Clinical Genomics: From Research to Reality

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Single Ventricle, Many Research Angles

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Setting the Standard for Cloacal Malformation Management

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Studying the Environment’s Impact on Pediatric Health Outcomes

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Teenage girl having stomach ache, young woman health care provider examining her.
Beyond the Bedside: Nurses Conducting Research to Transform Pediatric Outcomes
 Beyond the Bedside: Nurses Conducting Research to Transform Pediatric Outcomes 1024 683 Madison Storm
By: Madison Storm

Nurses are vital to clinical research – supporting and conducting it. At Nationwide Children’s Hospital, nurse scientists are dedicated to advancing prevention, diagnosis and treatment of pediatric health conditions.   Nurses at Nationwide Children’s Hospital have long been recognized for their compassionate care and clinical…

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Premature baby receiving respiratory support through a nasal cannula in a neonatal intensive care unit, monitored and cared for by a health care provider.
Mode of Respiratory Support at 36 Weeks Predicts Weaning Timeline for Infants With Severe Bronchopulmonary Dysplasia
 Mode of Respiratory Support at 36 Weeks Predicts Weaning Timeline for Infants With Severe Bronchopulmonary Dysplasia 1024 683 Lauren Dembeck
By: Lauren Dembeck

Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, and its incidence is rising due to advances in neonatal care that have improved survival for extremely premature infants. Respiratory support is a cornerstone of management for these patients, yet the expected timeline…

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Real-Life Impact of ETI Therapy in Cystic Fibrosis: Insights From a Large Treatment Center
 Real-Life Impact of ETI Therapy in Cystic Fibrosis: Insights From a Large Treatment Center 706 470 Pam Georgiana
By: Pam Georgiana

Greater clinical gains observed in patients with severe lung disease, regardless of genotype. A recent prospective observational study led by Shahid I. Sheikh, MD, pediatric pulmonologist at Nationwide Children’s Hospital and professor of Pediatrics at The Ohio State University College of Medicine, offers insights…

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Pediatric Restless Legs Syndrome: More Common (and Impactful) Than You Might Think
 Pediatric Restless Legs Syndrome: More Common (and Impactful) Than You Might Think 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

This underdiagnosed condition is more than just a bedtime annoyance — it may reflect nutrient deficiencies and have major impacts on daytime behavior. Restless legs syndrome (RLS) affects 2-4% of school-aged children, with symptoms that can significantly impact sleep quality, family relationships and daytime…

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Dynamic Contrast-Enhanced Ultrasound Shows Promise for Diagnosing Renal Obstruction
 Dynamic Contrast-Enhanced Ultrasound Shows Promise for Diagnosing Renal Obstruction 480 320 Pam Georgiana
By: Pam Georgiana

Feasibility study demonstrates DCEUS may be a safer, more accessible alternative to nuclear medicine. In a recent study, Bryan S. Sack, MD, chief of Pediatric Urology at Nationwide Children’s Hospital – Toledo, and colleagues demonstrated the potential of dynamic contrast-enhanced ultrasound (DCEUS) to diagnose…

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Featured Expert: Anna J. Kerlek, MD
 Featured Expert: Anna J. Kerlek, MD 150 150 Gina Vitale
By: Gina Vitale

Anna J. Kerlek, MD, is a physician specializing in child and adolescent psychiatry at Nationwide Children’s Hospital and is an Associate Professor at The Ohio State University College of Medicine. The Division of Behavioral Health at Nationwide Children’s is the largest of its kind…

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Featured Researcher: Laura Chavez, PhD, MPH
 Featured Researcher: Laura Chavez, PhD, MPH 150 150 Gina Vitale
By: Gina Vitale

Improving access to health care for all, regardless of age, race, gender and socioeconomic background, is essential for numerous health and economic reasons — especially for children. It’s vital to understand and prevent health disparities from impacting children to ensure the best outcomes for…

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Study Explores Impact of Duffy Null Phenotype on Neutrophil Count and Hydroxyurea Dosing in Children With Sickle Cell Disease
 Study Explores Impact of Duffy Null Phenotype on Neutrophil Count and Hydroxyurea Dosing in Children With Sickle Cell Disease 1024 683 Lauren Dembeck
By: Lauren Dembeck

Children with sickle cell disease and the Duffy null phenotype may have lower measured neutrophil counts, but new research suggests that there are opportunities to optimize hydroxyurea regardless of Duffy null status. Sickle cell disease (SCD) primarily affects individuals of minority populations and can…

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Close up color photo of little boy holding hands on his belly
Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms
 Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms 1024 680 Pam Georgiana
By: Pam Georgiana

A retrospective analysis of the clinical correlation between gastric emptying scintigraphy and antroduodenal manometry in pediatric patients with upper GI symptoms. Children with persistent nausea, vomiting or abdominal pain often undergo extensive testing to evaluate for underlying etiologies such as pediatric intestinal pseudo-obstruction, rumination…

