomes Change Over Development, After Urinary Tract Infection
Girls’ Perineal Microbiomes Change Over Development, After Urinary Tract Infection 150 150 Mary Bates, PhD

Next-generation sequencing reveals different flora associated with developmental milestones in girls, as well as disruptions in patients with a history of urinary tract infection. In a new pilot study, researchers from Nationwide Children’s Hospital evaluated the microbiomes of girls at specific developmental timepoints. They…

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Targeting FSHD With Designed Antisense RNAs
Targeting FSHD With Designed Antisense RNAs 1024 683 Abbie Roth

Researchers describe small nuclear RNA antisense expression cassettes as a way to silence the DUX4 gene underlying facioscapulohumeral muscular dystrophy. Facioscapulohumeral muscular dystrophy (FSHD) arises from genetic and epigenetic changes that result in expression of the DUX4 gene in muscle. DUX4 is a developmental…

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Immersive Virtual Reality-Based Training Improves Empathy Among Health Care Providers
Immersive Virtual Reality-Based Training Improves Empathy Among Health Care Providers 414 224 Lauren Dembeck

A novel VR-based training program helps providers develop knowledge, skills, and attitudes to understand how social determinants of health affect patients and how to mitigate their effects. Researchers recently reported their novel virtual reality (VR)-based empathy training program, Making Professionals Able THrough Immersion (MPATHI),…

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How Important is Fasting for Pediatric Routine Cholesterol Screening?
How Important is Fasting for Pediatric Routine Cholesterol Screening? 1024 575 Andrew Tran, MD

A nonfasting lipid panel is a great first-line screening tool to use. While it is ideal to have a fasting lipid panel, this can be difficult to obtain in practice. For the purposes of screening, I think that it is much more important to…

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No More Sitting in the Dark?
No More Sitting in the Dark? 1024 728 Laura Dattner

A new study from the Center for Injury Research and Policy, Sports Medicine and Emergency Medicine is the first to document objectively self-paced physical and cognitive activity post-concussion among youth. The results suggest they may be able to engage in physical and cognitive activity…

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Illustration of NK Cells, T Cells, other immune cells floating across white background
Modifying NK Cells With CRISPR/Cas9
Modifying NK Cells With CRISPR/Cas9 969 533 Mary Bates, PhD

A proof-of-concept study shows success in modifying NK cells for multiple myeloma. In a new proof-of-concept study, researchers from Nationwide Children’s Hospital used CRISPR/Cas9 technology to genetically modify natural killer immune cells, which they then showed are able to address a recognized hurdle in…

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Protecting an ‘Open Future:’ Improving Fertility Preservation Decision-Making for Young Males With Cancer
Protecting an ‘Open Future:’ Improving Fertility Preservation Decision-Making for Young Males With Cancer 1024 575 Katie Brind'Amour, PhD, MS, CHES

Evidence from a new study highlights the importance of family-centered decision processes and clinician facilitation in improving fertility preservation uptake prior to cancer treatment. Numerous cancer treatments can reduce fertility or render some patients entirely infertile, but fertility preservation (FP) services have historically had…

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A Quick and Reliable Method to Determine The Time to Full Weight Bearing in Patients Undergoing Intramedullary Limb Lengthening
A Quick and Reliable Method to Determine The Time to Full Weight Bearing in Patients Undergoing Intramedullary Limb Lengthening 1024 575 Lauren Dembeck

A new method to objectively measure bone healing may help the patient with an intramedullary lengthening nail make strides to full weight bearing status. Intramedullary limb lengthening is indicated for the treatment of limb length discrepancy and short stature. Traditionally, the procedure was done…

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Nurse caring for infant in Neonatal Intensive Care Unit (NICU)
No Evidence Supporting Prophylactic Indomethacin Treatment for Most Preterm Infants
No Evidence Supporting Prophylactic Indomethacin Treatment for Most Preterm Infants 1024 575 Lauren Dembeck

Inconsistency among studies prompted researchers to take a closer look at the drug’s effects. Despite limited evidence supporting its use, prophylactic indomethacin treatment is often administered to very preterm infants within the first 24-hours after birth to reduce the risks of intraventricular hemorrhage and…

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One Year Reflection: Behavioral Health Pavilion Adds to Industry-Leading Model of Care During Pandemic
One Year Reflection: Behavioral Health Pavilion Adds to Industry-Leading Model of Care During Pandemic 1024 538 Kaitlin Hall

The full impact of COVID-19 on children’s mental health likely won’t be known for some time. But even before the pandemic, pediatric mental health was in a national crisis, with one in five children living with a mental illness, and suicide the second leading…

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Investigating Youth Suicides Among Children Involved With the Welfare System
Investigating Youth Suicides Among Children Involved With the Welfare System 1024 683 Natalie Wilson

Youth with child welfare involvement are at an elevated risk for suicide but may benefit from suicide prevention interventions targeting health care settings and family-preservation. Suicide is the second leading cause of death among youth aged 5 to 21 years in the United States.…

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Featured Researcher — Jingzhen Ginger Yang, PhD, MPH
Featured Researcher — Jingzhen Ginger Yang, PhD, MPH 150 150 Natalie Wilson

Dr. Jingzhen (Ginger) Yang, a principal investigator in the Center for Injury Research and Policy at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, has a national and international reputation as a leader in pediatric injury prevention research. Currently, Dr. Yang is directing three NIH-funded…

