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Mouse Model Reflects Small Population but Could Provide Big Payoff
 Mouse Model Reflects Small Population but Could Provide Big Payoff 150 150 Kevin Mayhood
By: Kevin Mayhood

First model of exon duplication causing DMD enables testing for potential therapies Duplication of exons, the parts of a gene that code for amino acids, cause six to 10 percent of cases of Duchenne muscular dystrophy, which is due to mutations in theDMD gene.  New research suggests…

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Putting the Brakes on Myopia Progression
 Putting the Brakes on Myopia Progression 150 150 Abbie Miller
By: Abbie Miller

Researchers are studying how well commercially available bifocal contact lenses limit the progression of myopia. Myopia, or nearsightedness, is a growing problem in the United States and around the world. Research suggests 30 to 40 percent of adults in Europe and the United States…

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Using Antibiotics Alone for Children with Uncomplicated Appendicitis
 Using Antibiotics Alone for Children with Uncomplicated Appendicitis 150 150 Gina Bericchia
By: Gina Bericchia

One year follow-up of patients treated only with antibiotics found that 76 percent avoided surgery. Using antibiotics alone to treat children with uncomplicated acute appendicitis is a reasonable alternative to surgery when chosen by the family, finds a recent study led by researchers at…

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Boosting Research With a Down Syndrome Biobank
 Boosting Research With a Down Syndrome Biobank 150 150 Abbie Miller
By: Abbie Miller

A new biobank for Down syndrome blood samples will enable clinical and translational researchers everywhere to shed light on conditions related to Down syndrome, including Alzheimer’s disease. Certain conditions such as congenital heart disease, childhood leukemia and epilepsy are more common in patients with…

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Childhood Kidney Stones Associated With Atherosclerosis
 Childhood Kidney Stones Associated With Atherosclerosis 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Research could lead to early interventions to improve cardiovascular health. Kidney stones in children are increasingly common, and until recently were believed to be an isolated medical problem. But a study conducted by clinician-scientists at Nationwide Children’s Hospital has identified for the first time…

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HIV in the Millennial World
 HIV in the Millennial World 150 150 Abbie Miller
By: Abbie Miller

Adolescents and young adults ages 13 to 24 comprise an increasingly large proportion of new HIV infections in the United States. A new generation of youth is experiencing increasing rates of HIV transmission, and data from the Centers for Disease Control and Prevention (CDC)…

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Infantile Spasms Respond Poorly to Common First-Line Treatment
 Infantile Spasms Respond Poorly to Common First-Line Treatment 150 150 Jeb Phillips
By: Jeb Phillips

Researchers recommend other initial treatments after finding that topiramate has a low rate of infantile spasms remission. The early and effective treatment of infantile spasms has been associated with better developmental outcomes for patients, while delayed remission of the infantile spasms may contribute to…

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Can You Ration Health Care in a Just Society?
 Can You Ration Health Care in a Just Society? 150 150 Pedro Weisleder, MD, PhD
By: Pedro Weisleder, MD, PhD

How the Clinical Effectiveness Model enables the provision of uncompromised, yet fiscally responsible, medical care Health care costs in the United States are an unsustainable expense. In 2014, the United States’ gross domestic product (GDP) was about $17 trillion, and of that, close to…

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Zoledronic Acid Safe and Effective for Use in Children and Young Adults, Study Shows
 Zoledronic Acid Safe and Effective for Use in Children and Young Adults, Study Shows 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

The medication improves bone density and reduces fractures in patients with neuromuscular disorders that lead to paralysis. Children with neuromuscular disorders that lead to quadriplegia (paralysis of all four limbs) or paraplegia (paralysis of the legs and lower body) are at risk for low…

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Common Infections Associated With Childhood Stroke
 Common Infections Associated With Childhood Stroke 150 150 Kevin Mayhood
By: Kevin Mayhood

Routine vaccinations appear to be protective. Minor infections, including the common cold, appear to trigger arterial ischemic stroke (AIS) in children, an international study shows. At the same time, a full or nearly full regimen of childhood immunizations appears to be protective in children.…

