Biofilms: The Good, the Bad & the Groundbreaking

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From Scan to Plan: Making Virtual Surgical Planning the Standard of Care for Ortho-oncology Operations

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Making the Case for Interdisciplinary BPD Care
 Making the Case for Interdisciplinary BPD Care 150 150 Abbie Miller
By: Abbie Miller

A new review highlights benefits of interdisciplinary BPD management and offers advice on how program development. Bronchopulmonary dysplasia (BPD) affects more than 40% of preterm infants and is the most common lung disease in infancy. There are long term consequences and comorbidities associated with…

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Color image of young boy asleep in bed
Pediatric Obstructive Sleep Apnea Diagnosis and Treatment: What You Need to Know
 Pediatric Obstructive Sleep Apnea Diagnosis and Treatment: What You Need to Know 1024 575 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Pediatric obstructive sleep apnea, a common condition in children, is definitively diagnosed with sleep studies and can be treated through various modalities, depending on disease severity. Obstructive sleep apnea (OSA) is a disorder characterized by snoring, gas exchange abnormalities and disrupted sleep, with near-complete…

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How Does Cannabis Use During Pregnancy Affect Children?
 How Does Cannabis Use During Pregnancy Affect Children? 1024 683 Katelyn Scott
By: Katelyn Scott

A recent study shows that prenatal exposure to cannabis is associated with poorer thinking skills and behaviors.  In a study published in JAMA Pediatrics, researchers found prenatal cannabis exposure was associated in early childhood with poorer thinking skills and behaviors such as impulse control,…

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The Current and Future State of Scoliosis Care and Research
 The Current and Future State of Scoliosis Care and Research 1024 683 Madison Storm
By: Madison Storm

In the United States alone, scoliosis affects an estimated 7 million people – just under twice the population of Los Angeles – according to the Scoliosis Research Society. Each year, an estimated 30,000 children begin wearing braces for treatment.  Over time, the treatments available…

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Advancing Care for Infants with Hypoplastic Left Heart Syndrome: New Insights into Maternal and Community Health Factors
 Advancing Care for Infants with Hypoplastic Left Heart Syndrome: New Insights into Maternal and Community Health Factors 1024 537 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s Heart Center explores the impact of maternal and social determinants of health on congenital heart disease. While maternal-fetal environment factors are known to impact outcomes in babies who receive the traditional Norwood surgery to treat hypoplastic left heart syndrome (HLHS), there is…

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1 Trillion Cells: Nationwide Children’s Reaches New Milestone for Universal-Donor NK Cell Studies
 1 Trillion Cells: Nationwide Children’s Reaches New Milestone for Universal-Donor NK Cell Studies 1024 649 Abbie Miller
By: Abbie Miller

The Biologics Manufacturing Resource, Nationwide Children’s Cell and Tissue cGMP manufacturing facility, recently achieved a major milestone. The resource has now delivered more than 1 trillion universal donor natural killer (NK) cells to patients. These NK cells are being studied in clinical trials to…

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Subclinical Herpes Simplex Virus in Neonates: What to Do?
 Subclinical Herpes Simplex Virus in Neonates: What to Do? 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Neonates can test positive for HSV without having visible lesions or other classic symptoms, leaving clinical uncertainty regarding appropriate antiviral treatment and testing protocols. Researchers at Nationwide Children’s Hospital have shared data on a sample of 17 neonates who tested positive for herpes simplex…

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Featured Researcher – Ruoning Wang, PhD
 Featured Researcher – Ruoning Wang, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and a professor in the Department…

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What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections?
 What Is Insulin’s Role in Diabetes-Related Urinary Tract Infections? 1024 575 Pam Georgiana
By: Pam Georgiana

Two studies reveal how impaired insulin receptors compromise immunity in people with diabetes. While excess glucose in the urine is often thought to be the main factor behind urinary tract infections in people with diabetes, two recent studies led by Laura L. Schwartz, PhD,…

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Selective Dorsal Rhizotomy for Cerebral Palsy: Significant Gains in Mobility and Reduction in Spasticity Treatments
 Selective Dorsal Rhizotomy for Cerebral Palsy: Significant Gains in Mobility and Reduction in Spasticity Treatments 928 1024 Erin Gregory
By: Erin Gregory

Recent research shows that selective dorsal rhizotomy (SDR) significantly boosts motor function in children with cerebral palsy (CP), particularly those who are ambulatory. The study highlights motor improvements and a reduced need for spasticity treatments, emphasizing SDR’s potential to enhance outcomes and quality of…

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Identifying Ancestry-Based Predictors of Survival in Black Patients with Acute Myeloid Leukemia
 Identifying Ancestry-Based Predictors of Survival in Black Patients with Acute Myeloid Leukemia 1024 768 Alaina Doklovic
By: Alaina Doklovic