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Incidence and Impact of Acute Kidney Injury in Patients With Hypoplastic Left Heart Syndrome
Incidence and Impact of Acute Kidney Injury in Patients With Hypoplastic Left Heart Syndrome 150 150 Abbie Roth

While incidence of severe kidney injury after surgery for hypoplastic left heart syndrome is low, it may be linked to increased 30-day mortality. Acute kidney injury – the abrupt decline of renal function – following pediatric heart surgery leads to worse outcomes, including increased…

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Top-down view of heart valves
Novel Nitric Oxide-Mediated Mechanism Facilitates Calcific Aortic Valve Disease
Novel Nitric Oxide-Mediated Mechanism Facilitates Calcific Aortic Valve Disease 1024 752 Lauren Dembeck

The novel pathway could be targeted to prevent or reverse aortic valve calcification in humans. Researchers have recently described a novel nitric oxide-mediated mechanism in calcific aortic valve disease that involves the ubiqutin-proteasome pathway, and its modulation in animal models was shown to cause…

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boy with muscular dystrophy completing walk test
Natural Progression of Duchenne Muscular Dystrophy for Boys Taking Long-Term Steroid Therapy
Natural Progression of Duchenne Muscular Dystrophy for Boys Taking Long-Term Steroid Therapy 1024 575 Mary Bates, PhD

New data define expected motor performance at different ages and will help in clinical trial design and interpretation. Duchenne muscular dystrophy (DMD) is a devastating diagnosis, but there are many potential treatments in various stages of development. Clinical trials now target boys with DMD…

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Inverse Relationship Between Age and Dose of Blood Thinners for Children
Inverse Relationship Between Age and Dose of Blood Thinners for Children 1024 495 Natalie Wilson

Infants and young children require higher doses of enoxaparin to treat blood clots than do older children. A blood clot, or thrombosis, isn’t a common problem in children, but it can be a dangerous one. Without proper treatment, a thrombosis can cause a host…

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Neurodevelopmental Trajectory in Infants With Neonatal Opioid Withdrawal Syndrome
Neurodevelopmental Trajectory in Infants With Neonatal Opioid Withdrawal Syndrome 1024 575 Mary Bates, PhD

Infants exposed to opioids in utero begin showing cognitive and language deficits in their second year. In a new study, researchers from Nationwide Children’s Hospital report the neurodevelopmental outcomes of infants with pharmacologically treated neonatal opioid withdrawal syndrome (NOWS, formerly called neonatal abstinence syndrome,…

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Lisa Ulrich standing in hospital hallway
Increasing the Use of the Teach-Back Method in Asthma Education
Increasing the Use of the Teach-Back Method in Asthma Education 1024 575 JoAnna Pendergrass, DVM

A standardized approach to asthma education using the teach-back method helps respiratory therapists effectively address common issues with asthma management in pediatric patients. For the 8% of children and adults in the United States who have asthma, effective asthma education is essential to adequate…

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More Data on Rare GI Diseases, With Less Work
More Data on Rare GI Diseases, With Less Work 1024 535 Katie Brind'Amour, PhD, MS, CHES

Electronic health record systems can drive knowledge acquisition in rare gastrointestinal conditions — and other orphan diseases — without the burden of duplicative data entry. Rare diseases often remain poorly understood and inefficiently treated due to a lack of objective knowledge on their natural…

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What Puts Adolescent Patients With IBD at Risk for Suboptimal Transitions?
What Puts Adolescent Patients With IBD at Risk for Suboptimal Transitions? 1024 673 JoAnna Pendergrass, DVM

Psychosocial-related factors, such as mental health diagnoses and public insurance, have been shown to increase the risk of suboptimal transitions in adolescent patients with inflammatory bowel disease. Between ages 18 and 22, adolescent patients transition from pediatric to adult care. Ideally, at the time…

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Parent and child holding hands
Does Psychosocial Functioning Differ Among Children With and Without Differences of Sex Development?
Does Psychosocial Functioning Differ Among Children With and Without Differences of Sex Development? 1024 575 Lauren Dembeck

A multidisciplinary team of researchers recently found that children with differences of sex development (DSD) appear to be at greater risk for psychosocial problems relative to children with cleft lip and/or palate (CL/P) and unaffected peers. The study, which was published in the Journal of…

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COVID-19 and the Heart: SARS-CoV-2-Associated Myocardial Infection
COVID-19 and the Heart: SARS-CoV-2-Associated Myocardial Infection 150 150 Simon Lee

Myocardial infection following COVID-19 illness has made headlines. Simon Lee, MD, tackles some commonly asked questions about MIS-C and isolated myocarditis after COVID-19 recovery.

