Close
Enter your
text here
Posts By :

Abbie Miller

Don’t Oversize Your Tissue-Engineered Vascular Grafts: Insights for the Translation of New Surgical Technologies
 Don’t Oversize Your Tissue-Engineered Vascular Grafts: Insights for the Translation of New Surgical Technologies 1024 683 Abbie Miller
By: Abbie Miller

Study shows that adoption of a tissue engineered vascular graft technology currently in clinical trials would require a shift in surgical approach. Tissue engineered vascular grafts (TEVGs) are designed to overcome two important problems associated with synthetic conduits used in surgeries for children with congenital heart disease (CHD): the lack of growth potential and the…

How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy?
 How Does Modification of RNA Influence the Development of Pediatrics Dilated Cardiomyopathy? 1024 783 Abbie Miller
By: Abbie Miller

New study shows essential role of RNA methlytransferase-mediated m6A modification in regulating heart development. Traditional research to understand the origins of congenital heart disease have focused on understanding how genetic mutations may cause heart problems. Now, a team at Nationwide Children’s Hospital is exploring a new way to understand congenital heart disease (CHD). “How the…

Genetic Variation Contributing to Nephrotic Syndrome
 Genetic Variation Contributing to Nephrotic Syndrome 1024 683 Abbie Miller
By: Abbie Miller

Genetic variants in CR1 have significantly different population-specific frequencies and are linked with focal segmental glomerulosclerosis (FSGS) – the leading cause of nephrotic syndrome. Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome — a kidney disorder that causes proteins to leak into the urine causing a variety of complications. FSGS has an…

Who Do You Trust?
 Who Do You Trust? 1024 304 Abbie Miller
By: Abbie Miller

Health and science communicators face increasing challenges in a world where misinformation abounds and trust is a coveted commodity. You might have heard the phrase “post-truth world” used to describe the shifting dynamics of fact, fiction and trusted sources. With the increase in artificial intelligence (AI) generated content, the end of fact-checking on the world’s…

Clinical Genomics: From Research to Reality
 Clinical Genomics: From Research to Reality 1024 716 Abbie Miller
By: Abbie Miller

Without genomic sequencing, many genetic diseases would never be diagnosed. Genomic testing — whole exome or whole genome sequencing — is vital to reducing the diagnostic odyssey for children with rare, undiagnosed disease. But is genetic analysis only useful in these cases? Experts across the country have long suggested that genomic testing can be even…

From Bench to Bedside: Collaborations Drive Meaningful Change
 From Bench to Bedside: Collaborations Drive Meaningful Change 1024 360 Abbie Miller
By: Abbie Miller

The move from a research-first approach to genomic testing to offer more clinically available assays was driven in part by limitations in current clinical testing offerings, as well as by the decreasing cost and turn-around time of genomic sequencing. This environment drove the development of translational protocols. “Our team works with researchers, clinicians and others…

Genomic Analysis: Overcoming a Formidable Challenge
 Genomic Analysis: Overcoming a Formidable Challenge 1024 360 Abbie Miller
By: Abbie Miller

Despite the improvements in scale and speed of generating genomic sequencing data, the challenge of genomic analysis and its costs remains. “In my opinion, the cost of data analysis has always been the largest component of the overall cost,” says Elaine Mardis, PhD, co-executive director of the Steve and Cindy Rasmussen Institute for Genomic Medicine…

Meet Karen Texter, MD, Director of Fetal Echocardiography at Nationwide Children’s
 Meet Karen Texter, MD, Director of Fetal Echocardiography at Nationwide Children’s 1024 691 Abbie Miller
By: Abbie Miller

Karen Texter, MD, is a pediatric cardiologist and director of Fetal Echocardiography at Nationwide Children’s. Her clinical and research interests include echocardiography in congenital and acquired heart disease and fetal cardiology. What inspired you to pursue a career in pediatric cardiology? How did you get into fetal cardiology, specifically? My interest in pediatric cardiology really…

Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research
 Largest Pediatric ECMO Repository in the United States Celebrates 10 Years of Research 1024 537 Abbie Miller
By: Abbie Miller

The ECMO Repository at Nationwide Children’s Hospital is the first and larges of its kind in children’s hospitals in the United States. In December 2014, The Heart Center and Center for Cardiovascular Research at Nationwide Children’s Hospital launched an initiative to prospectively collect biologic samples from pediatric patients undergoing extracorporeal membrane oxygenation (ECMO) – a…

