Better Asthma Outcomes: A Systems-Level Approach

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Universal Donor CAR NK Cells: A New Platform Technology for Cancer

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How Medical-Legal Partnerships Support Families, Relieve Stress and Improve Health

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Cultivating Culture in a High-Growth, High-Performance Organization

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The Changing Medical and Legal Landscape for Cannabidiol
 The Changing Medical and Legal Landscape for Cannabidiol 150 150 Jeb Phillips
By: Jeb Phillips

About the authorAuthorArticles by the Author Jeb PhillipsJeb is the Managing Editor, Executive Communications, in the Department of Marketing and Public Relations at Nationwide Children's Hospital. He contributes feature stories and research news to PediatricsOnline, the hospital’s electronic newsletter for physicians and other health…

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Is Your Patient Really Allergic to Penicillin?
 Is Your Patient Really Allergic to Penicillin? 150 150 Abbie Miller
By: Abbie Miller

About the authorAuthorArticles by the Author Abbie MillerAbbie (Roth) Miller, MS, MWC, is a passionate communicator of science. As the manager of medical and science content at Nationwide Children’s Hospital, she shares stories about innovative research and discovery with audiences ranging from parents to…

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Cumulative Subconcussive Impacts in a Single Season of Youth Football Not Associated With Declines in Neurocognitive Measures
 Cumulative Subconcussive Impacts in a Single Season of Youth Football Not Associated With Declines in Neurocognitive Measures 1024 575 Abbie Miller
By: Abbie Miller

In an investigation of head impact burden and change in neurocognitive function during a season of youth football, researchers find that sub-concussive impacts are not correlated with worsening performance in neurocognitive function. Each year, more than 3 million children in primary and high school…

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Feeding Difficulties in Opioid-Exposed Infants — Mechanics and Possible Causes
 Feeding Difficulties in Opioid-Exposed Infants — Mechanics and Possible Causes 1024 575 Kevin Mayhood
By: Kevin Mayhood

A recent study suggests altered vagus nerve activity, creating resistance in the esophagus while swallowing. Infants exposed to opioids prenatally often show signs of gastroesophageal reflux disease. But a study by neonatologists at Nationwide Children’s Hospital found that feeding troubles are more likely due…

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Can Ultrasound or MRI Help Monitor Dysgenetic Gonads for Tumors?
 Can Ultrasound or MRI Help Monitor Dysgenetic Gonads for Tumors? 150 150 Jeb Phillips
By: Jeb Phillips

Dysplastic gonads that have neoplasms are often deemed “normal” in imaging studies. Patients with gonadal dysgenesis and a Y chromosome have a substantial risk of gonadal neoplasm, so providers have traditionally recommended bilateral gonadectomy for them. But relatively recent concerns about caring for children…

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Simple illustrated diagram of the GI track with organs colorized and body outline and background in blue
Saving Constipation Treatment Costs With a Bowel Management Program
 Saving Constipation Treatment Costs With a Bowel Management Program 1024 575 Jeb Phillips
By: Jeb Phillips

A protocolized approach significantly reduced ED visits and hospital admissions for children with chronic constipation – and became a driver for surgical referrals. If hospitals are willing to foot the bill for staffing and start-up costs, a structured bowel management program for children with…

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Color photo; environmental portrait ofDrs. Elaine Mardis and Richard Wilson
Generating the Genome: How Scientists Changed the Face of Cancer Research
 Generating the Genome: How Scientists Changed the Face of Cancer Research 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Team science. Ongoing innovation. Brilliant minds. Here’s how The Cancer Genome Atlas spawned a revolution in cancer research and technology. The Cancer Genome Atlas is wrapping up. Its data now lives online in the Genomic Data Commons, freely available to the public. Reports of the…

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Are We Turning Away Too Many Pediatric Donor Hearts?
 Are We Turning Away Too Many Pediatric Donor Hearts? 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

More than half of all pediatric donor hearts are declined for use each year, despite the fact that many children die waiting for a heart. But why? And what can be done about it?   As many as one in every four infants on…

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Close up color photo of little boy holding hands on his belly
Race, Insurance, and ED Visits for Pediatric Crohn’s Disease
 Race, Insurance, and ED Visits for Pediatric Crohn’s Disease 1024 680 Jeb Phillips
By: Jeb Phillips

Black children and children insured by Medicaid make more repeat emergency department visits for Crohn’s disease than their white and privately insured peers. In what appears to be the first nationally representative study evaluating the impact of race and insurance status on emergency department…

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Could Antimicrobial Peptides Be Biomarkers for Obstructive Uropathy?
 Could Antimicrobial Peptides Be Biomarkers for Obstructive Uropathy? 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

New research reveals the expression of antimicrobial peptides — long associated only with infections — in children with obstructive uropathy, creating the potential for a wide range of clinical applications. Previously only studied in the context of urinary tract and other infections, antimicrobial peptides…

