Biofilms: The Good, the Bad & the Groundbreaking

Learn More

Approaching Uncertainty in Medicine With a Growth Mindset

Read More

From Scan to Plan: Making Virtual Surgical Planning the Standard of Care for Ortho-oncology Operations

Find Out More

Lessons Learned: From First Gen Student to Chief Scientific Officer

Read Now

Empowering Therapists With Better Tools

Learn How
Close
Enter your
text here
Featured Researcher – Ruoning Wang, PhD
 Featured Researcher – Ruoning Wang, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and a professor in the Department…

read more
What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections?
 What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections? 1024 575 Pam Georgiana
By: Pam Georgiana

Two studies reveal how impaired insulin receptors compromise immunity in people with diabetes. While excess glucose in the urine is often thought to be the main factor behind urinary tract infections in people with diabetes, two recent studies led by Laura L. Schwartz, PhD,…

read more
Selective Dorsal Rhizotomy for Cerebral Palsy: Significant Gains in Mobility and Reduction in Spasticity Treatments
 Selective Dorsal Rhizotomy for Cerebral Palsy: Significant Gains in Mobility and Reduction in Spasticity Treatments 928 1024 Erin Gregory
By: Erin Gregory

Recent research shows that selective dorsal rhizotomy (SDR) significantly boosts motor function in children with cerebral palsy (CP), particularly those who are ambulatory. The study highlights motor improvements and a reduced need for spasticity treatments, emphasizing SDR’s potential to enhance outcomes and quality of…

read more
Identifying Ancestry-Based Predictors of Survival in Black Patients with Acute Myeloid Leukemia
 Identifying Ancestry-Based Predictors of Survival in Black Patients with Acute Myeloid Leukemia 1024 768 Alaina Doklovic
By: Alaina Doklovic

Researchers use multiomic profiling to understand ancestry-specific aspects of cancer onset and outcomes. In a recent study, published in ­­­Nature Genetics, researchers from Nationwide Children’s Hospital and The Ohio State University Comprehensive Cancer Center (OSUCCC – James) compared genomic profiles of patients diagnosed with…

read more
Heart with HLHS compared to typically developed heart
Researchers Identify Potential Prenatal Biomarkers of Congenital Heart Diseases
 Researchers Identify Potential Prenatal Biomarkers of Congenital Heart Diseases 1024 637 Katelyn Scott
By: Katelyn Scott

In a research letter published in Circulation Research, researchers at Nationwide Children’s describe a potential biomarker that would identify the presence of SVHD in a fetus based on a maternal blood test. Single ventricle heart diseases (SVHDs), the most severe type of congenital heart…

read more
Oncolytic Viroimmunotherapy Improved by Enhanced Cytokine Transgene Expression
 Oncolytic Viroimmunotherapy Improved by Enhanced Cytokine Transgene Expression 1024 575 Lauren Dembeck
By: Lauren Dembeck

Researchers were able to suppress in vivo tumor growth with an oncolytic virus by enhancing the production of the cytokine interleukin-12 in the tumors. Malignant peripheral nerve sheath tumors (MPNSTs) are rare, aggressive sarcomas that exhibit resistance to non-surgical treatment and have high rates…

read more
4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital
 4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital 1024 734 Abbie Miller
By: Abbie Miller

Led by V. Rama Jayanthi, MD, and Peter Cuckow, MB, BS, FRCS, the Bladder Exstrophy Program at Nationwide Children’s is poised to launch a new era of care for children in the United States. When Drs. Jayanthi and Cuckow start talking about their new…

read more
Pediatric Bladder Dysfunction: What to Do When Nothing Is Working
 Pediatric Bladder Dysfunction: What to Do When Nothing Is Working 1024 575 Pam Georgiana
By: Pam Georgiana

Experts review the options, helping providers and families choose the right third-line treatment for their child. Pediatric non-neurogenic bladder dysfunction, or disordered voiding, can harm patients’ self-esteem and cause stress on the family dynamic and routine. The standard pediatric treatment involves behavioral modifications such…

read more
What Types of Contraception Are Best Following Early Pregnancy Loss?
 What Types of Contraception Are Best Following Early Pregnancy Loss? 1024 683 Geri Hewitt, MD, Elise Berlan, MD, MPH and Johanna Taylor, APN
By: Geri Hewitt, MD, Elise Berlan, MD, MPH and Johanna Taylor, APN

