Close
Enter your
text here

Research

The Growing Use of Robotics in General Pediatric Surgical Procedures
 The Growing Use of Robotics in General Pediatric Surgical Procedures 1024 683 Lauren Dembeck
By: Lauren Dembeck

Pediatric surgeons are increasingly turning to robotic technology for the delivery of safe and enhanced minimally invasive surgical approaches for younger children. Over the past two decades, the use of minimally invasive surgery (MIS) techniques for both laparoscopic and thoracoscopic surgery have been widely adopted for the treatment of children requiring various surgical procedures. This…

From Biology to Bedside: How the Center for Childhood Cancer Research Is Shaping What Comes Next
 From Biology to Bedside: How the Center for Childhood Cancer Research Is Shaping What Comes Next 1024 627 Madison Storm
By: Madison Storm
Portrait of Alexander Bishop, DPhil, standing in a hospital lobby and smiling, wearing a navy blazer and light blue shirt.

An interview with Alexander Bishop, DPhil, director of the Center for Childhood Cancer Research, principal investigator and Richard J. Solove Endowed Chair in Cancer Clinical Developmental Therapeutics at Nationwide Children’s Hospital. At Nationwide Children’s Hospital, the mission of the Center for Childhood Cancer Research (CCCR) is to expand the understanding of childhood cancer pathogenesis and…

Tissue Engineered Vascular Grafts: A Breakthrough for Children With Heart Defects
 Tissue Engineered Vascular Grafts: A Breakthrough for Children With Heart Defects 968 1024 Abbie Miller
By: Abbie Miller
Illustration of a heart showing the Fontan surgery

An innovation 30 years in the making is poised to change the way children with single ventricle disease experience life after a Fontan procedure. Children with single ventricle disease are often described as having “half a heart.” What this really means is that one of their ventricles (either the right or left lower chamber of…

DNA Methylation-Based Diagnostics: Refining Diagnosis for the Most Complex Pediatric Brain Tumors
 DNA Methylation-Based Diagnostics: Refining Diagnosis for the Most Complex Pediatric Brain Tumors 1024 783 Lauren Dembeck
By: Lauren Dembeck

Developed at Nationwide Children’s, the MACDADI classifier is compatible with next-generation methylation arrays and quickly delivers more accurate tumor diagnoses, offering a clinically validated alternative to outdated and unregulated methylation classifiers. Diagnosing central nervous system (CNS) tumors in children is among the most challenging problems in pediatric oncology. Many tumor types share overlapping microscopic features,…

Shorter Antibiotic Courses Appear Safe for Uncomplicated Gram-Negative Bloodstream Infections in the NICU
 Shorter Antibiotic Courses Appear Safe for Uncomplicated Gram-Negative Bloodstream Infections in the NICU 1024 602 Pam Georgiana
By: Pam Georgiana
Newborn baby with nasal canula oxygen support receiving care in a neonatal intensive care unit (NICU) at a hospital, resting while monitored by medical staff.

Neonatology and pediatric pharmacy partner to advance antibiotic stewardship. For years, Pablo J. Sánchez, MD, principal investigator in the Center for Perinatal Research in the Abigail Wexner Research Institute at Nationwide Children’s Hospital, observed that approximately 7 days of antibiotic therapy appeared sufficient for selected neonates with uncomplicated gram-negative bloodstream infections that does not involve…

Understanding the Rising Suicide Risk Among Black Youth
 Understanding the Rising Suicide Risk Among Black Youth 1024 576 Alaina Doklovic
By: Alaina Doklovic

A new large-scale Medicaid study sheds light on complex factors driving risk and the protective factors that may help save lives. Suicide rates among Black youth (children, adolescents and young adults) have risen sharply in recent years, surpassing those of other racial and ethnic groups. In 2023, it was the third leading cause of death…

Registry Data Provide Insight Into Ultra-Rare Pediatric Tenosynovial Giant Cell Tumors
 Registry Data Provide Insight Into Ultra-Rare Pediatric Tenosynovial Giant Cell Tumors 1024 473 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

