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Center for Regenerative Medicine

Researchers Characterize Growth and Remodeling of Tissue-Engineered Blood Vessels
 Researchers Characterize Growth and Remodeling of Tissue-Engineered Blood Vessels 600 400 Lauren Dembeck
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Tissue engineered vascular graft

Tissue engineering may soon give babies with congenital heart disease new blood vessels capable of native function and growth.   Major cardiovascular reconstructive operations in babies with congenital heart defects require the use of artificial blood vessels called vascular grafts. Because these grafts are made of man-made materials, the recipients’ tissues eventually begin to outgrow…

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Featured Researcher — Mitchel Stacy, PhD
 Featured Researcher — Mitchel Stacy, PhD 150 150 Katie Brind'Amour, PhD, MS, CHES
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Mitchel Stacy, PhD, a principal investigator in the Center for Regenerative Medicine at Nationwide Children’s Hospital and assistant professor of Surgery at The Ohio State University, started his education with dietetics in mind. Finding his way instead to nuclear and molecular imaging of cardiovascular diseases, Dr. Stacy’s research blossomed during his postdoctoral fellowship and first…

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Repeated Injury to Stem Cells Could be a Significant Contributor to Chronic Lung Disease
 Repeated Injury to Stem Cells Could be a Significant Contributor to Chronic Lung Disease 1024 575 Abbie Roth
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Illustration of lungs on blue silhouette of upper chest on black background

A series of experiments shows that biological aging of tracheobronchial stem cells could drive the development of chronic lung disease. In a recent publication in STEM CELLS Translational Medicine (SCTM), researchers showed that repeated injury to epithelial cells in the airway caused biological aging of the stem cells located there. Tracheobronchial stem cells (TSCs) are…

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Featured Researcher — Tendy Chiang, MD, FACS
 Featured Researcher — Tendy Chiang, MD, FACS 150 150 Natalie Wilson
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​​​​​​​Tendy Chiang, MD, FACS is a principal investigator in the Center for Regenerative Medicine at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. His work focuses on understanding how airway tissue repairs and regenerates itself and using that information to design tissue-engineered trachea. Tissue engineering is the process of seeding cells on a biodegradable scaffold or support…

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Findings Show TEVG Stenosis Spontaneously Resolves
 Findings Show TEVG Stenosis Spontaneously Resolves 600 400 Katie Brind'Amour, PhD, MS, CHES
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Tissue engineered vascular graft

The complication that halted a clinical trial for tissue-engineered vascular grafts for children with congenital heart disease may reverse spontaneously without clinical complications. Based on promising laboratory and animal modeling of a biodegradable scaffold seeded with a patient’s own cells, a clinician-scientist research team now based at Nationwide Children’s Hospital initiated a pediatric tissue engineered…

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Uncovering Why Synthetic Tracheal Replacements Fail, and Hints for Success
 Uncovering Why Synthetic Tracheal Replacements Fail, and Hints for Success 1024 575 Kevin Mayhood
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“There is no ideal replacement for the trachea,” says Tendy Chiang, MD, a pediatric otolaryngologist and a principal investigator in the Center for Regenerative Medicine in the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital. “There are many surgical techniques that can manage tracheal defects and disorders, however, for longer-segment defects, they oftentimes require replacement tissue that…

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New Application of Nuclear Imaging in the Legs May Enable Early Detection of Cardiovascular Problems
 New Application of Nuclear Imaging in the Legs May Enable Early Detection of Cardiovascular Problems 150 150 Katie Brind'Amour, PhD, MS, CHES
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Researchers have used a non-invasive imaging modality to quantify perfusion reserve in specific muscles of the extremities — a novel approach with numerous potential clinical applications Researchers have shown for the first time that SPECT/CT imaging can be used to quantify perfusion reserve of specific muscle groups in the lower limbs, which they directly related…

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Using Computer Models to Predict How Tissue Engineered Vascular Grafts Will Work
 Using Computer Models to Predict How Tissue Engineered Vascular Grafts Will Work 150 150 Kevin Mayhood
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Model and experimental data strongly suggest testing TEVGs until scaffold has biodegraded Identical tissue engineered vascular grafts (TEVGs) being tested in small-diameter veins and arteries of a mouse model performed well for 12 weeks. At 14 weeks, all TEVGs in the veins continued performing well, but all in the arteries suddenly failed. During their effort to understand…

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Why Do Synthetic Tracheal Replacements Fail?
 Why Do Synthetic Tracheal Replacements Fail? 150 150 Lauren Dembeck
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Synthetic tracheal replacements experience infectious, inflammatory and mechanical failures. Tracheal defects in children and adults can often be addressed with current surgical techniques. However, when a defect is large, greater than 50% of an adult windpipe or 30% of a pediatric windpipe, few options exist to repair it without donor tissue. For decades, tissue engineers…

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From What-if to Widely Available – A Proposed Path for Tissue Engineered Vascular Grafts
 From What-if to Widely Available – A Proposed Path for Tissue Engineered Vascular Grafts 150 150 Abbie Roth
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What if you could utilize tissue engineering, imaging and 3D printing technologies to bring the benefits of a tissue engineered vascular graft to every child who needs one? Children born with a single ventricle heart defect undergo a series of surgeries and procedures to reroute the blood flow through their heart. The Fontan operation is…

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Growing Tissue to Help Children With Short Bowel Syndrome
 Growing Tissue to Help Children With Short Bowel Syndrome 1024 575 Kevin Mayhood
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Research using a small animal model shows that it matters where in the body the cultured intestine is grown. Researchers at Nationwide Children’s Hospital are hoping to use short bowel syndrome patients’ own cells to grow extra tissue needed for their small intestine to function properly. Using rat models, the team of physician-scientists found that…

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Taking Innovation to Heart: Next Gen Interventions in Heart Valve Disease
 Taking Innovation to Heart: Next Gen Interventions in Heart Valve Disease 1024 575 Abbie Roth
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From bioengineers to interventional cardiologists, molecular biologists to cardiothoracic surgeons, experts with diverse backgrounds are focusing on the problem of heart valve disease in children. Heart valve disease affects more than 5 million Americans. And while acquired disease in the adult population certainly accounts for much of this, children with heart valve disease face multiple…

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A Narrow Focus: Perfecting Tissue Engineered Vascular Grafts
 A Narrow Focus: Perfecting Tissue Engineered Vascular Grafts 1024 575 Abbie Roth
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image of heart with fontan conduit highlighted

A pair of surgeon-researchers is perfecting tissue engineered vascular grafts through bench, clinical and computational modeling studies.

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