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Can Spinal Replace General Anesthesia in Pediatric Urology Patients?
 Can Spinal Replace General Anesthesia in Pediatric Urology Patients? 150 150 Jeb Phillips
By: Jeb Phillips

Spinal anesthesia offers a viable low-risk alternative to general anesthesia for a wide range of pediatric procedures, particularly for urology patients. As research continues to illuminate the possibility of neurotoxic effects from general anesthesia in pediatric patients, surgeons and anesthesiologists at Nationwide Children’s Hospital…

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Cysteamine Appears to Help Clear Antibiotic-Resistant Bacteria from Cells of Patients With Cystic Fibrosis
 Cysteamine Appears to Help Clear Antibiotic-Resistant Bacteria from Cells of Patients With Cystic Fibrosis 150 150 Kevin Mayhood
By: Kevin Mayhood

The drug could help eradicate members of the B. cepacia complex and other bacteria in CF. Physicians and researchers from Nationwide Children’s Hospital have found that the drug cysteamine protects cells of patients with cystic fibrosis (CF) against a group of disease-causing and multi-drug…

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Building Heart Valves From Extracellular Matrix
 Building Heart Valves From Extracellular Matrix 150 150 Abbie Miller
By: Abbie Miller

Physicians at Nationwide Children’s Hospital describe the use of an extracellular matrix cylindar valve in the mitral position. At The Heart Center at Nationwide Children’s, Patrick McConnell, MD, a pediatric cardiothoracic surgeon, is using an alternative to the traditional cadaveric, mechanical or biological replacement valve.…

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Considerations for Integrating Behavioral Health and Primary Care
 Considerations for Integrating Behavioral Health and Primary Care 150 150 Cody Hostutler, PhD
By: Cody Hostutler, PhD

As increasing numbers of pediatric patients require behavioral health care, primary care providers look to integrate behavioral health providers in their practice. You know the story. It’s the middle of a busy Friday afternoon, you just finished up an adolescent well-visit, your hand is…

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Care Bundles Can Reduce Hospital-Acquired Pressure Injuries
 Care Bundles Can Reduce Hospital-Acquired Pressure Injuries 150 150 Brianne Moore
By: Brianne Moore

Reliable implementation of care bundles reduces the number of serious hospital-acquired pressure injuries Hospital-acquired pressure injuries (PI) are a significant cause of preventable harm that can increase hospitalization costs and length of stay. Up to 27 percent of pediatric intensive care unit (PICU) patients…

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Two Classes of GGAA-Microsatellites in a Ewing Sarcoma Context
 Two Classes of GGAA-Microsatellites in a Ewing Sarcoma Context 150 150 Abbie Miller
By: Abbie Miller

Characterization of GGAA-microsatellites provides insight in the role of noncoding DNA in cancer susceptibility and therapeutic development. In a study published in PLOS ONE, researchers describe two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma. Ewing sarcoma is the…

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Phase 1 Study Shows Promise of Gene Replacement Therapy for Spinal Muscular Atrophy Type 1
 Phase 1 Study Shows Promise of Gene Replacement Therapy for Spinal Muscular Atrophy Type 1 150 150 Abbie Miller
By: Abbie Miller

The phase 1 clinical study shows that gene therapy extends survival of patients and supports achievement of milestones previously unseen in the natural course of the disease. A one-time intravenous infusion of the high dose of gene therapy extended the survival of patients with…

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On the Road to Eliminating RSV
 On the Road to Eliminating RSV 150 150 Abbie Miller
By: Abbie Miller

With the recent publication of two papers, researchers shed light on factors that influence disease severity and immune response to respiratory syncytial virus infection in infants and young children. “RSV is a very common infection in infants and young children – almost everyone will…

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8 Ways You Can Support Families in Need of Behavioral Health Services
 8 Ways You Can Support Families in Need of Behavioral Health Services 150 150 Nancy Cunningham, PsyD
By: Nancy Cunningham, PsyD

Long wait times and difficulties accessing behavioral health services cause stress for many patients and families. As awareness grows about the prevalence of behavioral health challenges for children and adolescents, more patients and families are seeking specialized care. However, due to a shortage of…

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How Genes and Environment Interact to Raise Risk of Congenital Heart Defects
 How Genes and Environment Interact to Raise Risk of Congenital Heart Defects 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Genetic susceptibility plus maternal hyperglycemia interact to contribute to heart defects during fetal development. Infants of mothers with diabetes have a three- to five-fold increased risk of congenital heart defects. Such developmental defects are likely caused by a combination of genetic and environmental factors.…

