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Breaking New Ground in Cancer Immunotherapy
 Breaking New Ground in Cancer Immunotherapy 1024 683 Pam Georgiana
By: Pam Georgiana

Nationwide Children’s researchers develop a scalable, targeted approach to overcoming cancer’s toughest challenges. Despite significant advances in treatments, cancer remains one of the leading causes of death globally. Traditional therapies, while improving patient outcomes, still have limitations — such as the need for frequent dosing, complex and costly manufacturing and severe side effects. These challenges…

More Than One REMEDY for Genetic Disorders
 More Than One REMEDY for Genetic Disorders 1024 768 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

How a new approach to correcting heterozygous mutations and other novel techniques for gene editing are transforming the potential to combat disease The field of gene therapy has had some astounding success in recent years — much of which emerged from labs at Nationwide Children’s Hospital — but it has also stumbled over some serious…

Innovative Highchair Design Revolutionizes Pediatric Care: A Collaborative Journey From Concept to Prototype
 Innovative Highchair Design Revolutionizes Pediatric Care: A Collaborative Journey From Concept to Prototype 1024 683 Madison Storm
By: Madison Storm

Highchairs are common in homes with babies and toddlers, as well as in places such as hospitals and restaurants where young children are fed. In hospitals, they are mainly used in pediatric care for infants, toddlers and children undergoing treatment or recovery. Highchairs provide a safe, stable seating option during meals and interactions with family,…

CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies
 CD38-CAR NK Cell Therapy Has Antitumor Potential for Treating CD38-Expressing Hematologic Malignancies 1024 649 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital created fratricide-resistant and metabolically-enhanced chimeric antigen receptor (CAR) natural killer (NK) and T cells that have cytotoxic effects on many hematologic tumors. “One of the problems that we usually have with blood cancers is making effective therapies using immune cells, because the immune cells then recognize themselves as a threat…

Meet Daphne©, a ChatBot for Pediatric Health Care
 Meet Daphne©, a ChatBot for Pediatric Health Care 150 150 Madison Storm
By: Madison Storm

Machine learning and artificial intelligence (AI)have exploded across the worlds of marketing and commerce in recent years. At Nationwide Children’s, clinicians and researchers are focusing on how AI and related technologies can be used to reduce clinician workloads and improve patient outcomes. Emre Sezgin, PhD, principal investigator in the Center for Biobehavioral Health at Nationwide…

Accelerating Pediatric Medical Device Innovation 
 Accelerating Pediatric Medical Device Innovation  150 150 Erin Gregory
By: Erin Gregory

The Midwest Pediatric Device Consortium (MPDC) is a unique collective led by Nationwide Children’s Hospital and The Ohio State University, designed to facilitate the development, production, and distribution of pediatric medical devices. Comprising a diverse group of leaders in universities, healthcare systems, community organizations, and industry partners across Ohio, the MPDC is committed to transforming…

Novel Digital Storybook Intervention Aims to Support Children With Hearing Loss
 Novel Digital Storybook Intervention Aims to Support Children With Hearing Loss 1024 683 Abbie Miller
By: Abbie Miller

Hear Me Read, invented and developed at Nationwide Children’s Hospital, is now being validated in a prospective clinical trial. For children who are deaf or hard of hearing, access to sound via hearing aids and cochlear implants and intensive speech therapy with highly trained verbal therapists are important parts of developing speech and literacy. “Children…

Novel Approaches to Gene Therapies for Patients With Rare Genetic Diseases
 Novel Approaches to Gene Therapies for Patients With Rare Genetic Diseases 150 150 Jessica Nye, PhD
By: Jessica Nye, PhD

According to the National Institutes of Health (NIH), nearly 7,400 diseases have been identified and classified as “rare” or “orphan” — “rare” because each afflicts fewer than 200,000 people in the United States and “orphan” because drug companies, unlikely to recoup research and development costs from such small patient populations, have historically found them too…

Old Drug, New Use
 Old Drug, New Use 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
Nationwide Children's style illustration showing a row of houses with a prescription in front of it

Researchers have discovered an adult diabetes drug may provide a new and better way to treat children  with nephrotic syndrome.  Nephrotic syndrome is one of the most common kidney diseases seen in children. In most cases the cause is unknown. Nephrotic syndrome involves damage to the filtering units of the kidneys (glomeruli) leading to massive…

Growing Opportunities for Tissue Engineering
 Growing Opportunities for Tissue Engineering 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new system removes much of the expense and technical challenges surrounding cell seeding of tissue-engineered vascular grafts, making the technology more accessible to patients everywhere. One of the key challenges in congenital heart surgery is that current grafts used to correct heart defects are not living grafts—they don’t grow with the patient or function…

Featured Researcher — Amit Kapoor, PhD
 Featured Researcher — Amit Kapoor, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Amit Kapoor, PhD, joined Nationwide Children’s Hospital as a principal investigator in the Center for Vaccines and Immunity and The Ohio State University as an associate professor of Pediatrics in 2015. Dr. Kapoor’s lab is working to understand the immunopathogenesis of several viral pathogens that infect humans and animals. His lab is developing new animal…

Featured Researcher — Steve Goodman, PhD
 Featured Researcher — Steve Goodman, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Steven D. Goodman, PhD, is a principal investigator in the Center for Microbial Pathogenesis in the Abigail Wexner Research Institute at Nationwide Children’s Hospital. His research centers on bacterial biofilms — interactive ecosystems of bacteria that form a structure to help the bacteria thrive and fight off threats. These biofilms can be found wherever bacteria…

From Clinician Ideas to Commercially-Available Clinical Devices
 From Clinician Ideas to Commercially-Available Clinical Devices 150 150 Kevin Mayhood
By: Kevin Mayhood

Pressure wounds were a common complication following a tracheostomy, often resulting in advanced-stage wounds, national studies showed. Nationwide Children’s Hospital was no different but Kris Jatana, MD, and Charles Elmaraghy, MD, surgeons in the Department of Otolaryngology, knew they could improve these outcomes. Brendan Boyle, MD, and Alex Green, DO, were fellows in the Division…