Clinical Genomics: From Research to Reality

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Single Ventricle, Many Research Angles

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Setting the Standard for Cloacal Malformation Management

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Colorful illustration showing how fibrosis, or a spiky lumpy mass of scar tissue, forms over healthy liver tissue when the liver attempts to repair and replace damaged cells
Fighting Fibrosis
 Fighting Fibrosis 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Fibrosis is an unmet medical challenge with no satisfactory test and insufficient therapy. Now, one naturally occurring cellular component could simultaneously diagnose and heal patients. It’s much more than a million-dollar idea. The person who invents a simple blood or urine test that can…

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Preserving Biopreservation
 Preserving Biopreservation 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Funding challenges, operational complexity and poor visibility threaten the field of human tissue biobanking. How sustainable are biorepositories? The Children’s Oncology Group (COG) boasts the collaboration of more than 9,000 pediatric cancer experts. They treat patients and research disease at more than 200 hospitals around the…

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InSight: A Window to the Heart
 InSight: A Window to the Heart 720 530 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Cardiac MRI for Hypoplastic Left Heart Syndrome Hypoplastic left heart syndrome (HLHS) is a potentially fatal congenital heart defect affecting blood flow. It requires multiple palliative surgeries, starting within the first week of life. Nationwide Children’s employs a hybrid surgical approach. Hybrid Stage I (not…

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Patients Without Borders
 Patients Without Borders 150 150 Dave Ghose
By: Dave Ghose

Immigrant children represent the fastest growing segment of the U.S. population. What can pediatricians do to help these vulnerable patients? James Duffee, MD, MPH, watched the immigrant population change dramatically during his 15 years as a community health pediatrician and child psychiatrist in Springfield,…

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To Rest or Not To Rest?
 To Rest or Not To Rest? 150 150 Kevin Mayhood
By: Kevin Mayhood

About the authorAuthorArticles by the Author Kevin MayhoodKevin Mayhoodhttps://pediatricsnationwide.org/author/kevin-mayhood/January 5, 2015Probing for Links Between Psychotropic Drugs and Severe Liver DiseaseKevin Mayhoodhttps://pediatricsnationwide.org/author/kevin-mayhood/April 25, 2015Ebola in Children Creates Ethical QuandaryKevin Mayhoodhttps://pediatricsnationwide.org/author/kevin-mayhood/April 25, 2015Orphan Disease Seeks Parents, FundingKevin Mayhoodhttps://pediatricsnationwide.org/author/kevin-mayhood/October 23, 2015Suicides Rising Among Young Black Children, Rural…

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Ebola in Children Creates Ethical Quandary
 Ebola in Children Creates Ethical Quandary 150 150 Kevin Mayhood
By: Kevin Mayhood

Do you keep a parent in the room while the virus rages inside a child? The Ebola outbreak in Guinea, Liberia and Sierra Leone has challenged emergency preparedness at Children’s Hospitals and Clinics of Minnesota like nothing before — even more than the early days of…

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A Shift in the Antibiotic Prophylaxis Debate?
 A Shift in the Antibiotic Prophylaxis Debate? 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The RIVUR trial laid to rest certain questions surrounding antimicrobial prophylaxis in children with vesicoureteral reflux. But it also launched a new debate. The Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trialwas supposed to provide clear direction for pediatric urologists. To date, it…

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Conflicting Directions for BPD Treatment
 Conflicting Directions for BPD Treatment 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Treatment of bronchopulmonary dysplasia differs dramatically among institutions. But why does variation matter? Recent studies report extreme variation among hospitals ordering three common medications for chronic lung disease, or bronchopulmonary dysplasia, calling into question the appropriateness of their use and the reason for their…

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Placental Transfusion Confusion
 Placental Transfusion Confusion 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Medical professional organizations cannot reach consensus regarding delayed cord clamping and umbilical cord “milking.” Nearly every relevant professional organization has its own recommendations for placental transfusion techniques known as delayed umbilical cord clamping and milking. But it’s unclear whether additional research will lead to…

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Beyond the Basics: Enrolling Children in Research
 Beyond the Basics: Enrolling Children in Research 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The ethics of pediatric research include far more than the concepts of autonomy and assent. Consent and assent. Competence and autonomy. Physicians are familiar with the catchphrases of ethical research, but the deeper researchers dig, the more they find that the field’s current understanding…