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Dopamine: A Rescue Therapy for Fontan Patients With Protein-Losing Enteropathy?
 Dopamine: A Rescue Therapy for Fontan Patients With Protein-Losing Enteropathy? 150 150 Jeb Phillips
By: Jeb Phillips

Patients with quickly worsening PLE saw serum albumin levels stabilize after dopamine treatment. Patients who have undergone the Fontan procedure for single ventricle congenital heart disease do not often develop protein-losing enteropathy (PLE) – but those who do are at substantial risk of mortality…

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Speedy Development of Support Programs for Second Victims Demands Collaboration
 Speedy Development of Support Programs for Second Victims Demands Collaboration 150 150 John Hofmeister
By: John Hofmeister

Openly sharing research and resources results in rapid development and growth of peer program for health care workers experiencing second victim phenomena. A career in health care brings many rewards — but it also puts its practitioners at risk for depression, anxiety, shame or…

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The Evolution of Precision Medicine for Children With Aggressive Brain Tumors
 The Evolution of Precision Medicine for Children With Aggressive Brain Tumors 150 150 Jonathan Finlay, MB, ChB, FRCP
By: Jonathan Finlay, MB, ChB, FRCP

The Head Start 4 clinical trial introduces risk stratification and builds on the success of bone marrow transplantation for young children with malignant embryonal tumors. Cancers in the brain and spinal cord (the central nervous system, CNS) are now the most common cause of…

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A New Paradigm for Treating Transcription Factor-Driven Cancers
 A New Paradigm for Treating Transcription Factor-Driven Cancers 150 150 Abbie Miller
By: Abbie Miller

Researchers describe how the association of the EWS/FLI transcription factor with GGAA-microsatellites drives Ewing sarcoma. In the current issue of Proceedings of the National Academy of Sciences, researchers from Nationwide Children’s Hospital describe a new paradigm for treating transcription factor-driven cancers. The study focuses on…

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Family Focus Restructures Single Ventricle Care
 Family Focus Restructures Single Ventricle Care 150 150 Brianne Moore
By: Brianne Moore

Standardize, connected care in a multidisciplinary team environment aims to improve outcomes and quality of life for patients born with single ventricle heart anatomy. Children with single ventricle anatomy, one of the most harrowing of congenital heart defects, face unique challenges that require multiple…

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Could Nutritional Supplements Impact Autism Symptoms in Toddlers Born Preterm?
 Could Nutritional Supplements Impact Autism Symptoms in Toddlers Born Preterm? 150 150 Rachael Hardison
By: Rachael Hardison

Supplementing with omega-3 and -6 fatty acids impacts language development in preterm toddlers at risk for developing autism. Delay in language development is often an early indicator in children at risk for developing autism spectrum disorder (ASD), yet clinicians are still trying to understand…

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6 Strategies for Incorporating Behavioral Economics in Your Practice
 6 Strategies for Incorporating Behavioral Economics in Your Practice 150 150 Kevin Mayhood
By: Kevin Mayhood

Behavioral economics combines insights from psychology, economics and marketing to improve or direct decision-making. It can be used to “nudge” patients, their families and practitioners in the direction of better health if used by health care providers. While the use of behavioral economics strategies has…

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“Impatient” Therapy: Physicians Too Aggressive in Treatment of ITP
 “Impatient” Therapy: Physicians Too Aggressive in Treatment of ITP 150 150 Brianne Moore
By: Brianne Moore

Despite guidelines that advocate watching and waiting, physicians are still treating most patients with immune thrombocytopenia. When a child presents with easy bruising or bleeding, red skin spots and fatigue – symptoms similar to those for leukemia – families seek evaluation immediately. However, more…

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How to Improve Apparent Cause Analyses and Reduce Error Recurrence
 How to Improve Apparent Cause Analyses and Reduce Error Recurrence 150 150 Brianne Moore
By: Brianne Moore

A quality improvement team embarks on a project focused on the accuracy of future quality improvement initiatives. An apparent cause analysis (ACA) is a process used to investigate the cause or causes of a medium or low-risk safety event. Designed as a quality improvement…

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portrait of two physicians at the hospital smiling at the camera
Bouncing Back: Overcoming Physician Burnout With Resilience
 Bouncing Back: Overcoming Physician Burnout With Resilience 1024 575 Suzanne Reed, MD and John Mahan, MD
By: Suzanne Reed, MD and John Mahan, MD

Physician burnout is becoming increasingly recognized as an extensive and debilitating reality. Present in specialties across the spectrum of medicine, most disciplines report burnout rates of 50 to 60 percent or more, and these rates have been increasing over the last several years. Pediatrics…

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