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More Screening Needed for Young Females at Risk for von Willebrand Disease
 More Screening Needed for Young Females at Risk for von Willebrand Disease 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

A new study finds most girls with heavy menstrual bleeding are not screened for the bleeding disorder. Despite recommendations by the American College of Obstetricians and Gynecologists, approximately 90 percent of girls with heavy menstrual bleeding are not being screened for von Willebrand disease,…

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Why Obese Women Have More Surgical Infections After Cesarean Delivery
 Why Obese Women Have More Surgical Infections After Cesarean Delivery 1024 575 Jeb Phillips
By: Jeb Phillips

Even though all pregnant woman typically undergo a standardized antiseptic preparation before a cesarean delivery, obese women are twice as likely to develop a surgical site infection after the procedure as women with a normal body mass index. A new, first-of-its-kind study from The Ohio…

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Crafty Hepatitis E Virus Uses Decoy to Evade Immune System
 Crafty Hepatitis E Virus Uses Decoy to Evade Immune System 1024 683 Kevin Mayhood
By: Kevin Mayhood

Researchers find a related protein cloaking the virus has differences that could become treatment targets. A protein that doctors use as a marker of hepatitis E virus (HEV) infection is not directly involved in the virus lifecycle but acts as a decoy drawing away…

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Improving Feeding and Growth in Children With Cleft Palate
 Improving Feeding and Growth in Children With Cleft Palate 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Targeted interventions result in improved feeding efficiency and growth in infants with cleft lip and/or palate. Cleft lip and/or palate is a relatively common birth defect that occurs when certain parts of the face and mouth fail to fuse during development. Infants with the…

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How to Make a Viral Vector
 How to Make a Viral Vector 150 150 Abbie Miller
By: Abbie Miller

The Research Institute at Nationwide Children’s Hospital is the home to a current Good Manufacturing Practices (cGMP) Clinical Manufacturing Facility (CMF) that operates according to FDA cGMP Guidelines to ensure the safety of manufactured biologic products. The Space The CMF is a 9000-sq-ft space,…

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Bridging the Gap Between the Genomics Lab and the Cardiology Clinic: CardioGX for Phenotype-Driven Variant Analysis
 Bridging the Gap Between the Genomics Lab and the Cardiology Clinic: CardioGX for Phenotype-Driven Variant Analysis 150 150 Abbie Miller
By: Abbie Miller

The cloud-based platform is a free tool that empowers clinicians and fosters collaboration to find new genetic mutations that cause heart disease. Finding ways to support clinicians and researchers in accessing and utilizing genomic data is paramount to incorporating genomics into clinical care. CardioGX (CardioGenomics eXchange…

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Age-Related Racial Disparities in Suicide Rates Among Youth Ages 5 to 17 Years
 Age-Related Racial Disparities in Suicide Rates Among Youth Ages 5 to 17 Years 150 150 Abbie Miller
By: Abbie Miller

Under the age of 13, suicide rates are roughly double for black children compared with white children. Suicide rates in the United States have traditionally been higher among whites than blacks across all age groups. However, a new study from researchers at Nationwide Children’s…

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Cannabis-Derived Treatment Can Significantly Reduce Seizures in Hard-To-Treat Childhood Epilepsy
 Cannabis-Derived Treatment Can Significantly Reduce Seizures in Hard-To-Treat Childhood Epilepsy 150 150 Jeb Phillips
By: Jeb Phillips

A new study shows that cannabidiol is effective in children with Lennox-Gastaut syndrome. Children with Lennox-Gastaut syndrome can have hundreds of brief seizures every day. This complex form of epilepsy often does not respond to conventional epilepsy medication, leaving children at serious risk of…

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Room for Improvement: Heart Catheterization Risks in Young Patients With Pulmonary Hypertension
 Room for Improvement: Heart Catheterization Risks in Young Patients With Pulmonary Hypertension 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Identifying risk factors for cardiac catheterization complications offers physicians a way to improve pulmonary hypertension care. Up until a few years ago, cardiac catheterization in patients with pulmonary hypertension was considered a low-risk procedure for children and young adults. Some of the country’s best…

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How Primary Care Providers Can Help Justice-Involved Youth
 How Primary Care Providers Can Help Justice-Involved Youth 1024 683 Deena Chisolm, PhD
By: Deena Chisolm, PhD

