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Use Caution When Prescribing a Gluten-Free Diet
 Use Caution When Prescribing a Gluten-Free Diet 150 150 Kevin Mayhood
By: Kevin Mayhood

A gluten-free diet makes diagnosing underlying conditions difficult and can leave potential, long-term consequences unaddressed. The growing popularity of a gluten-free diet among adults appears to be spilling over to children, with help from the pediatrician’s office. “An increasing number of primary care physicians,…

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Oligodendrocytes Induce Motor Neuron Death in ALS
 Oligodendrocytes Induce Motor Neuron Death in ALS 150 150 Jeb Phillips
By: Jeb Phillips

A first-of-its-kind oligodendrocyte in vitro model shows that human cells normally supportive of motor neuron function play an active role in amyotrophic lateral sclerosis pathogenesis – and this discovery may point the way toward therapeutic timing and targets. A number of studies over the…

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Personal, Familial and Social Factors Surrounding Child Suicide
 Personal, Familial and Social Factors Surrounding Child Suicide 150 150 Brianne Moore
By: Brianne Moore

As suicide rates among children climb, researchers publish the first study exclusively focused on the precipitating circumstances of children and young adolescents who die by suicide. According to the Centers for Disease Control and Prevention (CDC), suicide was the 10th leading cause of death for…

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A Painful Reality: Care Providers Tend to Underestimate Pain During Pediatric Burn Dressing Changes
 A Painful Reality: Care Providers Tend to Underestimate Pain During Pediatric Burn Dressing Changes 150 150 Krista Wheeler
By: Krista Wheeler

Researchers call for an updated pain scale. Dressing changes have been identified as one of the major contributors to perceived pain during burn care, and so it is important that pain be assessed accurately. But a new study from the Center for Pediatric Trauma Research in…

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What Pediatricians Need to Know About the New Meningococcal B Vaccine
 What Pediatricians Need to Know About the New Meningococcal B Vaccine 150 150 Michael T. Brady, MD
By: Michael T. Brady, MD

Michael T. Brady, MD, infectious diseases specialist at Nationwide Children’s Hospital and primary author of the recent American Academy of Pediatrics position paper on the meningococcal B vaccine, shares what you need to know about this controversial vaccine. Meningococcal serotype B (MenB) causes the…

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Nine Factors for Predicting the Duration of Post-Concussion Symptoms
 Nine Factors for Predicting the Duration of Post-Concussion Symptoms 150 150 Jeb Phillips
By: Jeb Phillips

Concussion recovery is poorly understood, but new research suggests that some factors are predictive of recovery time. Several factors, including continued physical activity following a concussion, worsening symptoms from the time of injury to the time a patient seeks care, and a previous history…

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Finding a Better Way to Diagnose and Treat Iron Deficiency in Young Women
 Finding a Better Way to Diagnose and Treat Iron Deficiency in Young Women 150 150 Brianne Moore
By: Brianne Moore

Iron deficiency without anemia often goes undiagnosed in young women, and when caught, the standard treatment is often associated with poor compliance due to side effects. Dr. Sarah O’Brien’s research is focused on finding a solution. Even in developed countries, iron deficiency continues to…

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Specialized Test Detects Bacterial Infections in Youngest Infants with Fever
 Specialized Test Detects Bacterial Infections in Youngest Infants with Fever 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

The diagnostic test has potential to prevent painful testing, unnecessary antibiotics and hospitalizations for many of the more than 500,000 febrile infants who arrive at hospitals each year. Physicians from Children’s Hospital of Michigan, UC Davis Medical Center and Nationwide Children’s Hospital, in collaboration…

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Using Whole Exome Sequencing to Find Genetic Cause of Congenital Heart Disease in At-Risk Patients
 Using Whole Exome Sequencing to Find Genetic Cause of Congenital Heart Disease in At-Risk Patients 150 150 Brianne Moore
By: Brianne Moore

Whole exome sequencing has the ability to identify disease-causing mutations, contributing to the development of personalized medicine and bridging a crucial gap between scientific knowledge and clinical application. Congenital heart disease (CHD) is the most common type of birth defect, affecting approximately 40,000 births…

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Study Finds Genetic Loci Associated With Anxiety and Aggression in Dogs: What Does It Mean for Kids?
 Study Finds Genetic Loci Associated With Anxiety and Aggression in Dogs: What Does It Mean for Kids? 150 150 Carlos E. Alvarez, PhD
By: Carlos E. Alvarez, PhD