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Genetic Testing for Pediatric Epilepsy Can Be Complicated but Beneficial
 Genetic Testing for Pediatric Epilepsy Can Be Complicated but Beneficial 150 150 Gina Bericchia
By: Gina Bericchia

Application of genetic testing in pediatric epilepsy requires understanding of the advantages and limitations of testing modalities The use of genetic testing in pediatric epilepsy is complicated and the list of known epilepsy genes changes almost daily. The steps from a doctor initially evaluating a patient…

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Better Care and Better Business
 Better Care and Better Business 150 150 Dave Ghose
By: Dave Ghose

The changing economics of health care are forcing hospitals to find solutions that are good for patients and for the bottom line. A puzzled neonatologist approached Richard McClead, MD, after he spoke at a conference in Boston. It was 2010, and Dr. McClead just finished…

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InSight: Restoring Normal Habits
 InSight: Restoring Normal Habits 471 285 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

SACRAL NERVE STIMULATION (SNS) is a new treatment that helps control urinary incontinence and fecal soiling. For some children, the nerves that control urination and bowel movements do not work correctly. The SNS unit consists of a small, safe battery and wire under the skin…

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The Transfusion Evolution
 The Transfusion Evolution 576 367 Abbie Miller
By: Abbie Miller

The first successful open heart surgery with cardiopulmonary bypass was performed in 1953, but it wasn’t until the 1970s that these surgeries began to have high success rates — due in large part to the availability of fresh whole blood transfusions. However, fresh whole…

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Acetabular “Fleck” Sign Predictive of Labral Avulsion
 Acetabular “Fleck” Sign Predictive of Labral Avulsion 150 150 Abbie Miller
By: Abbie Miller

A “fleck” sign on the postreduction CT scan calls for high suspicion of labral pathology, even in cases of congruent closed reductions. Traumatic posterior hip dislocations and subluxations are typically treated with a closed reduction in pediatric patients. For patients who have a congruent hip…

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A Practical Guide to Beginning Clinical Research
 A Practical Guide to Beginning Clinical Research 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

You wouldn’t travel to unknown destinations without a map or GPS, so why do clinical research without a plan? Here’s what you need to know to get started. Although the process for clinical research varies from institution to institution, the initial hurdles are often…

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Illustration of NK Cells, T Cells, other immune cells floating across white background
Revealing the Secrets of Sepsis
 Revealing the Secrets of Sepsis 969 533 Abbie Miller
By: Abbie Miller

Charting new territory in the understanding of how the immune system responds to sepsis. Two children are admitted to the hospital with sepsis. Both receive antibiotics and fluid resuscitation within the critical first hour. Why does one get better after the initial crisis while…

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New Drug Advances Cystic Fibrosis Care
 New Drug Advances Cystic Fibrosis Care 150 150 Kevin Mayhood
By: Kevin Mayhood

Orkambi helps reduce infections and slows loss of lung function in some patients. Matt Hennessey knew he was on the experimental medicine and not a placebo just days after he began participating in a drug trial. He felt better. The addition of Orkambi pills…

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Sickle Cell Disease: Global Disparities in Prevalance and Outcomes
 Sickle Cell Disease: Global Disparities in Prevalance and Outcomes 150 150 Abbie Miller
By: Abbie Miller

Unique challenges exist for people with sickle cell disease depending on where they live. An estimated 300,000 to 500,000 babies worldwide are born with sickle cell disease (SCD) each year. In Africa and India, where SCD is most prevalent, newborn testing is not performed,…

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Marijuana Exposure in Young Children
 Marijuana Exposure in Young Children 150 150 Kevin Mayhood
By: Kevin Mayhood

Researchers call for states to enact controls protecting all minors. When states legalize marijuana for medical or recreational use, the number of children younger than 6 exposed to the drug spikes that year and continues to rise annually, researchers at Nationwide Children’s Hospital report.…

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