Filling the Pipeline for Behavioral Health Professionals
 Filling the Pipeline for Behavioral Health Professionals 150 150 Abbie Miller and Shannon Caldwell
By: Abbie Miller and Shannon Caldwell

Brittany Schaffner, IMFT-S, LPCC-S, shares how a new college course and professional resources are helping more students meet the need for behavioral health care in pediatrics. Tell us about your role at Nationwide Children’s Hospital. I’m a behavioral health clinical training supervisor here at Nationwide Children’s. I facilitate training programs for a wide range of…

Meet Prof Eileen Africa: Fulbright Scholar and Sports Medicine Expert
 Meet Prof Eileen Africa: Fulbright Scholar and Sports Medicine Expert 1024 683 Abbie Miller
By: Abbie Miller

Prof Eileen Africa, an associate professor in the Division of Movement Science and Exercise Therapy in the Department of Exercise, Sport, and Lifestyle Medicine at Stellenbosch University in South Africa and a Fulbright scholar, recently visited Nationwide Children’s to work with Dr. James MacDonald and the Sports Medicine Team conducting research about the effectiveness of…

Meet Antonio Cabrera, MD, Chief of Cardiology at Nationwide Children’s Hospital
 Meet Antonio Cabrera, MD, Chief of Cardiology at Nationwide Children’s Hospital 150 150 Abbie Miller
By: Abbie Miller

Antonio Cabrera, MD, FAAP, FAHA, FACC, FHFSA, is the division chief of cardiology and co-director of the Heart Center. He is a professor of pediatrics at The Ohio State University and currently holds the Nationwide George H. Dunlap Endowed Chair in Pediatric Cardiology. Previously, Dr. Cabrera served as the L. George Veasy Presidential Professor at…

Making the Case for Interdisciplinary BPD Care
 Making the Case for Interdisciplinary BPD Care 150 150 Abbie Miller
By: Abbie Miller

A new review highlights benefits of interdisciplinary BPD management and offers advice on how program development. Bronchopulmonary dysplasia (BPD) affects more than 40% of preterm infants and is the most common lung disease in infancy. There are long term consequences and comorbidities associated with BPD, including hospitalization, re-hospitalization, emergency department visits, recurrent wheezing and neurodevelopmental…

1 Trillion Cells: Nationwide Children’s Reaches New Milestone for Universal-Donor NK Cell Studies
 1 Trillion Cells: Nationwide Children’s Reaches New Milestone for Universal-Donor NK Cell Studies 1024 649 Abbie Miller
By: Abbie Miller

The Biologics Manufacturing Resource, Nationwide Children’s Cell and Tissue cGMP manufacturing facility, recently achieved a major milestone. The resource has now delivered more than 1 trillion universal donor natural killer (NK) cells to patients. These NK cells are being studied in clinical trials to learn if they can help children and adults with cancer. “This…

4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital
 4 Things to Know About Bladder Exstrophy at Nationwide Children’s Hospital 1024 734 Abbie Miller
By: Abbie Miller

Led by V. Rama Jayanthi, MD, and Peter Cuckow, MB, BS, FRCS, the Bladder Exstrophy Program at Nationwide Children’s is poised to launch a new era of care for children in the United States. When Drs. Jayanthi and Cuckow start talking about their new program, their excitement is palpable. “We’re so excited to bring this…

Treating Obesity With GLP-1s — Finding the Way Forward
 Treating Obesity With GLP-1s — Finding the Way Forward 150 150 Abbie Miller
By: Abbie Miller

Using lessons learned from medicating mental and behavioral health conditions, Stephen Cook, MD, offers suggestions about how medications approved for adolescents with obesity should become part of care.   For most of the time in Western medicine, people have treated obesity like a choice — not a disease. Like other conditions now understood to be…

Approaching Uncertainty in Medicine With a Growth Mindset
 Approaching Uncertainty in Medicine With a Growth Mindset 1024 531 Abbie Miller
By: Abbie Miller

In baseball, a really good batting average is .333 — which means the batter hits the ball and gets to first base a third of the time. That also means they miss —they fail — two-thirds of the time. Medical providers are expected to get things right 100% of the time,” says Michael Patrick, MD,…

Tissue-Engineered Vascular Grafts Resist Calcification
 Tissue-Engineered Vascular Grafts Resist Calcification 968 1024 Abbie Miller
By: Abbie Miller

