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Pediatric cancers

Speeding Up Science With Patient-Derived Xenografts
 Speeding Up Science With Patient-Derived Xenografts 1024 483 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
cropped microscopy image of lungs tissue with tumors

A perfect storm of advanced technologies and scientific collaboration opens doors to rapid progress in pediatric oncology research. The world of pediatric cancer research faces the challenges of small patient numbers, increased ethical considerations, limited funding and poorly classified diseases. In some ways, these challenges reflect the field’s successes over the past half century, which…

Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors
 Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors 1024 504 Lauren Dembeck
By: Lauren Dembeck

Due to within-tumor heterogeneity, telomere-based therapeutic interventions will likely need to target both known telomere maintenance mechanisms to prevent resistance and recurrence.   Normal differentiated somatic cells can divide only a limited number of times due to loss of the physical ends of their chromosomes, the telomeres, with each replication. When the telomeres reach their…