Optimizing Prenatal and Neonatal Care for Infants With Treatable Rare Diseases

Learn More

Unraveling the Genetic Mystery Behind a Rare Pediatric Disease

Read More

New National “Vital Signs” to Measure Population-wide Pediatric Health

Find Out More
Close
Enter your
text here
Disrupting Mitochondrial Pyruvate Uptake in Kidney Tubular Cells Bolsters Antioxidant Responses and Protects From Acute Kidney Injury
 Disrupting Mitochondrial Pyruvate Uptake in Kidney Tubular Cells Bolsters Antioxidant Responses and Protects From Acute Kidney Injury 1024 732 Jessica Nye, PhD
By: Jessica Nye, PhD

Blocking mitochondrial pyruvate uptake in the kidney was found to upregulate oxidant defense systems, ultimately mitigating the effects of an acute kidney injury (AKI). “The kidney has these reabsorption units, tubular cells, that reabsorb glucose, amino acids and specific ions. These units spend a…

read more
Uncovering Racial and Ethnic Disparities in Pediatric Sleep Research
 Uncovering Racial and Ethnic Disparities in Pediatric Sleep Research 1024 683 Erin Gregory
By: Erin Gregory

In a recent study published in the Journal of Biomedical Informatics, Mattina Davenport, PhD, principal investigator in the Center for Child Health Equity and Outcomes Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, explores the impact of biases in clinical documentation…

read more
Novel Brace for Hip Immobilization After Bladder Exstrophy Repair
 Novel Brace for Hip Immobilization After Bladder Exstrophy Repair 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

An innovative orthopedic brace allows families to avoid the disadvantages of casts, external fixators and traction devices after bladder exstrophy surgery. After bladder exstrophy repair — a complicated surgery to move a baby’s bladder from outside of the abdomen to the inside — postoperative…

read more
Featured Researcher – Christopher Bartlett, PhD
 Featured Researcher – Christopher Bartlett, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Throughout Dr. Bartlett’s career, he has dedicated his time to the development of innovative statistical methods to enhance our understanding of childhood development, from pre-term birth to young adulthood. Specializing in the design and application of data analytic paradigms, his work significantly contributes to…

read more
Does Coinfection Lead to Longer Ventilation Times?
 Does Coinfection Lead to Longer Ventilation Times? 1024 683 Pam Georgiana
By: Pam Georgiana

New multicenter study evaluates treatments and diagnoses of respiratory infections in young patients.    Lower respiratory tract infection, or bronchiolitis, is one of the most common reasons for intensive care unit (ICU) admissions and mechanical ventilation in children younger than two years old. Despite…

read more
Demystifying Machine Learning With AutoML
 Demystifying Machine Learning With AutoML 1024 683 Abbie Miller
By: Abbie Miller

A Nationwide Children’s Hospital team from the Office of Data Sciences recently won the Advanced ML tier in the precisionFDA Automated Machine Learning (AutoML) App-a-thon Challenge: Democratizing and Demystifying Artificial Intelligence (AI). Each year, the FDA hosts challenges centered around data science and bioinformatics.…

read more
person in scrubs holding a baby
Early Detection and Multidisciplinary Care: Successful Management of Duodenal Atresia
 Early Detection and Multidisciplinary Care: Successful Management of Duodenal Atresia 1024 737 Pam Georgiana
By: Pam Georgiana

The team in the Fetal Center at Nationwide Children’s Hospital shares their comprehensive approach for best possible outcomes.  When a routine ultrasound reveals two enlarged, fluid-filled bubbles in the baby’s abdomen, known as the “double bubble” sign, pregnant patients and their families often feel…

read more
Children on Pancreatic Enzymes Experience Fewer Acute Pancreatitis Episodes
 Children on Pancreatic Enzymes Experience Fewer Acute Pancreatitis Episodes 1024 429 Mary Bates, PhD
By: Mary Bates, PhD

Pancreatic enzyme therapy benefitted patients with pancreatic-sufficient acute recurrent pancreatitis and chronic pancreatitis.  A new study shows that children with both acute recurrent pancreatitis and chronic pancreatitis had significantly lower incidence of acute pancreatitis episodes per year after starting pancreatic enzyme therapy. The findings…

read more
sleeping infant
Comparing Outcomes Between Direct and ED Admissions for Neonatal Hyperbilirubinemia
 Comparing Outcomes Between Direct and ED Admissions for Neonatal Hyperbilirubinemia 1024 681 Pam Georgiana
By: Pam Georgiana

Does the method of admission affect care for patients with neonatal hyperbilirubinemia? Neonatal hyperbilirubinemia, with jaundice as its primary symptom, can be scary for parents of newborns. This condition requires a blood test to measure bilirubin levels for diagnosis. Despite its concerning appearance, hyperbilirubinemia…

read more
Featured Researcher: Henry Xiang, MD, MPH, PhD, MBA
 Featured Researcher: Henry Xiang, MD, MPH, PhD, MBA 150 150 Alaina Doklovic
By: Alaina Doklovic