Dystrophic calcification is the biggest reason for prosthetic biomaterial failure. Compared to expanded poly(tetrafluoroethylene) (PTFE) grafts, tissue-engineered vascular grafts (TEVGs) exhibited superior durability, including reduced late-term calcification, according to a study published in Nature Communications. “All of the biomaterials we routinely use for cardiovascular surgery are susceptible to dystrophic calcification,” says Christopher Breuer, MD, pediatric…

Virtual Surgical Planning for Musculoskeletal Oncology
 Virtual Surgical Planning for Musculoskeletal Oncology 150 150 Abbie Miller
By: Abbie Miller

CT of pelvis showing tumor MRI of pelvis showing tumor Step 1: Data acquisition: Computed tomography (CT) and magnetic resonance images (MRI) are obtained during the same visit with markers used to help align the scans to create the composite image. That composite is used to develop the virtual model. Step 2: The 3D Printing and Innovations…

From Scan to Plan: Making Virtual Surgical Planning the Standard of Care for Ortho-oncology Operations
 From Scan to Plan: Making Virtual Surgical Planning the Standard of Care for Ortho-oncology Operations 1024 281 Abbie Miller
By: Abbie Miller

“We deal in rarities,” says Thomas Scharschmidt, MD, director of the Pediatric Orthopedic Oncology Program at Nationwide Children’s Hospital and professor of Orthopedics at The Ohio State University. “When you consider that across the entire U.S. population, we have between 2,500 and 3,000 cases of primary malignant bone tumors each year, and only half of…

Supporting Tracheostomy Decision-Making for Families and Providers
 Supporting Tracheostomy Decision-Making for Families and Providers 1024 683 Abbie Miller
By: Abbie Miller

The Trach Scoring Tool, developed by leaders in bronchopulmonary dysplasia (BPD) at Nationwide Children’s Hospital, offers support for physicians and families. The decision of when to do a tracheostomy on an infant is difficult, to say the least, says Leif Nelin, MD, division chief of Neonatology at Nationwide Children’s Hospital. “Every family has different knowledge,…

Demystifying Machine Learning With AutoML
 Demystifying Machine Learning With AutoML 1024 683 Abbie Miller
By: Abbie Miller

A Nationwide Children’s Hospital team from the Office of Data Sciences recently won the Advanced ML tier in the precisionFDA Automated Machine Learning (AutoML) App-a-thon Challenge: Democratizing and Demystifying Artificial Intelligence (AI). Each year, the FDA hosts challenges centered around data science and bioinformatics. This year, the challenge focuses on AutoML, a low-code ML technique…

Transnasal Endoscopy: Easing Eosinophilic Esophagitis (EoE) Treatment Monitoring
 Transnasal Endoscopy: Easing Eosinophilic Esophagitis (EoE) Treatment Monitoring 1024 683 Abbie Miller
By: Abbie Miller

Finding the most effective treatment for EoE can be a challenging process. Transnasal endoscopy decreases the burden of repeated endoscopies. Eosinophilic gastrointestinal disorders are a chronic and complex group of diseases characterized by having abnormal numbers of eosinophils in parts of the GI tract. This results in chronic inflammation and tissue damage that can lead…

4 Questions With Jeffrey Leonard, MD
 4 Questions With Jeffrey Leonard, MD 1024 683 Abbie Miller
By: Abbie Miller

Jeffrey Leonard, MD, is chief of Neurosurgery and the Robert F. & Edgar T. Wolfe Foundation Endowed Chair in Neurosurgery at Nationwide Children’s Hospital. He is also a principal investigator in the Center for Childhood Cancer Research in the Abigail Wexner Research Institute and a professor of Neurological Surgery at The Ohio State University College…

Accelerating Advances in Epilepsy Surgery
 Accelerating Advances in Epilepsy Surgery 1024 683 Abbie Miller
By: Abbie Miller

One program is bringing together clinical care, surgery and research to create a brighter future for children with intractable epilepsy. Childhood-onset epilepsy affects 1% of children worldwide. Up to a third of patients with epilepsy will have medically refractory epilepsy, continuing to have seizures despite using two or more antiseizure medications. Options for this group…

Proton Therapy – A New Era of Cancer Therapy for Children
 Proton Therapy – A New Era of Cancer Therapy for Children 1024 683 Abbie Miller
By: Abbie Miller

Proton therapy offers benefits over traditional photon radiation therapy. Using proton therapy, doctors can give more specific, concentrated doses of radiation with less risk and damage to the surrounding tissue. Proton therapy is an advanced type of radiation treatment that uses protons instead of X-rays to kill cancer cells. Our proton therapy center uses the…

