In the first comprehensive study of its kind, researchers simultaneously analyzed both host and bacteria protein signatures from a single, tiny tissue sample. A novel study from researchers at Nationwide Children’s Hospital has shown that it is possible to obtain both host and bacteria…

New research shines a light on the role of MHCI in astrocyte-induced death of motor neurons in amyotrophic lateral sclerosis and pointing to a potential therapeutic target. Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a devastating progressive neurodegenerative disease that…

Research suggests teens weight gain on popular injectable contraceptive associated with micronutrient intake. Each year, thousands of teenage girls decide to use the injectable contraceptive depot medroxyprogesterone acetate (DMPA). They are drawn to DMPA’s long-acting convenience (it’s injected just four times a year) and…

First evaluation of pay-for-performance conducted by researchers at Nationwide Children’s Hospital. The first pay-for-performance (P4P) evaluation of pediatricians under a full-risk Medicaid accountable care organization (ACO) for children shows P4P incentives were partially responsible for higher performance on quality measures across Partners For Kids’ primary care…

Stakeholder involvement in clinical trial design leads to greater recruitment and retention rates. By seeking the advice of patients, families and other stakeholders in designing a clinical trial investigating pediatric appendicitis, researchers at Nationwide Children’s Hospital found a way to significantly increase the number…

Expression of HLA class I and β-2-microglobulin may show how susceptible some cancers are to T-cell based immunotherapies. A number of possible immunotherapies for cancer are based on T-cells that can target and kill tumors. These cytotoxic T lymphocytes (CTLs) can only recognize tumor…

Researchers investigate clinical and laboratory testing methods to accurately distinguish adenovirus from Kawasaki disease in children Kawasaki disease is a rare but serious condition in children that involves inflammation of the blood vessels, specifically the coronary arteries. It is the most common cause of pediatric…

Research shows children in Ohio’s Appalachian counties face similar health care challenges to those in metropolitan areas Despite the fact that previous research shows the Appalachian region of the United States as limited in access to health care services, researchers at Nationwide Children’s Hospital…

Early attempts associated with shorter hospital stays and lower incidence of bronchopulmonary dysplasia, even if reintubation is necessary Neonatologists often struggle with the timing of extubation. Although prolonged mechanical ventilation in premature infants is linked to the development of bronchopulmonary dysplasia (BPD), there has…

First model of exon duplication causing DMD enables testing for potential therapies Duplication of exons, the parts of a gene that code for amino acids, cause six to 10 percent of cases of Duchenne muscular dystrophy, which is due to mutations in theDMD gene.  New research suggests…

Researchers are studying how well commercially available bifocal contact lenses limit the progression of myopia. Myopia, or nearsightedness, is a growing problem in the United States and around the world. Research suggests 30 to 40 percent of adults in Europe and the United States…