Researchers use multiomic profiling to understand ancestry-specific aspects of cancer onset and outcomes. In a recent study, published in ­­­Nature Genetics, researchers from Nationwide Children’s Hospital and The Ohio State University Comprehensive Cancer Center (OSUCCC – James) compared genomic profiles of patients diagnosed with…

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Heart with HLHS compared to typically developed heart
Researchers Identify Potential Prenatal Biomarkers of Congenital Heart Diseases
 Researchers Identify Potential Prenatal Biomarkers of Congenital Heart Diseases 1024 637 Katelyn Scott
By: Katelyn Scott

In a research letter published in Circulation Research, researchers at Nationwide Children’s describe a potential biomarker that would identify the presence of SVHD in a fetus based on a maternal blood test. Single ventricle heart diseases (SVHDs), the most severe type of congenital heart…

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Oncolytic Viroimmunotherapy Improved by Enhanced Cytokine Transgene Expression
 Oncolytic Viroimmunotherapy Improved by Enhanced Cytokine Transgene Expression 1024 575 Lauren Dembeck
By: Lauren Dembeck

Researchers were able to suppress in vivo tumor growth with an oncolytic virus by enhancing the production of the cytokine interleukin-12 in the tumors. Malignant peripheral nerve sheath tumors (MPNSTs) are rare, aggressive sarcomas that exhibit resistance to non-surgical treatment and have high rates…

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4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital
 4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital 1024 734 Abbie Miller
By: Abbie Miller

Led by V. Rama Jayanthi, MD, and Peter Cuckow, MB, BS, FRCS, the Bladder Exstrophy Program at Nationwide Children’s is poised to launch a new era of care for children in the United States. When Drs. Jayanthi and Cuckow start talking about their new…

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Pediatric Bladder Dysfunction: What to Do When Nothing Is Working
 Pediatric Bladder Dysfunction: What to Do When Nothing Is Working 1024 575 Pam Georgiana
By: Pam Georgiana

Experts review the options, helping providers and families choose the right third-line treatment for their child. Pediatric non-neurogenic bladder dysfunction, or disordered voiding, can harm patients’ self-esteem and cause stress on the family dynamic and routine. The standard pediatric treatment involves behavioral modifications such…

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What Types of Contraception Are Best Following Early Pregnancy Loss?
 What Types of Contraception Are Best Following Early Pregnancy Loss? 1024 683 Geri Hewitt, MD, Elise Berlan, MD, MPH and Johanna Taylor, APN
By: Geri Hewitt, MD, Elise Berlan, MD, MPH and Johanna Taylor, APN

Following early pregnancy loss (EPL), miscarriage or spontaneous abortion, pregnancy tests remain positive for several weeks often creating a challenge for clinicians initiating contraception. Fertility returns rapidly after EPL and almost all adolescents may use their contraceptive method of choice immediately after the pregnancy.…

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Featured Researcher – Donna Ruch, PhD
 Featured Researcher – Donna Ruch, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Donna A. Ruch, PhD, is a principal investigator in the Center for Suicide Prevention and Research at Nationwide Children’s Hospital and a faculty member at The Ohio State University College of Medicine in Columbus, Ohio. Her research focuses on behavioral health and healthcare disparities, the…

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Differentiating True Measles Cases From Vaccine Shedding
 Differentiating True Measles Cases From Vaccine Shedding 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Shedding of measles vaccine RNA can occur for up to four weeks post vaccination. Detection of measles vaccine RNA following vaccination is not uncommon and may occur up to four weeks post-vaccination, according to a new study from Nationwide Children’s Hospital. “The frequency at…

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Proteinuria Reduction in Nephrotic Syndrome Without Suppressing the Immune System
 Proteinuria Reduction in Nephrotic Syndrome Without Suppressing the Immune System 375 280 Mary Bates, PhD
By: Mary Bates, PhD

Study suggests a distinct, non-immunosuppressive mechanism of action for drugs that ameliorate proteinuria in an NS model. Nephrotic syndrome (NS) is a leading cause of chronic kidney disease in children and adults. NS is characterized by dysregulation of the kidneys’ glomerular filtering units, resulting…

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Optimizing Outpatient Epilepsy Care With Digital Seizure Action Plans
 Optimizing Outpatient Epilepsy Care With Digital Seizure Action Plans 1024 683 Pam Georgiana
By: Pam Georgiana

Customized seizure action plans enhance care and family use. Many schools and caregivers require families of children with epilepsy to provide a written seizure action plan (SAP) signed by their primary care provider. The Epilepsy Foundation provides a printable PDF form to fill out,…

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