Deena Chisolm, PhD, shares how primary care physicians can support youth who may experience behavioral health issues related to justice involvement. For most people in the United States, the law enforcement and criminal justice systems support a sense of safety and security.  However, for…

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The Pediatrician’s Role in Health and Hope after Trauma
 The Pediatrician’s Role in Health and Hope after Trauma 150 150 Anna Kerlek, MD
By: Anna Kerlek, MD

A primary care provider’s ability to identify and treat symptoms associated with trauma can increase positive outcomes for patients and families. Almost two-thirds of the children and their caretakers in your office have experienced at least one trauma. Many have experienced more. As a…

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A Revolution in Deformity Correction Plus Limb Lengthening
 A Revolution in Deformity Correction Plus Limb Lengthening 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Orthopedic surgeons demonstrate that acute deformity correction and gradual limb lengthening can be accomplished simultaneously using an internal lengthening nail. In the past, limb lengthening and femoral deformity correction meant a long, painful, very visible process — an external fixator with manual adjusters, a…

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From What-if to Widely Available – A Proposed Path for Tissue Engineered Vascular Grafts
 From What-if to Widely Available – A Proposed Path for Tissue Engineered Vascular Grafts 150 150 Abbie Miller
By: Abbie Miller

What if you could utilize tissue engineering, imaging and 3D printing technologies to bring the benefits of a tissue engineered vascular graft to every child who needs one? Children born with a single ventricle heart defect undergo a series of surgeries and procedures to…

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Is Caregiver Education About Sickle Cell Trait Effective?
 Is Caregiver Education About Sickle Cell Trait Effective? 1024 575 Abbie Miller
By: Abbie Miller

Researchers evaluate the standardized education in Ohio to determine if it achieves high caregiver knowledge. Despite universal newborn screening that detects the presence of sickle cell trait (SCT), only 16 percent of Americans with SCT know their status. To address this issue, in Ohio,…

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How Can We Optimize Fertility Related Discussions With Male Survivors of Childhood Cancer?
 How Can We Optimize Fertility Related Discussions With Male Survivors of Childhood Cancer? 150 150 Abbie Miller
By: Abbie Miller

A recent study suggests that fertility is a “later” issue for adolescents and young adults, rather than a “now” concern, leading to low rates of conversation with health care providers. Survival rates for pediatric cancers exceed 80 percent. But late effects can persist throughout…

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Starting the Conversation on Sickle Cell Disease and Reproductive Health
 Starting the Conversation on Sickle Cell Disease and Reproductive Health 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Adolescents and young adults with sickle cell disease — and their caregivers — care about future fertility. But what should doctors tell them? Until just a few decades ago, sickle cell disease (SCD) was often fatal in childhood. Now that more patients reach adulthood,…

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Mapping the World of Pediatric Severe Sepsis
 Mapping the World of Pediatric Severe Sepsis 1024 576 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Researchers work to reveal the many subtypes of pediatric sepsis — and what to do about them. Once upon a time, sepsis was just sepsis. Children experiencing septic shock and its aftermath — any resulting organ failure — were viewed as a fairly homogenous…

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Femoral Nerve Blockade May Reduce Need for Intravenous Opioids
 Femoral Nerve Blockade May Reduce Need for Intravenous Opioids 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Researchers find no differences in postoperative pain measures for patients receiving intravenous opioids and those receiving regional anesthetic. Femur fractures often require surgical fixes and can be quite painful. Although traditionally treated with intravenous opioids, regional anesthesia may offer an alternative option. In a…

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Black and white photo of a young patient with cancer wearing a mask and gown and holding an IV poll smiling and giving a thumbs up in the hospital
How to Identify and Treat Blood Clots in Pediatric Patients With Cancer
 How to Identify and Treat Blood Clots in Pediatric Patients With Cancer 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

New guidelines will help doctors recognize and treat children at risk of venous thromboembolism. Prevention of blood clots is well described in adult cancer patients, but data on the problem in pediatric cancer patients is limited. In a new publication initiated at the request…

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New Guidelines Offer Practical Tools to Treat GI Reflux
 New Guidelines Offer Practical Tools to Treat GI Reflux 150 150 Jeb Phillips
By: Jeb Phillips

An international committee’s new recommendations reflect shifting opinions about acid-suppressive medications and include an expanded diagnostic algorithm. While reflux-related complaints are heard often by pediatric gastroenterologists and primary care physicians, it can be difficult to tell when gastroesophageal reflux (GER) crosses the line into…

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