Turning Evidence Into Advocacy

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A New Therapeutic Era for Sickle Cell Disease

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A Blueprint for Better Care: The Constant Drive for Quality Improvement in Primary Care

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Iron Deficiency Begins Before Anemia

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Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors
 Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors 1024 504 Lauren Dembeck
By: Lauren Dembeck

Due to within-tumor heterogeneity, telomere-based therapeutic interventions will likely need to target both known telomere maintenance mechanisms to prevent resistance and recurrence.   Normal differentiated somatic cells can divide only a limited number of times due to loss of the physical ends of their…

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A Decade of Evidence: The SIMPLE Program Shows Continued Success
 A Decade of Evidence: The SIMPLE Program Shows Continued Success 1024 575 Pam Georgiana
By: Pam Georgiana

In 2010, Nationwide Children’s Hospitals NICU leaders observed that infant feeding practices varied depending on the provider, resulting in significant variations in milestones and length of hospital stays (LOHS). They asked Sudarshan R. Jadcherla, MD, and Erika Osborn, NNP, to partner with stakeholders, including…

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Girl sitting on a bench with her phone smiling.
User Experiences With Subcutaneous Depot Medroxyprogesterone Acetate
 User Experiences With Subcutaneous Depot Medroxyprogesterone Acetate 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Survey reveals high satisfaction among adolescents and young adults using subcutaneous DMPA Depot medroxyprogesterone acetate (DMPA) is a progestin-only injectable contraceptive that is used as birth control method and in the treatment of heavy or painful menstrual periods, endometriosis, and for menstrual suppression. DMPA…

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Exploring the Clinical Journey of Children With Primary Hyperoxaluria
 Exploring the Clinical Journey of Children With Primary Hyperoxaluria 150 150 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Children with primary hyperoxaluria, a rare genetic disease, navigate a complicated clinical journey that includes a heavy reliance on health care services and usage of multidisciplinary care. Primary hyperoxaluria (PH) is a rare disease caused by genetic mutations of enzymes that regulate hepatic glyoxylate…

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Julie Samora, MD
Diagnosing and Treating Cubital Tunnel Syndrome in Adolescents
 Diagnosing and Treating Cubital Tunnel Syndrome in Adolescents 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Surgery leads to improved outcomes in pediatric patients with symptoms of cubital tunnel syndrome, even when electrodiagnostic studies are negative. In a new study, researchers from Nationwide Children’s Hospital demonstrate that pediatric patients who underwent surgical decompression for cubital tunnel syndrome achieved good resolution…

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Counseling Families of Patients with Hypoplastic Left Heart Syndrome
 Counseling Families of Patients with Hypoplastic Left Heart Syndrome 150 150 Mary Bates, PhD
By: Mary Bates, PhD

A new survey investigates how palliation strategies have changed in the last ten years. Approximately ten years ago, researchers at Nationwide Children’s Hospital surveyed pediatric cardiac providers regarding initial counseling for families of patients with hypoplastic left heart syndrome (HLHS). Given the evolution of…

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Using Machine Learning to Classify Treatment Approaches for Infants with Bronchopulmonary Dysplasia
 Using Machine Learning to Classify Treatment Approaches for Infants with Bronchopulmonary Dysplasia 1024 683 Pam Georgiana
By: Pam Georgiana

We don’t yet know the best way to help infants with severe bronchopulmonary dysplasia (BPD) breathe using ventilators. Currently, doctors across the country and around the world use a variety of different approaches.  These variations depend on the severity of a patient’s medical condition,…

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Smiling baby with Down syndrome
Changing the Odds: Survival Trends in Children With Down Syndrome and Congenital Heart Defects
 Changing the Odds: Survival Trends in Children With Down Syndrome and Congenital Heart Defects 1024 683 Pam Georgiana
By: Pam Georgiana

About half of the children born with Down syndrome also have congenital heart defects (CHD). As a transplant cardiologist, Lydia K Wright, MD, wanted to learn if CHD was still the most significant mortality risk for these patients before age five. [1] “Our aim…

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small baby with nose canula
Safe, Minimally Invasive Upper Urinary Tract Surgery for Infants
 Safe, Minimally Invasive Upper Urinary Tract Surgery for Infants 1024 575 Patti Doud
By: Patti Doud

Evidence supports robotic surgery as a safe approach to upper urinary tract procedures in infants 6 months or younger. While robotic surgery has risen in popularity and feasibility for procedures in both older children and adults alike, there has been little data to determine…

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Teen girl with backpack walking down a sidewalk facing away from the camera
Ask A Specialist: What Are the Recommendations for Sexually Transmitted Infections (STI) Screening in Primary Care?
 Ask A Specialist: What Are the Recommendations for Sexually Transmitted Infections (STI) Screening in Primary Care? 1024 575 Cynthia Holland-Hall, MD
By: Cynthia Holland-Hall, MD

