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Nurse caring for infant in Neonatal Intensive Care Unit (NICU)
Nephrotoxic Medications in the NICU
 Nephrotoxic Medications in the NICU 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

New study shows treatment with nephrotoxic medications in newborns is associated with the development of acute kidney injury, yet remains common. A multicenter analysis of nearly 50 pediatric hospitals showed that newborns are commonly treated with nephrotoxic medications and, troublingly, the prevalence of acute…

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Fertility Navigators Support Important Consultations in Pediatric Settings
 Fertility Navigators Support Important Consultations in Pediatric Settings 150 150 Mary Bates, PhD
By: Mary Bates, PhD

At Nationwide Children’s, hiring a full-time fertility navigator increased access to fertility care among pediatric patients. With advances in chemotherapy and radiation, more children are surviving cancer and entering adulthood. However, a potential consequence of such treatments is fertility impairment, which can affect about…

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Do Symptom Scores and pH Impedance Correlate in Infants Treated for Gastroesophageal Reflux?
 Do Symptom Scores and pH Impedance Correlate in Infants Treated for Gastroesophageal Reflux? 1024 683 Lauren Dembeck
By: Lauren Dembeck

Gastroesophageal reflux (GER) — the passage of gastric contents into the esophagus — is a physiologic process that can be considered normal or abnormal depending on whether troublesome symptoms and/or complications also occur. In infants, it is difficult for clinicians to distinguish between GER…

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Salivary MicroRNAs: A Promising Biomarker for Persistent Post-concussive Symptoms in Children With Concussion
 Salivary MicroRNAs: A Promising Biomarker for Persistent Post-concussive Symptoms in Children With Concussion 1024 768 Lauren Dembeck
By: Lauren Dembeck

The multidisciplinary study used children’s saliva and genomic analysis to identify promising biomarkers for persistent post-concussive symptoms. Predicting clinical recovery of children with concussion is challenging. While concussion symptoms typically resolve within one to three weeks, up to one-third of children develop persistent post-concussive…

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Collage of health technology tools
Telehealth Has the Potential to Bridge Gaps in Psychiatric and Behavioral Health Care
 Telehealth Has the Potential to Bridge Gaps in Psychiatric and Behavioral Health Care 1024 535 Jessica Nye, PhD
By: Jessica Nye, PhD

A growing body of evidence supports telebehavioral health delivery for children, adolescents and their families, as outcomes are comparable to in-person treatment delivery. Despite evidence of efficacy, regulatory and financial concerns and technology barriers continue to impede widespread uptake of telebehavioral health. “There have…

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What’s the Scope of Nephritis in Pediatric Patients With IgA Vasculitis?
 What’s the Scope of Nephritis in Pediatric Patients With IgA Vasculitis? 150 150 Jessica Nye, PhD
By: Jessica Nye, PhD

A multicenter study from the Pediatric Nephrology Research Consortium found that many pediatric patients with IgA vasculitis nephritis (IgAVN) are treated with immunosuppressive (IS) agents, and some had evidence of chronic kidney disease as early as 12 months after presentation.   IgA vasculitis (IgAV)…

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A Single-Dose Cancer Immunotherapy via Gene Transfer
 A Single-Dose Cancer Immunotherapy via Gene Transfer 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Researchers at Nationwide Children’s Hospital report proof-of-principle results for a new gene therapy cancer treatment. The off-the-shelf, single-dose immunotherapy serves as an alternative to CAR-T therapy and can be engineered to be on-demand. T cells redirected to cancer cells either via a chimeric antigen…

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Tissue engineered vascular graft
Researchers Characterize Growth and Remodeling of Tissue-Engineered Blood Vessels
 Researchers Characterize Growth and Remodeling of Tissue-Engineered Blood Vessels 600 400 Lauren Dembeck
By: Lauren Dembeck

Tissue engineering may soon give babies with congenital heart disease new blood vessels capable of native function and growth.   Major cardiovascular reconstructive operations in babies with congenital heart defects require the use of artificial blood vessels called vascular grafts. Because these grafts are…

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Quality Improvement Scorecard Enhances Safety for Newborns
 Quality Improvement Scorecard Enhances Safety for Newborns 1024 683 Emily Siebenmorgen
By: Emily Siebenmorgen

The collaborative program between academic and community hospitals improves neonatal care quality. In a recent study published in The Journal of Pediatrics, researchers from Nationwide Children’s Hospital and affiliated level one and two community hospital nurseries implemented a quality improvement (QI) scorecard and found…

