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Researchers Create Public Database of Nearly 40,000 Control Samples for Genetic Association Studies
 Researchers Create Public Database of Nearly 40,000 Control Samples for Genetic Association Studies 1024 575 Lauren Dembeck
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Genetic association studies provide powerful means of discovering relationships between genetic variants and disease risk. However, these studies require enrolling very large numbers of individuals with the disease (cases) and healthy individuals (controls) as well as collecting genetic data for all of those participants…

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New Zebrafish Pipeline Enables Functional Evaluation of Novel, Rare, Fusion-Oncogenes in vivo
 New Zebrafish Pipeline Enables Functional Evaluation of Novel, Rare, Fusion-Oncogenes in vivo 1024 683 Jessica Nye, PhD
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An innovative method that uses a zebrafish model to rapidly study novel fusion-oncogenes in vivo has been developed by investigators at Nationwide Children’s Hospital.   Fusion oncogenes are frequently observed in pediatric cancers. These fusion oncogenes are typically caused by a chromosomal translocation that…

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Meet Toni Pearson, MD: Pediatric Movement Disorders Expert
 Meet Toni Pearson, MD: Pediatric Movement Disorders Expert 150 150 Pam Georgiana
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Toni S. Pearson, MD, joined Nationwide Children’s in 2022 as an attending pediatric neurologist and professor of pediatrics at The Ohio State University College of Medicine. She specializes in childhood movement disorders, such as dystonia, chorea, parkinsonism, ataxia, myoclonus, tremors, tics, and spasticity. Dr.…

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Interactions Between Invading Tumor and Lung Cells Permit Metastatic Lung Colonization of Osteosarcoma
 Interactions Between Invading Tumor and Lung Cells Permit Metastatic Lung Colonization of Osteosarcoma 150 150 Lauren Dembeck
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Survival signals elicited by lung tissue interactions promote osteosarcoma metastasis and represent a promising target for clinical trials in both human and canine patients.   Osteosarcoma, the most common primary tumor of bone, occurs predominantly in children, teens and young adults. Patient survival largely…

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Featured Researcher – Amrik Khalsa, MD
 Featured Researcher – Amrik Khalsa, MD 150 150 Alaina Doklovic
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Amrik Khalsa, MD, is a physician and principal investigator in the Center for Child Health Equity and Outcomes Research (CCHEOR) in the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital. He is dual medically trained and board certified in Internal Medicine and Pediatrics…

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Kids With Concussions Need Specialized Assessment and Care
 Kids With Concussions Need Specialized Assessment and Care 1024 683 Sean Rose, MD
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Learn why cutting-edge care and research specifically for children matters. The 2020 National Health Interview Survey reported that 6.8% of children experience symptoms of a concussion or brain injury in their lifetime. However, only 3.9% had received a diagnosis or treatment of a concussion…

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Transforming Treatment for Paratesticular Rhabdomyosarcoma in Adolescents through Robotics
 Transforming Treatment for Paratesticular Rhabdomyosarcoma in Adolescents through Robotics 1024 683 Erin Gregory
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Retroperitoneal lymph node dissection (RPLND) has been a crucial component of treating testicular and paratesticular cancers for over a century. Recent advancements in minimally invasive techniques, such as robotic-assisted methods, have expanded the applicability of RPLND, offering reduced morbidity and faster recovery. However, concerns…

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Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2
 Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2 150 150 Lauren Dembeck
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Tuberous sclerosis complex (TSC) is a devastating genetic disease that affects nearly 1 in every 5,500 newborns and approximately 2 million people worldwide. The disease is characterized by the formation of non-malignant tumors throughout multiple organs, including the kidney, lungs, eyes, and heart, but…

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What Are the Risk Factors for Recurrent Wheezing in Late Preterm Infants?
 What Are the Risk Factors for Recurrent Wheezing in Late Preterm Infants? 1024 683 Pam Georgiana
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A collaboration between a pulmonary medicine fellow and allergy and immunology expert identifies four risk factors associated with recurrent wheezing in these patients.   When Brooke R. Gustafson, MD, a member of the Section of Pediatric Pulmonary Medicine at Nationwide Children’s and an assistant…

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GERD Less Likely Cause of Irritability and Back Arching in Infants
 GERD Less Likely Cause of Irritability and Back Arching in Infants 1024 683 Lauren Dembeck
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In infants, frequent irritability and arching of the back can be concerning to parents and providers. These symptoms are often attributed to gastroesophageal reflux disease (GERD), a disease in which the lower esophageal sphincter does not close or opens at the wrong time. As…