Principal investigator Carlos Alvarez, PhD, reports the genome wide mapping of nine fear and aggression traits in dogs and discusses the implications of the findings. Anxiety disorders are the most common type of mental illness in the United States. They are associated with increased…

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Chromatin’s Role in Cancer Development
 Chromatin’s Role in Cancer Development 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

A new study investigates the role of chromatin containing the histone H3 variant in the centromere region of chromosomes in the development of cancer. Although there are many types of cancer, all cancers have one thing in common: they develop when normal processes in…

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Researchers at Nationwide Children’s Hospital Describe New Type of Cancer Therapy
 Researchers at Nationwide Children’s Hospital Describe New Type of Cancer Therapy 150 150 Abbie Miller
By: Abbie Miller

The new chemotherapy is effective against both pediatric and adult cancers, and it allows other chemotherapies to more readily reach their targets. A study conducted at Nationwide Children’s Hospital has found that a new chemotherapy is effective against both pediatric and adult cancers, and…

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Considering Peptide Tuning of Natural Killer (NK) Cells
 Considering Peptide Tuning of Natural Killer (NK) Cells 150 150 Abbie Miller
By: Abbie Miller

Researchers combine modeling and functional studies of interactions between MHC-I and NK cells to learn how they operate on a molecular level. Natural killer (NK) cells are cytotoxic lymphocytes — important immune cells of the innate immune system. NK cells are increasingly understood to…

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An Effective Strategy for Disrupting Bacterial Biofilms
 An Effective Strategy for Disrupting Bacterial Biofilms 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

Using monoclonal antibodies to bind to proteins essential to biofilm structure and stability is highly effective against many types of bacteria that cause a variety of human disease. Biofilms are communities of bacteria that adhere to a surface and are nearly impossible to eradicate…

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When Should Kids With Severe Functional Constipation Have Surgery?
 When Should Kids With Severe Functional Constipation Have Surgery? 150 150 Jeb Phillips
By: Jeb Phillips

A protocol developed by pediatric surgeons and gastroenterologists allows patients to receive specific surgical interventions that will be most beneficial – and allows many patients originally referred for surgery to avoid it altogether. Children with severe functional constipation are most often referred for surgery…

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Counseling Pediatric Patients on Fertility and Sexual Function
 Counseling Pediatric Patients on Fertility and Sexual Function 150 150 Brianne Moore
By: Brianne Moore

How should we talk to patients and their families about these sensitive subjects? Since 2006, several medical societies have released guidelines for discussing fertility preservation prior to pediatric cancer treatment. According to the American Society for Reproductive Medicine, a “collaborative, multidisciplinary team approach” is…

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Often-Unreported MRI Finding May Indicate Neurodevelopmental Impairment in Premature Infants
 Often-Unreported MRI Finding May Indicate Neurodevelopmental Impairment in Premature Infants 150 150 Jeb Phillips
By: Jeb Phillips

Moderate-to-severe gyral maturation delay emerged as a significant predictor of overall neurodevelopmental delay in premature infants with extremely low birth weights Magnetic resonance imaging of the brain is increasingly used to predict neurodevelopmental outcomes in premature infants, but the existing systems of scoring those…

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For Infants Born Very Preterm, Transcatheter Device Closure of Patent Ductus Arteriosus is Feasible
 For Infants Born Very Preterm, Transcatheter Device Closure of Patent Ductus Arteriosus is Feasible 150 150 Jeb Phillips
By: Jeb Phillips

Optimal timing of procedures and reduction of adverse events are avenues for future study. Approximately half of babies born at less than 32 weeks of gestational age have persistent patent ductus arteriosus (PDA), a condition associated with higher odds of death and respiratory morbidity.…

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Specialty Pharmacy for Cystic Fibrosis Improves Access to Medication
 Specialty Pharmacy for Cystic Fibrosis Improves Access to Medication 150 150 Abbie Miller
By: Abbie Miller

In a project started to increase the number of patients taking Orkambi®, access and adherence increases for all medications. The Nationwide Children’s Hospital Cystic Fibrosis (CF) Program cares for a large population of patients of all ages with cystic fibrosis.  The program has participated in many…

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conceptual art of DNA
How Does Genomic Medicine Become a Reality for Children’s Health?
 How Does Genomic Medicine Become a Reality for Children’s Health? 1024 575 Jan Arthur
By: Jan Arthur

Perhaps one of the most important initiatives to advance our understanding of pediatric disease is genomic analysis. Genomics encompasses all aspects of understanding the human genetic code, especially how genetic information contained in every human cell can be interpreted to prevent disease and customize…

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