At A Glance Tenosynovial giant cell tumor (TGCT) is a rare condition that affects joints, mostly in adults but sometimes in children. New research using an international patient registry shows that children often wait more than a year for the correct diagnosis because symptoms such as pain and swelling can look like sports injuries or…

Filling a Critical Gap in Relapsed Sarcoma Treatment
 Filling a Critical Gap in Relapsed Sarcoma Treatment 1024 683 Pam Georgiana
By: Pam Georgiana
Blood Sample in test tube

A first-in-sarcoma trial at Nationwide Children’s Hospital tests universal-donor NK cells with chemotherapy to address poor survival rates.   The five-year overall survival rate for children and young adults with relapsed bone or soft tissue sarcomas is between 17 and 26%. For Bhuvana A. Setty, MD, pediatric hematologist and oncologist at Nationwide Children’s Hospital, that reality is not acceptable. …

Nationwide Children’s Hospital Completes One of the World’s First Prenatal Treatments for Spinal Muscular Atrophy
 Nationwide Children’s Hospital Completes One of the World’s First Prenatal Treatments for Spinal Muscular Atrophy 1024 600 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
Baby Bryson laughing at a check up following treatment for SMA.

Investigational third-trimester, transplacental “bridging” therapy with risdiplam — followed by rapid postnatal treatment — aims to protect motor neurons during a critical window before and immediately after birth.  When Stacy Auker found out she was pregnant with her third child, she knew a diagnosis of spinal muscular atrophy (SMA) was a possibility.  “We have relatives who have been affected, so I…

Selective Steroid Use After Kasai Portoenterostomy Improves Outcomes in Biliary Atresia
 Selective Steroid Use After Kasai Portoenterostomy Improves Outcomes in Biliary Atresia 1024 683 Pam Georgiana
By: Pam Georgiana

Postoperative protocol is associated with improved bile drainage and higher native liver survival without increased short-term risk. A new study published in the Journal of Pediatric Gastroenterology and Nutrition provides evidence that a selective, marker-guided approach to postoperative steroid use improves outcomes for infants with biliary atresia following Kasai portoenterostomy. Led by Jaimie D. Nathan,…

Study Shows Younger Children Experience Persistent Symptoms Following Concussion
 Study Shows Younger Children Experience Persistent Symptoms Following Concussion 1024 540 Abbie Miller and Katelyn Scott
By: Abbie Miller and Katelyn Scott

Nearly 30% of children younger than 6 years who had a concussion during the study had prolonged symptoms, which can affect learning and behavior later in childhood. When people typically think of concussion, the first type of patient that comes to mind is a youth athlete. However, concussion is also common in early childhood, due…

A New Candidate Therapeutic Target and Biomarker for Idiopathic Nephrotic Syndrome
 A New Candidate Therapeutic Target and Biomarker for Idiopathic Nephrotic Syndrome 1024 561 Abbie Miller
By: Abbie Miller
artistic representation of a kidney cross section

New data provides evidence for the role of endothelium in idiopathic nephrotic syndrome pathogenesis.

Behavioral Intervention Program for Children With Autism Spectrum Disorder Undergoing Epilepsy Evaluation: Increasing Phase 1 Monitoring Rates
 Behavioral Intervention Program for Children With Autism Spectrum Disorder Undergoing Epilepsy Evaluation: Increasing Phase 1 Monitoring Rates 1024 683 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

A behavioral intervention program that started as a quality improvement project evolved to a new standard of care — increasing access and compliance with Phase 1 monitoring for children with intractable epilepsy and autism spectrum disorder. A recent study led by Mary Wojnaroski, PhD, a psychologist at Nationwide Children’s Hospital, reported a sustained, multi-year increase…

Cardiometabolic Screening Gaps in Pediatric Congenital Heart Disease
 Cardiometabolic Screening Gaps in Pediatric Congenital Heart Disease 1024 683 Pam Georgiana
By: Pam Georgiana

Retrospective review reveals inconsistent HbA1c screening in eligible patients. Pediatric cardiology has achieved remarkable gains in survival for children with congenital heart disease. However, as more patients reach adolescence and adulthood, they are at risk for experiencing acquired cardiovascular and cardiometabolic conditions such as hypertension and diabetes. Little is known about how consistently clinicians identify…