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Ensuring All Children Have Access to Behavioral Health Care
 Ensuring All Children Have Access to Behavioral Health Care 531 213 Pam Georgiana
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New study reports the results of integrating psychologists into primary care clinics. Cody A. Hostutler, PhD, a psychologist in the Department of Pediatric Psychology and Neuropsychology at Nationwide Children’s, is concerned about the mental health of the children and adolescents visiting primary care centers.…

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Accelerating Pediatric Medical Device Innovation 
 Accelerating Pediatric Medical Device Innovation  150 150 Erin Gregory
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The Midwest Pediatric Device Consortium (MPDC) is a unique collective led by Nationwide Children’s Hospital and The Ohio State University, designed to facilitate the development, production, and distribution of pediatric medical devices. Comprising a diverse group of leaders in universities, healthcare systems, community organizations,…

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Researchers Create a Stem Cell Line to Study Alagille Syndrome
 Researchers Create a Stem Cell Line to Study Alagille Syndrome 1024 683 Mary Bates, PhD
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The patient-derived iPSCs have a mutation affecting the Notch signaling pathway. Researchers at Nationwide Children’s have developed an induced pluripotent stem cell (iPSC) line derived from a patient with Alagille syndrome, a multisystem genetic disease. Like the majority of patients with Alagille syndrome, the…

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Frequency of Pediatric Encounters Predicts Timely Transfer to Adult Care for Youth With Autism
 Frequency of Pediatric Encounters Predicts Timely Transfer to Adult Care for Youth With Autism 1024 683 JoAnna Pendergrass, DVM
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For adolescents and young adults with autism, the total number of pediatric appointments is strongly correlated with a timely transfer to adult care, while the reason for this correlation remains to be elucidated.   In a recent study, Laura Hart, MD, a pediatrician at…

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Rural-Urban Differences in Social and Emotional Protective Factors
 Rural-Urban Differences in Social and Emotional Protective Factors 1024 683 Mary Bates, PhD
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Efforts to improve child health and flourishing should consider communities’ unique sources of support. Children living in rural areas experience well-documented health and health care disparities compared to those living in urban areas. Protective factors, such as social connectedness and social engagement, also vary…

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coronavirus
A Novel Measles-Mumps Vaccine Delivers Multiple SARS-CoV-2 Spike Variants by Nose Drop
 A Novel Measles-Mumps Vaccine Delivers Multiple SARS-CoV-2 Spike Variants by Nose Drop 1024 512 Jessica Nye, PhD
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Investigators from Nationwide Children’s Hospital and The Ohio State University modified the measles and mumps viruses from the measles-mumps-rubella (MMR) vaccine to deliver three SARS-CoV-2 spike protein variants to the respiratory tract as an effective vaccine candidate. “We’re calling this a trivalent vaccine because…

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What Other Screening Tests Should be Administered to Celiac Disease Patients?
 What Other Screening Tests Should be Administered to Celiac Disease Patients? 1024 575 Mary Bates, PhD
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Eliminating some labs may reduce costs without impacting quality of patient care. Researchers from Nationwide Children’s Hospital found that several screening laboratory tests currently recommended for pediatric patients newly diagnosed with celiac disease are infrequently abnormal. In a new study published in the Journal…

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Surgical Hip Dislocation as a Treatment Modality in Children and Adolescents
 Surgical Hip Dislocation as a Treatment Modality in Children and Adolescents 150 150 Pam Georgiana
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What was once a complicated surgery has now become a safe and effective way to treat many hip conditions.   Treatment of hip conditions and disorders in children and adolescents can be tricky. Doctors must have a thorough understanding of the patient’s anatomy, growth…

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Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas
 Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas 1024 601 Pam Georgiana
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ACE treatment can lead to long-term clinical and quality-of-life improvement in children with defecation disorders.   For about 10-15% of the children who experience chronic constipation or other defecation disorders, the usual behavioral modification treatments and oral medications don’t help. These disorders can significantly…

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What Treatment is Best for Preventing Kidney Complications in STEC Infections?
 What Treatment is Best for Preventing Kidney Complications in STEC Infections? 150 150 Mary Bates, PhD
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Nationwide Children’s Hospital is participating in a multicenter trial to determine the optimal way to treat children with high-risk STEC infections. Shiga toxin-producing E. coli (STEC) infections can lead to systemic disease affecting multiple organ systems, including the kidneys. Up to 20% of children…

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