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Gastroenterology

Linaclotide: A New Option For Chronic Pediatric Constipation
 Linaclotide: A New Option For Chronic Pediatric Constipation 1024 668 Pam Georgiana
By: Pam Georgiana

Phase 3 Trial at Nationwide Children’s Supports Safety and Efficacy in Children Aged 6–17. Constipation, a common issue for children, can be a source of prolonged struggle and distress for young patients and their families. Despite many treatments being available, some children continue to battle with this condition for years. There is a lack of…

Establishing Meaningful Clinical Outcome Measures for Gastrointestinal Symptoms in Cystic Fibrosis
 Establishing Meaningful Clinical Outcome Measures for Gastrointestinal Symptoms in Cystic Fibrosis 1024 683 Lauren Dembeck
By: Lauren Dembeck

Understanding the minimal clinically important differences of PROMs is crucial in interpreting results in clinical trials. Patient-reported outcome measures (PROMs) are a set of standardized questions that directly assess the patient’s perspective of their symptoms and quality of life to better understand their experience with a disease or treatment. PROMs support patient-centered care and are…

Childhood-Onset Rumination Syndrome: Insights from 15 Years of Research
 Childhood-Onset Rumination Syndrome: Insights from 15 Years of Research 1024 680 Pam Georgiana
By: Pam Georgiana
Close up color photo of little boy holding hands on his belly

Education is needed to improve diagnostic timelines and treatment outcomes for pediatric patients. Childhood-onset rumination syndrome presents significant diagnostic challenges, even for gastroenterologists. Physicians often misdiagnose the symptoms as gastroesophageal reflux disease. Initial treatments frequently fail, leading to delays in accurate diagnosis. Patients can experience symptoms for 2 to 3 years before receiving an accurate…

Biofilms: The Good, the Bad & the Groundbreaking
 Biofilms: The Good, the Bad & the Groundbreaking 1024 615 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Decades of research into the structure and function of bacterial biofilms have begun to pay off in the form of imminent clinical applications capable of harnessing both the protective and problematic aspects of this universal phenomenon. Imagine a hospital emergency department filled with patients — those with painful ear infections, recurrent urinary tract infections, fevers…

Sacral Nerve Stimulation Improves Symptoms and Quality of Life in Children With Defecation Disorders
 Sacral Nerve Stimulation Improves Symptoms and Quality of Life in Children With Defecation Disorders 1024 656 Mary Bates, PhD
By: Mary Bates, PhD

A new study narrows down the patients who may benefit the most from the treatment. In a large prospective study, researchers from Nationwide Children’s Hospital found that sacral nerve stimulation can lead to significant and long-lasting improvements in fecal continence and quality of life in children with refractory defecation disorders. Sacral nerve stimulation (SNS) involves…

Study Reveals New Use for GER Tool in Neonates: Swallowing Analysis
 Study Reveals New Use for GER Tool in Neonates: Swallowing Analysis 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
Dr. Jadcherla

Investigators have repurposed a simple test for gastroesophageal reflux (GER) disease to provide valuable insight into multiple swallowing abnormalities in newborn babies. A tool used to diagnose gastroesophageal reflux disease (GERD) in hospitalized neonates now has another use: characterizing swallowing abilities. The researchers at Nationwide Children’s Hospital who pioneered the objective use of the test,…

Children on Pancreatic Enzymes Experience Fewer Acute Pancreatitis Episodes
 Children on Pancreatic Enzymes Experience Fewer Acute Pancreatitis Episodes 1024 429 Mary Bates, PhD
By: Mary Bates, PhD

Pancreatic enzyme therapy benefitted patients with pancreatic-sufficient acute recurrent pancreatitis and chronic pancreatitis.  A new study shows that children with both acute recurrent pancreatitis and chronic pancreatitis had significantly lower incidence of acute pancreatitis episodes per year after starting pancreatic enzyme therapy. The findings support the need for a clinical trial to determine the treatment’s…

