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Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders
 Creation of Patient-Derived Induced Pluripotent Stem Cell Lines for Studying Rare Pediatric Genitourinary Disorders 1024 683 Lauren Dembeck
By: Lauren Dembeck

Nationwide Children’s researchers create first-ever stem cell lines for rare genitourinary conditions. Induced pluripotent stem cells (iPSCs) have revolutionized medical research by providing powerful tools to study disease mechanisms, especially in rare genetic conditions. These versatile cells, derived directly from patients that have the condition, offer unprecedented opportunities to uncover the underlying genetic and cellular…

Surgical Repair of Cloacal Malformation Does Not Worsen Bladder Function
 Surgical Repair of Cloacal Malformation Does Not Worsen Bladder Function 1024 683 Mary Bates, PhD
By: Mary Bates, PhD

The complexity of the malformation, more than the surgical approach, determines post-operative urodynamics. Approximately 90% of girls with cloacal malformation exhibit some degree of bladder dysfunction. While associated conditions can impact bladder dynamics, the complex surgery required to repair cloacal malformation has also been hypothesized to cause bladder dysfunction. Strategies to repair cloacal malformation in…