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Lauren Bakaletz Named 2021 Allen Distinguished Scholar in Pediatric Research
Lauren Bakaletz Named 2021 Allen Distinguished Scholar in Pediatric Research 1024 575 Abbie Roth

Lauren Bakaletz, PhD, director of the Center for Microbial Pathogenesis in the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital, was named the 2021 Allen Distinguished Scholar in Pediatric Research. The award is given in honor of former Nationwide Children’s CEO, Steve Allen, MD, and…

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Novel Genetic Driver Discovered for Pediatric Meningiomas Using Molecular Profiling
Novel Genetic Driver Discovered for Pediatric Meningiomas Using Molecular Profiling 1024 575 Katie Brind'Amour, PhD, MS, CHES

Researchers have uncovered a rare subset of meningiomas with a genetic driver shared by another cancer type, opening the door to new therapeutic considerations. When an interesting or intractable cancer case arises at Nationwide Children’s Hospital, researchers and clinicians involved in the Brain Tumor…

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two houses: one in poor repair, one in good repair
Study Shows That When Housing Quality is Poor, Children Suffer
Study Shows That When Housing Quality is Poor, Children Suffer 1024 575 Jeb Phillips

Holes in floors, cracks in walls, plumbing issues and/or problems with pests are linked with overall poorer pediatric health and higher health care use in a nationally representative study. Housing instability and homelessness are widely understood to have an impact on health, and certain…

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Pediatric Kidney Care: A Complex Issue for Low-Resource Nations
Pediatric Kidney Care: A Complex Issue for Low-Resource Nations 1024 575 Eric Butterman

Children are dying from kidney disease at alarming rates in low-resource nations. And some procedures that could reduce this high mortality would be considered simple and low-cost for many countries, says William Smoyer, MD, vice president and director of the Center for Clinical and Translational Research in…

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Kevin Klingele, MD
Determining the Probability of a Sequential Slipped Hip
Determining the Probability of a Sequential Slipped Hip 1024 683 Mary Bates, PhD

A new predictive tool offers an objective method to help guide treatment in patients with unilateral slipped capital femoral epiphysis. In a recent study, researchers at Nationwide Children’s developed a scoring system based on radiological findings to predict sequential hip involvement in patients with unilateral…

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Batten Disease Experts Publish Common Key Practices For Enzyme Replacement Therapy
Batten Disease Experts Publish Common Key Practices For Enzyme Replacement Therapy 1024 683 Lauren Dembeck

Neuronal ceroid lipofuscinosis type 2 disease is a rare, rapidly-progressing, neurodegenerative lysosomal storage disorder caused by tripeptidyl peptidase 1 deficiency. This form of Batten disease has an onset between two to four years of age. Children with CLN2 disease may experience intractable epilepsy, progressive…

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Blood cells
CLABSI in Hematology and Oncology: Progress Toward Zero
CLABSI in Hematology and Oncology: Progress Toward Zero 1024 576 Katie Brind'Amour, PhD, MS, CHES

A thorough review of five years of CLABSI data reveals key gaps in clinical knowledge that must be addressed to further reduce infection rates. For some time, any bloodstream infection (BSI) in a patient with a central venous catheter was considered a central line-associated…

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small baby with nose canula
Polysomnography in Infants: How Much Total Sleep Time is Really Needed?
Polysomnography in Infants: How Much Total Sleep Time is Really Needed? 1024 575 Abbie Roth

Study identifies factors affecting total sleep time and suggests shorter sleep times can be effective for accurate interpretation and clinical decision making. In a recent study published in American Journal of Perinatology, experts from Nationwide Children’s Hospital investigated factors that affect total sleep time(TST) during infant…

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Novel Roles of the Urothelium in the Development of Congenital Anomalies of the Kidney and Urinary Tract
Novel Roles of the Urothelium in the Development of Congenital Anomalies of the Kidney and Urinary Tract 150 150 Lauren Dembeck

In addition to genetic defects, interactions of the developing urothelium with its underlying mesenchyme and superficial plaque may contribute to congenital anomalies of the kidney and urinary tract. Congenital anomalies of the kidney and urinary tract (CAKUTs) are the leading cause of chronic and…

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sleeping infant
Risk Stratification in Infants With Primary Pulmonary Vein Stenosis
Risk Stratification in Infants With Primary Pulmonary Vein Stenosis 1024 681 Mary Bates, PhD

Categorizing infants with pulmonary vein stenosis into stable and progressive groups could help inform treatment. Primary pulmonary vein stenosis is a rare, often lethal, cardiac disease. It is challenging to treat, as the disease can be progressive in some patients but not others. In a…

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Health care provider talking to male teen patient
Early Intervention is Key to Avoid Hospitalization for Cyclic Vomiting Syndrome
Early Intervention is Key to Avoid Hospitalization for Cyclic Vomiting Syndrome 1024 683 Mary Bates, PhD

Study finds that waiting to go to the emergency department for treatment increases likelihood of hospitalization. Cyclic vomiting syndrome is a functional gastrointestinal disorder characterized by periodic episodes of intense nausea and vomiting lasting hours to days. During episodes, some children become very sick…

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Boosting Natural Killer Cells for the Treatment of COVID-19
Boosting Natural Killer Cells for the Treatment of COVID-19 150 150 Lauren Dembeck

Natural killer cells — critical for immune surveillance and host defense — have an important role in cancer immunotherapy and antiviral responses. While driving to the laboratory one day, Brian Tullius, MA, MD, a fourth-year bone marrow transplant and cell therapies fellow at Nationwide…

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What Kids and Kidneys Can Teach Pediatricians About Racism in America
What Kids and Kidneys Can Teach Pediatricians About Racism in America 1024 575 Ray Bignall

O.N. Ray Bignall II, MD, FAAP, director of Kidney Health Advocacy and Community Engagement, explores how “race modifiers,” structural racism and health disparities are perpetuated in kidney care for kids, highlighting important areas primed for change.

