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Understanding How Youths With Autism Make the Move to Adult Health Care
 Understanding How Youths With Autism Make the Move to Adult Health Care 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Study finds overlap in the utilization of pediatric and adult health care is the norm. In a new study, researchers from Nationwide Children’s Hospital and The Ohio State University teamed up to better understand how adolescents and young adults with autism navigate the transition…

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Refining the Role of Basal Urothelial Cells in Bladder Development
 Refining the Role of Basal Urothelial Cells in Bladder Development 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Basal keratin 5 urothelial cells (K5-UCs) were found to be age-restricted progenitors in bladders and their progenitor potential could be rescued by exogenous proliferative cues.   “The identity of the bladder urothelium progenitor is controversial and confounded by slow turnover, and a low mitotic…

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How Does Hodgkin Lymphoma Differ With Age?
 How Does Hodgkin Lymphoma Differ With Age? 150 150 Pam Georgiana
By: Pam Georgiana

A new study reveals age-related differences in pathology and medical management. When Anthony N. Audino, MD, a pediatric oncologist in the Division of Pediatric Hematology/Oncology/BMT at Nationwide Children’s, first met a preschool-aged patient with Hodgkin lymphoma, he was surprised. “It was startling to see…

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New Study Demonstrates Potential for a Gene Therapy for Vanishing White Matter Disease
 New Study Demonstrates Potential for a Gene Therapy for Vanishing White Matter Disease 1024 552 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

The research, conducted in mouse models, shows promising safety and efficacy for a currently incurable, life-limiting condition. Researchers at Nationwide Children’s Hospital have confirmed initial safety and efficacy data for a gene supplementation therapy for Vanishing White Matter (VWM) disease in mouse models. Testing…

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Teen girl with backpack
Breaking the Cycle of Chronic Pain and Discomfort in Young Patients
 Breaking the Cycle of Chronic Pain and Discomfort in Young Patients 1024 575 Pam Georgiana
By: Pam Georgiana

The Comfort Ability Program at Nationwide Children’s brings specialized care to patients with chronic pain and discomfort. In January 2023, the wait for patients to see a pediatric pain psychologist at Nationwide Children’s was approximately nine months. This delay was due to the limited…

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Investigating a Minimally Invasive Alternative to Surgery for Transverse Aortic Arch Obstruction
 Investigating a Minimally Invasive Alternative to Surgery for Transverse Aortic Arch Obstruction 150 150 Erin Gregory
By: Erin Gregory

A new study evaluates the safety and efficacy of percutaneous balloon-expandable stents for transverse aortic arch obstruction, a form of congenital heart disease. A new study published in Circulation: Cardiovascular Interventions, conducted by Arash Salavitabar, MD, FSCAI, FPICS, FACC, FAAP, a congenital interventional cardiologist…

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School-Based Health Equity Initiative Improves T1D Management in Students
 School-Based Health Equity Initiative Improves T1D Management in Students 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

The Diabetes and School Health program is a school-based health equity initiative that has helped improve Type 1 diabetes management for students and increase confidence among school staff and caregivers in providing diabetes care. Children with Type 1 diabetes (T1D) face myriad daily challenges…

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Kevin Klingele, MD
Surgical Repair of Traumatic Hip Dislocations With Acetabular “Fleck” Signs
 Surgical Repair of Traumatic Hip Dislocations With Acetabular “Fleck” Signs 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Surgical hip dislocation with open labral repair produced excellent clinical outcomes in pediatric patients. The acetabular “fleck” sign is a radiographic finding indicative of significant labral injury in young patients with traumatic hip dislocations. In a new study, researchers from Nationwide Children’s Hospital show…

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Opportunities to Reduce Stress for Parents of Kids With Autism
 Opportunities to Reduce Stress for Parents of Kids With Autism 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Research suggests parenting self-efficacy and family resources influence parental stress levels, offering potential modifiable targets for clinicians aiming to help families thrive.   A study led by pediatric psychology experts at Nationwide Children’s Hospital has confirmed that parenting self-efficacy is associated with parental stress…

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Featured Researcher – Jamie Jackson, PhD
 Featured Researcher – Jamie Jackson, PhD 150 150 Alaina Doklovic
By: Alaina Doklovic

Jamie Jackson, PhD, is a principal investigator in the Center for Biobehavioral Health in the Abigail Wexner Medical Research Institute at Nationwide Children’s Hospital, an assistant professor of Pediatrics and Psychology in the College of Medicine and Department of Psychology at The Ohio State…

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A Noncardiomyocyte Signaling Pathway in Early Heart Development
 A Noncardiomyocyte Signaling Pathway in Early Heart Development 1024 670 Mary Bates, PhD
By: Mary Bates, PhD