STI screening is recommended for all sexually active adolescents. According to the American Academy of Pediatrics, nearly 1 in 4 teens have an STI. Safe sexual practices and routine screening can prevent these infections – that’s where health care providers come in. By offering…

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Color photo of Black father holding infant on shoulder in front of nursery background with clouds on the wall
Fertility Concerns in Boys and Men With Sickle Cell Disease
 Fertility Concerns in Boys and Men With Sickle Cell Disease 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Sickle cell disease and its treatments may impact fertility, but more research is needed to help counsel this population. Sickle cell disease (SCD) affects approximately 100,000 Americans, most of whom belong to underserved, minority populations. Advances in disease-modifying therapies, such as hydroxyurea, have led…

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Assessing Respiratory Stability in Infants Hospitalized with Bronchopulmonary Dysplasia
 Assessing Respiratory Stability in Infants Hospitalized with Bronchopulmonary Dysplasia 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

The Behavioral Signs of Respiratory Instability Scale is a valid, reliable measure of respiratory status and developmental ability. In a new study, researchers at Nationwide Children’s evaluated the Behavioral Signs of Respiratory Instability (BSRI) Scale, which was developed as an objective measure of developmental…

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Featured Researcher — Nilsa Ramirez, MD
 Featured Researcher — Nilsa Ramirez, MD 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Nilsa Del Carmen Ramirez Milan, MD, director of the Biopathology Center at Nationwide Children’s Hospital, leads the biorepository team that receives about 1,000 new specimens each day. These must be processed and stored properly—together with the rest of the biobank’s > 6 million specimens.…

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Home Infusions of Infliximab for Inflammatory Bowel Disease
 Home Infusions of Infliximab for Inflammatory Bowel Disease 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

With a standardized care approach, home infusions may be an effective alternative to hospital-based infusions. Pediatric inflammatory bowel disease (IBD) is often treated with infusions of infliximab in a hospital setting. However, these can be costly and present time and travel barriers to patients…

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Smiling boy outside
Expanding Use of Trikafta for Cystic Fibrosis to Patients as Young as 2 Years Old
 Expanding Use of Trikafta for Cystic Fibrosis to Patients as Young as 2 Years Old 1024 683 Karen McCoy, MD
By: Karen McCoy, MD

When I first started my pulmonary training, the average life expectancy in the United States was about 70 years, and the average life expectancy for someone with cystic fibrosis (CF) was 14 years! Intense study and pursuit of consistent care across the country yielded…

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Implementation Science to Expand Contraception Access for Adolescents Hospitalized with Mental Health Issues
 Implementation Science to Expand Contraception Access for Adolescents Hospitalized with Mental Health Issues 150 150 Pam Georgiana
By: Pam Georgiana

Research has documented that adolescents with mental health concerns have a higher need for contraceptive counseling and care because they are at a higher risk for unintended pregnancy.[i] [ii] Unintended pregnancies can make mental health symptoms worse, especially depressive symptoms. [iii] Counseling and use…

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Woman in scrubs with a stethoscope talking with teen.
Recent Trends in the Diagnosis and Treatment of Anxiety in US Children and Adolescents
 Recent Trends in the Diagnosis and Treatment of Anxiety in US Children and Adolescents 1024 683 Lauren Dembeck
By: Lauren Dembeck

In 2021, the American Academy of Pediatrics, American Academy of Child and Adolescent Psychiatry and Children’s Hospital Association joined together to declare a national state of emergency in children’s mental health. The declaration was motivated by steadily increasing rates of childhood mental health concerns…

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Pregnancy and Ebola: Maternal and Infant Health Outcomes in Ebola Survivors
 Pregnancy and Ebola: Maternal and Infant Health Outcomes in Ebola Survivors 150 150 Abbie Miller
By: Abbie Miller

Ebola virus disease during pregnancy is known to cause fetal demise, and preliminary evidence suggested that pregnancies conceived shortly after recovery from Ebola were also at heightened risk of adverse outcomes. Additionally, the perception that health care providers could contract Ebola from survivors during…

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Featured Researcher — Katherine Bline, MD
 Featured Researcher — Katherine Bline, MD 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Katherine Bline, MD, is a critical care medicine physician and principal investigator in the Center for Vaccines and Immunity at Nationwide Children’s Hospital. Experience caring for some of the hospital’s sickest children in the pediatric intensive care unit (PICU) and mentors who pushed her…

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What Drives Nephrotic Syndrome Hypercoagulopathy?
 What Drives Nephrotic Syndrome Hypercoagulopathy? 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Antithrombin deficiency does not play a major mechanistic role in the increased clotting risk of nephrotic syndrome, according to a new study. Patients with nephrotic syndrome are at risk for life-threatening venous thromboembolism complications. This risk is thought to be driven by an acquired…

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