Bladder

Long-Term Bladder Management and Continence in Girls With Cloacal Malformation
Long-Term Bladder Management and Continence in Girls With Cloacal Malformation 1024 683 Pam Georgiana
Molly Fuchs, MD

New insights on outcomes and quality of life from Nationwide Children’s comprehensive study of pediatric patients. Over the last decade, surgical innovation has revolutionized the treatment of cloacal malformation, a congenital anomaly affecting the development of the gastrointestinal, urinary and reproductive systems in girls. This condition occurs when the rectum, vagina and urinary tracts fail…

Refining the Role of Basal Urothelial Cells in Bladder Development
Refining the Role of Basal Urothelial Cells in Bladder Development 1024 683 Jessica Nye, PhD

Basal keratin 5 urothelial cells (K5-UCs) were found to be age-restricted progenitors in bladders and their progenitor potential could be rescued by exogenous proliferative cues.   “The identity of the bladder urothelium progenitor is controversial and confounded by slow turnover, and a low mitotic index during homeostasis,” says Ashley R. Jackson, PhD, principal investigator in…