Advancing Surgical Care for Pediatric Hip Dysplasia
 Advancing Surgical Care for Pediatric Hip Dysplasia 1024 575 Pam Georgiana
By: Pam Georgiana

A novel technique demonstrates safety, stability and reduced casting needs. For children with developmental dysplasia of the hip, open reduction surgery reliably restores the hip to the socket. However, recurrent instability, iatrogenic complications, residual dysplasia and prolonged casting can limit favorable outcomes. To improve these results, orthopedic surgeons at Nationwide Children’s Hospital have developed a…

Long-Term Kidney Complications Are Common Among Pediatric and Young Adult Cancer Survivors
 Long-Term Kidney Complications Are Common Among Pediatric and Young Adult Cancer Survivors 1024 683 Pam Georgiana
By: Pam Georgiana

Study reveals the need for improved surveillance and updated survivorship guidelines. As pediatric cancer survival rates continue to climb, focus is shifting to enhancing the long-term health of survivors. While treatments have become more precise, their delayed effects are not yet fully understood. A new study led by Diana Zepeda-Orozco, MD, principal investigator in the…

Watchful Waiting: The New Recommendation for Most Preterm Infants With PDA
 Watchful Waiting: The New Recommendation for Most Preterm Infants With PDA 1024 683 Abbie Miller
By: Abbie Miller

A study published in JAMA found that treating patent ductus arteriosus with medication did not help with disease management but was associated with higher mortality.   A new study from the Neonatal Research Network, published in JAMA, found that treating patent ductus arteriosus (PDA) in preterm infants with nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen at…

Setting the Stage the Next Era of Gene Therapy for Ultrarare Disease
 Setting the Stage the Next Era of Gene Therapy for Ultrarare Disease 1024 576 Abbie Miller
By: Abbie Miller

Researchers at Nationwide Children’s Hospital recently administered a novel gene therapy targeting SLC6A1, advancing precision medicine for children who previously could not be treated. Maxwell, age 8, made history this fall, when he received a bespoke gene therapy targeting his ultrarare disease. This wasn’t the first time he worked with the team at Nationwide Children’s…

Expanding the Evidence for Cannabidiol in Focal Epilepsy
 Expanding the Evidence for Cannabidiol in Focal Epilepsy 1024 575 Pam Georgiana
By: Pam Georgiana
Young boy turned sideways in front of a dark background, with dark lighting and an illustration of his brain appearing in front of the side of his head

A multicenter study led by Nationwide Children’s Hospital demonstrates long-term efficacy and safety of Epidiolex® for treatment-resistant seizures. As global use of cannabidiol for seizure management increases, most research has targeted generalized epilepsy. This leaves a major evidence gap for patients with focal seizures and epilepsy. Anup D. Patel, MD, FAAN, FAES, FCNS, neurologist and…

As Suicide Increases in Preteens, Investigators Expand Research into Causes and Prevention
 As Suicide Increases in Preteens, Investigators Expand Research into Causes and Prevention 1024 576 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

By tracking trends in suicide over time, researchers identify critical new directions for suicide prevention work. Last year, a study published in JAMA Network Open by researchers at Nationwide Children’s Hospital and collaborating institutions reported that suicide among preteens (children ages 8-12) had increased 8.2% annually from 2008 to 2022. “This has become a critical…

Rethinking Neonatal HSV Management: A Less Aggressive, Evidence-Informed Approach
 Rethinking Neonatal HSV Management: A Less Aggressive, Evidence-Informed Approach 1024 593 Alaina Doklovic
By: Alaina Doklovic

An alternative approach to neonatal HSV management helps keep mom and baby together during the nursery stay.  Neonatal herpes simplex virus infection (HSV) is a rare but often fatal disease when not treated correctly or in a timely manner. This makes diagnosis and preventive strategies extremely important when expectant mothers have active genital HSV infection when they deliver.   Neonatal HSV is a result of vertical transmission from mother to newborn and most…

Kids With GPA Often Show Lung Signs — But Few See Pulmonologists
 Kids With GPA Often Show Lung Signs — But Few See Pulmonologists 1024 683 Jessica Nye, PhD
By: Jessica Nye, PhD

