Turning Evidence Into Advocacy

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A New Therapeutic Era for Sickle Cell Disease

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A Blueprint for Better Care: The Constant Drive for Quality Improvement in Primary Care

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Iron Deficiency Begins Before Anemia

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An Ethical Discussion of Parental Care Preference
 An Ethical Discussion of Parental Care Preference 150 150 Jan Arthur
By: Jan Arthur

Two infants with the same prognosis have parents with different preferences in terms of care. What should the medical team do? The article, “Two Infants, Same Prognosis, Different Parental Preferences,” published in the May 2015 issue of Pediatrics, presents a challenging ethical dilemma that brings…

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Visualizing Gene Therapy for SMA
 Visualizing Gene Therapy for SMA 150 150 Abbie Miller
By: Abbie Miller

Spinal muscular atrophy (SMA), a degenerative neuromuscular disease, is the most common genetic cause of death for infants. Virtually all children affected with SMA type 1 die by 2 years of age. In 2014, Jerry Mendell, MD, director of the Center for Gene Therapy in the Research Institute…

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Study Links Acute Infections With Later Functional Gastrointestinal Disorders
 Study Links Acute Infections With Later Functional Gastrointestinal Disorders 150 150 Jeb Phillips
By: Jeb Phillips

Link between acute infection in preschoolers and development of FGIDs in school-aged children could point toward interventions. Functional gastrointestinal disorders (FGIDs) are among the most common pediatric health conditions and often first appear in school-aged children. Acute diarrhea, also very common, often first manifests…

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Delayed Umbilical Cord Clamping May Benefit Some High-Risk Newborns
 Delayed Umbilical Cord Clamping May Benefit Some High-Risk Newborns 150 150 Jeb Phillips
By: Jeb Phillips

Recent studies show the practice can offer circulatory advantages for infants born extremely preterm or with critical congenital heart disease. The practice of immediate or early umbilical cord clamping after birth has been the norm since research in the 1950s and 1960s showed that…

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Microvessles
Taking a Closer Look at the Relationship Between Type 2 Diabetes and Cardiovascular Disease
 Taking a Closer Look at the Relationship Between Type 2 Diabetes and Cardiovascular Disease 1024 575 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

A new study reveals surprising results regarding vascular stiffness of coronary microvessels in the presence of type 2 diabetes. Type 2 diabetes mellitus (T2DM) is a chronic condition that affects the glucose metabolism as a result of insulin resistance. Patients with T2DM are two to four…

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Become a Myth Buster: Use Evidence-Based Medicine to Change Clinical Care
 Become a Myth Buster: Use Evidence-Based Medicine to Change Clinical Care 150 150 David Stukus, MD
By: David Stukus, MD

Medical myths abound, even among good doctors. How are medical myths perpetuated and how can they be stopped? When was the last time you took a step back and questioned your medical decision making? Why did you decide to prescribe that treatment at that…

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Helping the Child by Helping the Mom
 Helping the Child by Helping the Mom 150 150 Dave Ghose
By: Dave Ghose

Pediatricians can help babies by doing a better job screening new mothers for postpartum depression. Up to 20 percent of new mothers experience postpartum depression, but studies show that nearly half go undiagnosed. If pediatricians were to play a greater role in identifying mothers…

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Planning, Teamwork and Technology Essential to Conjoined Twins’ Separation
 Planning, Teamwork and Technology Essential to Conjoined Twins’ Separation 150 150 Abbie Miller
By: Abbie Miller

In a meticulously planned 16-hour operation, a 30-person team from four specialties successfully separated 11-month-old twins conjoined at the buttocks and lower spine. Specialists from General Pediatric Surgery, Plastic and Reconstructive Surgery, Neurosurgery and Colorectal Surgery worked together to plan and execute a successful separation of…

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Stress Dose Hydrocortisone Effects on Neurodevelopment for Extremely Low Birthweight Infants
 Stress Dose Hydrocortisone Effects on Neurodevelopment for Extremely Low Birthweight Infants 150 150 Abbie Miller
By: Abbie Miller

First placebo-controlled study on stress dose hydrocortisone and neurodevelopment shows that higher doses of hydrocortisone are not associated with brain injury or neurodevelopmental impairments, but may not be effective in reducing risk for bronchopulmonary dysplasia. Hydrocortisone is one of the 15 most frequently prescribed…

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A close-up medical illustration of blood vessels showing normal round red blood cells flowing through the vessel, with a cluster of rigid, crescent-shaped sickle cells causing a blockage. White blood cells are also visible against the dark background.
Treating Sickle Cell Disease in the United States
 Treating Sickle Cell Disease in the United States 1024 575 Abbie Miller
By: Abbie Miller

