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A Noncardiomyocyte Signaling Pathway in Early Heart Development
 A Noncardiomyocyte Signaling Pathway in Early Heart Development 1024 670 Mary Bates, PhD
By: Mary Bates, PhD

Study demonstrates role for endocardial cells in myocardial trabeculation. A new study in Nature Communications from researchers at Nationwide Children’s Hospital provides novel insights into a signaling pathway that regulates the developing myocardium during early heart development. The findings have implications for understanding congenital heart disease and myocardial regeneration. This research was led by Deqiang…

Implanted Hemodynamic Monitoring in Patients With Fontan Circulation
 Implanted Hemodynamic Monitoring in Patients With Fontan Circulation 150 150 Mary Bates, PhD
By: Mary Bates, PhD

Pulmonary artery pressures obtained with the CardioMEMSTM system may be clinically useful. In a new study, researchers from The Ohio State University and Nationwide Children’s Hospital report on the use of invasive implanted hemodynamic monitoring (IHM) in patients with Fontan circulation. The findings suggest that IHM pressures in these patients are more closely associated with…

How Patient-Derived Stem Cells are Changing the Trajectory of Congenital Heart Disease Research
 How Patient-Derived Stem Cells are Changing the Trajectory of Congenital Heart Disease Research 1024 683 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

Small blood samples — and the patient-specific, induced pluripotent stem cells (iPSCs) they enable — turn into valuable research material for understanding congenital cardiovascular disorders, especially when united with modern genome sequencing and editing, animal models and three dimensional tissue growth technologies. Patient-derived induced pluripotent stem cells (iPSCs) have a significant downside for studying most…

Stent Implantations Are an Option for Small Patients
 Stent Implantations Are an Option for Small Patients 1024 670 Mary Bates, PhD
By: Mary Bates, PhD

Stents that can be dilated to adult size are safe and effective for the treatment of coarctation of the aorta in young patients. Studies have demonstrated stent implantation is more effective and safer than balloon angioplasty for the treatment of coarctation of the aorta in adult and older pediatric patients. In smaller patients, however, particularly…