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Center for Clinical and Translational Research

Old Drug, New Use
 Old Drug, New Use 1024 575 Katie Brind'Amour, PhD, MS, CHES
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Nationwide Children's style illustration showing a row of houses with a prescription in front of it

Researchers have discovered an adult diabetes drug may provide a new and better way to treat children  with nephrotic syndrome.  Nephrotic syndrome is one of the most common kidney diseases seen in children. In most cases the cause is unknown. Nephrotic syndrome involves damage to the filtering units of the kidneys (glomeruli) leading to massive…

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Identifying Which Children with Nephrotic Syndrome Will Respond to Steroids
 Identifying Which Children with Nephrotic Syndrome Will Respond to Steroids 1024 683 Mary Bates, PhD
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New research identifies potential biomarkers in the plasma of children with steroid resistant nephrotic syndrome. Nephrotic syndrome is among the most common forms of kidney disease in children. Although glucocorticoids (i.e., steroids) are the primary treatment, approximately 10 to 20% of children with nephrotic syndrome present with or develop steroid resistance. This is only discovered…

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Kidney and Urinary Tract Protein Demonstrates Antimicrobial Activity
 Kidney and Urinary Tract Protein Demonstrates Antimicrobial Activity 1024 683 Lauren Dembeck
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A little-studied peptide found in the urinary tract is a potential biomarker for urinary tract infection risk and could be developed into a novel therapeutic against drug-resistant bacteria.  Researchers at Nationwide Children’s Hospital have demonstrated that an understudied protein expressed in the human kidney and bladder kills the bacteria that cause urinary tract infections (UTI).…

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Self-Administered Electronic Assessment Tool Helps Clinicians Screen for Pediatric Bleeding Disorders
 Self-Administered Electronic Assessment Tool Helps Clinicians Screen for Pediatric Bleeding Disorders 1024 684 JoAnna Pendergrass, DVM
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teen girl using cell phone

An electronic self-administered bleeding assessment tool is a time-saving measure to comprehensively evaluate a pediatric patient’s bleeding symptoms. Bleeding assessment tools (BATs), originally developed as research tools, are used clinically to comprehensively evaluate a patient’s bleeding symptoms. Along with clinical judgement, “BATs are used to discriminate between patients who do and do not have a…

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Novel Roles of the Urothelium in the Development of Congenital Anomalies of the Kidney and Urinary Tract
 Novel Roles of the Urothelium in the Development of Congenital Anomalies of the Kidney and Urinary Tract 150 150 Lauren Dembeck
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In addition to genetic defects, interactions of the developing urothelium with its underlying mesenchyme and superficial plaque may contribute to congenital anomalies of the kidney and urinary tract. Congenital anomalies of the kidney and urinary tract (CAKUTs) are the leading cause of chronic and end-stage kidney disease in children. Collaborative translational research at Nationwide Children’s…

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An Imbalance of Immune Cells Leads to Kidney Scarring After Infection
 An Imbalance of Immune Cells Leads to Kidney Scarring After Infection 1024 732 Mary Bates, PhD
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In a preclinical mouse model, researchers identify the immune cell balancing act that determines whether renal scarring will occur following kidney infection More than half of urinary tract infections in children spread from the bladder to the kidneys, causing acute kidney infections that can lead to renal scarring. Renal scarring can have serious repercussions in…

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What Are the Clinical Implications of Crescentic Glomerulonephritis?
 What Are the Clinical Implications of Crescentic Glomerulonephritis? 1024 732 Abbie Roth
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The Pediatric Nephrology Research Consortium’s most recent study investigates the risk factors for disease progression in children with glomerulonephritis and crescents on kidney biopsy. In patients with glomerulonephritis (GN), the histopathology of the kidney may include crescents, which result from extra-capillary proliferation of cells within the glomerulus. A recent study from the Pediatric Nephrology Research…

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Can a Kidney Failure Risk Equation Validated in Adults Predict Kidney Failure in Children?
 Can a Kidney Failure Risk Equation Validated in Adults Predict Kidney Failure in Children? 1024 575 Lauren Dembeck
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Novel disease-specific biomarkers are needed to improve prediction models in pediatric disease. Obstructive uropathy is a frequent cause of kidney injury in children, and it is estimated to cause approximately one-sixth of pediatric kidney failure cases in North America. However, risk equations to predict kidney disease progression have not yet been developed for children. To…

