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Novel Treatment Ameliorates Proteinuria and Dyslipidemia in a Model of Noninflammatory Glomerular Disease
 Novel Treatment Ameliorates Proteinuria and Dyslipidemia in a Model of Noninflammatory Glomerular Disease 150 150 Lauren Dembeck
By: Lauren Dembeck

Idiopathic nephrotic syndrome — characterized by proteinuria, hypoalbuminemia, dyslipidemia, and edema — is one of the most common pediatric glomerular diseases. Glucocorticoids are first-line treatment, followed by calcineurin inhibitors for steroid-resistant disease; however, currently available calcineurin inhibitors can have numerous side effects, including dyslipidemia, and require frequent monitoring of drug levels in the blood. Since…

Increasing the Donor Pool for Young Children Waiting for Heart Transplants
 Increasing the Donor Pool for Young Children Waiting for Heart Transplants 150 150 Pam Georgiana
By: Pam Georgiana

The one-year survival rate following a pediatric heart transplant is over 90%, However, waitlist mortality in the United States for children remains high at 17%. Young and highly sensitized children typically experience longer waitlist times for a heart transplant, which increases their waitlist mortality. In response, doctors utilize various strategies to potentially increase the number…

Implanted Hemodynamic Monitoring in Patients With Fontan Circulation
 Implanted Hemodynamic Monitoring in Patients With Fontan Circulation 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Pulmonary artery pressures obtained with the CardioMEMSTM system may be clinically useful. In a new study, researchers from The Ohio State University and Nationwide Children’s Hospital report on the use of invasive implanted hemodynamic monitoring (IHM) in patients with Fontan circulation. The findings suggest that IHM pressures in these patients are more closely associated with…

Changing the Landscape of Blood Disorder Treatments: A Long Time Coming
 Changing the Landscape of Blood Disorder Treatments: A Long Time Coming 1024 574 Alaina Doklovic
By: Alaina Doklovic

New therapies, from virus-mediated gene therapy to CRISPR-based treatments, are poised to change the clinical landscape of blood disorder treatments and outcomes.   For more than two decades experts have been searching for curative therapies for blood disorders. They have invested time, money and expertise to bring these therapies to fruition, something that the Division…

Researchers Create Public Database of Nearly 40,000 Control Samples for Genetic Association Studies
 Researchers Create Public Database of Nearly 40,000 Control Samples for Genetic Association Studies 1024 575 Lauren Dembeck
By: Lauren Dembeck
conceptual art of DNA

Genetic association studies provide powerful means of discovering relationships between genetic variants and disease risk. However, these studies require enrolling very large numbers of individuals with the disease (cases) and healthy individuals (controls) as well as collecting genetic data for all of those participants — a time-consuming and expensive endeavor. “Sequencing DNA for a healthy…

New Zebrafish Pipeline Enables Functional Evaluation of Novel, Rare, Fusion-Oncogenes in vivo
 New Zebrafish Pipeline Enables Functional Evaluation of Novel, Rare, Fusion-Oncogenes in vivo 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

An innovative method that uses a zebrafish model to rapidly study novel fusion-oncogenes in vivo has been developed by investigators at Nationwide Children’s Hospital.   Fusion oncogenes are frequently observed in pediatric cancers. These fusion oncogenes are typically caused by a chromosomal translocation that produces gain-of-function chimeric gene activity. Although there has been experimental work…

Interactions Between Invading Tumor and Lung Cells Permit Metastatic Lung Colonization of Osteosarcoma
 Interactions Between Invading Tumor and Lung Cells Permit Metastatic Lung Colonization of Osteosarcoma 150 150 Lauren Dembeck
By: Lauren Dembeck

Survival signals elicited by lung tissue interactions promote osteosarcoma metastasis and represent a promising target for clinical trials in both human and canine patients.   Osteosarcoma, the most common primary tumor of bone, occurs predominantly in children, teens and young adults. Patient survival largely depends upon the presence or absence of metastasis. Within five years…

Kids With Concussions Need Specialized Assessment and Care
 Kids With Concussions Need Specialized Assessment and Care 1024 683 Sean Rose, MD
By: Sean Rose, MD

Learn why cutting-edge care and research specifically for children matters. The 2020 National Health Interview Survey reported that 6.8% of children experience symptoms of a concussion or brain injury in their lifetime. However, only 3.9% had received a diagnosis or treatment of a concussion or brain injury from a health care provider. The Concussion Center…

