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Office of Technology Commercialization

Tissue Engineered Vascular Grafts: A Breakthrough for Children With Heart Defects
 Tissue Engineered Vascular Grafts: A Breakthrough for Children With Heart Defects 968 1024 Abbie Miller
By: Abbie Miller
Illustration of a heart showing the Fontan surgery

An innovation 30 years in the making is poised to change the way children with single ventricle disease experience life after a Fontan procedure. Children with single ventricle disease are often described as having “half a heart.” What this really means is that one of their ventricles (either the right or left lower chamber of…

DNA Methylation-Based Diagnostics: Refining Diagnosis for the Most Complex Pediatric Brain Tumors
 DNA Methylation-Based Diagnostics: Refining Diagnosis for the Most Complex Pediatric Brain Tumors 1024 783 Lauren Dembeck
By: Lauren Dembeck

Developed at Nationwide Children’s, the MACDADI classifier is compatible with next-generation methylation arrays and quickly delivers more accurate tumor diagnoses, offering a clinically validated alternative to outdated and unregulated methylation classifiers. Diagnosing central nervous system (CNS) tumors in children is among the most challenging problems in pediatric oncology. Many tumor types share overlapping microscopic features,…

One Gene, Big Impact: The Science Behind a New Therapy for Brain and Muscle Health
 One Gene, Big Impact: The Science Behind a New Therapy for Brain and Muscle Health 1024 683 Madison Storm
By: Madison Storm
Dr. Zarife Sahenk, MD, PhD

A promising new gene therapy developed at Nationwide Children’s Hospital is offering hope for new patients with neurodegenerative and muscle disorders. Led by Zarife Sahenk, MD, PhD, a neurologist, principal investigator in the Jerry R. Mendell Center for Gene Therapy and director of Clinical and Experimental Neuromuscular Pathology at the Abigail Wexner Research Institute, the…

Startups Update: Where Are They Now?
 Startups Update: Where Are They Now? 1024 683 Madison Storm
By: Madison Storm

From cutting-edge gene therapies to transformative medical devices, startups are redefining what’s possible in-patient care and technology. Born from pioneering research and nurtured through strategic collaborations, startups are tackling critical challenges—from neonatal care to oncology and rare genetic disorders—while advancing toward commercialization. Supported by the Office of Technology Commercialization, which facilitates the transfer of breakthrough…

Norms, Needs and New Frontiers in Pediatric Mental Health
 Norms, Needs and New Frontiers in Pediatric Mental Health 1024 683 Madison Storm
By: Madison Storm
Eric Youngstrom, PhD

 An interview with Eric Youngstrom, PhD, director of the Institute for Mental and Behavioral Health Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. At Nationwide Children’s Hospital, the Institute for Mental and Behavioral Health Research (IMBHR) is driving discovery through improved assessments, effective treatments and digging deep to answer the ‘why’ behind…

Breaking New Ground in Cancer Immunotherapy
 Breaking New Ground in Cancer Immunotherapy 1024 683 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s researchers develop a scalable, targeted approach to overcoming cancer’s toughest challenges. Despite significant advances in treatments, cancer remains one of the leading causes of death globally. Traditional therapies, while improving patient outcomes, still have limitations — such as the need for frequent dosing, complex and costly manufacturing and severe side effects. These challenges…

Leveraging Technology and Partnerships to Transform Pediatric Orthopedic Care
 Leveraging Technology and Partnerships to Transform Pediatric Orthopedic Care 1024 683 Erin Gregory
By: Erin Gregory

An interview with Allen A. Kadado, MD, director of the Nationwide Children’s Hospital Center for Orthopedic Innovation, director of the Nationwide Children’s Pediatric Orthopedic Residency Program At Nationwide Children’s Hospital, the Department of Orthopedics drives pediatric health care innovation through collaborations that bridge clinical expertise and technological advancement. Specializing in areas like spinal deformities, trauma…

More Than One REMEDY for Genetic Disorders
 More Than One REMEDY for Genetic Disorders 1024 768 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

How a new approach to correcting heterozygous mutations and other novel techniques for gene editing are transforming the potential to combat disease The field of gene therapy has had some astounding success in recent years — much of which emerged from labs at Nationwide Children’s Hospital — but it has also stumbled over some serious…

Innovative Highchair Design Revolutionizes Pediatric Care: A Collaborative Journey From Concept to Prototype
 Innovative Highchair Design Revolutionizes Pediatric Care: A Collaborative Journey From Concept to Prototype 1024 683 Madison Storm
By: Madison Storm

Highchairs are common in homes with babies and toddlers, as well as in places such as hospitals and restaurants where young children are fed. In hospitals, they are mainly used in pediatric care for infants, toddlers and children undergoing treatment or recovery. Highchairs provide a safe, stable seating option during meals and interactions with family,…

Meet Daphne©, a ChatBot for Pediatric Health Care
 Meet Daphne©, a ChatBot for Pediatric Health Care 150 150 Madison Storm
By: Madison Storm

Machine learning and artificial intelligence (AI)have exploded across the worlds of marketing and commerce in recent years. At Nationwide Children’s, clinicians and researchers are focusing on how AI and related technologies can be used to reduce clinician workloads and improve patient outcomes. Emre Sezgin, PhD, principal investigator in the Center for Biobehavioral Health at Nationwide…

Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2
 Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2 150 150 Lauren Dembeck
By: Lauren Dembeck

Tuberous sclerosis complex (TSC) is a devastating genetic disease that affects nearly 1 in every 5,500 newborns and approximately 2 million people worldwide. The disease is characterized by the formation of non-malignant tumors throughout multiple organs, including the kidney, lungs, eyes, and heart, but predominantly the brain. It is typically diagnosed in infants and young…

Micro-dystrophin: A Small Gene With Big Promise
 Micro-dystrophin: A Small Gene With Big Promise 1024 632 Abbie Miller
By: Abbie Miller

SRP-9001 for Duchenne muscular dystrophy supplies a functional dystrophin gene via AAVrh74 gene therapy. In 1969, Jerry Mendell, MD, was working at the National Institute of Neurological Disorders and Stroke (NINDS) when he saw his first patient with Duchenne muscular dystrophy (DMD). DMD, a severe form of muscular dystrophy caused by a mutation in the…

Building Baby Brains With smallTalk: From Foreign Language Learning at Home to Bridging Gaps in the NICU
 Building Baby Brains With smallTalk: From Foreign Language Learning at Home to Bridging Gaps in the NICU 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD
smallTalk egg

The best language learners on the planet are children — especially babies. Your brain is most active in creating the language center of your brain, connecting neurons and creating the highways and pathways for processing language, during infancy. In fact, language learning begins in utero. The developing brain of a fetus starts to wire language…