Supporting Optimal Developmental Outcomes After Neonatal Opioid Withdrawal Syndrome
 Supporting Optimal Developmental Outcomes After Neonatal Opioid Withdrawal Syndrome 1024 575 Abbie Miller
By: Abbie Miller
Toddler playing with toys

Children with prenatal opioid exposure have a higher risk for developmental and behavioral concerns. Prenatal opioid exposure is still far too common. Experts estimate that one infant who has been exposed to opioids is born every 15 minutes in the United States.  While standard diagnostic criteria for neonatal opioid withdrawal syndrome (NOWS) were recently proposed,…

Clinical Trial Shows Promising Results for AAV Gene Therapy for LGMD 2E/R4
 Clinical Trial Shows Promising Results for AAV Gene Therapy for LGMD 2E/R4 1024 783 Abbie Miller
By: Abbie Miller

Recently published in Nature Medicine, interim results from a Phase 1/2 trial offer promising results.   Limb-girdle muscular dystrophy (LGMD) 2E/R4 is a rare, progressive neuromuscular disorder caused by mutations in the β-sarcoglycan (SGCB) gene. These mutations lead to SGCB protein deficiency, ultimately resulting in muscle loss. Progressive, debilitating weakness and wasting begin in the…

Novel Cause of Brain Mosaicism and Focal Epilepsy Identified
 Novel Cause of Brain Mosaicism and Focal Epilepsy Identified 1024 575 Abbie Miller
By: Abbie Miller

In Nature Genetics, researchers report a novel mechanism for the origin of brain chromosomal mosaicism and link brain mosaic chromosome 1q gain to a distinct clinical phenotype.   In most people, every cell in their body contains the same genetic information. However, sometimes people can have two or more genetically different sets of cells. This…

Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model
 Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model 898 504 Abbie Miller
By: Abbie Miller

Biofilm formulation of Limosilactobacillus reuteri protects against necrotizing enterocolitis in piglet model.  Necrotizing enterocolitis (NEC) is a debilitating and deadly condition affecting infants born preterm. In NEC cases, intestinal tissues become inflamed, and in severe cases, there is ischemia and death of the involved intestines. Treatment for NEC often involves surgery to remove the dying…

Building Hope, Recovery, and Life Beyond Substance Use Disorder
 Building Hope, Recovery, and Life Beyond Substance Use Disorder 1024 702 Abbie Miller
By: Abbie Miller

Five years ago, Pediatrics Nationwide dedicated its fall issue to a comprehensive look at the effects of the opioid crisis on children and families. At that time, Sarah Parker was working hard to stay sober, recovering from the very crisis holding the nation’s attention. Parker grew up in Chillicothe, Ohio, halfway between Portsmouth, Ohio, the…

Whole Child, Whole Family Care
 Whole Child, Whole Family Care 150 150 Abbie Miller and Jeb Phillips
By: Abbie Miller and Jeb Phillips

Meeting the needs of children and caregivers with evidence-based programming and intentional support for access. Parenting a young child can be tough in the best circumstances. But when you overlay poverty, inequity, and concerns about employment and education on top of it, parenting a young child can feel overwhelming. Whitney Raglin Bignall, PhD, has dedicated…

Preventing Accidental Ingestion of Marijuana
 Preventing Accidental Ingestion of Marijuana 1024 683 Abbie Miller
By: Abbie Miller

If you are a child, and you find a bag of fruit snacks — you don’t eat just one piece. The THC/marijuana products on the market today have an average of 10-20 mg in one serving. That’s one square of a chocolate bar, one gummy (which looks like a fruit snack) or one chip. “THC…

Should You Offer Fentanyl Test Strips in Your Office?
 Should You Offer Fentanyl Test Strips in Your Office? 150 150 Abbie Miller
By: Abbie Miller

Harm reduction approaches support the use of fentanyl test strips for individuals who are taking illicit substances but want to avoid fentanyl. Nichole Michaels, PhD, a principal investigator in the Center for Injury Research and Policy at Nationwide Children’s, is conducting two studies about the efficacy of offering and educating about fentanyl testing among adults.…

Supporting Children With Interstitial and Rare Lung Disease
 Supporting Children With Interstitial and Rare Lung Disease 1024 687 Abbie Miller
By: Abbie Miller