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Determining Ureteropelvic Junction Obstruction Surgical Success Using Biomarkers
 Determining Ureteropelvic Junction Obstruction Surgical Success Using Biomarkers 1024 575 Katie Brind'Amour, PhD, MS, CHES
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Biomarkers initially found to differ among patients with ureteropelvic junction obstruction and healthy controls may also objectively gauge post-surgical resolution of obstruction. A follow-up study of a trial that initially identified four biomarkers that differ between healthy controls and pediatric patients about to undergo surgery for ureteropelvic junction obstruction (UPJO) has confirmed that two of…

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Improving the Care and Management of Urinary Tract Infections Through Collaboration
 Improving the Care and Management of Urinary Tract Infections Through Collaboration 150 150 JoAnna Pendergrass, DVM
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The Urinary Tract Infection Global Alliance (UTIGA) is a new professional society that is dedicated to combatting the many challenges in UTI management and care through collaboration. With nearly 150 million people affected by urinary tract infections (UTIs) annually across the globe, UTIs are a major health problem. Both the term ‘UTI’ and the infection’s…

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Transforming Medical Science Through Research Affinity Groups
 Transforming Medical Science Through Research Affinity Groups 150 150 Katie Brind'Amour, PhD, MS, CHES
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Purposeful synergy drives the most meaningful medical science. Nephrology physician-scientists require tissue samples, urologists desire tests to know which patients truly require surgery, and basic scientists must find ways to meaningfully assess new animal models to yield clinically valuable data. If each of these professionals had a defined network of colleagues from the other disciplines…

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What is the Association Between Kidney Injury and Fluid Balance in Premature Newborns?
 What is the Association Between Kidney Injury and Fluid Balance in Premature Newborns? 1024 575 Mary Bates, PhD
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Nurse caring for infant in Neonatal Intensive Care Unit (NICU)

A positive fluid balance is associated with acute kidney injury and worse outcomes in a new study of premature infants. According to new research, there is an association between fluid balance and outcomes in preterm newborns, with a negative fluid balance during the first week of life emerging as a potential therapeutic target. Premature infants…

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In Defense Against Peritonitis, Antimicrobial Peptides May Help on Multiple Fronts
 In Defense Against Peritonitis, Antimicrobial Peptides May Help on Multiple Fronts 150 150 Kevin Mayhood
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Study suggests AMPs have potential as biomarkers for peritonitis, risk stratification and treatment. Antimicrobial peptides (AMPs) in the Ribonuclease A Superfamily exhibit distinct patterns when children and adults undergoing chronic peritoneal dialysis (PD) suffer from peritonitis, researchers have found. The findings, published in Scientific Reports, suggest that AMPs in peritoneal fluid are potentially useful as…

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RNase 7: Paving the Way for a Natural, Antibiotic-Free Treatment for Urinary Tract Infections
 RNase 7: Paving the Way for a Natural, Antibiotic-Free Treatment for Urinary Tract Infections 150 150 Katie Brind'Amour, PhD, MS, CHES
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The latest in the body of antimicrobial peptide research suggests RNase7 may be a useful prognostic marker and potential therapeutic option for UTIs. Building on their body of research focused on the naturally occurring antimicrobial peptides in the urinary tract, clinician-scientists at Nationwide Children’s Hospital have now confirmed the suspected role of Ribonuclease 7 (RNase…

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Largest Study of Glomerular Diseases Sheds Light on Pediatric Subtypes
 Largest Study of Glomerular Diseases Sheds Light on Pediatric Subtypes 150 150 Cyndie Trapasso
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In one of the first papers published from the largest study of glomerular diseases, researchers have found significant differences between patients who have IgA nephropathy and a subtype of the disease, IgA vasculitis, and between children and adults with these diagnoses. The paper is from Cure Glomerulonephropathy (CureGN) — a longitudinal observational study of nearly…

