Smiling baby with Down syndrome
Changing the Odds: Survival Trends in Children With Down Syndrome and Congenital Heart Defects
Changing the Odds: Survival Trends in Children With Down Syndrome and Congenital Heart Defects 1024 683 Pam Georgiana

About half of the children born with Down syndrome also have congenital heart defects (CHD). As a transplant cardiologist, Lydia K Wright, MD, wanted to learn if CHD was still the most significant mortality risk for these patients before age five. [1] “Our aim…

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small baby with nose canula
Safe, Minimally Invasive Upper Urinary Tract Surgery for Infants
Safe, Minimally Invasive Upper Urinary Tract Surgery for Infants 1024 575 Patti Doud

Evidence supports robotic surgery as a safe approach to upper urinary tract procedures in infants 6 months or younger. While robotic surgery has risen in popularity and feasibility for procedures in both older children and adults alike, there has been little data to determine…

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Teen girl with backpack
Ask A Specialist: What Are the Recommendations for Sexually Transmitted Infections (STI) Screening in Primary Care?
Ask A Specialist: What Are the Recommendations for Sexually Transmitted Infections (STI) Screening in Primary Care? 1024 575 Cynthia Holland-Hall, MD

STI screening is recommended for all sexually active adolescents. According to the American Academy of Pediatrics, nearly 1 in 4 teens have an STI. Safe sexual practices and routine screening can prevent these infections – that’s where health care providers come in. By offering…

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Color photo of Black father holding infant on shoulder in front of nursery background with clouds on the wall
Fertility Concerns in Boys and Men With Sickle Cell Disease
Fertility Concerns in Boys and Men With Sickle Cell Disease 1024 575 Mary Bates, PhD

Sickle cell disease and its treatments may impact fertility, but more research is needed to help counsel this population. Sickle cell disease (SCD) affects approximately 100,000 Americans, most of whom belong to underserved, minority populations. Advances in disease-modifying therapies, such as hydroxyurea, have led…

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Assessing Respiratory Stability in Infants Hospitalized with Bronchopulmonary Dysplasia
Assessing Respiratory Stability in Infants Hospitalized with Bronchopulmonary Dysplasia 1024 683 Mary Bates, PhD

The Behavioral Signs of Respiratory Instability Scale is a valid, reliable measure of respiratory status and developmental ability. In a new study, researchers at Nationwide Children’s evaluated the Behavioral Signs of Respiratory Instability (BSRI) Scale, which was developed as an objective measure of developmental…

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Featured Researcher — Nilsa Ramirez, MD
Featured Researcher — Nilsa Ramirez, MD 150 150 Katie Brind'Amour, PhD, MS, CHES

Nilsa Del Carmen Ramirez Milan, MD, director of the Biopathology Center at Nationwide Children’s Hospital, leads the biorepository team that receives about 1,000 new specimens each day. These must be processed and stored properly—together with the rest of the biobank’s > 6 million specimens.…

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Home Infusions of Infliximab for Inflammatory Bowel Disease
Home Infusions of Infliximab for Inflammatory Bowel Disease 1024 683 Mary Bates, PhD

With a standardized care approach, home infusions may be an effective alternative to hospital-based infusions. Pediatric inflammatory bowel disease (IBD) is often treated with infusions of infliximab in a hospital setting. However, these can be costly and present time and travel barriers to patients…

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Expanding Use of Trikafta for Cystic Fibrosis to Patients as Young as 2 Years Old
Expanding Use of Trikafta for Cystic Fibrosis to Patients as Young as 2 Years Old 1024 683 Karen McCoy, MD

When I first started my pulmonary training, the average life expectancy in the United States was about 70 years, and the average life expectancy for someone with cystic fibrosis (CF) was 14 years! Intense study and pursuit of consistent care across the country yielded…

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Implementation Science to Expand Contraception Access for Adolescents Hospitalized with Mental Health Issues
Implementation Science to Expand Contraception Access for Adolescents Hospitalized with Mental Health Issues 1024 575 Pam Georgiana

Research has documented that adolescents with mental health concerns have a higher need for contraceptive counseling and care because they are at a higher risk for unintended pregnancy.[i] [ii] Unintended pregnancies can make mental health symptoms worse, especially depressive symptoms. [iii] Counseling and use…

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Recent Trends in the Diagnosis and Treatment of Anxiety in US Children and Adolescents
Recent Trends in the Diagnosis and Treatment of Anxiety in US Children and Adolescents 1024 683 Lauren Dembeck

In 2021, the American Academy of Pediatrics, American Academy of Child and Adolescent Psychiatry and Children’s Hospital Association joined together to declare a national state of emergency in children’s mental health. The declaration was motivated by steadily increasing rates of childhood mental health concerns…

