What Pediatricians Need to Know About the New Meningococcal B VaccineWhat Pediatricians Need to Know About the New Meningococcal B Vaccine https://pediatricsnationwide.org/wp-content/themes/corpus/images/empty/thumbnail.jpg 150 150 Michael T. Brady, MD Michael T. Brady, MD https://pediatricsnationwide.org/wp-content/uploads/2021/03/Brady-crop.jpg
- September 08, 2016
- Michael T. Brady, MD
Michael T. Brady, MD, infectious diseases specialist at Nationwide Children’s Hospital and primary author of the recent American Academy of Pediatrics position paper on the meningococcal B vaccine, shares what you need to know about this controversial vaccine.
Meningococcal serotype B (MenB) causes the majority of invasive meningococcal disease in infants and young children. Though not the major cause of the disease in young adults, a few highly-publicized MenB outbreaks on college campuses have led to worries among college-age adolescents and their families.
Two MenB vaccines have recently been licensed for use in patients ages 10-25, and the U.S. Centers of Disease Control and Prevention has given them a first-of-its-kind “Category B” recommendation – meaning the vaccines are covered by federal and commercial insurance but not routinely recommended for most people. (There is a “Category A” or routine recommendation, for an entire population or specific risk groups).
The American Academy of Pediatrics has issued these guidelines for the vaccine’s use:
- The MenB vaccine should be routinely used in patients who are at increased risk of MenB disease – that is, patients with complement deficiency; patients with anatomic or functional asplenia; and healthy patients who live in an area with a MenB disease outbreak.
- The MenB vaccine is not recommended for routine use for those are not in the at-risk categories listed above.
- The MenB vaccine may be given to patients ages 16-23 (though the preferred range is 16-18) to provide short-term protection against MenB.
Important for physicians to know as they consult with families:
- Meningococcal disease caused by all serogroups ( B, C and Y) is at historically low levels in the United States. We don’t know why the decline began in the 1990s, even before the MenACWY vaccine was available. That means cases could rise just as unexpectedly.
- The incidence of MenB disease is not higher in college students than in the general population of the same age, despite a few well-known college outbreaks.
- Preliminary data show that 60 percent of MenB vaccine recipients maintain antibody levels at two years after vaccination. We do not know the long-term safety profile, but no unusual safety issues are expected
- Because the MenB vaccine is the first with a “Category B” designation, it’s not clear yet what liability a physician may have if she recommends the vaccine, has a family decline it and then the child is infected with MenB. Best practice is to document discussions with the family if they decide against the vaccine.
It is reasonable to give the MenB vaccine to young adults when they (or their families) are concerned about risk and ask for it. It’s also reasonable to inform families of availability even if they don’t ask.
The challenge is determining the importance of MenB vaccine when there are so many other important conversations to have with young adults. A pediatrician may need to decide whether the limited time available with a patient may be better spent on other conversations, or advocating for routine vaccines with clear proven benefits, such as MenACWY, the HPV series and influenza.
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