Additional Ventures: Investing in Congenital Heart Disease Research to Advance Care

Additional Ventures: Investing in Congenital Heart Disease Research to Advance Care 150 150 Natalie Wilson

Additional Ventures is a purpose-driven nonprofit that has developed the Single Ventricle Research Fund (SVRF), an annual research award program dedicated to accelerating research and improving care for people with single ventricle heart defects. The fund supports investigators through multi-year, high-impact grants focused on different elements in their carefully structured research roadmap.

By funding investigators focused on key areas of the development and amelioration of single ventricle congenital heart disease (SF CHD), Additional Ventures aims to make single ventricle defects better understood and more treatable.

Graphic with the following text: DRIVING SINGLE VENTRICLE CHD ADVANCEMENTS FROM EVERY ANGLE Foundational clinical and research resources Firm understanding of SV disease origins and risk factors Defined biological mechanisms of outcomes Predictable, preventable or treatable clinical sequelae Introduction of curative solutions

In 2020, Nationwide Children’s received a $1 million Innovation Fund endowed by Additional Ventures, joining a handful of other research institutions in a large-scale coordinated effort to find new ways to functionally cure patients with SV CHD.

Nationwide Children’s awarded portions of the Additional Ventures funding to three projects:

  • Elucidating Mechanisms of Ventricular Hypoplasia in PA-IVS Using Patient-Derived iPSCs
    • Co-principal investigators Vidu Garg, MD, PhD, director of the Center for Cardiovascular Research at The Heart Center, and Mingtao Zhao, DVM, PhD, principal investigator in the Center for Cardiovascular Research
  • Development of a Protocol to Risk Stratify Individuals With Single Ventricle Congenital Heart Disease Using Deep Phenotyping and Genome Sequencing
    • Co-principal investigators Kim McBride, MD, MS, division chief of Genetic and Genomic Medicine, and Peter White, PhD, senior director of Computational Genomics
  • Unlocking Our Regenerative Capacity: Elucidating the Role of LYST on Neotissue Formation in Tissue Engineered Constructs
    • Co-principal investigators Christopher Breuer, MD, director of the Center for Regenerative Medicine, and Rick Wilson, PhD, executive director of the Institute for Genomic Medicine

More information on Additional Ventures and their funded SV CHD studies can be found at

This article appears in the Fall/Winter 2021 print issue. Download the full issue.

Image credits: Nationwide Children’s

To learn more about CHD research at Nationwide Children’s, read How Patient-Derived Stem Cells are Changing the Trajectory of Congenital Heart Disease Research.

About the author

Marketing Strategist, Research Communications

Natalie is a passionate and enthusiastic writer working to highlight the groundbreaking research of the incredible faculty and staff across Nationwide Children's Hospital and the Abigail Wexner Research Institute. Her work at Nationwide Children's marries her past interests and experiences with her passion for helping children thrive and a long-held scientific curiosity that dates back to competing in the Jefferson Lab Science Bowl in middle school. Natalie holds a bachelor’s degree in sociology from Wake Forest University, as well as minors in women's, gender & sexuality studies and interdisciplinary writing. As an undergraduate student, Natalie studied writing and journalism, engaged with anthropological and sociological research with a focus on race and ethnic relations, served as executive editor for the student newspaper, the Old Gold & Black, and gained marketing experience as an intern for a nonprofit entrepreneurial incubator, Winston Starts, as well as by working for Wake Forest University School of Law Office of Communication and Public Relations and its Innocence and Justice Clinic.