Dr. Henry Xiang is the founding Director of the Center for Pediatric Trauma Research of the Abigail Wexner Research Institute at Nationwide Children’s Hospital. He is also a tenured full professor at the Ohio State University College of Medicine. Dr. Xiang directs the Pilot…

read more
Clinical Differences in Early-Onset and Adolescent-Onset Rumination Syndrome
 Clinical Differences in Early-Onset and Adolescent-Onset Rumination Syndrome 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Study suggests rumination syndrome in young children is less severe initially and improves over time.   Early-onset rumination syndrome is clinically distinct from adolescent-onset rumination syndrome, according to a new report out of Nationwide Children’s Hospital. In this largest study of pediatric patients with…

read more
What Pediatricians Need to Know About Over-the-Counter Oral Contraception
 What Pediatricians Need to Know About Over-the-Counter Oral Contraception 1024 683 Elise Berlan, MD, MPH and Caroline Weingart, MD
By: Elise Berlan, MD, MPH and Caroline Weingart, MD

The first over-the-counter contraceptive pill – the Opill® – is currently available in retail outlets and online. The FDA approved the sale of Opill® (nongestural 0.075mg), the first over-the-counter birth control pill without age restrictions, in July 2023. Now, nearly a year later, it…

read more
Understanding How Youths With Autism Make the Move to Adult Health Care
 Understanding How Youths With Autism Make the Move to Adult Health Care 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Study finds overlap in the utilization of pediatric and adult health care is the norm. In a new study, researchers from Nationwide Children’s Hospital and The Ohio State University teamed up to better understand how adolescents and young adults with autism navigate the transition…

read more
Refining the Role of Basal Urothelial Cells in Bladder Development
 Refining the Role of Basal Urothelial Cells in Bladder Development 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Basal keratin 5 urothelial cells (K5-UCs) were found to be age-restricted progenitors in bladders and their progenitor potential could be rescued by exogenous proliferative cues.   “The identity of the bladder urothelium progenitor is controversial and confounded by slow turnover, and a low mitotic…

read more
How Does Hodgkin Lymphoma Differ With Age?
 How Does Hodgkin Lymphoma Differ With Age? 150 150 Pam Georgiana
By: Pam Georgiana

A new study reveals age-related differences in pathology and medical management. When Anthony N. Audino, MD, a pediatric oncologist in the Division of Pediatric Hematology/Oncology/BMT at Nationwide Children’s, first met a preschool-aged patient with Hodgkin lymphoma, he was surprised. “It was startling to see…

read more
New Study Demonstrates Potential for a Gene Therapy for Vanishing White Matter Disease
 New Study Demonstrates Potential for a Gene Therapy for Vanishing White Matter Disease 1024 552 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The research, conducted in mouse models, shows promising safety and efficacy for a currently incurable, life-limiting condition. Researchers at Nationwide Children’s Hospital have confirmed initial safety and efficacy data for a gene supplementation therapy for Vanishing White Matter (VWM) disease in mouse models. Testing…

read more
Teen girl with backpack
Breaking the Cycle of Chronic Pain and Discomfort in Young Patients
 Breaking the Cycle of Chronic Pain and Discomfort in Young Patients 1024 575 Pam Georgiana
By: Pam Georgiana

The Comfort Ability Program at Nationwide Children’s brings specialized care to patients with chronic pain and discomfort. In January 2023, the wait for patients to see a pediatric pain psychologist at Nationwide Children’s was approximately nine months. This delay was due to the limited…

read more
Investigating a Minimally Invasive Alternative to Surgery for Transverse Aortic Arch Obstruction
 Investigating a Minimally Invasive Alternative to Surgery for Transverse Aortic Arch Obstruction 150 150 Erin Gregory
By: Erin Gregory

A new study evaluates the safety and efficacy of percutaneous balloon-expandable stents for transverse aortic arch obstruction, a form of congenital heart disease. A new study published in Circulation: Cardiovascular Interventions, conducted by Arash Salavitabar, MD, FSCAI, FPICS, FACC, FAAP, a congenital interventional cardiologist…

read more
School-Based Health Equity Initiative Improves T1D Management in Students
 School-Based Health Equity Initiative Improves T1D Management in Students 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

The Diabetes and School Health program is a school-based health equity initiative that has helped improve Type 1 diabetes management for students and increase confidence among school staff and caregivers in providing diabetes care. Children with Type 1 diabetes (T1D) face myriad daily challenges…

read more
Kevin Klingele, MD
Surgical Repair of Traumatic Hip Dislocations With Acetabular “Fleck” Signs
 Surgical Repair of Traumatic Hip Dislocations With Acetabular “Fleck” Signs 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Surgical hip dislocation with open labral repair produced excellent clinical outcomes in pediatric patients. The acetabular “fleck” sign is a radiographic finding indicative of significant labral injury in young patients with traumatic hip dislocations. In a new study, researchers from Nationwide Children’s Hospital show…

read more