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Using Whole Exome Sequencing to Find Genetic Cause of Congenital Heart Disease in At-Risk Patients
 Using Whole Exome Sequencing to Find Genetic Cause of Congenital Heart Disease in At-Risk Patients 150 150 Brianne Moore
By: Brianne Moore

Whole exome sequencing has the ability to identify disease-causing mutations, contributing to the development of personalized medicine and bridging a crucial gap between scientific knowledge and clinical application. Congenital heart disease (CHD) is the most common type of birth defect, affecting approximately 40,000 births…

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Study Finds Genetic Loci Associated With Anxiety and Aggression in Dogs: What Does It Mean for Kids?
 Study Finds Genetic Loci Associated With Anxiety and Aggression in Dogs: What Does It Mean for Kids? 150 150 Carlos E. Alvarez, PhD
By: Carlos E. Alvarez, PhD

Principal investigator Carlos Alvarez, PhD, reports the genome wide mapping of nine fear and aggression traits in dogs and discusses the implications of the findings. Anxiety disorders are the most common type of mental illness in the United States. They are associated with increased…

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Chromatin’s Role in Cancer Development
 Chromatin’s Role in Cancer Development 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

A new study investigates the role of chromatin containing the histone H3 variant in the centromere region of chromosomes in the development of cancer. Although there are many types of cancer, all cancers have one thing in common: they develop when normal processes in…

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Researchers at Nationwide Children’s Hospital Describe New Type of Cancer Therapy
 Researchers at Nationwide Children’s Hospital Describe New Type of Cancer Therapy 150 150 Abbie Miller
By: Abbie Miller

The new chemotherapy is effective against both pediatric and adult cancers, and it allows other chemotherapies to more readily reach their targets. A study conducted at Nationwide Children’s Hospital has found that a new chemotherapy is effective against both pediatric and adult cancers, and…

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Considering Peptide Tuning of Natural Killer (NK) Cells
 Considering Peptide Tuning of Natural Killer (NK) Cells 150 150 Abbie Miller
By: Abbie Miller

Researchers combine modeling and functional studies of interactions between MHC-I and NK cells to learn how they operate on a molecular level. Natural killer (NK) cells are cytotoxic lymphocytes — important immune cells of the innate immune system. NK cells are increasingly understood to…

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An Effective Strategy for Disrupting Bacterial Biofilms
 An Effective Strategy for Disrupting Bacterial Biofilms 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

Using monoclonal antibodies to bind to proteins essential to biofilm structure and stability is highly effective against many types of bacteria that cause a variety of human disease. Biofilms are communities of bacteria that adhere to a surface and are nearly impossible to eradicate…

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When Should Kids With Severe Functional Constipation Have Surgery?
 When Should Kids With Severe Functional Constipation Have Surgery? 150 150 Jeb Phillips
By: Jeb Phillips

A protocol developed by pediatric surgeons and gastroenterologists allows patients to receive specific surgical interventions that will be most beneficial – and allows many patients originally referred for surgery to avoid it altogether. Children with severe functional constipation are most often referred for surgery…

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Counseling Pediatric Patients on Fertility and Sexual Function
 Counseling Pediatric Patients on Fertility and Sexual Function 150 150 Brianne Moore
By: Brianne Moore

How should we talk to patients and their families about these sensitive subjects? Since 2006, several medical societies have released guidelines for discussing fertility preservation prior to pediatric cancer treatment. According to the American Society for Reproductive Medicine, a “collaborative, multidisciplinary team approach” is…

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Often-Unreported MRI Finding May Indicate Neurodevelopmental Impairment in Premature Infants
 Often-Unreported MRI Finding May Indicate Neurodevelopmental Impairment in Premature Infants 150 150 Jeb Phillips
By: Jeb Phillips

Moderate-to-severe gyral maturation delay emerged as a significant predictor of overall neurodevelopmental delay in premature infants with extremely low birth weights Magnetic resonance imaging of the brain is increasingly used to predict neurodevelopmental outcomes in premature infants, but the existing systems of scoring those…

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For Infants Born Very Preterm, Transcatheter Device Closure of Patent Ductus Arteriosus is Feasible
 For Infants Born Very Preterm, Transcatheter Device Closure of Patent Ductus Arteriosus is Feasible 150 150 Jeb Phillips
By: Jeb Phillips

Optimal timing of procedures and reduction of adverse events are avenues for future study. Approximately half of babies born at less than 32 weeks of gestational age have persistent patent ductus arteriosus (PDA), a condition associated with higher odds of death and respiratory morbidity.…