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Uroplakin Plaque Key to Protecting Kidney During Urinary Tract Obstruction
 Uroplakin Plaque Key to Protecting Kidney During Urinary Tract Obstruction 150 150 Kevin Mayhood
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Plaque appears to help remodel urothelium, allowing kidney to hold excess urine without damage, Urinary tract obstruction (UTO) is the leading cause of chronic kidney disease and end-stage renal disease in children. But the extent of damage caused by obstruction differs from child to child. Researchers at Nationwide Children’s Hospital studying why suggest that uroplakin…

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Lymphocyte Response After a Burn Predicts Infection
 Lymphocyte Response After a Burn Predicts Infection 150 150 Mary Bates, PhD
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Could Antimicrobial Peptides Be Biomarkers for Obstructive Uropathy?
 Could Antimicrobial Peptides Be Biomarkers for Obstructive Uropathy? 1024 683 Katie Brind'Amour, PhD, MS, CHES
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New research reveals the expression of antimicrobial peptides — long associated only with infections — in children with obstructive uropathy, creating the potential for a wide range of clinical applications. Previously only studied in the context of urinary tract and other infections, antimicrobial peptides (AMPs) — naturally occurring antibiotic molecules that our bodies may use…

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Is Whole Exome Sequencing the Future of Kidney Stone Management?
 Is Whole Exome Sequencing the Future of Kidney Stone Management? 150 150 Katie Brind'Amour, PhD, MS, CHES
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The first use of whole exome sequencing for monogenic causes of kidney stone disease reveals the diagnostic tool is ripe for clinical application. In the first-ever study of whole exome sequencing for early-onset kidney stone disease, an international team of researchers led by clinician-scientists at Boston Children’s Hospital expanded on their prior finding that many…

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Solving the Puzzle of Transfusion-Related Immune Reactions
 Solving the Puzzle of Transfusion-Related Immune Reactions 576 367 Katie Brind'Amour, PhD, MS, CHES
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Now that physicians have the “how” of blood transfusions mastered, they are starting to explore the “what” — and they’re learning that the effects of sharing human blood may be even more far-reaching and complex than previously imagined. With the initial safety challenges addressed and the technical barriers of donor blood storage and cleaning improved,…

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Immune Cell Subtype Tied to Asthma in Mice Found in Humans With Viral Infections
 Immune Cell Subtype Tied to Asthma in Mice Found in Humans With Viral Infections 969 533 Kevin Mayhood
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Illustration of NK Cells, T Cells, other immune cells floating across white background

If asthma development in people parallels mice, the cells’ mechanisms may provide a target for disease prevention. A subtype of neutrophil, labeled CD49d+ PMN, which is necessary to drive asthma and allergies in a mouse model, also accumulates in the nasal fluid of people with symptoms of an upper respiratory viral infection, researchers have discovered. Neutrophils are…

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Why Patients With Diabetes Have More UTIs
 Why Patients With Diabetes Have More UTIs 150 150 Mary Bates, PhD
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Insulin regulates an antimicrobial peptide that is suppressed in patients with diabetes. A recent study led by clinicians and researchers at Nationwide Children’s Hospital reports a potential explanation for why urinary tract infections (UTIs) are so common in patients with diabetes – insulin regulates an antimicrobial peptide (AMP) that is suppressed in those patients. Patients…

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Childhood Kidney Stones Associated With Atherosclerosis
 Childhood Kidney Stones Associated With Atherosclerosis 150 150 Katie Brind'Amour, PhD, MS, CHES
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Research could lead to early interventions to improve cardiovascular health. Kidney stones in children are increasingly common, and until recently were believed to be an isolated medical problem. But a study conducted by clinician-scientists at Nationwide Children’s Hospital has identified for the first time a significant association between kidney stones and atherosclerosis in children. Previous…

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Fighting Fibrosis
 Fighting Fibrosis 1024 575 Katie Brind'Amour, PhD, MS, CHES
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Colorful illustration showing how fibrosis, or a spiky lumpy mass of scar tissue, forms over healthy liver tissue when the liver attempts to repair and replace damaged cells

Fibrosis is an unmet medical challenge with no satisfactory test and insufficient therapy. Now, one naturally occurring cellular component could simultaneously diagnose and heal patients. It’s much more than a million-dollar idea. The person who invents a simple blood or urine test that can accurately measure the severity of scarring in internal organs will have…

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