Clinical Differences in Early-Onset and Adolescent-Onset Rumination Syndrome
 Clinical Differences in Early-Onset and Adolescent-Onset Rumination Syndrome 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Study suggests rumination syndrome in young children is less severe initially and improves over time.   Early-onset rumination syndrome is clinically distinct from adolescent-onset rumination syndrome, according to a new report out of Nationwide Children’s Hospital. In this largest study of pediatric patients with rumination syndrome to date, researchers found differences in sex distribution, co-occurring…

Transnasal Endoscopy: Easing Eosinophilic Esophagitis (EoE) Treatment Monitoring
 Transnasal Endoscopy: Easing Eosinophilic Esophagitis (EoE) Treatment Monitoring 1024 683 Abbie Miller
By: Abbie Miller

Finding the most effective treatment for EoE can be a challenging process. Transnasal endoscopy decreases the burden of repeated endoscopies. Eosinophilic gastrointestinal disorders are a chronic and complex group of diseases characterized by having abnormal numbers of eosinophils in parts of the GI tract. This results in chronic inflammation and tissue damage that can lead…

How Does Thickened Formula Affect Reflux in Infants?
 How Does Thickened Formula Affect Reflux in Infants? 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Infants in the neonatal intensive care unit with suspected gastroesophageal reflux disease (GERD) are often fed formula with added rice cereal or other thickeners, despite limited evidence of its efficacy or long-term consequences. Additionally, the consequences of thickened feeds are not well-studied, says Sudarshan Jadcherla, MD, a principal investigator at the Center for Perinatal Research…

Telemedicine’s Past, Present and Future Role in Pediatric Inflammatory Bowel Disease Care
 Telemedicine’s Past, Present and Future Role in Pediatric Inflammatory Bowel Disease Care 1024 683 Erin Gregory
By: Erin Gregory

A recent study sheds light on how telemedicine’s use during the pandemic has reshaped care delivery for children with IBD.   A recent study published in Journal of Pediatric Gastroenterology and Nutrition utilized electronic medical record data to compare the volume, duration and nature of office and telemedicine visits for pediatric patients with inflammatory bowel…

Infliximab Biosimilars Improve Growth Outcomes in Children With Inflammatory Bowel Disease
 Infliximab Biosimilars Improve Growth Outcomes in Children With Inflammatory Bowel Disease 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Treatment with either the infliximab originator or a biosimilar improves clinical and growth outcomes. In a new study, researchers at Nationwide Children’s Hospital report that children with inflammatory bowel disease showed similar growth and clinical outcomes whether they were treated with the infliximab originator or a biosimilar agent. The results add to the growing literature…

Addressing Gastrointestinal Disorders to Improve Quality of Life for Individuals With Down Syndrome
 Addressing Gastrointestinal Disorders to Improve Quality of Life for Individuals With Down Syndrome 1024 661 Erin Gregory
By: Erin Gregory

Down syndrome (DS) affects approximately 1 in 700 children born in the United States, presenting with intellectual disability and distinct physical features. Alongside these challenges, individuals with DS often contend with various medical issues that impact their quality of life (QoL), including gastrointestinal (GI) disorders. Recent research published in the American Journal of Medical Genetics,…

GERD Less Likely Cause of Irritability and Back Arching in Infants
 GERD Less Likely Cause of Irritability and Back Arching in Infants 1024 683 Lauren Dembeck
By: Lauren Dembeck

In infants, frequent irritability and arching of the back can be concerning to parents and providers. These symptoms are often attributed to gastroesophageal reflux disease (GERD), a disease in which the lower esophageal sphincter does not close or opens at the wrong time. As a result, food and stomach acid can come back up into…

