Clinical Genomics: From Research to Reality

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Single Ventricle, Many Research Angles

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Setting the Standard for Cloacal Malformation Management

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The End of “Under 12″
 The End of “Under 12″ 150 150 Kelli Whitlock Burton
By: Kelli Whitlock Burton

UNOS board eliminates age classification for child lung transplant candidates and alters rules for pediatric heart transplants. Many in the pediatric field were surprised last year when a federal judge ordered that a 10-year-old Pennsylvania girl with cystic fibrosis be added to the national adult…

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Mock MRI Scanners to Reduce Anesthesia Use
 Mock MRI Scanners to Reduce Anesthesia Use 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Initial research supports the use of MRI practice sessions and mock scanners to avoid sedation and alleviate patient and parent anxiety before an MRI. Studies exist for populations such as patients with ADHD and diabetes, but to date no studies appear to investigate the use of a…

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Using Zinc for Growth Delays in Babies Born Preterm
 Using Zinc for Growth Delays in Babies Born Preterm 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Zinc supplementation in extremely low birth-weight (ELBW) infants with chronic lung disease improves weight gain and linear growth, according to a retrospective study performed at Nationwide Children’s Hospital. The study is one of the first to look at the association between zinc supplementation and growth in…

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Do Your Patients Understand You? Strategies to Improve Patient-Provider Communication
 Do Your Patients Understand You? Strategies to Improve Patient-Provider Communication 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

The Patient Protection and Affordable Care Act of 2010, Title V, defines health literacy as the degree to which an individual has the capacity to obtain, communicate, process and understand basic health information and services to make appropriate health decisions. However, over a third…

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The Dilemma of Undertriaged Trauma Cases
 The Dilemma of Undertriaged Trauma Cases 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Nationally, at least one in three children ages 5 and under with major trauma receive their definitive care at a level III trauma center or non-trauma center, according to arecent study in the American Journal of Emergency Medicine. Among children ages 6 to 17, the…

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Out of Drugs: Planning for the Unthinkable
 Out of Drugs: Planning for the Unthinkable 150 150 Dave Ghose
By: Dave Ghose

Pediatric cancer specialists have faced an enormous challenge in recent years. With critical chemotherapy drugs often in short supply, they’ve been forced to improvise alternative treatments or purchase medicine from questionable secondary sources. These practices raise safety and ethical concerns. Emerging evidence indicates that…

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ADHD Medications Do Not Curb Adult Height
 ADHD Medications Do Not Curb Adult Height 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

According to the Centers for Disease Control and Prevention, the number of children being diagnosed with attention deficit hyperactivity disorder (ADHD) has increased from 7.8 percent to 11 percent in the last decade. Specifically, approximately 2 million more U.S. children between the ages of 4…

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AAP Statement on School Start Times May Be Challenging to Implement
 AAP Statement on School Start Times May Be Challenging to Implement 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The American Academy of Pediatrics published a statement in August supporting delayed start times for middle and high schools to help combat chronic sleep deprivation. Research indicates adolescents naturally experience a shift in their circadian rhythm that makes sleep difficult prior to 11 PM. But since…

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Sinus Infection Test Could Curb Antibiotic Overuse
 Sinus Infection Test Could Curb Antibiotic Overuse 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

Antibiotic misuse, overuse and resistance have significant consequences for patients and hospitals, but determining the primary cause of sinusitis remains a clinical challenge for physicians. Now, diagnostic technology co-invented by researchers at The Ohio State University and Nationwide Children’s Hospital will better equip physicians…

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Reframing Hope in Pediatric End-of-Life Care
 Reframing Hope in Pediatric End-of-Life Care 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

As physicians, you want to do more good than harm. And it is often believed that telling the truth about poor end-of-life expectations will lead to hopelessness in patients and families, causing more harm than good. But study after study on prognostication has shown…

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“Learning” Health Care Organizations
 “Learning” Health Care Organizations 150 150 Kelly Kelleher, MD, MPH
By: Kelly Kelleher, MD, MPH

In the push toward innovative health care, “learning” systems may offer solutions for evaluating new technologies without the challenges of randomized trials. “The only constant is change.” – Heraclitus The pace of innovation in health care is breathtaking and unlikely to slow in our…

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1 in 8 Children Exposed to Violence 5 or More Times in a Year
 1 in 8 Children Exposed to Violence 5 or More Times in a Year 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

The average pediatric subspecialist sees two to four child polyvictims each day. What can physicians do to help these children and their families? According to the National Survey of Children’s Exposure to Violence (NatSCEV), 60 percent of children have directly experienced or indirectly witnessed…

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Liquid Danger
 Liquid Danger 150 150 Dave Ghose
By: Dave Ghose

Henry Spiller, MS, DABT, never used to worry too much about nicotine poisoning. If a child ate a cigarette, he might throw up but wasn’t going to die. Then e-cigarettes took off about seven years ago and changed the equation. Now, Spiller and other…

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Witnessing a Parent’s Injury Can Leave Kids with PTSD, Study Suggests
 Witnessing a Parent’s Injury Can Leave Kids with PTSD, Study Suggests 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

When parents have an injury, their children are more likely to experience symptoms of post-traumatic stress disorder, or PTSD. What can pediatric health professionals do to help these families? In June, Pediatrics published the first-ever study examining the effect of civilian parents’ injuries on their uninjured…

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Antibiotics Alone are a Successful Treatment for Uncomplicated Acute Appendicitis in Children
 Antibiotics Alone are a Successful Treatment for Uncomplicated Acute Appendicitis in Children 150 150 Kelli Whitlock Burton
By: Kelli Whitlock Burton

Using antibiotics alone to treat children with uncomplicated acute appendicitis is a reasonable alternative to surgery that leads to less pain and fewer missed school days, according to a pilot study. The research, led by a team at Nationwide Children’s Hospital and published online…

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Mentoring Junior Faculty: Fostering Tomorrow’s Leaders
 Mentoring Junior Faculty: Fostering Tomorrow’s Leaders 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Clinicians from institutions nationwide offer insight on how to piece together effective mentorship strategies in pediatrics. Mentoring may be a familiar concept to most pediatric professionals, but whether it occurs effectively in practice is less obvious. Research on the topic suggests a widespread lack…

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Gene Therapy’s Road to Redemption
 Gene Therapy’s Road to Redemption 150 150 Kelli Whitlock Burton
By: Kelli Whitlock Burton

Fifteen years ago, gene therapy suffered a highly visible fatality, leaving the field in shambles. Now, one team’s efforts at gene therapy for muscular dystrophy suggest the field may finally be on track to deliver on its initial promise. During the first few weeks…

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Aiming for Zero
 Aiming for Zero 150 150 Kelli Whitlock Burton
By: Kelli Whitlock Burton

Efforts to eliminate preventable harm in pediatric care are making progress. But can we make it to zero? In October 2008, Richard Brilli, MD, stood in a silent conference room, waiting for his audience to digest the news he’d just delivered: hundreds of significant…

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Evolution of an Atlas
 Evolution of an Atlas 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Adult brain atlases have existed for years. Why is it so crucial — and so difficult — to build one for preemies? Even experts need maps. They give perspective, scale and orientation. They can show both current location and the final destination. And in…

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A Brave New World of Data
 A Brave New World of Data 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

According to William C. Ray, PhD, of the Battelle Center for Mathematical Medicine in The Research Institute at Nationwide Children’s Hospital, novel techniques prototyped for understanding protein data could soon enable the visualization of large sets of demographic data, displaying contingency tables and group…

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