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Toddler playing with toys
How Has the COVID-19 Pandemic Affected Measles Vaccination Rates?
How Has the COVID-19 Pandemic Affected Measles Vaccination Rates? 1024 575 Mary Bates, PhD

Researchers are concerned about declining vaccination rates in the Nationwide Children’s Hospital pediatric primary care network. One consequence of the COVID-19 pandemic is that more families are putting off their children’s preventive care visits, causing pediatric providers to worry about missed vaccines. In a…

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An Imbalance of Immune Cells Leads to Kidney Scarring After Infection
An Imbalance of Immune Cells Leads to Kidney Scarring After Infection 1024 732 Mary Bates, PhD

In a preclinical mouse model, researchers identify the immune cell balancing act that determines whether renal scarring will occur following kidney infection More than half of urinary tract infections in children spread from the bladder to the kidneys, causing acute kidney infections that can…

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small baby with nose canula
Taking on Bronchiolitis in the Age of COVID-19
Taking on Bronchiolitis in the Age of COVID-19 1024 575 Eric Butterman

In a recent episode of PediaCast CME, Drs. Asuncion Mejias and Gerd McGwire address the diagnosis and management of bronchiolitis – and special considerations during the COVID-19 pandemic. Bronchiolitis is the leading cause of hospitalizations for young infants around the world, and in a…

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Dr. Jayanthi standing in OR
Do Surgical Outcomes Differ Between Minimally Invasive Pyeloplasty Procedures in Treating Ureteropelvic Junction Obstruction?
Do Surgical Outcomes Differ Between Minimally Invasive Pyeloplasty Procedures in Treating Ureteropelvic Junction Obstruction? 1024 575 JoAnna Pendergrass, DVM

Minimally invasive pyeloplasty has become increasingly popular over open dismembered pyeloplasty, the traditional treatment for ureteropelvic junction obstruction. Robotic-assisted pyeloplasty (RALP) and laparoscopic pyeloplasty (LP) are minimally invasive procedures that produce smaller scars and less postoperative pain. These are advantages that appeal to parents…

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Illustration of lungs on blue silhouette of upper chest on black background
How Have Respiratory Outcomes Changed With New Spinal Muscular Atrophy Treatments?
How Have Respiratory Outcomes Changed With New Spinal Muscular Atrophy Treatments? 1024 575 Mary Bates, PhD

Three new therapies are changing the prognosis for spinal muscular atrophy, but long-term monitoring of respiratory outcomes is still necessary.

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Reinforcing Education for Adrenal Insufficiency Self-Management Improves Patient Outcomes
Reinforcing Education for Adrenal Insufficiency Self-Management Improves Patient Outcomes 150 150 Lauren Dembeck

Patients with adrenal insufficiency (AI) receiving daily maintenance corticosteroid replacement therapy may develop signs and symptoms of AI when encountered with physical stress events, such as fever, infection, pain from injury or surgery. Patient education on stress dosing of hydrocortisone at the time of…

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microscopic image of brain organoid
Cerebral Organoids Provide Insight into Human Brain Development and Neurological Disease
Cerebral Organoids Provide Insight into Human Brain Development and Neurological Disease 1024 575 JoAnna Pendergrass, DVM

Correlations between the neuroelectrical maturation and cellular development of cerebral organoids highlight the organoids’ translational and therapeutical potential in early neurodevelopmental disorders. Cerebral organoids are three-dimensional miniature organs that resemble the human brain. Derived from human pluripotent stem cells, cerebral organoids have emerged to…

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Reducing Opioid-Induced Constipation in Patients After Orthopedic Spine Surgery
Reducing Opioid-Induced Constipation in Patients After Orthopedic Spine Surgery 1024 575 JoAnna Pendergrass, DVM

In pediatric patients undergoing orthopedic spine surgery, a step-wise bowel management plan can effectively reduce opioid-induced constipation and unplanned emergency department visits after surgery. Orthopedic spine surgery can generate pain in the immediate post-surgery period. Opioids are needed to mitigate this pain but commonly…

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Young child
Transplant-Free Survival Among Children With Hypoplastic Left Heart Syndrome Undergoing Hybrid Palliation
Transplant-Free Survival Among Children With Hypoplastic Left Heart Syndrome Undergoing Hybrid Palliation 1024 683 Katie Brind'Amour, PhD, MS, CHES

The first long-term evaluation of kids with hypoplastic left heart syndrome undergoing hybrid palliation procedures finds transplant-free survival similar to that of the standard treatment at age 15 years. As one of the few teams in the world almost exclusively performing hybrid palliation surgery…

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The Role of Health Care Voice Assistants During a Pandemic and Beyond
The Role of Health Care Voice Assistants During a Pandemic and Beyond 1024 576 Mary Bates, PhD

The COVID-19 pandemic has magnified the need for telehealth and other digital tools to deliver health care remotely. In a recent commentary published in NPJ Digital Medicine, researchers from Nationwide Children’s examined the state of voice assistants as an emerging tool for remote care delivery and discussed…

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Does Low Baseline Renal Volume Lead to Renal Insufficiency in Children With Cloacal Anomalies?
Does Low Baseline Renal Volume Lead to Renal Insufficiency in Children With Cloacal Anomalies? 1024 683 Lauren Dembeck