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Specialty Pharmacy for Cystic Fibrosis Improves Access to Medication
 Specialty Pharmacy for Cystic Fibrosis Improves Access to Medication 150 150 Abbie Miller
By: Abbie Miller

In a project started to increase the number of patients taking Orkambi®, access and adherence increases for all medications. The Nationwide Children’s Hospital Cystic Fibrosis (CF) Program cares for a large population of patients of all ages with cystic fibrosis.  The program has participated in many…

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conceptual art of DNA
How Does Genomic Medicine Become a Reality for Children’s Health?
 How Does Genomic Medicine Become a Reality for Children’s Health? 1024 575 Jan Arthur
By: Jan Arthur

Perhaps one of the most important initiatives to advance our understanding of pediatric disease is genomic analysis. Genomics encompasses all aspects of understanding the human genetic code, especially how genetic information contained in every human cell can be interpreted to prevent disease and customize…

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A Novel, Promising Strategy for Diagnosing UTIs in Children
 A Novel, Promising Strategy for Diagnosing UTIs in Children 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

Antimicrobial peptides may be effective biomarkers for diagnosing urinary tract infections in children. Urinary tract infections (UTIs) are one of the most common infections in children and account for millions of unplanned pediatrician and urgent care visits each year in the United States. Previous…

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Long Acting Reversible Contraceptives: A First-Line Approach to Prevent Teen Pregnancy
 Long Acting Reversible Contraceptives: A First-Line Approach to Prevent Teen Pregnancy 150 150 Elise Berlan, MD, MPH
By: Elise Berlan, MD, MPH

Unplanned teen pregnancies remain a problem in American society. In the United States, 82 percent of teen pregnancies are unplanned, and the United States has the highest teenage pregnancy rate among high income nations. Despite being highly effective and safe, misconceptions around long acting…

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Despite Safety Concerns, Nearly 1 in 4 Babies in the NICU Receive Acid Suppressing Medications
 Despite Safety Concerns, Nearly 1 in 4 Babies in the NICU Receive Acid Suppressing Medications 150 150 Jeb Phillips
By: Jeb Phillips

While use is dropping overall as doctors heed warnings, acid suppressing medication originally formulated for older children and adults is still being given to nearly 25 percent of babies in the NICU. Since 2006, several published studies have associated the use of some acid…

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Uncovering Racial Disparities in Down Syndrome
 Uncovering Racial Disparities in Down Syndrome 1024 575 Stephanie Santoro, MD
By: Stephanie Santoro, MD

Life expectancy for people with Down syndrome varies depending on race, but why? An estimated 6000 infants with Down syndrome (DS) are born in the United States annually, making it the most common liveborn trisomy and chromosomal condition.[1] And a significant increase in overall…

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First Implantable Hemodynamic Monitoring Device in Single Ventricle Fontan Anatomy
 First Implantable Hemodynamic Monitoring Device in Single Ventricle Fontan Anatomy 150 150 Abbie Miller
By: Abbie Miller

The first IHM in a patient with Fontan anatomy and physiology enables real-time monitoring of central venous and pulmonary artery pressures. While the Fontan procedure has improved the short- and mid-term outcomes for patients born with single ventricle anatomy, long-term complications of Fontan circulation…

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Aerial view of a suburban neighborhood showing closely spaced single-family homes with light-colored roofs, small yards and intersecting streets arranged in a grid pattern.
Creating the Patient-Centered Medical Neighborhood
 Creating the Patient-Centered Medical Neighborhood 1024 575 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

How do we create a more integrated healthcare delivery system to improve outcomes in our community? The Agency for Healthcare Research and Quality (AHRQ) conceptualizes the medical neighborhood as a patient-centered medical home (PCMH) and the network of other clinicians providing health care services to patients…

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Using Social Media to Advance Care
 Using Social Media to Advance Care 150 150 Nationwide Children's
By: Nationwide Children's

As the use of social media has grown, so has the medical community’s understanding of how it can be harnessed for health care. From collaborating with peers and educating the public to building your career, physicians have a growing responsibility and growing presence in…

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conceptual art of DNA
Achieving CLARITY
 Achieving CLARITY 1024 575 Abbie Miller
By: Abbie Miller

Multidisciplinary team from Nationwide Children’s wins international genomics competition. Accurate, patient-centered, comprehensive. That’s how the judges and leaders of the CLARITY Undiagnosed Challenge described the work of a team from Nationwide Children’s Hospital. Those same words could be used to describe the highly motivated and diverse team who surprised themselves by winning…

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