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Predicting Disease Severity and Assessing Long-Term Outcomes of Pediatric La Crosse Virus
 Predicting Disease Severity and Assessing Long-Term Outcomes of Pediatric La Crosse Virus 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Limited data exist on mosquito-borne La Crosse Virus in children, underscoring the importance of determining which patients are at risk for severe disease and long-term neurobehavioral difficulties.   La Crosse Virus (LACV) is a neuroinvasive arbovirus spread by the Aedes triseriatus mosquito, causing symptoms…

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Featured Researcher — Mitchel Stacy, PhD
 Featured Researcher — Mitchel Stacy, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Mitchel Stacy, PhD, a principal investigator in the Center for Regenerative Medicine at Nationwide Children’s Hospital and assistant professor of Surgery at The Ohio State University, started his education with dietetics in mind. Finding his way instead to nuclear and molecular imaging of cardiovascular…

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artistic rendering of an NK cell on a faded blue background with other cells faintly visible in the background
Investigators Develop Technique to Effectively Edit NK Cells to Target Specific Cancer Cells
 Investigators Develop Technique to Effectively Edit NK Cells to Target Specific Cancer Cells 1024 649 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The third of three major challenges in enabling the clinical potential of NK cells for cancer therapy has just been addressed, thanks to the combined talents of gene editing experts and NK cell specialists at Nationwide Children’s Hospital.   Originally, NK cells seemed promising…

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Cardiopulmonary Rehabilitation Post-COVID: Could Your Patient Benefit?
 Cardiopulmonary Rehabilitation Post-COVID: Could Your Patient Benefit? 1024 728 Abbie Miller
By: Abbie Miller

The road to recovery from COVID-19, the disease caused by SARS-CoV-2, is not always smooth, short or straight. For adults and children, long COVID, a condition where symptoms such as fatigue, headache and decreased respiratory function persist after the virus has “cleared” the body,…

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How Do Children With IBD and Their Caregivers Perceive Biosimilars?
 How Do Children With IBD and Their Caregivers Perceive Biosimilars? 640 427 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Many pediatric patients with inflammatory bowel disease and their caregivers are unaware of biosimilars, creating an opportunity for providers to educate patients and their families about this effective and less expensive treatment option. Infliximab is a biologic therapy that effectively manages inflammatory bowel disease…

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BRUE: What Is It? How Is It Treated?
 BRUE: What Is It? How Is It Treated? 1024 575 Abbie Miller
By: Abbie Miller

BRUE –brief resolved unexplained event – whether you pronounce it brew-EE or brOO, it might be a term you haven’t run across since medical school. In a recent resident-led episode of PediaCast CME, Meghan Fennell, MD, and Vanessa Thiel, MD, break down everything you…

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Featured Researcher — Ashley Jackson, PhD
 Featured Researcher — Ashley Jackson, PhD 150 150 Natalie Wilson
By: Natalie Wilson

Ashley Jackson, PhD, is a principal investigator in The Kidney and Urinary Tract Center at Nationwide Children’s studying renal urothelium, the special surface tissue that lines most of the urinary tract, or the drainage system of the kidneys, to slow kidney disease progression in…

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Functional Neurological Disorders: What Pediatric Neurologists Should Know
 Functional Neurological Disorders: What Pediatric Neurologists Should Know 150 150 Mary Bates, PhD
By: Mary Bates, PhD

The diagnosis is common, yet this group of disorders has been subjected to confusion and stigma throughout history. Functional neurological disorders are a collection of disorders in which patients experience neurological symptoms, such as numbness, weakness, seizure-like events, or abnormal gait or movements, but…

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Self-Harm Risk Among Youth With First-Episode Psychosis
 Self-Harm Risk Among Youth With First-Episode Psychosis 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Study narrows down period of acute risk and finds shared and unique risk factors among adolescents and young adults. Although it is known that young people with psychosis are at an elevated risk for suicide and suicide-related behavior, it has not been clear which…

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Variability in Cardiac Diagnostics and Therapies for Patients with Duchenne Muscular Dystrophy
 Variability in Cardiac Diagnostics and Therapies for Patients with Duchenne Muscular Dystrophy 1024 670 Mary Bates, PhD
By: Mary Bates, PhD

Survey shows different approaches to cardiac diagnostics and therapy among a multicenter collaborative network. Cardiac disease is a major cause of mortality in Duchenne muscular dystrophy (DMD), yet data regarding outcomes and cardiac disease progression are lacking. This has led to a highly variable…

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The True History of the Nuremberg Code: Leo Alexander’s Blueprint Uncovered
 The True History of the Nuremberg Code: Leo Alexander’s Blueprint Uncovered 150 150 Abbie Miller
By: Abbie Miller

An investigation of Duke University’s Medical Center’s Archives boxes labeled “Alexander’s Papers” reveals a document containing six principles, which were included nearly word-for-word in the Nuremberg Code.  At the end of the famous Doctors’ Trial, the trial of Nazi doctors for their crimes and…

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