Inside the Science of Pediatric Lung Disease

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Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery?
 Why Aren’t Pediatric Kidney Stone Patients Returning for Follow-up After Surgery? 1024 732 Lauren Dembeck
By: Lauren Dembeck

Kidney stones in children are on the rise, and many of these children miss critical post-op follow-ups. What prevents them from returning, and how can we help? Since 2000, kidney stone cases in the U.S. pediatric population have risen by 6–10% annually, leading to…

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Illustration of lungs on blue silhouette of upper chest on black background
What’s New in Pulmonary Care for Children With Sickle Cell Disease?
 What’s New in Pulmonary Care for Children With Sickle Cell Disease? 1024 575 Erin Gregory
By: Erin Gregory

A recent publication reviews the impact of pulmonary complications on children and youth with sickle cell disease (SCD) and offers suggestions to improve outcomes. Pulmonary complications are a leading cause of morbidity and mortality in children with sickle cell disease (SCD), yet they remain…

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Pivotal New Research Fuels Possibilities for Aggressive Pediatric Brain Cancer
 Pivotal New Research Fuels Possibilities for Aggressive Pediatric Brain Cancer 1024 414 Wendy Margolin
By: Wendy Margolin

A new umbrella trial of molecularly driven therapies for high-grade gliomas (HGG) and diffuse intrinsic pontine glioma (DIPG) aims to improve quality of live and extend survival rates for these aggressive tumors. The diagnosis of high-grade glioma (HGG), a type of aggressive, malignant brain…

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artistic rendering of an NK cell on a faded blue background with other cells faintly visible in the background
CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies
 CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies 1024 649 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital created fratricide-resistant and metabolically-enhanced chimeric antigen receptor (CAR) natural killer (NK) and T cells that have cytotoxic effects on many hematologic tumors. “One of the problems that we usually have with blood cancers is making effective therapies using immune…

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Meet Karen Texter, MD, Director of Fetal Echocardiography at Nationwide Children’s
 Meet Karen Texter, MD, Director of Fetal Echocardiography at Nationwide Children’s 1024 691 Abbie Miller
By: Abbie Miller

Karen Texter, MD, is a pediatric cardiologist and director of Fetal Echocardiography at Nationwide Children’s. Her clinical and research interests include echocardiography in congenital and acquired heart disease and fetal cardiology. What inspired you to pursue a career in pediatric cardiology? How did you…

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Featured Researcher – Eric Sribnick, MD, PhD
 Featured Researcher – Eric Sribnick, MD, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

When children experience a traumatic brain injury (TBI) as well as significant injuries elsewhere in the body—such as a liver or spleen laceration or a broken bone—they face a substantially increased risk of subsequent infection. Research suggests this may stem from a sort of…

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Linaclotide: A New Option For Chronic Pediatric Constipation
 Linaclotide: A New Option For Chronic Pediatric Constipation 1024 668 Pam Georgiana
By: Pam Georgiana

Phase 3 Trial at Nationwide Children’s Supports Safety and Efficacy in Children Aged 6–17. Constipation, a common issue for children, can be a source of prolonged struggle and distress for young patients and their families. Despite many treatments being available, some children continue to…

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What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s
 What Pediatric Endocrinologists Need to Know About Diabetes in the Age of GLP-1s 1024 683 Erin Gregory
By: Erin Gregory

GLP-1 receptor agonists such as Ozempic (semaglutide) offer new opportunities for managing pediatric diabetes and obesity. These medications target insulin resistance and related comorbidities, but their use raises questions about safety, access and ethical considerations. In the following interview, Leena Mamilly, MD, and Rohan…

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Real-Time Arrhythmia Detection in Adults With Fontan Palliation
 Real-Time Arrhythmia Detection in Adults With Fontan Palliation 1024 683 Pam Georgiana
By: Pam Georgiana

Evaluating the Utility and Accuracy of Patient-Driven Wearable EKG Monitoring Devices Patient-driven diagnostic wearables, such as personal EKG devices, are popular among adults interested in heart health. However, little is known about the accuracy of these devices for adults with congenital heart disease. “Research…

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How Accurate is Pediatric Bipolar Disorder Testing?
 How Accurate is Pediatric Bipolar Disorder Testing? 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Symptom-based bipolar disorder tests accurately diagnose pediatric bipolar disorder, with parent-reported tests being among the most accurate. According to a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of bipolar disorder index tests, parent-reported tests are more accurate than self- or teacher-reported…