Most patients with pediatric granulomatosis with polyangiitis (GPA) have respiratory manifestations, but fewer than half are evaluated by a pulmonologist within 6 months of diagnosis, finds a study published in Pediatric Pulmonology.   “Pediatric GPA is a very rare autoimmune rheumatologic disorder that can have significant impact on the lungs. But nobody has really described the…

Prematurity Increases Morbidity and Mortality Risk in Preterm Neonates with Down Syndrome in the NICU
 Prematurity Increases Morbidity and Mortality Risk in Preterm Neonates with Down Syndrome in the NICU 1024 624 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

  Premature neonates with Down syndrome who are admitted to the neonatal intensive care unit experience higher rates of health complications and an increased mortality risk.   A retrospective study led by Emily Messick, DO, at Nationwide Children’s Hospital, reported the increased risk of adverse health outcomes in preterm neonates with Down syndrome in the…

Rethinking Routine Kidney Ultrasounds in Children With Mild Anorectal Malformations
 Rethinking Routine Kidney Ultrasounds in Children With Mild Anorectal Malformations 1024 683 Lauren Dembeck
By: Lauren Dembeck
Molly Fuchs, MD

  Annual scans rarely identify new kidney concerns in symptom-free children. Children born with anorectal malformations (ARMs), a group of congenital conditions affecting the anus and rectum, are routinely screened for kidney abnormalities because of the association between ARM and urinary tract anomalies. The likelihood of urologic complications  increases with the complexity of the malformation.…

Challenges in Medication Titration in Children with Heart Failure
 Challenges in Medication Titration in Children with Heart Failure 1024 537 Pam Georgiana
By: Pam Georgiana

Beyond the guidelines: implementing consensus-based care for complex patients. Pediatric heart failure is a complex clinical diagnosis, with a growing body of evidence to suggest there are critical differences between pediatric and adult heart failure. In a recent review published in JHLT Open, Jessie Yester, MD, PhD and Deipanjan Nandi, MD highlight the unique challenges…

Defining Urinary Tract Infection: Why Standardization Matters for Research and Care
 Defining Urinary Tract Infection: Why Standardization Matters for Research and Care 1024 683 Pam Georgiana
By: Pam Georgiana

Urinary tract infections (UTIs) are one of the most common bacterial infections worldwide, affecting an estimated 150 million people annually and costing more than $5 billion in the United States alone. However, despite their prevalence, there is still no universally accepted definition of what constitutes a UTI. This lack of clarity complicates both research and…

Nationwide Children’s Team Builds Award-Winning AI Tool to Drive Mental Health Research
 Nationwide Children’s Team Builds Award-Winning AI Tool to Drive Mental Health Research 1024 502 Abbie Miller
By: Abbie Miller

DREAM project wins the 2025 Gartner Eye on Innovation Mid-Size Enterprise Award in the Americas region. In recognition of its innovative application of technology to address critical health care challenges, the Office of Data Sciences was selected as the winner for the prestigious 2025 Gartner Eye on Innovation Awards, Mid-Size Enterprise, Americas.  This international honor…

Food-Based Tube Feeding: Balancing Parental Demand With Pediatric Nutrition Science
 Food-Based Tube Feeding: Balancing Parental Demand With Pediatric Nutrition Science 1024 575 Pam Georgiana
By: Pam Georgiana
Color image of enteral complete liquid nutritional products of several brands

New research from Nationwide Children’s reveals significant differences in nutrient adequacy across commercial food-based formulas. In the last two decades, enteral nutrition has undergone a significant transformation. Fifteen to 20 years ago, pediatric patients requiring gastrostomy tube feeding had only one option: synthetic, cow milk-based formulas designed to meet caloric and macronutrient needs but containing…

Parents’ Perceptions Highlight Gaps in Supporting Children with Epilepsy in School
 Parents’ Perceptions Highlight Gaps in Supporting Children with Epilepsy in School 1024 579 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM

Discussions with parents of children with epilepsy revealed concerning gaps in school-based seizure education and care, underscoring the need for better lines of communication between medical teams, school personnel, and the children’s families.   A qualitative study led by Mary Kay Irwin, EdD, and Anup Patel, MD, FAAN, FAES, FCNS, at Nationwide Children’s Hospital reported…