Transforming Treatment for Paratesticular Rhabdomyosarcoma in Adolescents through Robotics
 Transforming Treatment for Paratesticular Rhabdomyosarcoma in Adolescents through Robotics 1024 683 Erin Gregory
By: Erin Gregory

Retroperitoneal lymph node dissection (RPLND) has been a crucial component of treating testicular and paratesticular cancers for over a century. Recent advancements in minimally invasive techniques, such as robotic-assisted methods, have expanded the applicability of RPLND, offering reduced morbidity and faster recovery. However, concerns persist regarding the equivalence of oncological outcomes compared to traditional open…

Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2
 Innovative Gene Therapy Approach for Treating Patients with Tuberous Sclerosis Type 2 150 150 Lauren Dembeck
By: Lauren Dembeck

Tuberous sclerosis complex (TSC) is a devastating genetic disease that affects nearly 1 in every 5,500 newborns and approximately 2 million people worldwide. The disease is characterized by the formation of non-malignant tumors throughout multiple organs, including the kidney, lungs, eyes, and heart, but predominantly the brain. It is typically diagnosed in infants and young…

What Are the Risk Factors for Recurrent Wheezing in Late Preterm Infants?
 What Are the Risk Factors for Recurrent Wheezing in Late Preterm Infants? 1024 683 Pam Georgiana
By: Pam Georgiana

A collaboration between a pulmonary medicine fellow and allergy and immunology expert identifies four risk factors associated with recurrent wheezing in these patients.   When Brooke R. Gustafson, MD, a member of the Section of Pediatric Pulmonary Medicine at Nationwide Children’s and an assistant professor of pediatrics at The Ohio State University College of Medicine,…

GERD Less Likely Cause of Irritability and Back Arching in Infants
 GERD Less Likely Cause of Irritability and Back Arching in Infants 1024 683 Lauren Dembeck
By: Lauren Dembeck

In infants, frequent irritability and arching of the back can be concerning to parents and providers. These symptoms are often attributed to gastroesophageal reflux disease (GERD), a disease in which the lower esophageal sphincter does not close or opens at the wrong time. As a result, food and stomach acid can come back up into…

Ensuring All Children Have Access to Behavioral Health Care
 Ensuring All Children Have Access to Behavioral Health Care 531 213 Pam Georgiana
By: Pam Georgiana

New study reports the results of integrating psychologists into primary care clinics. Cody A. Hostutler, PhD, a psychologist in the Department of Pediatric Psychology and Neuropsychology at Nationwide Children’s, is concerned about the mental health of the children and adolescents visiting primary care centers. “There is a mental health crisis for kids happening right now.…

Accelerating Pediatric Medical Device Innovation 
 Accelerating Pediatric Medical Device Innovation  150 150 Erin Gregory
By: Erin Gregory

The Midwest Pediatric Device Consortium (MPDC) is a unique collective led by Nationwide Children’s Hospital and The Ohio State University, designed to facilitate the development, production, and distribution of pediatric medical devices. Comprising a diverse group of leaders in universities, healthcare systems, community organizations, and industry partners across Ohio, the MPDC is committed to transforming…

Researchers Create a Stem Cell Line to Study Alagille Syndrome
 Researchers Create a Stem Cell Line to Study Alagille Syndrome 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

The patient-derived iPSCs have a mutation affecting the Notch signaling pathway. Researchers at Nationwide Children’s have developed an induced pluripotent stem cell (iPSC) line derived from a patient with Alagille syndrome, a multisystem genetic disease. Like the majority of patients with Alagille syndrome, the stem cells have a pathogenic mutation in the JAG1 gene, part…

Frequency of Pediatric Encounters Predicts Timely Transfer to Adult Care for Youth With Autism
 Frequency of Pediatric Encounters Predicts Timely Transfer to Adult Care for Youth With Autism 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

For adolescents and young adults with autism, the total number of pediatric appointments is strongly correlated with a timely transfer to adult care, while the reason for this correlation remains to be elucidated.   In a recent study, Laura Hart, MD, a pediatrician at Nationwide Children’s Hospital, and her research team reported a strong correlation…

Rural-Urban Differences in Social and Emotional Protective Factors
 Rural-Urban Differences in Social and Emotional Protective Factors 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Efforts to improve child health and flourishing should consider communities’ unique sources of support. Children living in rural areas experience well-documented health and health care disparities compared to those living in urban areas. Protective factors, such as social connectedness and social engagement, also vary by geography, yet their contribution to differences in child health is…