What Other Screening Tests Should be Administered to Celiac Disease Patients?
 What Other Screening Tests Should be Administered to Celiac Disease Patients? 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Eliminating some labs may reduce costs without impacting quality of patient care. Researchers from Nationwide Children’s Hospital found that several screening laboratory tests currently recommended for pediatric patients newly diagnosed with celiac disease are infrequently abnormal. In a new study published in the Journal of Pediatrics, they suggest a more streamlined approach to decrease the…

Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas
 Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas 1024 601 Pam Georgiana
By: Pam Georgiana

ACE treatment can lead to long-term clinical and quality-of-life improvement in children with defecation disorders.   For about 10-15% of the children who experience chronic constipation or other defecation disorders, the usual behavioral modification treatments and oral medications don’t help. These disorders can significantly impact their quality of life, yet other treatment options are limited.…

QI Initiative Reduces Emergency Room Visits for Functional Constipation
 QI Initiative Reduces Emergency Room Visits for Functional Constipation 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Preliminary data from a large accountable care organization’s quality improvement efforts suggest advanced care visits dropped 27% in two years. Partners For Kids (PFK), the nation’s oldest and largest pediatric accountable care organization, launched a series of quality improvement (QI) projects targeting disease management strategies that could significantly impact healthcare utilization and outcomes for children…

A Decade of Evidence: The SIMPLE Program Shows Continued Success
 A Decade of Evidence: The SIMPLE Program Shows Continued Success 1024 575 Pam Georgiana
By: Pam Georgiana

In 2010, Nationwide Children’s Hospitals NICU leaders observed that infant feeding practices varied depending on the provider, resulting in significant variations in milestones and length of hospital stays (LOHS). They asked Sudarshan R. Jadcherla, MD, and Erika Osborn, NNP, to partner with stakeholders, including nurses, physicians, nutritionists, lactation experts, and others, to develop an evidence-based…

Straightforward Stitch Technique Dramatically Reduces Post-Operative Anorectoplasty Complications
 Straightforward Stitch Technique Dramatically Reduces Post-Operative Anorectoplasty Complications 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The novel para-U-stitch keeps post-operative wound dehiscence to a minimum, helping patients with anorectal malformations avoid readmission, reoperation and infection. After recognizing a pattern of wound dehiscence and postoperative complications in patients with anorectal malformations (ARMs) repaired without a colostomy bag — meaning they stool directly through the surgical site as it heals — surgeons…

Evaluating Chronic Constipation and Abnormal Colonic Motility in Children With Autism Spectrum Disorder
 Evaluating Chronic Constipation and Abnormal Colonic Motility in Children With Autism Spectrum Disorder 1024 680 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM
Close up color photo of little boy holding hands on his belly

In children with chronic constipation, rates of abnormal colonic motility are similar between children with and without autism spectrum disorder (ASD). For children with ASD, symptom duration and soiling due to fecal retention are risk factors for abnormal colonic motility.   Treating constipation in children with autism spectrum disorder (ASD) is challenging because of feeding…

Improving the Diagnosis and Treatment of Iron Deficiency and Anemia in Children With Inflammatory Bowel Disease
 Improving the Diagnosis and Treatment of Iron Deficiency and Anemia in Children With Inflammatory Bowel Disease 150 150 Lauren Dembeck
By: Lauren Dembeck

Iron deficiency with and without anemia is under-recognized and under-treated in children with inflammatory bowel disease.   Anemia is the most common extr-aintestinal manifestation of inflammatory bowel disease (IBD), which includes conditions such as Crohn’s disease and ulcerative colitis, and iron deficiency is the most prevalent cause of anemia in children with IBD. Several factors…

Multidisciplinary Treatment Is Effective for Patients With Rumination Syndrome
 Multidisciplinary Treatment Is Effective for Patients With Rumination Syndrome 150 150 Jessica Nye, PhD
By: Jessica Nye, PhD

Tiered, multidisciplinary behavioral treatment is effective at improving symptoms of rumination syndrome (RS) among children and adolescents, even in the outpatient setting.   Children with RS present with repeated, effortless regurgitation of undigested food. Although limited data about treatment are available, previous studies have indicated that inpatient treatment can improve outcomes among pediatric patients with…