In pediatrics, some causes of lung dysfunction, while rare in their own right, are fairly common – such as cystic fibrosis, bronchopulmonary dysplasia and asthma. Interstitial and rare lung disease (IRLD) is an umbrella term for 30-50 diseases that affect children worldwide. IRLD may affect 0.1 to 16 per 100,000 children, according to Katelyn Krivchenia,…

Pregnancy and Ebola: Maternal and Infant Health Outcomes in Ebola Survivors
 Pregnancy and Ebola: Maternal and Infant Health Outcomes in Ebola Survivors 150 150 Abbie Miller
By: Abbie Miller

Ebola virus disease during pregnancy is known to cause fetal demise, and preliminary evidence suggested that pregnancies conceived shortly after recovery from Ebola were also at heightened risk of adverse outcomes. Additionally, the perception that health care providers could contract Ebola from survivors during delivery led to stigmatization and barriers to care for pregnant women…

FDA Approves Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy
 FDA Approves Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy 1024 632 Abbie Miller
By: Abbie Miller

On June 22, 2023, the FDA announced accelerated approval for SRP-9001/ELEVIDYS for Duchenne muscular dystrophy (DMD) following decades of research in the Center for Gene Therapy at Nationwide Children’s Hospital. The FDA approved the treatment for pediatric patients 4-5 years old with DMD. Jerry Mendell, MD, principal investigator in the Center for Gene Therapy at…

Mapping the 3D Structure of Rhabdomyosarcoma Chromatin
 Mapping the 3D Structure of Rhabdomyosarcoma Chromatin 1024 575 Abbie Miller
By: Abbie Miller
yellow squiggly lines representing chromatin strands in the nucleus

Researchers published the first comprehensive, 3D analysis of the complete rhabdomyosarcoma genome. In a paper published in Nucleic Acids Research Cancer (NAR Cancer), researchers from the Center for Childhood Cancer Research at Nationwide Children’s and their collaborators report a comprehensive 3D chromatin structural analysis and characterization of rhabdomyosarcoma (RMS). RMS is a pediatric soft-tissue tumor…

1 Year In, the Molecular Characterization Initiative Has Analyzed Samples From Over 1,000 Patients
 1 Year In, the Molecular Characterization Initiative Has Analyzed Samples From Over 1,000 Patients 1024 614 Abbie Miller
By: Abbie Miller
abstract art of magnifying glass over DNA strand

Data from the analysis helps clinicians confirm diagnoses and identify targeted treatments. The data also support new pediatric cancer research through the National Cancer Institute’s Childhood Cancer Data Initiative.   The CCDI Molecular Characterization Initiative (MCI) is a project that aims to collect, analyze and report clinical and molecular data and is currently supporting Children’s…

Tissue Engineering and Fetal Medicine: A New Frontier for Congenital Heart Disease
 Tissue Engineering and Fetal Medicine: A New Frontier for Congenital Heart Disease 1024 575 Abbie Miller
By: Abbie Miller
Fetus in utero receiving valvuloplasty

Procedures that utilize cardiac catheterization to improve fetal heart development are often successful, but they are not without risk. And even if they can successfully prevent the development of single ventricle disease, there is always ongoing heart valve disease (HVD). HVD may not be as life-threatening as single ventricle disease, but it requires lifelong care.…

What Pediatricians Need to Know About Lymphedema in Pediatrics
 What Pediatricians Need to Know About Lymphedema in Pediatrics 150 150 Abbie Miller
By: Abbie Miller

Lymphedema is chronic, progressive swelling caused by maldevelopment or disruption of the lymphatic system. Typically, patients present with an asymmetric swelling of an arm or leg that progressively worsens. Min-Jeong Cho, MD, a microsurgeon and assistant professor at The Ohio State University and Nationwide Children’s Hospital, says that lymphedema affects more children and teens than…

Micro-dystrophin: A Small Gene With Big Promise
 Micro-dystrophin: A Small Gene With Big Promise 1024 632 Abbie Miller
By: Abbie Miller

SRP-9001 for Duchenne muscular dystrophy supplies a functional dystrophin gene via AAVrh74 gene therapy. In 1969, Jerry Mendell, MD, was working at the National Institute of Neurological Disorders and Stroke (NINDS) when he saw his first patient with Duchenne muscular dystrophy (DMD). DMD, a severe form of muscular dystrophy caused by a mutation in the…

