Optimizing Prenatal and Neonatal Care for Infants With Treatable Rare Diseases

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Unraveling the Genetic Mystery Behind a Rare Pediatric Disease

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New National “Vital Signs” to Measure Population-wide Pediatric Health

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Significant Weight Gain Observed in Low-Income Youth During the Early COVID-19 Pandemic
 Significant Weight Gain Observed in Low-Income Youth During the Early COVID-19 Pandemic 150 150 JoAnna Pendergrass, DVM
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Low-income youth experienced significant weight gain during the first six months of the COVID-19 pandemic, highlighting the need for simultaneous childhood obesity prevention and treatment.   The COVID-19 pandemic and subsequent mitigation efforts profoundly affected children. Specifically, remote learning and cancellation of extracurricular activities…

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illustrated cross section of islets from pancreas
InSight: Total Pancreatectomy With Islet Autotranplantation: The Basics
 InSight: Total Pancreatectomy With Islet Autotranplantation: The Basics 1024 500 Katie Brind'Amour, PhD, MS, CHES
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Download a PDF version of this image.       This feature was published in the Fall/Winter 2022 print issue. Download the full issue.  Image credit: Mandy Root-Thompson for Nationwide Children’s

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American Academy of Pediatrics Updates Guidelines for the Management of Neonatal Hyperbilirubinemia
 American Academy of Pediatrics Updates Guidelines for the Management of Neonatal Hyperbilirubinemia 1024 737 Emily Siebenmorgen
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Nationwide Children’s physicians collaborate on updates to testing, treatment and follow-up recommendations for preventing hazardous hyperbilirubinemia and possible brain damage. The American Academy of Pediatrics’ (AAP) recommendations for managing hyperbilirubinemia in infants 35 gestational weeks and older are among its most accessed sets of…

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New Initiative Aims to Bring Personalized Diagnosis and Treatment to Children With Solid Tumors
 New Initiative Aims to Bring Personalized Diagnosis and Treatment to Children With Solid Tumors 1024 614 Lauren Dembeck
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Collaboration among National Cancer Institute, Children’s Oncology Group and Nationwide Children’s Hospital will offer molecular characterization of childhood cancers. The National Institutes of Health’s National Cancer Institute (NCI), Children’s Oncology Group (COG), and Nationwide Children’s Hospital are poised to change the direction of pediatric…

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What’s the Relevance of Emotional Intelligence in Medicine?
 What’s the Relevance of Emotional Intelligence in Medicine? 1024 386 Mike Patrick, MD and Erica Banta, MBA, LDSS
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The practice of clinical medicine requires an intelligent mindset. Strong cognitive intelligence (IQ) is required to develop and maintain a substantial knowledge base and to call upon the critical thinking skills needed to synthesize a hundred points of data into a meaningful clinical picture,…

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illustrated cross section of islets from pancreas
TPIAT: A Way Forward for Chronic Pancreatitis
 TPIAT: A Way Forward for Chronic Pancreatitis 1024 500 Katie Brind'Amour, PhD, MS, CHES
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Nationwide Children’s Hospital has assembled a veritable “dream team” of pancreatitis and pediatric transplant surgery experts to offer what they hope will become the world’s preeminent pediatric center for complex pancreatic care. Imagine your child suffering from a sudden, debilitating episode of abdominal pain.…

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How One Family In Appalachia Changed the Medical Field’s Understanding of Pancreatitis
 How One Family In Appalachia Changed the Medical Field’s Understanding of Pancreatitis 150 150 Katie Brind'Amour, PhD, MS, CHES
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More than 30 years ago, a teenager from Kentucky named Kevin Slone had his first attack of acute pancreatitis. Doctors at the Cleveland Clinic urged his father, Bobby Slone, to try to document whether other people in the family had similar stomach problems. Bobby…

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Integrating Behavioral Health and Primary Care Increases Access and Equity
 Integrating Behavioral Health and Primary Care Increases Access and Equity 1024 683 Mary Bates, PhD
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With mental health concerns on the rise, more primary care providers are integrating behavioral health services in their practices.  Despite increasing demand for behavioral health care, multiple barriers still exist that limit access for pediatric patients. In recent years, primary care settings across the…

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Understanding Pediatric Critical COVID-19 Disease Around the World
 Understanding Pediatric Critical COVID-19 Disease Around the World 150 150 Natalie Wilson
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A large, multinational study found more children hospitalized with critical COVID-19 died than was indicated by previous studies.   Children under 18 represent around 22% of the population in the United States. Yet, just 15% of over 75 million U.S. COVID-19 cases reported to the…

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Multimodal Molecular Profiles Offer Clinically Valuable Information to Oncologists
 Multimodal Molecular Profiles Offer Clinically Valuable Information to Oncologists 150 150 Katie Brind'Amour, PhD, MS, CHES
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Expanding the profiling ordered for central nervous system (CNS) tumors may meaningfully impact diagnosis and treatment. Prajwal Rajappa, MD, MS, a physician-scientist and principal investigator for the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital, has long advocated for…