Re-evaluating GI Medication Regimens in People With Cystic Fibrosis
 Re-evaluating GI Medication Regimens in People With Cystic Fibrosis 1024 681 Emily Siebenmorgen
By: Emily Siebenmorgen

After widespread adoption of highly effective modulator therapy (HEMT), a new study evaluated the GI medication regimens of people with cystic fibrosis (CF). The study, published in Pediatric Pulmonolgy, found patient-initiated decreases in dosing and withdrawal from common GI medications is already occurring, yet there is no evidence to support this practice. Highly effective modulator…

Anal Sphincter Botox Injections for Children With Severe Constipation
 Anal Sphincter Botox Injections for Children With Severe Constipation 1024 680 Mary Bates, PhD
By: Mary Bates, PhD
Close up color photo of little boy holding hands on his belly

The treatment is safe and effective for many children with Hirschsprung disease and, to a lesser extent, functional constipation. In a new prospective study, researchers at Nationwide Children’s evaluated children with severe, refractory constipation treated with anal sphincter botulinum toxin (Botox) injection. They found the treatment can be effective in patients with both Hirschsprung disease…

Do Symptom Scores and pH Impedance Correlate in Infants Treated for Gastroesophageal Reflux?
 Do Symptom Scores and pH Impedance Correlate in Infants Treated for Gastroesophageal Reflux? 1024 683 Lauren Dembeck
By: Lauren Dembeck

Gastroesophageal reflux (GER) — the passage of gastric contents into the esophagus — is a physiologic process that can be considered normal or abnormal depending on whether troublesome symptoms and/or complications also occur. In infants, it is difficult for clinicians to distinguish between GER and pathophysiologic GER disease (GERD). “Current diagnostic criteria for GERD are…

How Do Children With IBD and Their Caregivers Perceive Biosimilars?
 How Do Children With IBD and Their Caregivers Perceive Biosimilars? 640 427 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Many pediatric patients with inflammatory bowel disease and their caregivers are unaware of biosimilars, creating an opportunity for providers to educate patients and their families about this effective and less expensive treatment option. Infliximab is a biologic therapy that effectively manages inflammatory bowel disease (IBD) in adult and pediatric patients. However, biologic therapies are expensive,…

Is 3D Anorectal Manometry Preferable to Traditional Anorectal Manometry in Children With Functional Constipation?
 Is 3D Anorectal Manometry Preferable to Traditional Anorectal Manometry in Children With Functional Constipation? 1024 680 Mary Bates, PhD
By: Mary Bates, PhD
Close up color photo of little boy holding hands on his belly

Study finds 3D-ARM is less comfortable and does not provide additional information compared to traditional ARM.   In a recent pilot study, researchers from Nationwide Children’s compared outcomes and patient experience of a new three-dimensional (3D) anorectal manometry (ARM) technique compared to regular ARM in children with functional constipation. They found that the use of…

Stress Increases Systemic Inflammation and Anxiety in Mouse Model of IBD
 Stress Increases Systemic Inflammation and Anxiety in Mouse Model of IBD 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Exposure to stress did not induce a relapse in colitis in the mice. In a new study, researchers at Nationwide Children’s Hospital and the Abigail Wexner Research Institute tested whether exposure to stress would lead to flares of intestinal inflammation in a mouse model of inflammatory bowel disease. They found stress did not exacerbate colitis…

Polyethylene Glycol 3350 Does Not Lead to Behavior Changes in Animal Model
 Polyethylene Glycol 3350 Does Not Lead to Behavior Changes in Animal Model 1024 683 Mary Bates, PhD
By: Mary Bates, PhD
Ross Maltz, MD

The laxative affected stool consistency and gut bacteria but did not alter anxiety-like behavior in mice. Polyethylene glycol 3350 (PEG3350) is a laxative commonly used to treat constipation in children. Over the years, the Food and Drug Administration has received some reports of neuropsychiatric symptoms in children administered PEG3350, including anxiety, aggression and obsessive-compulsive behaviors.…