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Difficult, But Essential Conversations: Talking With Kids About Suicide
 Difficult, But Essential Conversations: Talking With Kids About Suicide 1024 575 Gina Bericchia
By: Gina Bericchia

Experts say open conversations with kids about suicide could save lives. As kids head back to school this year, many of them will be struggling. According to national statistics, we lose more than 2,000 children and teens per year to suicide. Experts say parents…

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Housing for Health: An Early Look at What Can Happen When a Pediatric Health System Begins to Treat a Neighborhood as a Patient
 Housing for Health: An Early Look at What Can Happen When a Pediatric Health System Begins to Treat a Neighborhood as a Patient 150 150 Abbie Miller
By: Abbie Miller

In a recent publication in the journal Pediatrics, researchers from Nationwide Children’s Hospital present a case study for treating a neighborhood as a patient. Neighborhood effect syndrome, characterized by symptoms of extreme poverty including blight, housing insecurity, racial segregation, trauma, violence, poorly performing schools,…

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Quality Improvement Study Shifts HPV Vaccine Initiation to Earlier Age
 Quality Improvement Study Shifts HPV Vaccine Initiation to Earlier Age 150 150 Aimee Swartz, MPH
By: Aimee Swartz, MPH

A QI project shows that it is feasible, and possibly beneficial, to routinely administer HPV vaccine at age 9. It is feasible, and possibly beneficial, to routinely administer the human papillomavirus (HPV) vaccine beginning at age 9 — two to three years earlier than…

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Guidance on Counseling Children at Risk for Fertility and Sexual Function Issues
 Guidance on Counseling Children at Risk for Fertility and Sexual Function Issues 150 150 Jeb Phillips
By: Jeb Phillips

Many childhood medical conditions and treatments can affect reproductive health. A new report from the American Academy of Pediatrics explains when and how doctors should address those concerns. While fertility and sexual function are most often considered adult issues, even very young children may…

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Antibiotic-Induced Disruption of Intestinal Microbiota Leads to Increased Mortality From a Respiratory Viral Infection
 Antibiotic-Induced Disruption of Intestinal Microbiota Leads to Increased Mortality From a Respiratory Viral Infection 150 150 Lauren Dembeck
By: Lauren Dembeck

Recent study indicates that antibiotic use disrupts gastrointestinal microbial communities and can indirectly influence host immune response, even in distant tissues. “The indiscriminate and overuse of antibiotics may have further reaching consequences than just evolution of antibacterial-resistant superbugs,” says physician-scientist Mitchell Grayson, MD, lead author…

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Preclinical Gene Therapy Study Shows Muscle Restoration in Charcot-Marie-Tooth Disease Model
 Preclinical Gene Therapy Study Shows Muscle Restoration in Charcot-Marie-Tooth Disease Model 150 150 Kevin Mayhood
By: Kevin Mayhood

Tests of NT-3 gene therapy on mouse models suggest potential to treat a host of muscle-wasting conditions.

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QI Project Improves Response Time to Nurse Triage Phone Calls in Busy ENT Practice
 QI Project Improves Response Time to Nurse Triage Phone Calls in Busy ENT Practice 1024 683 Abbie Miller
By: Abbie Miller

A high-volume pediatric otolaryngology practice receives a lot of phone calls from patients and families. The practice at Nationwide Children’s Hospital, which sees 32,000 clinic visits and 9,000 surgical patients each year, averaged more than 200 triage calls per week over the last 5…

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A Better Way to Administer Probiotics?
 A Better Way to Administer Probiotics? 150 150 Abbie Miller
By: Abbie Miller

Researchers have designed a delivery system to treat premature infants with necrotizing enterocolitis that may have applications beyond the NICU. Most of the time, we think biofilms are bad news. And when pathogenic microbes form biofilms, they are. The biofilms created by pathogenic microbes…

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Could Earlier Spirometry Get CF Inpatients Home Sooner?
 Could Earlier Spirometry Get CF Inpatients Home Sooner? 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A retrospective chart review suggests early spirometry is associated with shorter length of stay. As multicenter studies examine whether length of hospital stay and duration of treatment can be safely shortened for cystic fibrosis-related pulmonary exacerbations, physician-researchers at Nationwide Children’s Hospital have been exploring…

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Black and white photo of boy sitting up on hospital bed
Reducing Radiation Exposure and Imaging Costs for Children With Appendicitis
 Reducing Radiation Exposure and Imaging Costs for Children With Appendicitis 1024 575 Rachael Hardison
By: Rachael Hardison

Appendicitis is one of the most common indications for abdominal surgery in children. Accurate, efficient diagnosis is critical for initiating timely treatment. Current imaging options for diagnosing appendicitis include ultrasound and computed tomography (CT). CT scans, while readily available and highly sensitive, require radiation…

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