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Improving Pediatric Clinical Trials by Incorporating Parent Input
 Improving Pediatric Clinical Trials by Incorporating Parent Input 1024 681 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A Parent Council in an ongoing pediatric stroke rehabilitation trial provides important insights into how parent involvement can inform and enrich the research process. While the need for diverse and inclusive clinical trial populations has been acknowledged for the last few decades, the value…

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Treatment for Substance Use Disorder in the Synthetic Opioid Era
 Treatment for Substance Use Disorder in the Synthetic Opioid Era 1024 683 Alaina Doklovic
By: Alaina Doklovic

Medications for opioid use disorder (MOUD) is the recommended first line treatment for adolescents with opioid use disorder (OUD), the chronic use of opioids and/or synthetic opioids that causes clinically significant distress or impairment. Buprenorphine is the most accessible medication for MOUD. Studies show…

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Introducing the Fourth Wave of the Drug Epidemic
 Introducing the Fourth Wave of the Drug Epidemic 1024 575 Alaina Doklovic
By: Alaina Doklovic

Drug overdoses and poisoning are the third leading cause of pediatric death. In recent years, there has been a dramatic increase in the number of fentanyl-related overdoses, with 15-19 year olds being the most affected. In the Ohio illicit drug supply, as shared by…

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Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are
 Harm Reduction: Meeting Patients With Substance Use Disorders Where They Are 1024 768 Alaina Doklovic
By: Alaina Doklovic

According to the U.S. Department of Health and Human Services, fewer than 10% of adolescents with a substance use disorder receive care. Of those 10%, many are not ready to engage in treatment. They are often brought in by a parent or guardian. Harm…

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Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research
 Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research 1024 537 Abbie Miller
By: Abbie Miller

The ECMO Repository at Nationwide Children’s Hospital is the first and larges of its kind in children’s hospitals in the United States. In December 2014, The Heart Center and Center for Cardiovascular Research at Nationwide Children’s Hospital launched an initiative to prospectively collect biologic…

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Filling the Pipeline for Behavioral Health Professionals
 Filling the Pipeline for Behavioral Health Professionals 150 150 Abbie Miller and Shannon Caldwell
By: Abbie Miller and Shannon Caldwell

Brittany Schaffner, IMFT-S, LPCC-S, shares how a new college course and professional resources are helping more students meet the need for behavioral health care in pediatrics. Tell us about your role at Nationwide Children’s Hospital. I’m a behavioral health clinical training supervisor here at…

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Nephrotoxic-Associated Acute Kidney Injury (NAKI) Is Avoidable
 Nephrotoxic-Associated Acute Kidney Injury (NAKI) Is Avoidable 375 280 Pam Georgiana
By: Pam Georgiana

Quality improvement initiative at Nationwide Children’s Hospital leads to significant reductions in NAKI. Nephrotoxic-associated acute kidney injury (NAKI) — an under-recognized but serious risk in pediatric hospital care — affects up to 25% of hospitalized children. It occurs when medications or toxins reduce kidney…

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Meet Prof Eileen Africa: Fulbright Scholar and Sports Medicine Expert
 Meet Prof Eileen Africa: Fulbright Scholar and Sports Medicine Expert 1024 683 Abbie Miller
By: Abbie Miller

Prof Eileen Africa, an associate professor in the Division of Movement Science and Exercise Therapy in the Department of Exercise, Sport, and Lifestyle Medicine at Stellenbosch University in South Africa and a Fulbright scholar, recently visited Nationwide Children’s to work with Dr. James MacDonald…

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Meet Antonio Cabrera, MD, Chief of Cardiology at Nationwide Children’s Hospital
 Meet Antonio Cabrera, MD, Chief of Cardiology at Nationwide Children’s Hospital 150 150 Abbie Miller
By: Abbie Miller

Antonio Cabrera, MD, FAAP, FAHA, FACC, FHFSA, is the division chief of cardiology and co-director of the Heart Center. He is a professor of pediatrics at The Ohio State University and currently holds the Nationwide George H. Dunlap Endowed Chair in Pediatric Cardiology. Previously,…

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Bridging the Fertility Awareness Gap in Adolescents With PCOS
 Bridging the Fertility Awareness Gap in Adolescents With PCOS 1024 683 Pam Georgiana
By: Pam Georgiana

Assessing knowledge, concerns and quality of life to inform early clinical counseling While polycystic ovary syndrome (PCOS) is common in adolescent females, little is known about how the potential for long-term complications like infertility affect young patients’ well-being. Research with adult PCOS patients has…

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