Addition of a Radiation-Free Evaluation and Parent-Chosen Feeding Method Leads to Superior Outcomes for Infants With Swallowing Difficulties
 Addition of a Radiation-Free Evaluation and Parent-Chosen Feeding Method Leads to Superior Outcomes for Infants With Swallowing Difficulties 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A recent NIH-NIDDK-funded study suggests that application of novel high-resolution manometry along with guided parental involvement can improve oral feeding success for infants with swallowing difficulties. The prevalence of swallowing difficulties among neonatal intensive care graduates is increasing.  Swallowing difficulties or dysphagia in infants are associated with airway and digestive consequences often presenting with signs…

A Patient-Centered Medical Home for Pediatric Inflammatory Bowel Disease
 A Patient-Centered Medical Home for Pediatric Inflammatory Bowel Disease 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

The Center for Pediatric and Adolescent IBD serves as a case study for comprehensive, multidisciplinary care. In a new paper published in Inflammatory Bowel Disease, researchers from Nationwide Children’s describe the multidisciplinary care model at the Center for Pediatric and Adolescent Inflammatory Bowel Disease as an example of a pediatric specialty medical home. The researchers…

Lubiprostone Found to be Safe, as Effective as Placebo in Children With Constipation
 Lubiprostone Found to be Safe, as Effective as Placebo in Children With Constipation 1024 680 Mary Bates, PhD
By: Mary Bates, PhD
Close up color photo of little boy holding hands on his belly

The medication, FDA-approved for adults, may benefit older pediatric patients with less of a behavioral component to their constipation. Pediatric functional constipation, though common, remains challenging to treat. Lubiprostone is a medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of constipation and irritable bowel syndrome with constipation in adults. In…

Study Highlights Relationship Between SI Gene and Chronic, Idiopathic Loose Stool in Some Children
 Study Highlights Relationship Between SI Gene and Chronic, Idiopathic Loose Stool in Some Children 1024 680 Abbie Miller
By: Abbie Miller
Close up color photo of little boy holding hands on his belly

Researchers conducted one of the largest prospective, multicenter trials in pediatrics looking at the connection between SI variants and common gastrointestinal symptoms. The SI gene codes for the sucrase-isomaltase enzyme, which is expressed in the intestinal brush border. This enzyme is important to the digestion of sucrose, and without it, maldigestion and poor absorption of…

Unraveling Intractable Functional Constipation: Manometries Are Still the Gold Standard
 Unraveling Intractable Functional Constipation: Manometries Are Still the Gold Standard 1024 680 Natalie Wilson
By: Natalie Wilson
Close up color photo of little boy holding hands on his belly

Cine-MRI recordings can’t replace colonic manometries when assessing motility among children with functional constipation, but they may offer additional information. And conducting both MRIs and manometries simultaneously is feasible. While functional constipation (FC) is common in childhood, and most children who experience it respond well to behavioral interventions or treatment with laxatives, some children continue…

Calls to Poison Centers About High-Powered Magnets Increased by 444% After Ban Lifts
 Calls to Poison Centers About High-Powered Magnets Increased by 444% After Ban Lifts 1024 521 Laura Dattner
By: Laura Dattner
cube made of ball magnets in the palm of a hand

High-powered magnets are small, shiny and made from powerful rare earth metals. Since they started showing up in children’s toys in the early 2000s and then later in desk sets in 2009, high-powered magnets have caused thousands of injuries and are considered to be among the most dangerous ingestion hazards in children. When more than one…

More Data on Rare GI Diseases, With Less Work
 More Data on Rare GI Diseases, With Less Work 1024 535 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
Collage of health technology tools