Using Machine Learning in the Electronic Medical Record to Save Lives
 Using Machine Learning in the Electronic Medical Record to Save Lives 1024 683 Abbie Miller
By: Abbie Miller
physicians in white coats looking at a tablet

The deterioration risk index identifies patients at risk for deterioration and poor outcomes, triggering the care team to act before a crisis happens. In a report published in Pediatric Critical Care Medicine, a team from Nationwide Children’s Hospital describes a machine learning tool for timely identification of hospitalized children at risk for deterioration – a…

Pediatric Obesity Can Be Treated Safely and Effectively
 Pediatric Obesity Can Be Treated Safely and Effectively 1024 575 Abbie Miller
By: Abbie Miller

New guidelines from the American Academy of Pediatrics emphasize evidence for safe, effective treatment of pediatric obesity for long-term benefit of children and adolescents.   More than 14.4 million U.S. children and adolescents have obesity, making it one of the most common chronic conditions facing American youth and families. Obesity is a chronic disease associated…

5 Things to Know About Prune Belly Syndrome
 5 Things to Know About Prune Belly Syndrome 1024 683 Abbie Miller
By: Abbie Miller
Linda Baker, MD

Linda Baker, MD, urologist, principal investigator, and one of the world’s foremost experts on prune belly syndrome, recently joined Nationwide Children’s Hospital as the co-director of the Kidney and Urinary Tract Center. She shares some important things to know about this rare disease. 1. Prune belly is a rare, congenital malformation. Prune belly syndrome (PBS)…

New Guidelines for Care of Children With Cerebral Palsy
 New Guidelines for Care of Children With Cerebral Palsy 1024 683 Abbie Miller
By: Abbie Miller
Young child with Cerebral Palsy

Guidelines from the American Academy of Pediatrics and the American Academy for Cerebral Palsy and Developmental Medicine highlight advances in diagnosis, care and outcomes for children and adolescents with cerebral palsy. In late 2022, the American Academy of Pediatrics and the American Academy for Cerebral Palsy and Developmental Medicine released new guidelines to help primary…

Predicting Risk of Nosocomial Infection in Pediatric Burn Patients: Can Measures of Adaptive Immune Function Help?
 Predicting Risk of Nosocomial Infection in Pediatric Burn Patients: Can Measures of Adaptive Immune Function Help? 150 150 Abbie Miller
By: Abbie Miller

Pediatric burn injuries affect 1 million children each year in the United States. While burn care improvements have decreased mortality, infection-related complications remain a significant problem. According to the National Burn Repository, four of the top five complications of pediatric burns are infection related. Plus, infection-related complications occur in up to 60% of patients with…

New Guidelines Offer a Clear Path for Expandable Endoprosthesis Use in Post-Sarcoma Limb Reconstruction
 New Guidelines Offer a Clear Path for Expandable Endoprosthesis Use in Post-Sarcoma Limb Reconstruction 150 150 Abbie Miller
By: Abbie Miller

Limb salvage operation is the standard of care for pediatric extremity bone sarcomas. These tumors often occur during the second decade of life, when children are growing rapidly. Reconstructive surgeries must account for anticipated remaining growth and the potential for resulting limb inequity. Osteosarcoma and Ewing sarcoma are the most common primary malignant bone tumors,…

Ewing Sarcoma Transcription Factor Mediates Changes in Transcription by Reprogramming Chromatin Structure
 Ewing Sarcoma Transcription Factor Mediates Changes in Transcription by Reprogramming Chromatin Structure 1024 575 Abbie Miller
By: Abbie Miller
yellow squiggly lines representing chromatin strands in the nucleus

By binding to DNA in the nucleus, the Ewing sarcoma-specific transcription factor EWS/FLI changes chromatin organization, leading to altered gene expression and the development of Ewing sarcoma.   A new report, published in Nucleic Acids Research, focuses on how the Ewing sarcoma-specific transcription factor EWS/FLI changes spatial organization of DNA in the nucleus of Ewing…

New Disorder of Copper Metabolism Identified, Caused by Variants in CTR1 Gene
 New Disorder of Copper Metabolism Identified, Caused by Variants in CTR1 Gene 1024 575 Abbie Miller
By: Abbie Miller

A novel missense mutation in identical twins leads to discovery and definition of new inherited disorder of brain copper metabolism. Copper is essential for many cellular functions, including cellular respiration, antioxidant defense, neurotransmitter biosynthesis and neuropeptide amidation, among others. Until recently, only two inborn errors of copper metabolism were well established. Both are rare. Wilson’s…