Clinical Genomics: From Research to Reality

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Single Ventricle, Many Research Angles

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Setting the Standard for Cloacal Malformation Management

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How Accurate is Pediatric Bipolar Disorder Testing?
 How Accurate is Pediatric Bipolar Disorder Testing? 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Symptom-based bipolar disorder tests accurately diagnose pediatric bipolar disorder, with parent-reported tests being among the most accurate. According to a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of bipolar disorder index tests, parent-reported tests are more accurate than self- or teacher-reported…

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Improving Pediatric Clinical Trials by Incorporating Parent Input
 Improving Pediatric Clinical Trials by Incorporating Parent Input 1024 681 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A Parent Council in an ongoing pediatric stroke rehabilitation trial provides important insights into how parent involvement can inform and enrich the research process. While the need for diverse and inclusive clinical trial populations has been acknowledged for the last few decades, the value…

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Treatment for Substance Use Disorder in the Synthetic Opioid Era
 Treatment for Substance Use Disorder in the Synthetic Opioid Era 1024 683 Alaina Doklovic
By: Alaina Doklovic

Medications for opioid use disorder (MOUD) is the recommended first line treatment for adolescents with opioid use disorder (OUD), the chronic use of opioids and/or synthetic opioids that causes clinically significant distress or impairment. Buprenorphine is the most accessible medication for MOUD. Studies show…

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Introducing the Fourth Wave of the Drug Epidemic
 Introducing the Fourth Wave of the Drug Epidemic 1024 575 Alaina Doklovic
By: Alaina Doklovic

Drug overdoses and poisoning are the third leading cause of pediatric death. In recent years, there has been a dramatic increase in the number of fentanyl-related overdoses, with 15-19 year olds being the most affected. In the Ohio illicit drug supply, as shared by…

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Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are
 Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are 1024 768 Alaina Doklovic
By: Alaina Doklovic

According to the U.S. Department of Health and Human Services, fewer than 10% of adolescents with a substance use disorder receive care. Of those 10%, many are not ready to engage in treatment. They are often brought in by a parent or guardian. Harm…

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Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research
 Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research 1024 537 Abbie Miller
By: Abbie Miller

The ECMO Repository at Nationwide Children’s Hospital is the first and larges of its kind in children’s hospitals in the United States. In December 2014, The Heart Center and Center for Cardiovascular Research at Nationwide Children’s Hospital launched an initiative to prospectively collect biologic…

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Filling the Pipeline for Behavioral Health Professionals
 Filling the Pipeline for Behavioral Health Professionals 150 150 Abbie Miller and Shannon Caldwell
By: Abbie Miller and Shannon Caldwell

Brittany Schaffner, IMFT-S, LPCC-S, shares how a new college course and professional resources are helping more students meet the need for behavioral health care in pediatrics. Tell us about your role at Nationwide Children’s Hospital. I’m a behavioral health clinical training supervisor here at…

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Nephrotoxic-Associated Acute Kidney Injury (NAKI) Is Avoidable
 Nephrotoxic-Associated Acute Kidney Injury (NAKI) Is Avoidable 375 280 Pam Georgiana
By: Pam Georgiana

Quality improvement initiative at Nationwide Children’s Hospital leads to significant reductions in NAKI. Nephrotoxic-associated acute kidney injury (NAKI) — an under-recognized but serious risk in pediatric hospital care — affects up to 25% of hospitalized children. It occurs when medications or toxins reduce kidney…

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Meet Prof Eileen Africa: Fulbright Scholar and Sports Medicine Expert
 Meet Prof Eileen Africa: Fulbright Scholar and Sports Medicine Expert 1024 683 Abbie Miller
By: Abbie Miller

Prof Eileen Africa, an associate professor in the Division of Movement Science and Exercise Therapy in the Department of Exercise, Sport, and Lifestyle Medicine at Stellenbosch University in South Africa and a Fulbright scholar, recently visited Nationwide Children’s to work with Dr. James MacDonald…

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Meet Antonio Cabrera, MD, Chief of Cardiology at Nationwide Children’s Hospital
 Meet Antonio Cabrera, MD, Chief of Cardiology at Nationwide Children’s Hospital 150 150 Abbie Miller
By: Abbie Miller

Antonio Cabrera, MD, FAAP, FAHA, FACC, FHFSA, is the division chief of cardiology and co-director of the Heart Center. He is a professor of pediatrics at The Ohio State University and currently holds the Nationwide George H. Dunlap Endowed Chair in Pediatric Cardiology. Previously,…

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Bridging the Fertility Awareness Gap in Adolescents With PCOS
 Bridging the Fertility Awareness Gap in Adolescents With PCOS 1024 683 Pam Georgiana
By: Pam Georgiana