Electronic health record systems can drive knowledge acquisition in rare gastrointestinal conditions — and other orphan diseases — without the burden of duplicative data entry. Rare diseases often remain poorly understood and inefficiently treated due to a lack of objective knowledge on their natural history, pathophysiology or clinical outcomes in response to various therapies. Collecting…

What Puts Adolescent Patients With IBD at Risk for Suboptimal Transitions?
 What Puts Adolescent Patients With IBD at Risk for Suboptimal Transitions? 1024 673 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Psychosocial-related factors, such as mental health diagnoses and public insurance, have been shown to increase the risk of suboptimal transitions in adolescent patients with inflammatory bowel disease. Between ages 18 and 22, adolescent patients transition from pediatric to adult care. Ideally, at the time of transition, patients have the skills to manage their disease and…

Early Intervention is Key to Avoid Hospitalization for Cyclic Vomiting Syndrome
 Early Intervention is Key to Avoid Hospitalization for Cyclic Vomiting Syndrome 1024 683 Mary Bates, PhD
By: Mary Bates, PhD
Health care provider talking to male teen patient

Study finds that waiting to go to the emergency department for treatment increases likelihood of hospitalization. Cyclic vomiting syndrome is a functional gastrointestinal disorder characterized by periodic episodes of intense nausea and vomiting lasting hours to days. During episodes, some children become very sick and require emergency department care and hospitalization to manage symptoms and…

Reducing Opioid-Induced Constipation in Patients After Orthopedic Spine Surgery
 Reducing Opioid-Induced Constipation in Patients After Orthopedic Spine Surgery 1024 575 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM
Julie Samora, MD

In pediatric patients undergoing orthopedic spine surgery, a step-wise bowel management plan can effectively reduce opioid-induced constipation and unplanned emergency department visits after surgery. Orthopedic spine surgery can generate pain in the immediate post-surgery period. Opioids are needed to mitigate this pain but commonly cause constipation and other gastrointestinal side effects. Opioid-induced constipation causes abdominal…

Exploring the Use of Complementary and Alternative Medicine in Pediatric Functional Abdominal Pain Disorders
 Exploring the Use of Complementary and Alternative Medicine in Pediatric Functional Abdominal Pain Disorders 1024 680 Mary Bates, PhD
By: Mary Bates, PhD
Close up color photo of little boy holding hands on his belly

A survey finds most children with functional abdominal pain disorders use at least one form of complementary and alternative medicine. Functional abdominal pain disorders, which include functional dyspepsia, irritable bowel syndrome and abdominal migraine, are influenced by both biological and psychosocial factors. The underlying mechanisms are complex and largely unknown, making treatment challenging. Researchers from…

Probiotics are Safe and Feasible for Gastrointestinal Symptoms in Autism Spectrum Disorders
 Probiotics are Safe and Feasible for Gastrointestinal Symptoms in Autism Spectrum Disorders 150 150 Mary Bates, PhD
By: Mary Bates, PhD

A pilot trial found a trend toward improvements in quality of life in patients treated with probiotics. Gastrointestinal disorders and anxiety symptoms are commonly reported in children with autism spectrum disorder (ASD). Recent research in rodent models and neurotypical humans has demonstrated that changing the gut microbiota can improve gastrointestinal (GI) symptoms. Some studies even…

Advances in Neonatal GERD
 Advances in Neonatal GERD 1024 683 Mary Bates, PhD
By: Mary Bates, PhD
Dr. Jadcherla

New studies from the Jadcherla Lab provide insights into diagnosing, classifying and treating GERD in infants. Differentiating gastroesophageal reflux (GER), which is defined as the passage of gastric contents into the esophagus, from GER disease (GERD), when reflux is associated with troubling symptoms, remains a challenge in infants. Symptom-based diagnosis and treatment of GERD has…

Redo Surgery After Anorectal Malformation Repair Can Improve Functional Outcomes
 Redo Surgery After Anorectal Malformation Repair Can Improve Functional Outcomes 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

