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Katie Brind'Amour, PhD, MS, CHES

Building the Modern-Day Vaccine
Building the Modern-Day Vaccine 150 150 Katie Brind'Amour, PhD, MS, CHES

Vaccine development used to be straightforward. Now, the challenges are many and the successes are few. What will it take to overcome the obstacles presented by both immunology and society? For 160 years, vaccine after vaccine succeeded at safely and effectively preventing its targeted illness using a set of standard strategies. Scientists knew they simply…

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InSight: Working Up the Nerve
InSight: Working Up the Nerve 150 150 Katie Brind'Amour, PhD, MS, CHES

Using regional anesthesia to numb nerves reduces pain and speeds recovery in pediatric orthopedic surgery. Ultrasound-guided regional anesthesia has been used in adult patients for more than a decade but is now being used more regularly in pediatric patients, especially for orthopedic procedures. Femoral nerve block, in which the femoral nerve is numbed, is among…

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Body, Heal Thyself: Harnessing Our Innate Immunity
Body, Heal Thyself: Harnessing Our Innate Immunity 150 150 Katie Brind'Amour, PhD, MS, CHES

What the urinary tract’s front-line defenses can teach us about our innate ability to self-heal …. and thwart antibiotic resistance. Antibiotic resistance is on the rise, health care-acquired infections are becoming harder to treat and even simple infectious illnesses account for billions of dollars per year in spending in the United States alone. As with…

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Enteral Therapy on Trial
Enteral Therapy on Trial 150 150 Katie Brind'Amour, PhD, MS, CHES

Micah Cohen sat down at the dining room table in his family’s Columbus, Ohio, home and took the first sip of a new therapy he hoped would relieve the symptoms of his Crohn’s disease. The thick, sweet chocolate shake, rich with nutrients, felt heavy in the 14-year-old’s stomach. Can I really drink six of these a…

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Delays and Difficulties: Fecal Microbiota Transplants as Therapy
Delays and Difficulties: Fecal Microbiota Transplants as Therapy 150 150 Katie Brind'Amour, PhD, MS, CHES

Use of fecal microbiota transplantation to treat a wide range of disorders is in limbo while the FDA decides how to regulate the therapy. Between 1997 and 2007, Clostridium difficile bacterial infections among U.S. children more than doubled and its mortality rate among all U.S. cases more than quadrupled. Clinicians are turning to a number of treatment…

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Thinking Outside the (Tool) Box: How Techniques From Alzheimer’s Research Illuminate the Pathophysiology of Preeclampsia
Thinking Outside the (Tool) Box: How Techniques From Alzheimer’s Research Illuminate the Pathophysiology of Preeclampsia 150 150 Katie Brind'Amour, PhD, MS, CHES

Irina Buhimschi, MD, has a habit of getting lost. In July 2007, that poor sense of direction proved to be a fortunate flaw. Having wandered into the wrong presentation at the Protein Society’s national conference, she hovered in the back to get her bearings. Up front, a speaker discussed how misfolded proteins accumulate in the…

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Mock MRI Scanners to Reduce Anesthesia Use
Mock MRI Scanners to Reduce Anesthesia Use 150 150 Katie Brind'Amour, PhD, MS, CHES

Initial research supports the use of MRI practice sessions and mock scanners to avoid sedation and alleviate patient and parent anxiety before an MRI. Studies exist for populations such as patients with ADHD and diabetes, but to date no studies appear to investigate the use of a mock MRI machine for young children with a wide range of…

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Using Zinc for Growth Delays in Babies Born Preterm
Using Zinc for Growth Delays in Babies Born Preterm 150 150 Katie Brind'Amour, PhD, MS, CHES

Zinc supplementation in extremely low birth-weight (ELBW) infants with chronic lung disease improves weight gain and linear growth, according to a retrospective study performed at Nationwide Children’s Hospital. The study is one of the first to look at the association between zinc supplementation and growth in ELBW babies with chronic lung disease, also known as bronchopulmonary dysplasia.…

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The Dilemma of Undertriaged Trauma Cases
The Dilemma of Undertriaged Trauma Cases 150 150 Katie Brind'Amour, PhD, MS, CHES

Nationally, at least one in three children ages 5 and under with major trauma receive their definitive care at a level III trauma center or non-trauma center, according to arecent study in the American Journal of Emergency Medicine. Among children ages 6 to 17, the frequency of undertriage decreases to one in every four major trauma…

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AAP Statement on School Start Times May Be Challenging to Implement
AAP Statement on School Start Times May Be Challenging to Implement 150 150 Katie Brind'Amour, PhD, MS, CHES

The American Academy of Pediatrics published a statement in August supporting delayed start times for middle and high schools to help combat chronic sleep deprivation. Research indicates adolescents naturally experience a shift in their circadian rhythm that makes sleep difficult prior to 11 PM. But since many middle and high schools begin classes before 8:30 AM, teens…

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Mentoring Junior Faculty: Fostering Tomorrow’s Leaders
Mentoring Junior Faculty: Fostering Tomorrow’s Leaders 150 150 Katie Brind'Amour, PhD, MS, CHES

Clinicians from institutions nationwide offer insight on how to piece together effective mentorship strategies in pediatrics. Mentoring may be a familiar concept to most pediatric professionals, but whether it occurs effectively in practice is less obvious. Research on the topic suggests a widespread lack of formal mentoring programs at academic medical institutions. Other studies point…

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Evolution of an Atlas
Evolution of an Atlas 150 150 Katie Brind'Amour, PhD, MS, CHES

Adult brain atlases have existed for years. Why is it so crucial — and so difficult — to build one for preemies? Even experts need maps. They give perspective, scale and orientation. They can show both current location and the final destination. And in the world of premature brains, they can offer vital information about…

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A Brave New World of Data
A Brave New World of Data 150 150 Katie Brind'Amour, PhD, MS, CHES

According to William C. Ray, PhD, of the Battelle Center for Mathematical Medicine in The Research Institute at Nationwide Children’s Hospital, novel techniques prototyped for understanding protein data could soon enable the visualization of large sets of demographic data, displaying contingency tables and group relationships through visual representations of positive and negative correlation, covariance and…

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Printed Motion: Holding Molecular Movement
Printed Motion: Holding Molecular Movement 150 150 Katie Brind'Amour, PhD, MS, CHES

When student researcher Shareef Dabdoub discovered the appealing aesthetics of a transcriptional regulator from the Streptococcus family, he knew that cellular biology had handed him a work of art. And by using a computer program to predict the 3-D configuration of the molecule and its most probable pathway for rearranging from one state to another, he observed…

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Diagnosis Focus
Diagnosis Focus 150 150 Katie Brind'Amour, PhD, MS, CHES

Up to one in 10 blood clots in women occur in teen contraceptive users. When a teenage girl presents with chest pain, most doctors likely think first of anxiety, muscle injury or heartburn. In most cases, this is entirely appropriate. But if the girl is taking birth control pills, the problem could be a pulmonary…

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(Some Other) Mother’s Milk
(Some Other) Mother’s Milk 150 150 Katie Brind'Amour, PhD, MS, CHES

Women who can’t breastfeed often turn to the Internet for breast milk. But is it safe?

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