Cellular Therapy and Cancer Immunotherapy

Modifying NK Cells With CRISPR/Cas9
Modifying NK Cells With CRISPR/Cas9 969 533 Mary Bates, PhD
Illustration of NK Cells, T Cells, other immune cells floating across white background

A proof-of-concept study shows success in modifying NK cells for multiple myeloma. In a new proof-of-concept study, researchers from Nationwide Children’s Hospital used CRISPR/Cas9 technology to genetically modify natural killer immune cells, which they then showed are able to address a recognized hurdle in immunotherapy of multiple myeloma. “It was an amazing feeling when we…

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Boosting Natural Killer Cells for the Treatment of COVID-19
Boosting Natural Killer Cells for the Treatment of COVID-19 150 150 Lauren Dembeck

Natural killer cells — critical for immune surveillance and host defense — have an important role in cancer immunotherapy and antiviral responses. While driving to the laboratory one day, Brian Tullius, MA, MD, a fourth-year bone marrow transplant and cell therapies fellow at Nationwide Children’s in the Lee Lab, had an epiphany. “I thought, ‘wait…

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What Could COVID-19 Mean for Pediatrics?
What Could COVID-19 Mean for Pediatrics? 1024 683 Abbie Roth

As COVID-19 spreads across the globe, experts are digging into the data and establishing protocols to better understand the illness in the context of pediatrics. As COVID-19, the illness caused by a novel coronavirus, has reached pandemic status, life has changed dramatically. At Nationwide Children’s Hospital, the halls are uncharacteristically quiet as a “stay at…

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From Natural Killer Cells to Virus-Specific T Cells: What’s Next in Cellular Therapy
From Natural Killer Cells to Virus-Specific T Cells: What’s Next in Cellular Therapy 969 533 Abbie Roth
Illustration of NK Cells, T Cells, other immune cells floating across white background

Harnessing the power of the immune system to overcome cancer, improve outcomes of bone marrow transplants and fight viral infections in immunocompromised pediatric patients is at the heart of cell therapy research.   Natural Killers in Action Natural killer (NK) cells are a component of the innate immune system that mediates the death of cancer…

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An Infant. A Virus. An Emergency IND. A Life Saved.
An Infant. A Virus. An Emergency IND. A Life Saved. 150 150 Abbie Roth

Clinician scientists collaborate to use virus-specific T-cells from the mother to successfully treat a systemic adenovirus infection in a preterm infant. It’s not every day that researchers can say that they’ve written and submitted and emergency investigational new drug (EIND) application to the Food & Drug Administration (FDA) and saved a life. But that’s what…

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Harnessing the Immune System: Has the Cure for Cancer Been Within Us All Along?
Harnessing the Immune System: Has the Cure for Cancer Been Within Us All Along? 1024 575 Abbie Roth

By learning to manipulate the immune system to target cancer cells, clinician-scientists are ushering in a new era in cancer treatments. The advances in cancer immunotherapy have been headline-making, and some clinical studies have produced stories of near-miraculous recoveries. From the immunotherapy drug credited with curing former president Jimmy Carter’s cancer (pembrolizumab) to the promising…

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