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Ewing Sarcoma Transcription Factor Mediates Changes in Transcription by Reprogramming Chromatin Structure
 Ewing Sarcoma Transcription Factor Mediates Changes in Transcription by Reprogramming Chromatin Structure 1024 575 Abbie Miller
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By binding to DNA in the nucleus, the Ewing sarcoma-specific transcription factor EWS/FLI changes chromatin organization, leading to altered gene expression and the development of Ewing sarcoma.   A new report, published in Nucleic Acids Research, focuses on how the Ewing sarcoma-specific transcription factor…

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Breast Surgery in Adolescents: When Should You Consider It?
 Breast Surgery in Adolescents: When Should You Consider It? 150 150 Ibrahim Khansa, MD
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Research shows that addressing macromastia, breast asymmetry and gynecomastia in adolescence can improve physical symptoms as well as quality of life and mental wellbeing. Breast disorders such as macromastia, breast asymmetry and gynecomastia are in adolescents.2 Those conditions can negatively impair quality-of-life, and their…

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Microscopy image of cerebral organoid sections
Brain Organoids Provide Novel Mechanistic Insight into Microcephaly Associated with AUTS2 Syndrome
 Brain Organoids Provide Novel Mechanistic Insight into Microcephaly Associated with AUTS2 Syndrome 873 552 Lauren Dembeck
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Researchers have functionally validated a genotype-phenotype relationship between a variant in the AUTS2 gene and neurodevelopmental deficits in AUTS2 syndrome using patient-derived brain organoids. Genetic variants in more than 100 genes, including the gene AUTS2, have been associated with autism spectrum disorders. However, the…

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Featured Researcher — Sarah O’Brien, MD
 Featured Researcher — Sarah O’Brien, MD 150 150 Katie Brind'Amour, PhD, MS, CHES
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The lab of Sarah O’Brien, MD, principal investigator in the Center for Child Health Equity and Outcomes Research at Nationwide Children’s Hospital, operates at the intersection of hematology and women’s health. Dr. O’Brien, who also leads the Young Women’s Hematology Clinic at Nationwide Children’s,…

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Predicting Response to Bronchodilators in Infants with Bronchopulmonary Dysplasia
 Predicting Response to Bronchodilators in Infants with Bronchopulmonary Dysplasia 1024 683 Mary Bates, PhD
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Study emphasizes importance of identifying those patients who will respond to treatment. Certain pulmonary function test parameters in newborns with bronchopulmonary dysplasia are associated with bronchodilator response, according to a new study from researchers at Nationwide Children’s Hospital. The team also found that responders…

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Study Shows 1 in 4 Girls Born With Anorectal Malformations Have Co-occurring Gynecologic Anomalies
 Study Shows 1 in 4 Girls Born With Anorectal Malformations Have Co-occurring Gynecologic Anomalies 1024 575 Jessica Nye, PhD
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Gynecological anomalies are common among girls with anorectal malformations (ARM) with or without associated vertebral, anorectal, cardiovascular, trachea-esophageal, renal and limb (VACTERL) anomalies. One in 5,000 live births have ARM and 20%-70% co-occur with other congenital anomalies, including VACTERL. For girls born with ARM,…

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Discovering the Genetic Causes of Congenital Heart Defects
 Discovering the Genetic Causes of Congenital Heart Defects 1024 575 Lauren Dembeck
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By studying the genomes of children and members of their family, researchers have discovered novel disease genes in families impacted by cardiac defects. Congenital heart disease is a leading cause of death in children under one year of age, and evidence supports a strong…

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Quality of Life in Pediatric Patients With Non-ambulatory Cerebral Palsy and Epilepsy
 Quality of Life in Pediatric Patients With Non-ambulatory Cerebral Palsy and Epilepsy 600 400 Mary Bates, PhD
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Study indicates that quality of life in young people with non-ambulatory cerebral palsy decreases with the use of more antiseizure medications. In a new study, researchers from Nationwide Children’s Hospital assessed the relationship between epilepsy-specific characteristics and proxy-reported health-related quality of life in children…

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Is There a Role for D-Mannose, Cranberry or Probiotics in Preventing Pediatric UTIs?
 Is There a Role for D-Mannose, Cranberry or Probiotics in Preventing Pediatric UTIs? 1024 683 Deborah L. Ungerleider, MD, FAAP
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Alternatives for prophylaxis of UTIs in children may help reduce antibiotic overuse. Preventing urinary tract infections (UTIs) in children is important, as multiple UTIs can lead to scarring of the kidneys, which can then lead to hypertension or end-stage renal disease.1 UTIs in children…

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Parent and child holding hands
Factors Modulating Parenting Stress in Families of Children with Autism Spectrum Disorder
 Factors Modulating Parenting Stress in Families of Children with Autism Spectrum Disorder 1024 575 Mary Bates, PhD
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Parenting self-efficacy and family resources impact the relationship between behavior problems in children with autism spectrum disorder and parenting stress. Children with autism spectrum disorder (ASD) often exhibit co-occurring conditions that may increase parenting stress. These include externalizing behaviors, such as tantrums and disruptive…

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