According to the results of a recent study published in Urology, children with cloacal anomalies have baseline renal volumes similar to those of children without cloacal anomalies, indicating that the increased risk of renal insufficiency in children with cloacal anomalies appears to be due to…

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Prematurity and Genomics: Can Complications For a Baby Born Preterm Be Predicted?
Prematurity and Genomics: Can Complications For a Baby Born Preterm Be Predicted? 1024 575 Eric Butterman

Complications from being born preterm are the number one cause of death in the world for children under the age of five, says Leif Nelin, MD, division chief of Neonatology at Nationwide Children’s Hospital and professor of Pediatrics at The Ohio State University . But why…

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What Are the Clinical Implications of Crescentic Glomerulonephritis?
What Are the Clinical Implications of Crescentic Glomerulonephritis? 1024 732 Abbie Roth

The Pediatric Nephrology Research Consortium’s most recent study investigates the risk factors for disease progression in children with glomerulonephritis and crescents on kidney biopsy. In patients with glomerulonephritis (GN), the histopathology of the kidney may include crescents, which result from extra-capillary proliferation of cells…

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teen girl using cell phone
Can Smartphone Apps Keep AYA Oncology Patients Plugged in to Their Medication Routines?
Can Smartphone Apps Keep AYA Oncology Patients Plugged in to Their Medication Routines? 1024 684 Natalie Wilson

Studies show that suboptimal medication adherence may be a barrier to increased survival rates among adolescents and young adults with cancer. Anthony Audino, MD, explores the utility of medication adherence apps to meet the unique needs of these patients. The incidence of cancer among…

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Fatty Acid Supplements May Improve Social and Emotional Wellbeing Even in Toddlers
Fatty Acid Supplements May Improve Social and Emotional Wellbeing Even in Toddlers 150 150 Natalie Wilson

Children who were given supplements of Docosahexaenoic acid (DHA), an omega-3 fatty acid that serves as an important building block in babies’ developing brains, were less likely to meet the threshold on a test that determines whether they should be further evaluated for Autism…

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Close up color photo of little boy holding hands on his belly
Exploring the Use of Complementary and Alternative Medicine in Pediatric Functional Abdominal Pain Disorders
Exploring the Use of Complementary and Alternative Medicine in Pediatric Functional Abdominal Pain Disorders 1024 680 Mary Bates, PhD

A survey finds most children with functional abdominal pain disorders use at least one form of complementary and alternative medicine. Functional abdominal pain disorders, which include functional dyspepsia, irritable bowel syndrome and abdominal migraine, are influenced by both biological and psychosocial factors. The underlying…

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Probiotics are Safe and Feasible for Gastrointestinal Symptoms in Autism Spectrum Disorders
Probiotics are Safe and Feasible for Gastrointestinal Symptoms in Autism Spectrum Disorders 150 150 Mary Bates, PhD

A pilot trial found a trend toward improvements in quality of life in patients treated with probiotics. Gastrointestinal disorders and anxiety symptoms are commonly reported in children with autism spectrum disorder (ASD). Recent research in rodent models and neurotypical humans has demonstrated that changing…

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Illustration of lungs on blue silhouette of upper chest on black background
Measuring the Progression of CF in School-Aged Children
Measuring the Progression of CF in School-Aged Children 1024 575 Abbie Roth

A multicenter study utilized chest computed tomography and lung function tests taken repeatedly over two years in school-aged children with mild cystic fibrosis. Understanding disease progression in chronic illnesses is important to managing patients and improving outcomes. For children with cystic fibrosis, it can…

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Device for monitoring glucose placed on girl's arm
Comprehensive Type 1 Diabetes Wellness Score to Help Patients and Providers
Comprehensive Type 1 Diabetes Wellness Score to Help Patients and Providers 1024 683 Katie Brind'Amour, PhD, MS, CHES

A quality improvement effort resulted in the first-known composite score to track multiple clinical indicators of diabetes-related health in patients with Type 1. Despite the traditional use of hemoglobin A1c (HbA1c) as the standard metric for diabetes control, it has its shortcomings, such as…

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Increases in Number and Severity of Suicide-Related Calls to U.S. Poison Control Centers Involving Over-the-Counter Pain Relievers
Increases in Number and Severity of Suicide-Related Calls to U.S. Poison Control Centers Involving Over-the-Counter Pain Relievers 1024 575 Laura Dattner

Experts call for increased regulation, prevention efforts. Over-the-counter (OTC) analgesics such as acetaminophen, ibuprofen and acetylsalicylic acid (aspirin) have long been a staple in households for managing pain, fevers and other common ailments. However, the accessibility of these medications can make them easy to…

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Paying for Telehealth After COVID-19
Paying for Telehealth After COVID-19 1024 535 Jeb Phillips

Telehealth has become an essential part of health care delivery during the COVID-19 pandemic, but its future depends on reimbursement and other financial questions. Just weeks into the COVID-19 pandemic in the United States, health care stakeholders across the country were talking about the…

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Intractable Epilepsy Linked to Brain-Specific Genetic Mutation
Intractable Epilepsy Linked to Brain-Specific Genetic Mutation 1024 794 Lauren Dembeck

DNA replication errors during development are revealed by genomic study. As part of an ongoing, collaborative study between neurologists and genomics experts at Nationwide Children’s Hospital, researchers have identified somatic mosaicism in the resected brain tissues of a child with treatment-resistant, intractable epilepsy. One…

