Close
Enter your
text here

high-grade gliomas

Pivotal New Research Fuels Possibilities for Aggressive Pediatric Brain Cancer
 Pivotal New Research Fuels Possibilities for Aggressive Pediatric Brain Cancer 1024 414 Wendy Margolin
By: Wendy Margolin

A new umbrella trial of molecularly driven therapies for high-grade gliomas (HGG) and diffuse intrinsic pontine glioma (DIPG) aims to improve quality of live and extend survival rates for these aggressive tumors. The diagnosis of high-grade glioma (HGG), a type of aggressive, malignant brain tumor, in pediatric patients is particularly heartbreaking. HGGs are one of…

Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors
 Coexistence of Different Telomere Maintenance Mechanisms in Pediatric High-Grade Glioma Tumors 1024 504 Lauren Dembeck
By: Lauren Dembeck

Due to within-tumor heterogeneity, telomere-based therapeutic interventions will likely need to target both known telomere maintenance mechanisms to prevent resistance and recurrence.   Normal differentiated somatic cells can divide only a limited number of times due to loss of the physical ends of their chromosomes, the telomeres, with each replication. When the telomeres reach their…