Assessing knowledge, concerns and quality of life to inform early clinical counseling While polycystic ovary syndrome (PCOS) is common in adolescent females, little is known about how the potential for long-term complications like infertility affect young patients’ well-being. Research with adult PCOS patients has…

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A Novel EEG Evaluation Method for Children With Infantile Spasms
 A Novel EEG Evaluation Method for Children With Infantile Spasms 1024 677 Lauren Dembeck
By: Lauren Dembeck

Clinician-researchers have developed a rapid training program to learn the BASED score, a novel EEG evaluation method. The easily accessible training program allows clinicians to reliably determine the response to treatment. Infantile epileptic spasms syndrome is a severe form of early childhood epilepsy. Onset…

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Baby in NICU
The Nurse Perception of Infant Condition (NPIC) Scale: A Tool for NICU Nurses to Evaluate Neonatal Well-being
 The Nurse Perception of Infant Condition (NPIC) Scale: A Tool for NICU Nurses to Evaluate Neonatal Well-being 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital developed a tool for nurses to use when assessing a neonate’s wellbeing, called the Nurse Perception of Infant Condition (NPIC) Scale. “For neonates, it was hard to find a scale that was relevant and would allow us to measure…

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Establishing Meaningful Clinical Outcome Measures for Gastrointestinal Symptoms in Cystic Fibrosis
 Establishing Meaningful Clinical Outcome Measures for Gastrointestinal Symptoms in Cystic Fibrosis 1024 683 Lauren Dembeck
By: Lauren Dembeck

Understanding the minimal clinically important differences of PROMs is crucial in interpreting results in clinical trials. Patient-reported outcome measures (PROMs) are a set of standardized questions that directly assess the patient’s perspective of their symptoms and quality of life to better understand their experience…

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Black Youth Experience Disparities in Care for First-Episode Psychosis in Ohio
 Black Youth Experience Disparities in Care for First-Episode Psychosis in Ohio 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Black youth enrolled in Medicaid were more likely to experience a first-episode psychosis (FEP) event and be diagnosed with schizophrenia spectrum disorder but less likely to receive key early intervention services than White youth.   “It’s been known for a long time, especially in…

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Close up color photo of little boy holding hands on his belly
Childhood-Onset Rumination Syndrome: Insights from 15 Years of Research
 Childhood-Onset Rumination Syndrome: Insights from 15 Years of Research 1024 680 Pam Georgiana
By: Pam Georgiana

Education is needed to improve diagnostic timelines and treatment outcomes for pediatric patients. Childhood-onset rumination syndrome presents significant diagnostic challenges, even for gastroenterologists. Physicians often misdiagnose the symptoms as gastroesophageal reflux disease. Initial treatments frequently fail, leading to delays in accurate diagnosis. Patients can…

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Exploring Pediatric Diffuse Alveolar Hemorrhage: Causes and Outcomes
 Exploring Pediatric Diffuse Alveolar Hemorrhage: Causes and Outcomes 1024 575 Erin Gregory
By: Erin Gregory

In a groundbreaking study published in Pediatric Pulmonology, Sarah P. Cohen, MD, MS, and Katelyn Krivchenia, MD — both from Nationwide Children’s Hospital — along with their team investigate diffuse alveolar hemorrhage (DAH) in children, a rare but life-threatening condition involving bleeding into the lungs.…

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Challenges in Clinical Decision-Making for Patients with Spinal Muscular Atrophy
 Challenges in Clinical Decision-Making for Patients with Spinal Muscular Atrophy 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

There are three approved genetic therapies for SMA, but little guidance in treatment selection. Spinal muscular atrophy (SMA) was once a leading cause of inherited infant death in the United States. Today, there are three genetic therapies approved by the Food and Drug Administration…

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Making the Case for Interdisciplinary BPD Care
 Making the Case for Interdisciplinary BPD Care 150 150 Abbie Miller
By: Abbie Miller

A new review highlights benefits of interdisciplinary BPD management and offers advice on how program development. Bronchopulmonary dysplasia (BPD) affects more than 40% of preterm infants and is the most common lung disease in infancy. There are long term consequences and comorbidities associated with…

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Color image of young boy asleep in bed
Pediatric Obstructive Sleep Apnea Diagnosis and Treatment: What You Need to Know
 Pediatric Obstructive Sleep Apnea Diagnosis and Treatment: What You Need to Know 1024 575 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Pediatric obstructive sleep apnea, a common condition in children, is definitively diagnosed with sleep studies and can be treated through various modalities, depending on disease severity. Obstructive sleep apnea (OSA) is a disorder characterized by snoring, gas exchange abnormalities and disrupted sleep, with near-complete…

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