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More to Telehealth Than Meets the Screen
More to Telehealth Than Meets the Screen 1024 535 Abbie Roth

Telehealth has become essential to American health care during the COVID-19 pandemic, but is it really the solution to our biggest access-to-care problems? When COVID-19 ignited stay-at-home orders, public and private insurers quickly relaxed the rules for covering telehealth visits. Health care systems responded…

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Updated Guidance on Oral Food Challenges
Updated Guidance on Oral Food Challenges 1024 575 Mary Bates, PhD

New report offers guidelines and examples for safely performing oral food challenges in clinical practice. Oral food challenges are integral for allergists to diagnose food allergies. In 2009, the Adverse Reactions to Foods Committee within the American Academy of Allergy, Asthma & Immunology published…

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The New Emergency Department — for Behavioral Health
The New Emergency Department — for Behavioral Health 1024 575 Katie Brind'Amour, PhD, MS, CHES

How pediatric hospitals are creatively tackling the unique care needs of a growing population of youths in crisis. From attention deficit disorder to anxiety or depression, mental health conditions affect about 1 in every 5 children. While some of these cases resolve, many children…

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Richard J. Brilli, MD
Obsessed with Zero: Reflections on the Career and Achievements of Richard J. Brili, MD
Obsessed with Zero: Reflections on the Career and Achievements of Richard J. Brili, MD 1024 575 John Barnard, MD

In 2008, Richard “Rich” Brilli, MD, was recruited to Nationwide Children’s Hospital as its chief medical officer. Among other physician executive duties, he was charged with lowering the rate of preventable harm as leader of the hospital’s quality and safety programs. After a few…

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Dr. Jadcherla
Advances in Neonatal GERD
Advances in Neonatal GERD 1024 683 Mary Bates, PhD

New studies from the Jadcherla Lab provide insights into diagnosing, classifying and treating GERD in infants. Differentiating gastroesophageal reflux (GER), which is defined as the passage of gastric contents into the esophagus, from GER disease (GERD), when reflux is associated with troubling symptoms, remains…

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Tissue engineered vascular graft
Findings Show TEVG Stenosis Spontaneously Resolves
Findings Show TEVG Stenosis Spontaneously Resolves 600 400 Katie Brind'Amour, PhD, MS, CHES

The complication that halted a clinical trial for tissue-engineered vascular grafts for children with congenital heart disease may reverse spontaneously without clinical complications. Based on promising laboratory and animal modeling of a biodegradable scaffold seeded with a patient’s own cells, a clinician-scientist research team…

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Pediatric Vital Signs: Measuring and Improving the Health of a Population
Pediatric Vital Signs: Measuring and Improving the Health of a Population 150 150 Jeb Phillips

Nationwide Children’s Hospital and its community partners have begun an “audacious” project to help every child in their region. Despite the best efforts of primary care providers and children’s hospitals, some children do not receive the care they need. Patients can only spend a…

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Diagnosing Adolescent Polycystic Ovary Syndrome
Diagnosing Adolescent Polycystic Ovary Syndrome 1024 673 JoAnna Pendergrass, DVM

New adolescent-specific guidelines provide more precise guidance on diagnosing polycystic ovary syndrome in adolescent females. Polycystic ovary syndrome (PCOS), the most common female reproductive endocrine disorder, presents diagnostic challenges in adolescents, highlighting the need for adolescent-specific diagnostic guidelines for PCOS. “We can’t use the…

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A Collaborative Approach to Preventive Cardiology
A Collaborative Approach to Preventive Cardiology 1024 575 Andrew Tran, MD

Many of us have friends or family members who have had an early heart attack. The event is sudden, unexpected and sobering. Those who recover often make drastic changes to their diet and lifestyle, along with taking medications, and endeavor to delay and undo…

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Assessing the Impact of COVID-19 on Pediatric Cancer Research
Assessing the Impact of COVID-19 on Pediatric Cancer Research 1024 575 Lauren Dembeck

Times of uncertainty offer an opportunity to reflect and reevaluate priorities. “This is a time that warrants resiliency and different approaches for dealing with difficulties, and pediatric cancer research is a field that reflects the resilient spirit of the kids that we are striving…

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Cardiomyopathy in Mothers of Boys With Muscular Dystrophy
Cardiomyopathy in Mothers of Boys With Muscular Dystrophy 1024 670 Mary Bates, PhD

Female carriers of the genetic defect that causes muscular dystrophy in boys show evidence of cardiac fibrosis. An interdisciplinary team from Nationwide Children’s Hospital reports about half of women who carry the genetic defect responsible for muscular dystrophy show evidence of cardiac fibrosis. The…

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Finding the Best Treatment for Stable but Severe Slipped Capital Femoral Epiphysis
Finding the Best Treatment for Stable but Severe Slipped Capital Femoral Epiphysis 1024 575 Katie Brind'Amour, PhD, MS, CHES

A novel comparison of the modified Dunn procedure for children with stable vs unstable SCFE has identified a new target to improve surgical outcomes. The modified Dunn procedure uses a surgical hip dislocation approach to realign the hip joint in adolescents with slipped capital…

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Krabbe Disease Successfully Treated With Gene Therapy in Preclinical Animal Model
Krabbe Disease Successfully Treated With Gene Therapy in Preclinical Animal Model 1024 575 Lauren Dembeck