While people with sickle cell disease have better outcomes in the United States and other Western countries, progress in treating the disease has been slow moving. Sickle cell disease is marked by painful sickle cell crises, in which sickle-shaped cells get distorted in the…

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Challenges of Adolescent and Young Adult Cancer
 Challenges of Adolescent and Young Adult Cancer 150 150 Anthony Audino, MD
By: Anthony Audino, MD

Among the unique challenges of AYA cancer, anxiety often increases after treatments are completed as the patient reintegrates back into “normal life.” The definition of the adolescent and young adult (AYA) cancer patient has evolved over time, but it is now formally defined as…

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Three beautiful children with blond hair and freckles standing with parents outdoors. Boy is 4 years old. Main focus on the girls (6 and 9 years).
Understanding Genetic Predisposition to Cancer
 Understanding Genetic Predisposition to Cancer 1024 683 Susan Colasce, MD and Elizabeth Varga
By: Susan Colasce, MD and Elizabeth Varga

When should families who have children with cancer be concerned about inherited cancer predisposition? One of the most common questions parents ask when their child is diagnosed with cancer is, “Does this put my other children at higher risk for developing cancer as well?”…

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Psychological Strategies for Pediatric Weight Management
 Psychological Strategies for Pediatric Weight Management 150 150 Tyanna Snider, Psy.D
By: Tyanna Snider, Psy.D

Motivational interviewing, having developmentally appropriate expectations, and behavioral strategies are among the tools needed to support pediatric weight management. Almost everyone has tried to stop a bad habit or change a negative behavior – it’s hard! Think about all the New Year’s resolutions you’ve…

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Making Progress: Advances in Life-Long Care for ACHD
 Making Progress: Advances in Life-Long Care for ACHD 150 150 Abbie Miller
By: Abbie Miller

With adults comprising two-thirds of the CHD population, the AHA has released a scientific statement outlining the needs of this growing demographic. The need for a life-long approach to cardiac care for patients with congenital heart disease is a crusade that has been long…

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Enteral Therapy Thursday: Professionals Sharing the Patient Experience
 Enteral Therapy Thursday: Professionals Sharing the Patient Experience 150 150 Jennifer Smith, MS, RD, CSP, LD, LMT
By: Jennifer Smith, MS, RD, CSP, LD, LMT

A multidisciplinary team puts themselves on enteral nutrition for a day to gain insights into the patient experience. Enteral nutrition for Crohn’s disease is a well-established practice using liquid formulas to treat Crohn’s disease.  Patients who choose this form of treatment either drink the…

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Using Informatics to Help Identify Patients for Research
 Using Informatics to Help Identify Patients for Research 150 150 Tiasha Letostak, PhD
By: Tiasha Letostak, PhD

Researchers use Informatics for Integrating Biology and the Bedside (i2b2), a system that can rapidly convert a large amount of clinical data into searchable information, to dramatically reduce the time needed for patient cohort identification. Patient cohort identification, or the process of finding patients…

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Researchers Describe Molecular Switch Controlling “Chameleon” Bacteria
 Researchers Describe Molecular Switch Controlling “Chameleon” Bacteria 150 150 Abbie Miller
By: Abbie Miller

Closing the gap on developing a vaccine for middle ear infections. Researchers at Nationwide Children’s Hospital in Columbus, Ohio, and Griffith University’s Institute for Glycomics in Australia have discovered groundbreaking evidence that will help vaccine developers in their search for a vaccine against multiple infections of the…

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Racism in Our Hospitals and Communities: Everyone Matters
 Racism in Our Hospitals and Communities: Everyone Matters 150 150 Kelly Kelleher, MD, MPH
By: Kelly Kelleher, MD, MPH

Let’s touch all families by erasing racism from children’s hospitals. Here at Nationwide Children’s Hospital, we are engaged in an important new initiative: Everyone Matters. The idea is simple — we each have effects that ripple far beyond us through our everyday actions and attitudes toward…

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Photo of a toddler playing with toys
The Childhood Roots of Illness
 The Childhood Roots of Illness 1024 575 Dave Ghose
By: Dave Ghose

A growing body of scientific evidence reveals the dramatic impact of early-life adversity on lifelong health. Kelly Kelleher, MD, compares childhood health to a boulder sitting on the peak of a mountain. A slight push could send the boulder in many directions. And once…

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Do Overly Restrictive Feeding Practices Contribute to Obesity?
 Do Overly Restrictive Feeding Practices Contribute to Obesity? 150 150 Anne Unger
By: Anne Unger

Researchers are discovering that the way caregivers feed their kids may be just as important as what they give them to eat. It is estimated that by 2020, 16 million kids under the age of 5 will be obese. Currently, most public health initiatives…

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