A Novel Measles-Mumps Vaccine Delivers Multiple SARS-CoV-2 Spike Variants by Nose Drop
 A Novel Measles-Mumps Vaccine Delivers Multiple SARS-CoV-2 Spike Variants by Nose Drop 1024 512 Jessica Nye, PhD
By: Jessica Nye, PhD
coronavirus

Investigators from Nationwide Children’s Hospital and The Ohio State University modified the measles and mumps viruses from the measles-mumps-rubella (MMR) vaccine to deliver three SARS-CoV-2 spike protein variants to the respiratory tract as an effective vaccine candidate. “We’re calling this a trivalent vaccine because it protects against three different variants of SARS-CoV-2,” says Mark Peeples,…

What Other Screening Tests Should be Administered to Celiac Disease Patients?
 What Other Screening Tests Should be Administered to Celiac Disease Patients? 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Eliminating some labs may reduce costs without impacting quality of patient care. Researchers from Nationwide Children’s Hospital found that several screening laboratory tests currently recommended for pediatric patients newly diagnosed with celiac disease are infrequently abnormal. In a new study published in the Journal of Pediatrics, they suggest a more streamlined approach to decrease the…

Surgical Hip Dislocation as a Treatment Modality in Children and Adolescents
 Surgical Hip Dislocation as a Treatment Modality in Children and Adolescents 150 150 Pam Georgiana
By: Pam Georgiana

What was once a complicated surgery has now become a safe and effective way to treat many hip conditions.   Treatment of hip conditions and disorders in children and adolescents can be tricky. Doctors must have a thorough understanding of the patient’s anatomy, growth plates, and blood supply, as well as the existence of any…

Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas
 Long-Term Outcomes and Quality of Life for Children Treated With Antegrade Continence Enemas 1024 601 Pam Georgiana
By: Pam Georgiana

ACE treatment can lead to long-term clinical and quality-of-life improvement in children with defecation disorders.   For about 10-15% of the children who experience chronic constipation or other defecation disorders, the usual behavioral modification treatments and oral medications don’t help. These disorders can significantly impact their quality of life, yet other treatment options are limited.…

What Treatment is Best for Preventing Kidney Complications in STEC Infections?
 What Treatment is Best for Preventing Kidney Complications in STEC Infections? 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Nationwide Children’s Hospital is participating in a multicenter trial to determine the optimal way to treat children with high-risk STEC infections. Shiga toxin-producing E. coli (STEC) infections can lead to systemic disease affecting multiple organ systems, including the kidneys. Up to 20% of children infected by high-risk STEC develop hemolytic uremic syndrome (HUS), a devastating…

Is Dextranomer/Hyaluronic Acid an Effective Bladder Neck Bulking Agent for Patients with Persistent Incontinence Following Bladder Neck Reconstruction?
 Is Dextranomer/Hyaluronic Acid an Effective Bladder Neck Bulking Agent for Patients with Persistent Incontinence Following Bladder Neck Reconstruction? 1024 575 Pam Georgiana
By: Pam Georgiana
Dr. Jayanthi standing in OR

Urinary incontinence caused by bladder neck incompetence is common in children diagnosed with neurogenic bladder. Many patients undergo surgery to increase bladder outlet resistance to incontinence, but some still experience it even after surgery. Endoscopic injection of bulking agents has previously been utilized and studied for use in the bladder neck as follow-up treatment for…

Modulator Therapy Improves Lives of Patients With Cystic Fibrosis With Severe Lung Disease
 Modulator Therapy Improves Lives of Patients With Cystic Fibrosis With Severe Lung Disease 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Patients receiving ETI on a compassionate use basis experienced substantial clinical improvement. The development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs, most recently elexacaftor/tezacaftor/ivacaftor (ETI), has transformed the treatment of patients with cystic fibrosis. A new study from researchers at Nationwide Children’s Hospital shows that ETI therapy has the potential to change even…

Outcomes After Surgical Interventions for Abusive Head Trauma
 Outcomes After Surgical Interventions for Abusive Head Trauma 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Study suggests that most children can make clinically meaningful recoveries after neurosurgical intervention. Abusive head trauma (AHT) is a leading cause of injury and death in children under 5 years, according to the Centers for Disease Control and Prevention (CDC), yet the scientific literature on neurosurgical intervention for this population is mixed. Given the range…