Gene therapy shows promise for clinical benefit in demyelinating, neurodegenerative disease. Krabbe disease is an aggressive, incurable pediatric neurodegenerative disease caused by mutations in the galactosylceramidase (GALC) gene. Deficiency of the GALC protein activity leads to cytotoxic accumulation of a cellular metabolite called psychosine,…

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How Domestic Violence Affects Child Development
How Domestic Violence Affects Child Development 1024 575 Kristin Crichton, DO, MPH

Domestic violence in the home affects more than just the immediate victim. If children are present to see and/or hear it, it takes a toll on their healthy, natural development unless they receive support to help them cope and heal. Children exposed to violence…

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Managing Lymphatic Flow Disorders: Expanding Care Through Collaboration
Managing Lymphatic Flow Disorders: Expanding Care Through Collaboration 1024 683 Abbie Roth

Alteration in the Lymphatic System Leading to Flow Disorders The lymphatic system plays a critical role in circulating a clear to yellow-colored fluid called lymph, which contains proteins, immune factors and cells throughout the body. It is also responsible for collecting fats and fat-soluble…

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CMS Approves New Code for Adult Congenital Heart Disease Subspecialty
CMS Approves New Code for Adult Congenital Heart Disease Subspecialty 1024 683 Katie Brind'Amour, PhD, MS, CHES

The official billing code will enable growth of the subspecialty and is expected to result in improved patient care. In March, the Centers for Medicare and Medicaid Services (CMS) approved a unique code for subspecialists in adult congenital heart disease (ACHD). The code will…

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Can a Kidney Failure Risk Equation Validated in Adults Predict Kidney Failure in Children?
Can a Kidney Failure Risk Equation Validated in Adults Predict Kidney Failure in Children? 1024 575 Lauren Dembeck

Novel disease-specific biomarkers are needed to improve prediction models in pediatric disease. Obstructive uropathy is a frequent cause of kidney injury in children, and it is estimated to cause approximately one-sixth of pediatric kidney failure cases in North America. However, risk equations to predict…

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Improving Guidelines for Pediatric Hypertension Diagnosis
Improving Guidelines for Pediatric Hypertension Diagnosis 1024 683 Natalie Wilson

It is vital to accurately recognize and diagnose hypertension in children to avoid long term morbidity and allow for appropriate treatment. A recent pilot study highlights additional diagnostic criteria for clinicians to consider. Pediatric hypertension, or high blood pressure (BP), has become increasingly common…

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Redo Surgery After Anorectal Malformation Repair Can Improve Functional Outcomes
Redo Surgery After Anorectal Malformation Repair Can Improve Functional Outcomes 1024 575 Mary Bates, PhD

A reoperation can improve continence and quality of life in children still struggling with fecal incontinence following ARM repair. In a new study, researchers from Nationwide Children’s Hospital show that redo surgeries are   safe and may be an effective option for patients with fecal…

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When Should Breastfed Babies Be Supplemented?
When Should Breastfed Babies Be Supplemented? 1024 575 Vanessa Shanks

This question has received increasing attention in the last several years, especially when considering supplementation for late preterm and early term babies. As more hospitals focus on promoting and supporting breastfeeding, supplementation rates have decreased for infants in the newborn nursery. However, there has…

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New Newborn Screening Approach Allows for Earlier Detection of Menkes Disease
New Newborn Screening Approach Allows for Earlier Detection of Menkes Disease 1024 575 Natalie Wilson

Targeted next generation DNA sequencing can enable improved clinical outcomes for any genetic disorder not detectable through other biochemical newborn screening methods. Menkes disease is a rare, X-linked recessive pediatric disease caused by gene mutations of the copper transporter gene, ATP7A, leading to low levels…

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Colorful illustration of gene therapy in action
An Expanded, Multicenter Look at Gene Therapy for Spinal Muscular Atrophy
An Expanded, Multicenter Look at Gene Therapy for Spinal Muscular Atrophy 1024 575 Mary Bates, PhD

New study confirms safety and efficacy in children under two years old. In May 2019, the U.S. Food and Drug Administration (FDA) approved a gene replacement therapy for the inherited, progressive neuromuscular disease 5q-linked spinal muscular atrophy (SMA). Approval included all children with SMA under the…

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Best Practices for Patient-Centered Contraception Counseling About the Etonogestrel Implant
Best Practices for Patient-Centered Contraception Counseling About the Etonogestrel Implant 1024 683 JoAnna Pendergrass, DVM

Patient-centered, age-appropriate contraception counseling helps health care providers educate adolescents about the etonogestrel implant and other contraceptive methods. Preventing unplanned pregnancies in adolescents with effective and easy-to-use contraception is key to ensuring that adolescents do not become parents before they are ready. Nexplanon, the…

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Novel Genetic Variant Identified in CARMIL2 Deficiency
Novel Genetic Variant Identified in CARMIL2 Deficiency 1024 575 Lauren Dembeck

International program facilitates the diagnosis of a rare immunodeficiency in two children caused by a novel genetic variant. A multidisciplinary team of physicians and scientists at Nationwide Children’s Hospital have identified a novel loss-of-function variant causing CARMIL2 deficiency, an inborn error of immunity, in…