A reoperation can improve continence and quality of life in children still struggling with fecal incontinence following ARM repair. In a new study, researchers from Nationwide Children’s Hospital show that redo surgeries are   safe and may be an effective option for patients with fecal incontinence after an anorectal malformation repair. For many patients, a reoperation…

Exploring the Link Between Cystic Fibrosis and Celiac Disease
 Exploring the Link Between Cystic Fibrosis and Celiac Disease 1024 575 Lauren Dembeck
By: Lauren Dembeck

Overlapping symptoms can cause delayed diagnosis of celiac disease in patients with cystic fibrosis. Physician scientists at Nationwide Children’s Hospital have recently identified three cases of patients with cystic fibrosis, all of whom had the same genotype, were treated with the CFTR modulator, ivacaftor, and were diagnosed with celiac disease. This adds to a novel body…

New Celiac Care Index Improves Adherence to Care Guidelines
 New Celiac Care Index Improves Adherence to Care Guidelines 1024 575 Lauren Dembeck
By: Lauren Dembeck

The recent implementation of a Celiac Care Index (CCI) at Nationwide Children’s Hospital resulted in improved adherence to published care guidelines, reduced variability in baseline evaluations, and indicated potentially unnecessary baseline laboratory tests for further evaluation. The study, which was published in The Journal of Pediatrics, describes the quality improvement (QI) strategy implemented at the hospital.…

Botox Appears Safe for Treatment of Defecation Disorders
 Botox Appears Safe for Treatment of Defecation Disorders 150 150 Kevin Mayhood
By: Kevin Mayhood

Anal botulinum toxin injections (Botox) have increasingly been used in children with functional anorectal and colonic disorders during the past 15 years. A study at Nationwide Children’s Hospital, combined with a review of published literature, shows this off-label use of Botox is safe and complications are rare. Complications occurred in less than 0.7% of 1332…

From Clinician Ideas to Commercially-Available Clinical Devices
 From Clinician Ideas to Commercially-Available Clinical Devices 150 150 Kevin Mayhood
By: Kevin Mayhood

Pressure wounds were a common complication following a tracheostomy, often resulting in advanced-stage wounds, national studies showed. Nationwide Children’s Hospital was no different but Kris Jatana, MD, and Charles Elmaraghy, MD, surgeons in the Department of Otolaryngology, knew they could improve these outcomes. Brendan Boyle, MD, and Alex Green, DO, were fellows in the Division…

Rethinking Gastroesophageal Reflux Disease (GERD) in Infants
 Rethinking Gastroesophageal Reflux Disease (GERD) in Infants 150 150 Lauren Dembeck
By: Lauren Dembeck

Novel use of existing technology points to other causes of GERD-like symptoms. While typically attributed to gastroesophageal reflux disease (GERD), supra-esophageal symptoms, such as cough, back arching and gagging, can be temporally associated with aerophagia, according to a new study by researchers at Nationwide Children’s Hospital. The findings come from the novel implementation of standard…

Type of Anorectal Malformation at Birth is Predictive of Fecal Continence
 Type of Anorectal Malformation at Birth is Predictive of Fecal Continence 150 150 Kevin Mayhood
By: Kevin Mayhood

Study also finds fecal continence rates for children born with ARMs are lower than previously reported. Recently published research shows the rate of fecal continence among 4-year-olds who underwent surgery for an anorectal malformation (ARM) as infants averages 40%, and the type of malformation — which reflects severity — is predictive of the outcome. Though…

A New Therapeutic Era in Pediatric Functional and Motility Disorders
 A New Therapeutic Era in Pediatric Functional and Motility Disorders 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

20 years ago, treatment options were limited for children with functional gastrointestinal (GI) and motility disorders. Now, a growing list of drugs, behavioral and dietary care plans, and an advanced, forward-looking technique – neuromodulation – are transforming pediatric GI care. Gastrointestinal (GI) disorders are notoriously difficult to diagnose. Virtually all functional and motility-related GI problems…

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