Study demonstrates role for endocardial cells in myocardial trabeculation. A new study in Nature Communications from researchers at Nationwide Children’s Hospital provides novel insights into a signaling pathway that regulates the developing myocardium during early heart development. The findings have implications for understanding congenital…

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Ask a Specialist: Glucose Testing Follow-Up
 Ask a Specialist: Glucose Testing Follow-Up 150 150 Rohan Henry, MD, MS
By: Rohan Henry, MD, MS

For a patient with obesity and polycystic ovarian syndrome (PCOS) with impaired glucose tolerance on an oral glucose tolerance test, how often should her glycemia be tested? And with which test?   Pediatric research studies addressing this specific question are lacking. A gap in…

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Transnasal Endoscopy: Easing Eosinophilic Esophagitis (EoE) Treatment Monitoring
 Transnasal Endoscopy: Easing Eosinophilic Esophagitis (EoE) Treatment Monitoring 1024 683 Abbie Miller
By: Abbie Miller

Finding the most effective treatment for EoE can be a challenging process. Transnasal endoscopy decreases the burden of repeated endoscopies. Eosinophilic gastrointestinal disorders are a chronic and complex group of diseases characterized by having abnormal numbers of eosinophils in parts of the GI tract.…

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What Pediatricians Need to Know About Cannabinoid Hyperemesis
 What Pediatricians Need to Know About Cannabinoid Hyperemesis 1024 683 Alaina Doklovic
By: Alaina Doklovic

In a recent PediaCast CME episode, guest host Alicia McVity, FNP talks with Leah Middelberg, MD, and Alek Adkins, MD, about the rise of cannabinoid hyperemesis cases in emergency rooms, and how Ohio’s recent legalization of marijuana may have an impact on this number.…

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Outcomes of Colonic Pull-Through for Patients With Cloacal Exstrophy: Is it Really Helping Kids?
 Outcomes of Colonic Pull-Through for Patients With Cloacal Exstrophy: Is it Really Helping Kids? 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Collaborative study reveals infrequent utilization of the procedure and identifies factors correlated with success. Cloacal exstrophy is a rare grouping of congenital anorectal malformations. Although once nearly uniformly fatal, survival has increased significantly, and with it, the focus on long-term outcomes. In the last…

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Black and white photo of boy sitting up on hospital bed
Reducing Hospital Stays After Fontan Procedures by More Than 66%
 Reducing Hospital Stays After Fontan Procedures by More Than 66% 1024 575 Pam Georgiana
By: Pam Georgiana

A new quality improvement initiative implements new guidelines using an innovative chest tube commonly used in adults.   Before April 2020, the average length of hospital stay for patients undergoing the Fontan procedure at Nationwide Children’s was about 23 days. This prolonged hospitalization stay…

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4 Questions With Jeffrey Leonard, MD
 4 Questions With Jeffrey Leonard, MD 1024 683 Abbie Miller
By: Abbie Miller

Jeffrey Leonard, MD, is chief of Neurosurgery and the Robert F. & Edgar T. Wolfe Foundation Endowed Chair in Neurosurgery at Nationwide Children’s Hospital. He is also a principal investigator in the Center for Childhood Cancer Research in the Abigail Wexner Research Institute and…

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How Does Thickened Formula Affect Reflux in Infants?
 How Does Thickened Formula Affect Reflux in Infants? 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

Infants in the neonatal intensive care unit with suspected gastroesophageal reflux disease (GERD) are often fed formula with added rice cereal or other thickeners, despite limited evidence of its efficacy or long-term consequences. Additionally, the consequences of thickened feeds are not well-studied, says Sudarshan…

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artistic rendering of an NK cell on a faded blue background with other cells faintly visible in the background
Donor-Derived NK Cells Safe and Efficacious in Relapsed and Refractory AML
 Donor-Derived NK Cells Safe and Efficacious in Relapsed and Refractory AML 1024 649 Lauren Dembeck
By: Lauren Dembeck

Researchers have used their approach for growing large numbers of NK cells to allow repeated dosing for a more effective and less toxic treatment.   Outcomes for patients with relapsed and refractory acute myeloid leukemia (R/R AML) have not significantly improved over the last…

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Telemedicine’s Past, Present and Future Role in Pediatric Inflammatory Bowel Disease Care
 Telemedicine’s Past, Present and Future Role in Pediatric Inflammatory Bowel Disease Care 1024 683 Erin Gregory
By: Erin Gregory

A recent study sheds light on how telemedicine’s use during the pandemic has reshaped care delivery for children with IBD.   A recent study published in Journal of Pediatric Gastroenterology and Nutrition utilized electronic medical record data to compare the volume, duration and nature…

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