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Parent and provider at child's hospital bed
How Do Parents and Surgeons Evaluate Treatment Options for Uncomplicated Appendicitis?
How Do Parents and Surgeons Evaluate Treatment Options for Uncomplicated Appendicitis? 1024 575 Natalie Wilson

The most recent in a series of publications on management of uncomplicated appendicitis showed patients and families cited the same concerns when electing either surgery or nonoperative treatment. Antibiotics alone have been shown to successfully treat uncomplicated appendicitis in children. But patients, families and…

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Novel Intervention Helps Infants With Cerebral Palsy Develop Arm and Hand Function
Novel Intervention Helps Infants With Cerebral Palsy Develop Arm and Hand Function 1024 683 Abbie Roth

A new NIH-funded randomized controlled trial shows that an intervention combining a patented soft restraint harness, therapist coaching and parent training increases reach smoothness, fine motor skills and tactile sensation in the more-affected upper extremity. For the first time in infants with CP under…

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Additions to Neuro-Oncology Team Bring CONNECT Consortium to Nationwide Children’s
Additions to Neuro-Oncology Team Bring CONNECT Consortium to Nationwide Children’s 1024 575 Abbie Roth

Maryam Fouladi, MD, has been named the co-executive director of the Pediatric Neuro-Oncology Program at Nationwide Children’s Hospital and Rachid Drissi, PhD, will join the Center for Childhood Cancer and Blood Diseases in the Abigail Wexner Research Institute as a principal investigator focused on cellular aging and telomerase inhibitors to…

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COVID-19 in Children With Congenital Heart Disease
COVID-19 in Children With Congenital Heart Disease 1024 683 Mary Bates, PhD

Data are still emerging, but COVID-19 – and the subsequent inflammatory syndrome sometimes seen in children – could have serious cardiac impacts. In a recent review article, researchers from institutions including Nationwide Children’s Hospital outlined the impact of COVID-19 in pediatric patients with heart…

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Choking Education an Important Element of Care for Prader-Willi Syndrome Families
Choking Education an Important Element of Care for Prader-Willi Syndrome Families 1024 575 Katie Brind'Amour, PhD, MS, CHES

Choking prevention and intervention education offer a simple way to address this common cause of death among PWS patients. Individuals with Prader-Willi Syndrome (PWS) suffer from poor oral muscle control, generalized low muscle tone that can make it hard to swallow properly, a poor…

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Combining Multiple Surgical Procedures Helps Children With Patellar Instability Return to Normal Activities
Combining Multiple Surgical Procedures Helps Children With Patellar Instability Return to Normal Activities 1024 575 JoAnna Pendergrass, DVM

A four-in-one surgical procedure demonstrates effectiveness in treating pediatric lateral patellar instability and helping children return to their normal pre-surgical activities. Lateral patellar instability in the skeletally immature knee is a complex orthopedic condition with myriad treatment challenges. Classified as obligatory, fixed (congenital) or…

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Midwest Pediatric Surgery Consortium Finds Antibiotics Alone Successfully Treat Uncomplicated Appendicitis in Children
Midwest Pediatric Surgery Consortium Finds Antibiotics Alone Successfully Treat Uncomplicated Appendicitis in Children 1024 822 Natalie Wilson

New research expands on a 2015 pilot study to demonstrate that nonoperative management of uncomplicated appendicitis is a safe and effective option in a variety of healthcare systems. Appendicitis is the most common cause for emergency abdominal surgery in childhood, affecting 80,000 children in…

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Race Is a Risk Factor for Postoperative Death in Apparently Healthy Children in United States
Race Is a Risk Factor for Postoperative Death in Apparently Healthy Children in United States 1024 683 Abbie Roth

African American children were nearly 3.5 times more likely to die within 30 days after surgery, compared to white peers. In a new study, published in Pediatrics, researchers have shown that being African American was strongly associated with a higher risk of postoperative complications and mortality…

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Prevention and Treatment of Early-Onset Sepsis in Newborns
Prevention and Treatment of Early-Onset Sepsis in Newborns 1024 575 Mary Bates, PhD

Continued surveillance is needed to monitor pathogen distribution and antibiotic resistance. Early-onset sepsis remains a potentially fatal condition among newborns, particularly pre-term infants. According to a new study published in JAMA Pediatrics, ongoing surveillance is required to optimize prevention and treatment strategies. The study included…

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When the Neighborhood Improves, Does Pediatric Health Care Utilization Decrease?
When the Neighborhood Improves, Does Pediatric Health Care Utilization Decrease? 1024 683 Jeb Phillips

A new study finds decreased rates of high-cost care after a community development initiative, which may exceed decreases in similar neighborhoods. More than a decade into the community development initiative called Healthy Neighborhoods Healthy Families, the 30-block Southern Orchards neighborhood on Columbus’ South Side had…

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Illustration showing the precise pattern of a biofilm - a perfect, 3D matrix
Targeting Bacterial Biofilm Linchpin Prevents and Treats Recalcitrant Biofilm-Mediated Infections
Targeting Bacterial Biofilm Linchpin Prevents and Treats Recalcitrant Biofilm-Mediated Infections 1024 575 Abbie Roth

A new study highlights two approaches with substantive efficacy and potential for broad application to combat biofilm-mediated diseases. Chronic and recurrent bacterial diseases are treatment-resistant due to the ability of the pathogens to establish biofilms, which act as fortresses built of extracellular DNA and…

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