Expanding Access to Genomic Testing in Level IV Neonatal Intensive Care Units
 Expanding Access to Genomic Testing in Level IV Neonatal Intensive Care Units 1024 575 Pam Georgiana
By: Pam Georgiana
conceptual art of DNA

Recent study identifies variations in availability and highlights opportunities to improve access to genomic testing in the United States and Canada. In the Nationwide Children’s Hospital neonatal intensive care unit, patients needing rapid genome sequencing can get it on demand without administrative approval. However, that is not the case in all level IV neonatal intensive…

Congenital Heart Disease and Extracardiac Phenotypes Associated With Novel Pathogenic Variant in GATA6
 Congenital Heart Disease and Extracardiac Phenotypes Associated With Novel Pathogenic Variant in GATA6 1024 575 Jessica Nye, PhD
By: Jessica Nye, PhD

A study published in Pediatric Research describes a novel pathogenic variant in the gene GATA binding protein 6 (GATA6) associated with congenital heart disease (CHD), diabetes mellitus and necrotizing enterocolitis.   GATA is a family of transcription factors that encode zinc finger DNA binding proteins which are critical regulators during organogenesis. Pathogenic variants in three…

Enhancing Intestinal Rehabilitation Workflow with Disease-Specific Documentation Tools
 Enhancing Intestinal Rehabilitation Workflow with Disease-Specific Documentation Tools 150 150 Erin Gregory
By: Erin Gregory

Structured data entry not only reduces the amount of time physicians are spending in the electronic health record but also opens the door for new research. A recent study published in JAMA Pediatrics by Nationwide Children’s Hospital’s Ethan Mezoff, MD, Jennifer Lee, MD, and team has shed light on a promising solution to improve the…

Treating Pediatric Melanoma: Ultrasound Surveillance vs. Completion Lymph Node Dissection for Sentinel Node Positive Patients
 Treating Pediatric Melanoma: Ultrasound Surveillance vs. Completion Lymph Node Dissection for Sentinel Node Positive Patients 1024 683 Pam Georgiana
By: Pam Georgiana

Treatments for pediatric melanoma are usually based on adult studies, but increasing recognition of the differences between pediatric and adult melanoma could change that. Pediatric melanoma is rare in the United States. The Skin Cancer Foundation reports that about 400 children under 20 years old are diagnosed with melanoma each year in the United States.…

Novel Cause of Brain Mosaicism and Focal Epilepsy Identified
 Novel Cause of Brain Mosaicism and Focal Epilepsy Identified 1024 575 Abbie Miller
By: Abbie Miller

In Nature Genetics, researchers report a novel mechanism for the origin of brain chromosomal mosaicism and link brain mosaic chromosome 1q gain to a distinct clinical phenotype.   In most people, every cell in their body contains the same genetic information. However, sometimes people can have two or more genetically different sets of cells. This…

Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model
 Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model 898 504 Abbie Miller
By: Abbie Miller

Biofilm formulation of Limosilactobacillus reuteri protects against necrotizing enterocolitis in piglet model.  Necrotizing enterocolitis (NEC) is a debilitating and deadly condition affecting infants born preterm. In NEC cases, intestinal tissues become inflamed, and in severe cases, there is ischemia and death of the involved intestines. Treatment for NEC often involves surgery to remove the dying…

Increasing Same-Day Amoxicillin Graded Dose Challenges
 Increasing Same-Day Amoxicillin Graded Dose Challenges 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

A quality improvement initiative overcomes several barriers to de-labeling penicillin allergies. In a study published in The Journal of Allergy and Clinical Immunology: In Practice, a research team led by Margaret Redmond, MD, a pediatric allergist at Nationwide Children’s Hospital, reported on a quality improvement (QI) initiative that sustainably increased rates of same-day amoxicillin graded…

Whole Child, Whole Family Care
 Whole Child, Whole Family Care 150 150 Abbie Miller and Jeb Phillips
By: Abbie Miller and Jeb Phillips

Meeting the needs of children and caregivers with evidence-based programming and intentional support for access. Parenting a young child can be tough in the best circumstances. But when you overlay poverty, inequity, and concerns about employment and education on top of it, parenting a young child can feel overwhelming. Whitney Raglin Bignall, PhD, has dedicated…

Tissue Engineered Trachea: State of the Research
 Tissue Engineered Trachea: State of the Research 150 150 Lauren Dembeck
By: Lauren Dembeck