Closing the Treatment Gap: Opioid Use Disorder Medications in Adolescents and Young Adults
 Closing the Treatment Gap: Opioid Use Disorder Medications in Adolescents and Young Adults 1024 683 Pam Georgiana
By: Pam Georgiana
silhouette girl portrait

Findings from the PROUD trial highlight the need for youth-centered prescription strategies in primary care. Adolescents and young adults are far less likely than older adults to receive evidence-based medications for opioid use disorder (OUD), even though buprenorphine and extended-release naltrexone are recommended treatments. Despite their effectiveness, these therapies remain consistently underutilized in youth. To…

Virtual Reality Training Model Aims to Transform Workplace Safety in Health Care
 Virtual Reality Training Model Aims to Transform Workplace Safety in Health Care 1024 683 Madison Storm
By: Madison Storm

A virtual reality (VR) training module developed at Nationwide Children’s Hospital, called DEFUSE, which stands for De-escalate Effectively, Foster Understanding, Safeguard Environments, is setting a new standard for workplace violence prevention in health care settings. Funded by the Ohio Bureau of Workers’ Compensation, the project equips health care professionals with critical skills in situational awareness,…

Post-Ictal Rhythmic Thalamic Activity in the Central Media Nucleus May Play a Role in Seizure Termination in Drug-Resistant Epilepsy
 Post-Ictal Rhythmic Thalamic Activity in the Central Media Nucleus May Play a Role in Seizure Termination in Drug-Resistant Epilepsy 1024 677 Jessica Nye, PhD
By: Jessica Nye, PhD

Investigators from Nationwide Children’s Hospital are the first to describe post-ictal rhythmic thalamic activity (PIRTA) in the central media nucleus (CMN) during focal onset seizure. “When this paper was published, it was a period where understanding the role of the center of the thalamus and seizures was a novel thing,” says senior author Ammar Shaikhouni,…

Norms, Needs and New Frontiers in Pediatric Mental Health
 Norms, Needs and New Frontiers in Pediatric Mental Health 1024 683 Madison Storm
By: Madison Storm

An interview with Eric Youngstrom, PhD, director of the Institute for Mental and Behavioral Health Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital.   At Nationwide Children’s Hospital, the Institute for Mental and Behavioral Research (IMBHR) is driving discovery through improved assessments, effective treatments and digging deep to answer the ‘why’ behind…

Enhanced IV Line Clamp: A New Spin on a Classic
 Enhanced IV Line Clamp: A New Spin on a Classic 1024 683 Madison Storm
By: Madison Storm
Close-up of newly designed IV line clamps that improve patient safety and usability in hospitals by providing secure, easy-to-adjust flow control for intravenous therapy.

Revolutionizing patient care through human-centered design The IV line clamp is a long-standing technology used to deliver intravenous medications and fluids. For over 90 years, the simplistic, gravity-based design has remained unchanged, despite the growing complexity of patient care and significant advancements in medical technology. Enter Jenna Merandi, PharmD, MS, CCPS, medication safety officer, and…

How Medical-Legal Partnerships Support Families, Relieve Stress and Improve Health
 How Medical-Legal Partnerships Support Families, Relieve Stress and Improve Health 1024 320 Wendy Margolin
By: Wendy Margolin

With a small team of dedicated attorneys working as part of a medical-legal partnership, Lawyers for Kids is making an outsized impact for families at Nationwide Children’s Hospital. A classic example of a medical-legal partnership case is a child with asthma who frequently visits the emergency room. The parents and doctors know the cause is…

Universal Donor CAR NK Cells: A New Platform Technology for Cancer
 Universal Donor CAR NK Cells: A New Platform Technology for Cancer 1024 559 Abbie Miller
By: Abbie Miller
Intravenous (IV) chemotherapy or Cell therapy treatment bag surrounded by cancer cells, fighting the disease

A first-in-human study of universal donor CAR NK cells for acute myeloid leukemia could pave a path for a new approach to treating cancer If you ask Dean Lee, MD, PhD, the new first-in-human trial to evaluate universal donor chimeric antigen receptor (CAR) natural killer (NK) cells in patients with advanced, high-risk acute myeloid leukemia…

New Study Finds Sharp Increase in Nicotine Pouch Ingestions Among Young Children
 New Study Finds Sharp Increase in Nicotine Pouch Ingestions Among Young Children 1024 683 Laura Dattner
By: Laura Dattner
Close-up of nicotine pouches in a plastic container on a dark background, illustrating smokeless tobacco alternatives and nicotine addiction and poisoning risks.