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Study Finds Cow’s Milk is Added to Breast Milk and Sold to Parents Online
 Study Finds Cow’s Milk is Added to Breast Milk and Sold to Parents Online 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Deceptive Internet advertisements for human breast milk may put infants at risk. What do parents (and doctors) need to know about milk sharing? A study published yesterday on the safety of human breast milk bought over the Internet found that 10 percent of samples contained added…

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The Continence Predictor Index
 The Continence Predictor Index 150 150 Marc Levitt, MD
By: Marc Levitt, MD

About the authorAuthorArticles by the Author Marc Levitt, MDMarc Levitt, MDhttps://pediatricsnationwide.org/author/marc-levitt-md/June 30, 2015Designing a Center for Collaborative Care

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Are We Properly Capturing the Maternal-Child Health Continuum?
 Are We Properly Capturing the Maternal-Child Health Continuum? 150 150 Irina Buhimschi
By: Irina Buhimschi

An obstetrician doing research at a children’s hospital may seem out of place. But not according to one clinician-scientist, who believes that maternal health and child health are inextricably intertwined. Traditionally, doctors divide into those who practice adult medicine and those who practice pediatrics.…

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Advancing Pediatric Anesthesiology Through Research
 Advancing Pediatric Anesthesiology Through Research 150 150 Joseph Tobias, MD
By: Joseph Tobias, MD

Pediatric anesthesiology research is a relatively new phenomenon. But one clinician-scientist believes it is the key to bringing the field into the “big leagues” of evidence-based medicine. Over the past 30 years, the field of pediatric anesthesiology has expanded with the recognition of the…

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Big Data: Ride the Bandwagon, Sell Hot Dogs at the Show, or Jump Out of the Way?
 Big Data: Ride the Bandwagon, Sell Hot Dogs at the Show, or Jump Out of the Way? 150 150 William Ray, PhD
By: William Ray, PhD

Big Data has big potential. But can it truly tell you what you want to know? Big Data. It’s all the rage, and if you listen to the hype, you might get the impression that it’s going to cure cancer, bring about world peace…

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Early Detection of Bipolar Spectrum Disorders in High-Risk Children
 Early Detection of Bipolar Spectrum Disorders in High-Risk Children 150 150 Abbie Miller
By: Abbie Miller

A new study finds key symptoms are associated with the development of bipolar disorder among children of parents with the condition. New research published today in the American Journal of Psychiatry indicates a strong link between subthreshold manic episodes and likelihood of developing bipolar disorder…

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Illuminating Vasospasm in Children with Traumatic Brain Injury
 Illuminating Vasospasm in Children with Traumatic Brain Injury 150 150 Jan Arthur
By: Jan Arthur

Understanding reasons for dangerous vessel constriction following brain injury may help define treatment or prevention options. Vasospasm, or severe narrowing of blood vessels, is a dangerous complication observed in children with moderate to severe traumatic brain injury. In a paper recently published in Critical Care…

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Bacterial or Viral? New Technique to Clear Muddy Waters
 Bacterial or Viral? New Technique to Clear Muddy Waters 150 150 Jan Arthur
By: Jan Arthur

Transcriptional profiling could help reduce inappropriate administration of antibiotics for lower respiratory infections in hospitalized patients. Lower respiratory tract infections (LRTIs) are one of the most frequent reasons for hospitalization in adults and children worldwide. However, in most cases, establishing the cause of the…

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Speeding Up the Genome Analysis Process
 Speeding Up the Genome Analysis Process 150 150 Jan Arthur
By: Jan Arthur

New software analyzes human genomes faster than other available technologies, empowering population-scale genomic analysis. Investigators at Nationwide Children’s Hospital have developed an analysis “pipeline” that slashes the time it takes to search a person’s genome for disease-causing variations from weeks to hours. An article…

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Cholesterol Screening: What’s the Right Approach?
 Cholesterol Screening: What’s the Right Approach? 150 150 Dave Ghose
By: Dave Ghose

The jury is still out on whether universal testing of children is a good thing. To screen or not to screen? For pediatricians, that question is far from answered when it comes to universal cholesterol testing. Despite an endorsement of the practice from an…

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