The promise of tissue-engineered trachea grafts is moving closer to the clinic, as recent preclinical studies have shown successful implantation and neovascularization. Breathing is an essential biological function that provides our bodies with the oxygen necessary for survival. However, most of us rarely think about the biological structures that make it possible. The trachea, commonly…

User Experiences with Subcutaneous DMPA
 User Experiences with Subcutaneous DMPA 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Survey reveals high satisfaction among adolescents and young adults using subcutaneous DMPA. Depot medroxyprogesterone acetate (DMPA) is a progestin-only injectable contraceptive that is used as a birth control method and in the treatment of heavy or painful menstrual periods, endometriosis, and for menstrual suppression. DMPA can be injected intramuscularly or subcutaneously, with no difference in…

Should You Offer Fentanyl Test Strips in Your Office?
 Should You Offer Fentanyl Test Strips in Your Office? 150 150 Abbie Miller
By: Abbie Miller

Harm reduction approaches support the use of fentanyl test strips for individuals who are taking illicit substances but want to avoid fentanyl. Nichole Michaels, PhD, a principal investigator in the Center for Injury Research and Policy at Nationwide Children’s, is conducting two studies about the efficacy of offering and educating about fentanyl testing among adults.…

Combined Pediatric-Adult Anticoagulation Program Exceeds Goals
 Combined Pediatric-Adult Anticoagulation Program Exceeds Goals 1024 580 Mary Bates, PhD
By: Mary Bates, PhD

The program achieved excellent quality of anticoagulation therapy in children and adults. The goal of most anticoagulation programs is to improve the care of adult patients on warfarin therapy, specifically by treating and preventing thromboembolic events while minimizing bleeding risk. In a new study, researchers from Nationwide Children’s Hospital report excellent outcomes for a combined…

Growing Clinical Research at Nationwide Children’s With Cynthia Gerhardt, PhD
 Growing Clinical Research at Nationwide Children’s With Cynthia Gerhardt, PhD 1024 683 Cynthia Gerhardt, PhD and Natalie Wilson
By: Cynthia Gerhardt, PhD and Natalie Wilson

Dr. Gerhardt was appointed Chief Clinical Research Officer at Nationwide Children’s Hospital in April 2023. With integrating clinical care and research at the heart of the hospital’s strategic plan, she has big plans for ensuring our clinical research infrastructure continues to grow and evolve to support the best bench-to-bedside-and-back science for best outcomes. Learn more…

Associations Between Blood-Based and Biochemical Markers of Inflammation and Body Mass
 Associations Between Blood-Based and Biochemical Markers of Inflammation and Body Mass 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Blood-based markers of inflammation increased with increasing body mass in healthy adolescents. The chronic inflammatory disease atherosclerosis has its origins in childhood and adolescence; however, there are currently no simple methods to easily identify at-risk adolescents.  In a new study, researchers at Nationwide Children’s Hospital explored the relationships between blood-based and biochemical markers of inflammation…

Oncolytic Virus Immunotherapy Safe and Tolerable in Children With Relapsed or Refractory Solid Tumors
 Oncolytic Virus Immunotherapy Safe and Tolerable in Children With Relapsed or Refractory Solid Tumors 1024 683 Lauren Dembeck
By: Lauren Dembeck

The overall survival rates for children with childhood cancers is now over 80%; however, for children with relapsed and refractory tumors, the survival rates remain low. “For example, children with relapsed or refractory neuroblastoma have a five-year survival of less than ten percent,” explains Keri A. Streby, MD, director of the Neuroblastoma Program in the…

Recognizing the Benefits of Music and Massage Co-therapy in Pediatric Palliative Care
 Recognizing the Benefits of Music and Massage Co-therapy in Pediatric Palliative Care 1024 680 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

For adolescent patients in home-based pediatric palliative care, co-treatment with music therapy and massage therapy benefits both the patients and their families. A case study recently published in Music & Medicine reported the benefits of co-treatment with music therapy and massage therapy for a patient in home-based pediatric palliative care. Complementary therapies, such as music…

QI Initiative Reduces Emergency Room Visits for Functional Constipation
 QI Initiative Reduces Emergency Room Visits for Functional Constipation 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Preliminary data from a large accountable care organization’s quality improvement efforts suggest advanced care visits dropped 27% in two years. Partners For Kids (PFK), the nation’s oldest and largest pediatric accountable care organization, launched a series of quality improvement (QI) projects targeting disease management strategies that could significantly impact healthcare utilization and outcomes for children…