Experts urge stronger regulations, a ban on flavors for all nicotine products and secure at-home storage to help prevent nicotine ingestions. A new study reveals that ingestions of nicotine pouches by young children in the United States have surged in recent years. Researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital…

From the Operating Room to the Clinic: A New Protocol for Ear Tube Surgery
 From the Operating Room to the Clinic: A New Protocol for Ear Tube Surgery 675 450 Alaina Doklovic
By: Alaina Doklovic
Pediatric patient at a follow-up appointment after in-office ear tube insertion, with a doctor examining the child’s ear while the mother provides support.

Nationwide Children’s Hospital is one of the only pediatric hospitals to offer in-office ear tubes as an established choice in their standard of care.  In the United States, bilateral myringotomy/ tympanostomy tube insertion (BTI), also known as ear tube surgery, is the most performed ambulatory pediatric surgery with about 667,000 children needing the procedure every…

Assessing the Clinical Utility of a Fetal Echocardiogram When a Sibling Has Congenital Heart Disease
 Assessing the Clinical Utility of a Fetal Echocardiogram When a Sibling Has Congenital Heart Disease 1024 695 JoAnna Pendergrass, DVM
By: JoAnna Pendergrass, DVM
Pregnant woman smiling and holding her belly while awaiting a fetal echocardiogram to check her baby’s heart health during pregnancy.

A fetal echocardiogram when a sibling has congenital heart disease may not be clinically necessary if the fetus has a normal second-trimester level II ultrasound. A retrospective study led by Kacy Taylor, MSAH, RDCS, FASE, concluded that critical congenital heart disease (CHD) was not missed when a level two ultrasound (LII-US) was normal in a…

Beyond the Bedside: Nurses Conducting Research to Transform Pediatric Outcomes
 Beyond the Bedside: Nurses Conducting Research to Transform Pediatric Outcomes 1024 683 Madison Storm
By: Madison Storm
Teenage girl having stomach ache, young woman health care provider examining her.

Nurses are vital to clinical research – supporting and conducting it. At Nationwide Children’s Hospital, nurse scientists are dedicated to advancing prevention, diagnosis and treatment of pediatric health conditions.   Nurses at Nationwide Children’s Hospital have long been recognized for their compassionate care and clinical expertise. These high-performing clinicians consistently collaborate with other teams to ensure…

Mode of Respiratory Support at 36 Weeks Predicts Weaning Timeline for Infants With Severe Bronchopulmonary Dysplasia
 Mode of Respiratory Support at 36 Weeks Predicts Weaning Timeline for Infants With Severe Bronchopulmonary Dysplasia 1024 683 Lauren Dembeck
By: Lauren Dembeck
Premature baby receiving respiratory support through a nasal cannula in a neonatal intensive care unit, monitored and cared for by a health care provider.

Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, and its incidence is rising due to advances in neonatal care that have improved survival for extremely premature infants. Respiratory support is a cornerstone of management for these patients, yet the expected timeline for weaning in those with moderate-to-severe (grade 2/3) BPD is not…

Real-Life Impact of ETI Therapy in Cystic Fibrosis: Insights From a Large Treatment Center
 Real-Life Impact of ETI Therapy in Cystic Fibrosis: Insights From a Large Treatment Center 706 470 Pam Georgiana
By: Pam Georgiana

Greater clinical gains observed in patients with severe lung disease, regardless of genotype. A recent prospective observational study led by Shahid I. Sheikh, MD, pediatric pulmonologist at Nationwide Children’s Hospital and professor of Pediatrics at The Ohio State University College of Medicine, offers insights into the effectiveness of a new medication for adolescents and adults…

Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms
 Comparing Two Diagnostic Tools for Upper Gastroenterology Symptoms 1024 680 Pam Georgiana
By: Pam Georgiana
Close up color photo of little boy holding hands on his belly

A retrospective analysis of the clinical correlation between gastric emptying scintigraphy and antroduodenal manometry in pediatric patients with upper GI symptoms. Children with persistent nausea, vomiting or abdominal pain often undergo extensive testing to evaluate for underlying etiologies such as pediatric intestinal pseudo-obstruction, rumination or gastroparesis. Two primary diagnostic tools, gastric emptying scintigraphy (GES) and…

Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms
 Predicting Acute Kidney Injury in Neonates Using Machine Learning Algorithms 480 320 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES

A new model accurately identifies neonates at risk of acute kidney injury (AKI) — and the factors physicians should address to prevent it — offering the first AKI prediction tool specific to this vulnerable population. Acute kidney injury (AKI) is common and irreversible, making preventive measures essential to maintaining health. Multiple risk prediction tools exist…

Studying the Clinical Progression of Congenital Hypopituitarism
 Studying the Clinical Progression of Congenital Hypopituitarism 1024 683 Pam Georgiana
By: Pam Georgiana
Black baby smiling up at his mother

New research reveals the clinical progression and evolution of pituitary hormone deficiencies in the first 3 years of life. In a recent retrospective study published in Clinical Endocrinology, Jennifer M. Ladd, MD, MSc, pediatric physician in the Division of Endocrinology and associate program director of the Endocrinology Fellowship Program at Nationwide Children’s Hospital, and colleagues…

Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants
 Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants 1024 575 Jessica Nye, PhD
By: Jessica Nye, PhD
small baby with nose canula

A positive first hip ultrasound (HUS) is highly predictive of having developmental dysplasia of the hip (DDH) among preterm infants, according to results of a study published in the American Journal of Perinatology. “In term babies, more is known about the accuracy of ultrasounds for congenital or developmental hip dysplasia. But in preterm babies, there…

Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network
 Streamlining Autism Diagnosis: How Electronic Health Record Tools Increased Early Identification and Referrals in a Primary Care Network 1024 575 Erin Gregory
By: Erin Gregory
Toddler playing with toys

In their recent publication, Boosting Autism Screening and Referrals with EHR-Integrated Tools at Well-Child Visits, Elizabeth W. Barnhardt, DO, MAEd, developmental-behavioral pediatrician at Nationwide Children’s Hospital and faculty member at The Ohio State University College of Medicine, and her team describe a quality improvement initiative designed to improve the early identification of autism spectrum disorder…

Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1
 Assessing Sleep Disturbances Across the Lifespan in Myotonic Dystrophy Type 1 1024 683 Pam Georgiana
By: Pam Georgiana
physicians in white coats looking at a tablet

Pilot study supports the use of sleep questionnaires to identify underrecognized symptoms in children and adults with DM1. Myotonic Dystrophy Type 1 (DM1) is a genetic, multisystemic neuromuscular disorder that affects skeletal muscle, cardiac function, the endocrine system and the central nervous system. In addition to myotonia (the inability to relax muscles) and progressive muscle…

Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer
 Improving Fertility Discussions and Decision-Making for Adolescent Males With Cancer 1024 683 Pam Georgiana
By: Pam Georgiana

 A pilot study shows promise in enhancing shared decision-making and patient satisfaction through family-centered support. Fertility preservation is a critical yet underutilized aspect of cancer care for adolescent males. Despite being a medically low-risk and effective option, only a minority of young patients attempt sperm banking. Barriers exist at both the system and individual/family levels,…

Transforming the Approach to Cancer Epigenomic Studies
 Transforming the Approach to Cancer Epigenomic Studies 1024 764 Abbie Miller
By: Abbie Miller

Two new publications from the Center for Childhood Cancer Research at Nationwide Children’s offer a new platform technology and proof of concept that illuminates the role of a known gene fusion driving rhabdomyosarcoma.  Synergy is an important part of scientific endeavors, and people, teams and organizations who can harness the energy of ideas and passion…