Pediatric cancers

Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors
Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors 1024 504 Lauren Dembeck

Due to within-tumor heterogeneity, telomere-based therapeutic interventions will likely need to target both known telomere maintenance mechanisms to prevent resistance and recurrence.   Normal differentiated somatic cells can divide only a limited number of times due to loss of the physical ends of their chromosomes, the telomeres, with each replication. When the telomeres reach their…