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Monthly Archives :

May 2021

Leaving No Stone Unturned: Nationwide Children’s Joins Children’s Oncology Group Pediatric Early Phase Clinical Trial Network
 Leaving No Stone Unturned: Nationwide Children’s Joins Children’s Oncology Group Pediatric Early Phase Clinical Trial Network 1024 683 Natalie Wilson
By: Natalie Wilson

The Children’s Oncology Group (COG), the world’s largest and most recognized pediatric cancer research collaborative, recently selected Nationwide Children’s Hospital to join its Pediatric Early Phase Clinical Trial Network (PEP-CTN) through a peer review process. The COG PEP-CTN is a re-iteration of the COG Phase 1/Pilot Consortium and is comprised of 21 core member sites…

9 Facts About the COVID-19 Vaccine
 9 Facts About the COVID-19 Vaccine 1024 683 Abbie Miller
By: Abbie Miller

COVID-19 is a disease caused by the SARS-CoV-2 virus. In the United States, three vaccines are approved for emergency use, those produced by Pfizer, Moderna and Johnson & Johnson (J&J). These vaccines dramatically reduce your risk of getting severely ill or dying from COVID-19. The vaccines are also being shown to reduce the spread of…

Surgical Management of Recurrent Patellar Instability in the Pediatric Population
 Surgical Management of Recurrent Patellar Instability in the Pediatric Population 1024 575 Mary Bates, PhD
By: Mary Bates, PhD

Medial patellofemoral ligament reconstruction via the quadriceps turndown technique is safe and effective in young patients. In a new study, researchers from Nationwide Children’s Hospital demonstrate the safety and efficacy of the quadriceps turndown technique for medial patellofemoral ligament reconstruction in pediatric and adolescent patients. Patellar instability is a common knee condition in children and…

Antibodies to Spinal Muscular Atrophy Gene Therapy Vector May Dissipate, Allowing More Children to Receive Treatment
 Antibodies to Spinal Muscular Atrophy Gene Therapy Vector May Dissipate, Allowing More Children to Receive Treatment 1024 681 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
sleeping infant

A review of antibody titers for SMA patients revealed that levels may decrease with time, potentially enabling delayed dosing for children who otherwise might have been excluded from life-saving gene therapy. Adeno-associated viral (AAV) vectors are used to deliver gene therapies such as onasemnogene abeparvovec-xioi (ZOLGENSMA®), a recently approved gene therapy for spinal muscular atrophy…

Keeping in Touch: Renin-Producing Cells Require Cell Adhesion Molecule to Survive
 Keeping in Touch: Renin-Producing Cells Require Cell Adhesion Molecule to Survive 1024 575 Lauren Dembeck
By: Lauren Dembeck

Uncovering the molecular mechanisms underlying the renin-angiotensin-aldosterone system may provide insights into the long-term effects of hypertension and antihypertensive medications.  As the main source of renin in the human body, juxtaglomerular (JG) cells are crucial for blood pressure and fluid-electrolyte homeostasis. However, these cells cannot be cultured in vitro, making it challenging to study the…

The Sound of Silence: The Impact of “Silent” Genetic Variation in Health and Disease
 The Sound of Silence: The Impact of “Silent” Genetic Variation in Health and Disease 1024 575 Lauren Dembeck
By: Lauren Dembeck

Despite widespread scientific interest in messenger RNA (mRNA) structure, its role in human health and disease remains poorly understood. Researchers at Nationwide Children’s Hospital have developed novel software and metrics to identify “silent” genetic variants that affect mRNA folding and may underlie rare genetic disorders. Historically, synonymous or “silent” genetic variants — those in protein-coding…

Growth Hormone is Still Important Beyond the Growing Years
 Growth Hormone is Still Important Beyond the Growing Years 1024 683 Rohan Henry, MD, MS
By: Rohan Henry, MD, MS

The History of Growth Hormone The first reported use of growth hormone (GH) as treatment for severe growth retardation occurred in the 1950s.1 Since that time, growth hormone’s importance in growth promotion has been clear. Its role in promoting normal metabolism even after growth has ended, however, was only recognized in the late 1980s.2 Beginning…

Pediatric Acute Care Cardiology Collaborative: Shared Focus on Quality to Improve Outcomes and Family Experiences
 Pediatric Acute Care Cardiology Collaborative: Shared Focus on Quality to Improve Outcomes and Family Experiences 1024 575 Katie Brind'Amour, PhD, MS, CHES
By: Katie Brind'Amour, PhD, MS, CHES
Illustration of heart, CAVD

The PAC3 has released three recent studies describing care practices and outcomes across member institutions in an effort to drive improved care. Established in 2014 with the aim of improving acute care outcomes and experience among pediatric cardiology patients, families, clinicians and hospitals, the Pediatric Acute Care Cardiology Collaborative (PAC3) has started to deliver on…

Featured Researcher — Susan Creary, MD, MSc
 Featured Researcher — Susan Creary, MD, MSc 150 150 Natalie Wilson
By: Natalie Wilson

Susan Creary, MD, MSc, is a principal investigator in the Center for Child Health Equity and Outcomes Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, a physician in the Hematology, Oncology and Blood and Marrow Transplant (BMT) Clinic at Nationwide Children’s, and an associate professor of Pediatrics at The Ohio State University.…

What is “Dry Drowning,” and How Do I Talk to Parents About It?
 What is “Dry Drowning,” and How Do I Talk to Parents About It? 1024 683 Daniel Scherzer, MD and Bema Bonsu, MD
By: Daniel Scherzer, MD and Bema Bonsu, MD

The concern about so called “dry drowning” (which is not an actual medical phrase; neither is “secondary drowning”) is based on the fear that a child can unexpectedly succumb to respiratory problems some unpredictable time after swimming. This fear has been exacerbated by media reports dramatizing events without fully explaining them. The concept that dry…