Following early pregnancy loss (EPL), miscarriage or spontaneous abortion, pregnancy tests remain positive for several weeks often creating a challenge for clinicians initiating contraception. Fertility returns rapidly after EPL and almost all adolescents may use their contraceptive method of choice immediately after the pregnancy.…

read more
Featured Researcher – Donna Ruch, PhD
 Featured Researcher – Donna Ruch, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Donna A. Ruch, PhD, is a principal investigator in the Center for Suicide Prevention and Research at Nationwide Children’s Hospital and a faculty member at The Ohio State University College of Medicine in Columbus, Ohio. Her research focuses on behavioral health and healthcare disparities, the…

read more
Differentiating True Measles Cases From Vaccine Shedding
 Differentiating True Measles Cases From Vaccine Shedding 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Shedding of measles vaccine RNA can occur for up to four weeks post vaccination. Detection of measles vaccine RNA following vaccination is not uncommon and may occur up to four weeks post-vaccination, according to a new study from Nationwide Children’s Hospital. “The frequency at…

read more
Proteinuria Reduction in Nephrotic Syndrome Without Suppressing the Immune System
 Proteinuria Reduction in Nephrotic Syndrome Without Suppressing the Immune System 375 280 Mary Bates, PhD
By: Mary Bates, PhD

Study suggests a distinct, non-immunosuppressive mechanism of action for drugs that ameliorate proteinuria in an NS model. Nephrotic syndrome (NS) is a leading cause of chronic kidney disease in children and adults. NS is characterized by dysregulation of the kidneys’ glomerular filtering units, resulting…

read more
Optimizing Outpatient Epilepsy Care With Digital Seizure Action Plans
 Optimizing Outpatient Epilepsy Care With Digital Seizure Action Plans 1024 683 Pam Georgiana
By: Pam Georgiana

Customized seizure action plans enhance care and family use. Many schools and caregivers require families of children with epilepsy to provide a written seizure action plan (SAP) signed by their primary care provider. The Epilepsy Foundation provides a printable PDF form to fill out,…

read more
Meet David Axelson, MD, Chief of Psychiatry and Behavioral Health
 Meet David Axelson, MD, Chief of Psychiatry and Behavioral Health 1024 647 Shannon Caldwell
By: Shannon Caldwell

Dr. Axelson and his team have achieved amazing things in the last decade, from more than doubling the volume of patients served to establishing a new research institute for mental and behavioral health, and they’re not slowing down. We recently sat down to talk…

read more
Weighing the Risk of Blood Clots With Reward of Less Pain
 Weighing the Risk of Blood Clots With Reward of Less Pain 1024 683 Pam Georgiana
By: Pam Georgiana

For people with sickle cell disease who menstruate, hormonal contraception can be effective against SCD-related pain, but it also raises the risk of thrombosis.   As people with sickle cell disease (SCD) transition into their reproductive years, health care providers are increasingly focused on…

read more
What Primary Care Providers Need to Know About Precocious Puberty
 What Primary Care Providers Need to Know About Precocious Puberty 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

PCPs are the first line of defense in recognizing and referring possible cases of precocious puberty to endocrinologists for formal diagnosis and treatment. Precocious puberty — signs of the onset of puberty before the age of 8 in girls and 9 in boys —…

read more
Illustration of NK Cells, T Cells, other immune cells floating across white background
Shedding Light on Immune Responses in Children With Acute Asthma Exacerbations
 Shedding Light on Immune Responses in Children With Acute Asthma Exacerbations 969 533 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

The innate immune system is upregulated in children hospitalized with acute asthma exacerbations, signaling a need for therapies that target innate immune pathways to help control acute asthma flare-ups more effectively.  Asthma affects more than 6 million children in the United States, yet little…

read more
Treating Obesity With GLP-1s — Finding the Way Forward
 Treating Obesity With GLP-1s — Finding the Way Forward 150 150 Abbie Miller
By: Abbie Miller

Using lessons learned from medicating mental and behavioral health conditions, Stephen Cook, MD, offers suggestions about how medications approved for adolescents with obesity should become part of care.   For most of the time in Western medicine, people have treated obesity like a choice…

read more
Approaching Uncertainty in Medicine With a Growth Mindset
 Approaching Uncertainty in Medicine With a Growth Mindset 1024 531 Abbie Miller
By: Abbie Miller

In baseball, a really good batting average is .333 — which means the batter hits the ball and gets to first base a third of the time. That also means they miss —they fail — two-thirds of the time. Medical providers are expected to…

read more
Tissue-Engineered Vascular Grafts Resist Calcification
 Tissue-Engineered Vascular Grafts Resist Calcification 968 1024 Abbie Miller
By: Abbie Miller

Dystrophic calcification is the biggest reason for prosthetic biomaterial failure. Compared to expanded poly(tetrafluoroethylene) (PTFE) grafts, tissue-engineered vascular grafts (TEVGs) exhibited superior durability, including reduced late-term calcification, according to a study published in Nature Communications. “All of the biomaterials we routinely use for cardiovascular…

read more