Rhabdomyosarcoma

Unraveling the Role of Pioneer Factors in Childhood Cancer
Unraveling the Role of Pioneer Factors in Childhood Cancer 150 150 Abbie Roth

New study implicates PAX3-FOXO1, an oncogenic driver of rhabdomyosarcoma, as a chimeric pioneer factor. Transcription factors are proteins that read the DNA sequences and can direct the transcription of that sequence into mRNA for translation into a protein. Transcription can become deregulated in cancer. Normally, transcription factors read sequences of DNA that are described as…

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