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Pregnancy and Ebola: Maternal and Infant Health Outcomes in Ebola Survivors
Pregnancy and Ebola: Maternal and Infant Health Outcomes in Ebola Survivors 150 150 Abbie Miller

Ebola virus disease during pregnancy is known to cause fetal demise, and preliminary evidence suggested that pregnancies conceived shortly after recovery from Ebola were also at heightened risk of adverse outcomes. Additionally, the perception that health care providers could contract Ebola from survivors during…

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Featured Researcher — Katherine Bline, MD
Featured Researcher — Katherine Bline, MD 150 150 Katie Brind'Amour, PhD, MS, CHES

Katherine Bline, MD, is a critical care medicine physician and principal investigator in the Center for Vaccines and Immunity at Nationwide Children’s Hospital. Experience caring for some of the hospital’s sickest children in the pediatric intensive care unit (PICU) and mentors who pushed her…

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What Drives Nephrotic Syndrome Hypercoagulopathy?
What Drives Nephrotic Syndrome Hypercoagulopathy? 150 150 Mary Bates, PhD

Antithrombin deficiency does not play a major mechanistic role in the increased clotting risk of nephrotic syndrome, according to a new study. Patients with nephrotic syndrome are at risk for life-threatening venous thromboembolism complications. This risk is thought to be driven by an acquired…

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Straightforward Stitch Technique Dramatically Reduces Post-Operative Anorectoplasty Complications
Straightforward Stitch Technique Dramatically Reduces Post-Operative Anorectoplasty Complications 150 150 Katie Brind'Amour, PhD, MS, CHES

The novel para-U-stitch keeps post-operative wound dehiscence to a minimum, helping patients with anorectal malformations avoid readmission, reoperation and infection. After recognizing a pattern of wound dehiscence and postoperative complications in patients with anorectal malformations (ARMs) repaired without a colostomy bag — meaning they…

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Preemptive Stenting of the Left Pulmonary Artery During Surgery for Hypoplastic Left Heart Syndrome
Preemptive Stenting of the Left Pulmonary Artery During Surgery for Hypoplastic Left Heart Syndrome 150 150 Lauren Dembeck

Perioperative stenting during the comprehensive stage 2 surgery does not negatively impact overall outcomes. However, Preemptive stenting has a survival advantage of babies relative to those who had reactionary stenting.   Each year, approximately 1,000 babies in the United States are born with one…

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Mapping the 3D Structure of Rhabdomyosarcoma Chromatin
Mapping the 3D Structure of Rhabdomyosarcoma Chromatin 1024 575 Abbie Miller

Researchers published the first comprehensive, 3D analysis of the complete rhabdomyosarcoma genome. In a paper published in Nucleic Acids Research Cancer (NAR Cancer), researchers from the Center for Childhood Cancer Research at Nationwide Children’s and their collaborators report a comprehensive 3D chromatin structural analysis…

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Exploring Disordered Eating Beyond Binge Eating in Youth with Obesity
Exploring Disordered Eating Beyond Binge Eating in Youth with Obesity 150 150 JoAnna Pendergrass, DVM

Youth with obesity can suffer from various disordered eating behaviors beyond binge eating. A holistic approach to caring for these youth can help improve their long-term physical and psychological health outcomes. A literature review recently published in Nutrients shed light on eating disorders beyond…

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Ask A Specialist: What Running Distances Are Safe for Children?
Ask A Specialist: What Running Distances Are Safe for Children? 1024 895 Gabriella Gonzales, MD and James MacDonald, MD, MPH

Sports Medicine experts offer advice for pediatricians about what age it is appropriate for children to run and train for races such as the 5K, 10K, half marathon and marathon. Running is a great activity! It requires very little equipment and can be done…

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Targeted Muscle Reinnervation Prevents Neuroma and Phantom Limb Pain in Children After Amputation
Targeted Muscle Reinnervation Prevents Neuroma and Phantom Limb Pain in Children After Amputation 1024 684 Lauren Dembeck

In certain cases, such as limb traumas and sarcomas, amputation may be chosen to optimize patients’ physical function. Persistent postamputation residual limb or “stump” pain and phantom limb pain can be debilitating and has been associated with prosthetic abandonment in patients who have undergone…

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Is Growth Hormone Replacement Safe Following Central Nervous System Tumors?
Is Growth Hormone Replacement Safe Following Central Nervous System Tumors? 1024 683 Mary Bates, PhD

Research suggests the benefits of growth hormone therapy outweigh the risks for pediatric cancer survivors. In a new review paper, researchers from Nationwide Children’s Hospital evaluated the risks and benefits associated with administering growth hormone to pediatric patients after diagnosis of a central nervous…

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