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Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms
 Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms 480 320 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new model accurately identifies neonates at risk of acute kidney injury (AKI) — and the factors physicians should address to prevent it — offering the first AKI prediction tool specific to this vulnerable population. Acute kidney injury (AKI) is common and irreversible, making…

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Black baby smiling up at his mother
Studying the Clinical Progression of Congenital Hypopituitarism
 Studying the Clinical Progression of Congenital Hypopituitarism 1024 683 Pam Georgiana
By: Pam Georgiana

New research reveals the clinical progression and evolution of pituitary hormone deficiencies in the first 3 years of life. In a recent retrospective study published in Clinical Endocrinology, Jennifer M. Ladd, MD, MSc, pediatric physician in the Division of Endocrinology and associate program director…

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High Rates of Readmission and Airway Complications Found in Tracheostomy-Dependent Infants With BPD
 High Rates of Readmission and Airway Complications Found in Tracheostomy-Dependent Infants With BPD 1024 575 Lauren Dembeck
By: Lauren Dembeck

While tracheostomy can be lifesaving for infants with severe bronchopulmonary dysplasia, new data highlights the risks and outcomes that families and providers must be prepared to face. Infants with bronchopulmonary dysplasia (BPD), the most common morbidity of prematurity, often require long-term respiratory support. Severe…

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small baby with nose canula
Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants
 Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants 1024 575 Jessica Nye, PhD
By: Jessica Nye, PhD

A positive first hip ultrasound (HUS) is highly predictive of having developmental dysplasia of the hip (DDH) among preterm infants, according to results of a study published in the American Journal of Perinatology. “In term babies, more is known about the accuracy of ultrasounds…

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Toddler playing with toys
Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network
 Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network 1024 575 Erin Gregory
By: Erin Gregory

In their recent publication, Boosting Autism Screening and Referrals with EHR-Integrated Tools at Well-Child Visits, Elizabeth W. Barnhardt, DO, MAEd, developmental-behavioral pediatrician at Nationwide Children’s Hospital and faculty member at The Ohio State University College of Medicine, and her team describe a quality improvement…

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physicians in white coats looking at a tablet
Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1
 Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1 1024 683 Pam Georgiana
By: Pam Georgiana

Pilot study supports the use of sleep questionnaires to identify underrecognized symptoms in children and adults with DM1. Myotonic Dystrophy Type 1 (DM1) is a genetic, multisystemic neuromuscular disorder that affects skeletal muscle, cardiac function, the endocrine system and the central nervous system. In…

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Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer
 Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer 1024 683 Pam Georgiana
By: Pam Georgiana

 A pilot study shows promise in enhancing shared decision-making and patient satisfaction through family-centered support. Fertility preservation is a critical yet underutilized aspect of cancer care for adolescent males. Despite being a medically low-risk and effective option, only a minority of young patients attempt…

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Transforming the Approach to Cancer Epigenomic Studies
 Transforming the Approach to Cancer Epigenomic Studies 1024 764 Abbie Miller
By: Abbie Miller

Two new publications from the Center for Childhood Cancer Research at Nationwide Children’s offer a new platform technology and proof of concept that illuminates the role of a known gene fusion driving rhabdomyosarcoma.  Synergy is an important part of scientific endeavors, and people, teams…

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National Study Reveals Gaps in Antidepressant Treatment Quality for Youth
 National Study Reveals Gaps in Antidepressant Treatment Quality for Youth 1024 683 Pam Georgiana
By: Pam Georgiana

Findings highlight critical disparities and opportunities to improve care. A national study led by Cynthia A. Fontanella, PhD, principal investigator in the Center for Suicide Prevention and Research in the Abigail Wexner Research Institute at Nationwide Children’s Hospital and professor of Psychiatry and Behavioral…

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Featured Researcher: Mykyta Artomov, PhD
 Featured Researcher: Mykyta Artomov, PhD 150 150 Gina Vitale
By: Gina Vitale

Bioinformatics combines the natural sciences and information technology. This rapidly developing field has become an essential piece of genomic medicine, which is currently experiencing unprecedented scientific progress in understanding inherited susceptibilities for many diseases – identification of disease risk genes, pathways and affected cell…

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Meet Our Expert: Albert Isaacs, MD, PhD, Neurosurgeon and Genomic Scientist
 Meet Our Expert: Albert Isaacs, MD, PhD, Neurosurgeon and Genomic Scientist 864 576 Lauren Dembeck
By: Lauren Dembeck

Albert Isaacs, MD, PhD, is a pediatric neurosurgeon at Nationwide Children’s Hospital and an assistant professor of Neurological Surgery at The Ohio State University College of Medicine. His research focuses on uncovering the molecular and immunologic drivers of neonatal hydrocephalus, with the goal of…

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