Racial Disparities in Healthcare Use Among Medicaid-Covered Children With Congenital Heart Disease
 Racial Disparities in Healthcare Use Among Medicaid-Covered Children With Congenital Heart Disease 1024 683 Lauren Dembeck
By: Lauren Dembeck

In the United States, congenital heart disease is the most common birth anomaly, with almost 40,000 newborns diagnosed each year. As these children grow, they are at increased risk of developing cardiovascular complications. Thus, ensuring they receive recommended cardiology care is essential to their long-term health and well-being. Racial disparities in health outcomes have been…

Ensuring Vulnerable Babies Receive the Benefits of Human Milk
 Ensuring Vulnerable Babies Receive the Benefits of Human Milk 1024 575 Mary Bates, PhD
By: Mary Bates, PhD
small baby with nose canula

A QI project increases human milk consumption among newborns hospitalized with congenital heart disease. The American Academy of Pediatrics and the World Health Organization recommend human milk for infants because of its important health benefits. However, most newborns with congenital heart disease (CHD) are separated from their mothers shortly after birth and admitted to a…

Bridging Language Barriers to Advance Health Care Equity in Developmental Screenings
 Bridging Language Barriers to Advance Health Care Equity in Developmental Screenings 1024 575 Pam Georgiana
By: Pam Georgiana

A QI project to utilize interpreters for screening questionnaires eliminated completion disparities between English speakers and people who prefer a language other than English.  In primary care pediatrics, there are several standard screenings for development delay in children younger than 30 months. Nationwide Children’s Hospital has a high rate of screening completion – over 90%.…

5 Keys to Managing Iron Deficiency in Children Undergoing Intestinal Rehabilitation
 5 Keys to Managing Iron Deficiency in Children Undergoing Intestinal Rehabilitation 150 150 Erin Gregory
By: Erin Gregory

A new position paper offers recommendations for the evaluation and management of iron deficiency in children undergoing intestinal rehabilitation. Iron deficiency is a prevalent concern among children with certain digestive problems, presenting various health challenges. A position paper from the NASPGHAN Intestinal Rehabilitation Special Interest Group, led by Ethan Mezoff, MD, a pediatric gastroenterologist at…

Bridging Gaps in Cerebral Palsy Treatment
 Bridging Gaps in Cerebral Palsy Treatment 1024 575 Erin Gregory
By: Erin Gregory

Researchers investigate disparities in selective dorsal rhizotomy (SDR) access and follow-up care. A surgical procedure called selective dorsal rhizotomy (SDR) can help improve the lives of young patients living with cerebral palsy (CP) by reducing muscle stiffness in the lower limbs. A recent study published in Pediatric Neurology, conducted by Nationwide Children’s Hospital’s experts Jeffrey…

Developing Predictive Tools for CAKUT
 Developing Predictive Tools for CAKUT 1024 575 Leslie Feldman
By: Leslie Feldman

Pediatric nephrologists routinely see infants and children with congenital anomalies of the kidney and urinary tract (CAKUT) — the most frequent cause of childhood chronic kidney disease (CKD). Some of these anomalies are not clinically significant, while others result in varying degrees of kidney function impairment. Half of all children receiving dialysis or kidney transplants…

NIDDK Grant Awarded to Launch Integrated Islet Distribution Program Islet Isolation Center
 NIDDK Grant Awarded to Launch Integrated Islet Distribution Program Islet Isolation Center 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A Nationwide Children’s Hospital research team has received federal funding to become a hub for the isolation and distribution of high-quality human islet cells for the diabetes research community. Since joining Nationwide Children’s Hospital in 2022 as director of the Islet Cell Isolation Program, Balamurugan Appakalai, PhD, has been leading one of the nation’s most…

Supporting Children With Interstitial and Rare Lung Disease
 Supporting Children With Interstitial and Rare Lung Disease 1024 687 Abbie Miller
By: Abbie Miller

In pediatrics, some causes of lung dysfunction, while rare in their own right, are fairly common – such as cystic fibrosis, bronchopulmonary dysplasia and asthma. Interstitial and rare lung disease (IRLD) is an umbrella term for 30-50 diseases that affect children worldwide. IRLD may affect 0.1 to 16 per 100,000 children, according to Katelyn Krivchenia,…